The metastasis-promoting roles of tumor-associated immune cells

The connection between lymphangiogenic signalling and prostaglandin biology: A missing link in the metastatic pathway

(2015) Tara Karnezis et al.   Oncotarget

Plasticity in Tumor-Promoting Inflammation: Impairment of Macrophage Recruitment Evokes a Compensatory Neutrophil Response

(2015) Jessica C. Pahler et al.   NEOPLASIA

B Lymphocytes Promote Lymphogenous Metastasis of Lymphoma and Melanoma

(2015) Alanna Ruddell et al.   NEOPLASIA

Neutrophils Promote Liver Metastasis via Mac-1–Mediated Interactions with Circulating Tumor Cells

(2012) Jonathan D. Spicer et al.   CANCER RESEARCH

Tumor-associated neutrophils: friend or foe?

(2012) Z. G. Fridlender et al.   CARCINOGENESIS

CCR2-Dependent Recruitment of Macrophages by Tumor-Educated Mesenchymal Stromal Cells Promotes Tumor Development and Is Mimicked by TNFα

(2012) Guangwen Ren et al.   Cell Stem Cell

CCL2 is critical for immunosuppression to promote cancer metastasis

(2012) Chie Kudo-Saito et al.   CLINICAL & EXPERIMENTAL METASTASIS

IDO Expression in Brain Tumors Increases the Recruitment of Regulatory T Cells and Negatively Impacts Survival

(2012) D. A. Wainwright et al.   CLINICAL CANCER RESEARCH

Helper T cell diversity and plasticity

(2012) Shingo Nakayamada et al.   CURRENT OPINION IN IMMUNOLOGY

Non-steroidal Anti-Inflammatory Drugs and Melanoma

(2012) Virginia Sanz-Motilva et al.   CURRENT PHARMACEUTICAL DESIGN

The pro-metastatic role of bone marrow-derived cells: a focus on MSCs and regulatory T cells

(2012) Bong Ihn Koh et al.   EMBO REPORTS

PGE2-Driven Induction and Maintenance of Cancer-Associated Myeloid-Derived Suppressor Cells

(2012) Nataša Obermajer et al.   IMMUNOLOGICAL INVESTIGATIONS

Tumor-Expressed Inducible Nitric Oxide Synthase Controls Induction of Functional Myeloid-Derived Suppressor Cells through Modulation of Vascular Endothelial Growth Factor Release

(2012) P. Jayaraman et al.   JOURNAL OF IMMUNOLOGY

PD-1 Blockade Augments Th1 and Th17 and Suppresses Th2 Responses in Peripheral Blood From Patients With Prostate and Advanced Melanoma Cancer

(2012) John Dulos et al.   JOURNAL OF IMMUNOTHERAPY

Immunomodulating antibodies in the treatment of metastatic melanoma: The experience with anti-CTLA-4, anti-CD137, and anti-PD1

(2012) Ester Simeone et al.   Journal of Immunotoxicology

Significance of IL-6 in the transition of hormone-resistant prostate cancer and the induction of myeloid-derived suppressor cells

(2012) Chun-Te Wu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Genomic Predictors of Outcome and Treatment Response in Breast Cancer

(2012) Lara Dunn et al.   Molecular Diagnosis & Therapy

Inflammation linking EMT and cancer stem cells

(2012) Chenchen Zhou et al.   ORAL ONCOLOGY

iNKT Cells Suppress the CD8+ T Cell Response to a Murine Burkitt’s-Like B Cell Lymphoma

(2012) Ryan L. Bjordahl et al.   PLoS One

TGF-β-induced epithelial-mesenchymal transition: A link between cancer and inflammation

(2012) Jonas Fuxe et al.   SEMINARS IN CANCER BIOLOGY

The split nature of tumor-infiltrating leukocytes

(2012) Telma Lança et al.   OncoImmunology

Know thy enemy

(2012) Andrea Facciabene et al.   OncoImmunology

Proangiogenic Tie2+ Macrophages Infiltrate Human and Murine Endometriotic Lesions and Dictate Their Growth in a Mouse Model of the Disease

(2011) Annalisa Capobianco et al.   AMERICAN JOURNAL OF PATHOLOGY

VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors

(2011) Xin Lu et al.   CANCER CELL

Macrophage Binding to Receptor VCAM-1 Transmits Survival Signals in Breast Cancer Cells that Invade the Lungs

(2011) Qing Chen et al.   CANCER CELL

Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

(2011) Myriam Labelle et al.   CANCER CELL

Tumor-Evoked Regulatory B Cells Promote Breast Cancer Metastasis by Converting Resting CD4+ T Cells to T-Regulatory Cells

(2011) P. B. Olkhanud et al.   CANCER RESEARCH

Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast

(2011) Christina Scheel et al.   CELL

Ipilimumab: An Anti-CTLA-4 Antibody for Metastatic Melanoma

(2011) E. J. Lipson et al.   CLINICAL CANCER RESEARCH

Roles of Metalloproteases in Metastatic Niche

(2011) N. Rucci et al.   CURRENT MOLECULAR MEDICINE

Chronic inflammation and immunologic-based constraints in malignant disease

(2011) Devin B Lowe et al.   Immunotherapy

Leukocytes as paracrine regulators of metastasis and determinants of organ-specific colonization

(2011) Neta Erez et al.   INTERNATIONAL JOURNAL OF CANCER

An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition

(2011) Philip A. Gregory et al.   MOLECULAR BIOLOGY OF THE CELL

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

(2011) Stephen J Galli et al.   NATURE IMMUNOLOGY

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

The secreted factors responsible for pre-metastatic niche formation: Old sayings and new thoughts

(2011) Héctor Peinado et al.   SEMINARS IN CANCER BIOLOGY

Mesenchymal Transition and Dissemination of Cancer Cells Is Driven by Myeloid-Derived Suppressor Cells Infiltrating the Primary Tumor

(2011) Benjamin Toh et al.   PLOS BIOLOGY

Complexity of tumor vasculature in clear cell renal cell carcinoma

(2010) Chao-Nan Qian et al.   CANCER

Why not treat human cancer with interleukin-1 blockade?

(2010) Charles A. Dinarello   CANCER AND METASTASIS REVIEWS

Hypoxia, inflammation, and the tumor microenvironment in metastatic disease

(2010) Elizabeth C. Finger et al.   CANCER AND METASTASIS REVIEWS

Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity

(2010) Suzanne Ostrand-Rosenberg   CANCER IMMUNOLOGY IMMUNOTHERAPY

NF-κB promotes epithelial–mesenchymal transition, migration and invasion of pancreatic carcinoma cells

(2010) Harald J. Maier et al.   CANCER LETTERS

Human Bone Marrow-Derived MSCs Can Home to Orthotopic Breast Cancer Tumors and Promote Bone Metastasis

(2010) R. H. Goldstein et al.   CANCER RESEARCH

Smad Signaling Is Required to Maintain Epigenetic Silencing during Breast Cancer Progression

(2010) P. Papageorgis et al.   CANCER RESEARCH

Gr-1+CD11b+ Myeloid Cells Tip the Balance of Immune Protection to Tumor Promotion in the Premetastatic Lung

(2010) H. H. Yan et al.   CANCER RESEARCH

Angiopoietin-2 Regulates Gene Expression in TIE2-Expressing Monocytes and Augments Their Inherent Proangiogenic Functions

(2010) S. B. Coffelt et al.   CANCER RESEARCH

Homeoprotein Six1 Increases TGF-  Type I Receptor and Converts TGF-  Signaling from Suppressive to Supportive for Tumor Growth

(2010) D. S. Micalizzi et al.   CANCER RESEARCH

Insulin-like growth factor-binding protein-3 promotes transforming growth factor-β1-mediated epithelial-to-mesenchymal transition and motility in transformed human esophageal cells

(2010) Mitsuteru Natsuizaka et al.   CARCINOGENESIS

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Involvement of NF-κB/miR-448 regulatory feedback loop in chemotherapy-induced epithelial–mesenchymal transition of breast cancer cells

(2010) Q-Q Li et al.   CELL DEATH AND DIFFERENTIATION

Interleukin-6 Increases Expression and Secretion of Cathepsin B by Breast Tumor-Associated Monocytes

(2010) Mona Mohamed et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Novel Bone-Targeted Strategies in Oncology

(2010) S. Vallet et al.   CLINICAL CANCER RESEARCH

Interleukin-6 in bone metastasis and cancer progression

(2010) Tasnim Ara et al.   EUROPEAN JOURNAL OF CANCER

Convergent pathways of macrophage polarization: The role of B cells

(2010) Antonio Sica et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion

(2010) V. Gocheva et al.   GENES & DEVELOPMENT

Tumor-Conditioned Macrophages Secrete Migration-Stimulating Factor: A New Marker for M2-Polarization, Influencing Tumor Cell Motility

(2010) G. Solinas et al.   JOURNAL OF IMMUNOLOGY

The platelet contribution to cancer progression

(2010) N. M. BAMBACE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Na,K-ATPase Subunits as Markers for Epithelial-Mesenchymal Transition in Cancer and Fibrosis

(2010) S. A. Rajasekaran et al.   MOLECULAR CANCER THERAPEUTICS

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

AZGP1 is a tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-β-mediated ERK signaling

(2010) B Kong et al.   ONCOGENE

Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice

(2010) L Sevenich et al.   ONCOGENE

Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas

(2010) J Braun et al.   ONCOGENE

Mast cells have a protumorigenic role in human thyroid cancer

(2010) R M Melillo et al.   ONCOGENE

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

(2010) A Singh et al.   ONCOGENE

Effect of classification based on combination of mutation and methylation in colorectal cancer prognosis

(2010) Iida   ONCOLOGY REPORTS

Annexin A1 regulates TGF-  signaling and promotes metastasis formation of basal-like breast cancer cells

(2010) M. de Graauw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concise Review: Dissecting a Discrepancy in the Literature: Do Mesenchymal Stem Cells Support or Suppress Tumor Growth?

(2010) Ann H. Klopp et al.   STEM CELLS

Evidence for a cross-talk between human neutrophils and Th17 cells

(2009) M. Pelletier et al.   BLOOD

Cancer Metastasis Is Accelerated through Immunosuppression during Snail-Induced EMT of Cancer Cells

(2009) Chie Kudo-Saito et al.   CANCER CELL

The Yin-Yang of Tumor-Associated Neutrophils

(2009) Alberto Mantovani   CANCER CELL

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

(2009) David G. DeNardo et al.   CANCER CELL

Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion

(2009) Yadi Wu et al.   CANCER CELL

Breast Cancer Lung Metastasis Requires Expression of Chemokine Receptor CCR4 and Regulatory T Cells

(2009) P. B. Olkhanud et al.   CANCER RESEARCH

Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome

(2009) M. Gobert et al.   CANCER RESEARCH

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Chemokine receptors CXCR4 and CCR7 promote metastasis by preventing anoikis in cancer cells

(2009) M Kochetkova et al.   CELL DEATH AND DIFFERENTIATION

Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

(2009) B. B. Aggarwal et al.   CLINICAL CANCER RESEARCH

Lymphocytes in cancer development: Polarization towards pro-tumor immunity

(2009) Brian Ruffell et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Inflammation and EMT: an alliance towards organ fibrosis and cancer progression

(2009) Jose Miguel López-Novoa et al.   EMBO Molecular Medicine

Chemokines and chemokine receptors: an overview

(2009) Raffaella Bonecchi   Frontiers in Bioscience-Landmark

Systemic inflammation increases cancer cell adhesion to hepatic sinusoids by neutrophil mediated mechanisms

(2009) Braedon McDonald et al.   INTERNATIONAL JOURNAL OF CANCER

Chemokine (C-C Motif) Ligand 2 Engages CCR2+Stromal Cells of Monocytic Origin to Promote Breast Cancer Metastasis to Lung and Bone

(2009) Xin Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TNF-α induces TGF-β1expression in lung fibroblasts at the transcriptional levelviaAP-1 activation

(2009) Deborah E. Sullivan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

EMT: When epithelial cells decide to become mesenchymal-like cells

(2009) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway

(2009) Lin Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

(2009) Shaoguang Wu et al.   NATURE MEDICINE

Anticancer strategies involving the vasculature

(2009) Victoria L. Heath et al.   Nature Reviews Clinical Oncology

An overview of small-molecule inhibitors of VEGFR signaling

(2009) S. Percy Ivy et al.   Nature Reviews Clinical Oncology

Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells

(2009) N J Sullivan et al.   ONCOGENE

Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction

(2009) S Baritaki et al.   ONCOGENE

Cancer Associated Fibroblasts Promote Tumor Growth and Metastasis by Modulating the Tumor Immune Microenvironment in a 4T1 Murine Breast Cancer Model

(2009) Debbie Liao et al.   PLoS One

Colitis-associated cancer: the role of T cells in tumor development

(2009) Maximilian J. Waldner et al.   Seminars in Immunopathology

Lymphatic Vessel Activation in Cancer

(2008) Suvendu Das et al.   Annals of the New York Academy of Sciences

VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma

(2008) B M Beckermann et al.   BRITISH JOURNAL OF CANCER

Systemic Spread Is an Early Step in Breast Cancer

(2008) Yves Hüsemann et al.   CANCER CELL

Tumor-Targeted Interferon-α Delivery by Tie2-Expressing Monocytes Inhibits Tumor Growth and Metastasis

(2008) Michele De Palma et al.   CANCER CELL

Altered TAB1:I B Kinase Interaction Promotes Transforming Growth Factor  -Mediated Nuclear Factor- B Activation during Breast Cancer Progression

(2008) J. R. Neil et al.   CANCER RESEARCH

The Chemokine Receptor CX3CR1 Is Involved in the Neural Tropism and Malignant Behavior of Pancreatic Ductal Adenocarcinoma

(2008) Federica Marchesi et al.   CANCER RESEARCH

TGFβ in Cancer

(2008) Joan Massagué   CELL

Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization

(2008) Daniel P. Fitzgerald et al.   CLINICAL & EXPERIMENTAL METASTASIS

Antimetastatic Effect of an Orally Active Heparin Derivative on Experimentally Induced Metastasis

(2008) D. Y. Lee et al.   CLINICAL CANCER RESEARCH

Immune surveillance: a balance between protumor and antitumor immunity

(2008) Suzanne Ostrand-Rosenberg   CURRENT OPINION IN GENETICS & DEVELOPMENT

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

(2008) Ulrike Burk et al.   EMBO REPORTS

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

(2008) S.-M. Park et al.   GENES & DEVELOPMENT

Twist Is Transcriptionally Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function

(2008) George Z. Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional RepressorsZEB1andZEB2

(2008) Manav Korpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stat3 mediates myeloid cell–dependent tumor angiogenesis in mice

(2008) Maciej Kujawski et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-155 Is Regulated by the Transforming Growth Factor  /Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA

(2008) W. Kong et al.   MOLECULAR AND CELLULAR BIOLOGY

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase

(2008) Sachie Hiratsuka et al.   NATURE CELL BIOLOGY

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY

Transcriptional regulation of cell polarity in EMT and cancer

(2008) G Moreno-Bueno et al.   ONCOGENE

Mesenchymal Stem Cells in Cancer

(2008) John Stagg   Stem Cell Reviews and Reports

The Anti-Inflammatory and Anti-Angiogenic Role of Mesenchymal Stem Cells in Corneal Wound Healing Following Chemical Injury

(2008) Joo Youn Oh et al.   STEM CELLS