Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD
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Title
Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD
Authors
Keywords
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Journal
Nature Reviews Gastroenterology & Hepatology
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2017-08-30
DOI
10.1038/nrgastro.2017.101
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Note: Only part of the references are listed.- Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis
- (2017) Sophie Van Welden et al. JOURNAL OF PATHOLOGY
- A Novel Hypoxia-Inducible Factor−Prolyl Hydroxylase Inhibitor (GSK1278863) for Anemia in CKD: A 28-Day, Phase 2A Randomized Trial
- (2016) Richard A. Brigandi et al. AMERICAN JOURNAL OF KIDNEY DISEASES
- Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-β1 signaling
- (2016) Mario C. Manresa et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche
- (2016) David Clever et al. CELL
- Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism
- (2016) Annelies Quaegebeur et al. Cell Metabolism
- Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2αCLINICAL PERSPECTIVE
- (2016) Zhiyu Dai et al. CIRCULATION
- Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat (FG-4592) for the Treatment of Anemia in Patients with CKD
- (2016) R. Provenzano et al. Clinical Journal of the American Society of Nephrology
- Immunosuppressive activities of adenosine in cancer
- (2016) Bertrand Allard et al. CURRENT OPINION IN PHARMACOLOGY
- Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease
- (2016) Pablo E. Pergola et al. KIDNEY INTERNATIONAL
- The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice
- (2016) Pinelopi P. Kapitsinou et al. MOLECULAR AND CELLULAR BIOLOGY
- PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages
- (2016) Annemarie Guentsch et al. MOLECULAR AND CELLULAR BIOLOGY
- Prolyl hydroxylase 3 (PHD3) expression augments the development of regulatory T cells
- (2016) Yogesh Singh et al. MOLECULAR IMMUNOLOGY
- Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system
- (2016) Sung Hoon Cho et al. NATURE
- Role of hypoxia-inducible factor-1α in pathogenesis and disease evaluation of ulcerative colitis
- (2016) CHUNMEI XU et al. Experimental and Therapeutic Medicine
- Prolyl hydroxylase 2 (PHD2) inhibition protects human renal epithelial cells and mice kidney from hypoxia injury
- (2016) Yi Fang et al. Oncotarget
- Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling
- (2016) Shuo Wang et al. Oncotarget
- The Dual Role of Neutrophils in Inflammatory Bowel Diseases
- (2016) Odile Wéra et al. Journal of Clinical Medicine
- Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function
- (2015) Caleb J. Kelly et al. Cell Host & Microbe
- Lipophilic modification enhances anti-colitic properties of rosmarinic acid by potentiating its HIF-prolyl hydroxylases inhibitory activity
- (2015) Seongkeun Jeong et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Oral Delivery of Prolyl Hydroxylase Inhibitor
- (2015) Ellen Marks et al. INFLAMMATORY BOWEL DISEASES
- The role of hypoxia in inflammatory disease (Review)
- (2015) JOHN BIDDLESTONE et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- PHD3 Stabilizes the Tight Junction Protein Occludin and Protects Intestinal Epithelial Barrier Function
- (2015) Ying Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis
- (2015) Murtaza M. Tambuwala et al. JOURNAL OF CONTROLLED RELEASE
- Cutting Edge: Hypoxia-Inducible Factor 1 Negatively Regulates Th1 Function
- (2015) Hussein Shehade et al. JOURNAL OF IMMUNOLOGY
- Hypoxia-Inducible Factor-2 Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury
- (2015) J. Zhang et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity
- (2015) Bejan J. Saeedi et al. MOLECULAR BIOLOGY OF THE CELL
- Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis
- (2015) C M Aherne et al. Mucosal Immunology
- Hypoxia-inducible factor 1 in dendritic cells is crucial for the activation of protective regulatory T cells in murine colitis
- (2015) K Flück et al. Mucosal Immunology
- Adenosine Receptor 2A Blockade Increases the Efficacy of Anti–PD-1 through Enhanced Antitumor T-cell Responses
- (2015) Paul A. Beavis et al. Cancer Immunology Research
- Activation of HIF-1α does not increase intestinal tumorigenesis
- (2014) Xiang Xue et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation
- (2014) Eric L. Campbell et al. IMMUNITY
- Prevalence of Anemia in Inflammatory Bowel Diseases in European Countries
- (2014) Natalie Filmann et al. INFLAMMATORY BOWEL DISEASES
- Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions
- (2014) Lija Swain et al. JOURNAL OF LEUKOCYTE BIOLOGY
- The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis
- (2014) Marco Genua et al. Journal of Translational Medicine
- Hypoxia-Inducible Factor/MAZ-Dependent Induction of Caveolin-1 Regulates Colon Permeability through Suppression of Occludin, Leading to Hypoxia-Induced Inflammation
- (2014) Liwei Xie et al. MOLECULAR AND CELLULAR BIOLOGY
- The Role of Macrophage Polarization in Infectious and Inflammatory Diseases
- (2014) Adam C. Labonte et al. MOLECULES AND CELLS
- PHD Inhibition Mitigates and Protects Against Radiation-Induced Gastrointestinal Toxicity via HIF2
- (2014) C. M. Taniguchi et al. Science Translational Medicine
- Role of hypoxia inducible factor-1α for interferon synthesis in mouse dendritic cells
- (2013) Regina Wobben et al. BIOLOGICAL CHEMISTRY
- Hypoxia-inducible factor 2 regulates key neutrophil functions in humans, mice, and zebrafish
- (2013) A. A. R. Thompson et al. BLOOD
- Noninvasive Monitoring of Small Intestinal Oxygen in a Rat Model of Chronic Mesenteric Ischemia
- (2013) Elaine M. Fisher et al. CELL BIOCHEMISTRY AND BIOPHYSICS
- Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs
- (2013) B. Allard et al. CLINICAL CANCER RESEARCH
- Endothelial PAS Domain Protein 1 Activates the Inflammatory Response in the Intestinal Epithelium to Promote Colitis in Mice
- (2013) Xiang Xue et al. GASTROENTEROLOGY
- Risk of Colorectal High-Grade Dysplasia and Cancer in a Prospective Observational Cohort of Patients With Inflammatory Bowel Disease
- (2013) Laurent Beaugerie et al. GASTROENTEROLOGY
- Iron Deficiency Generates Secondary Thrombocytosis and Platelet Activation in IBD
- (2013) Stefanie Kulnigg-Dabsch et al. INFLAMMATORY BOWEL DISEASES
- Loss of prolyl hydroxylase-2 in myeloid cells and T-lymphocytes impairs tumor development
- (2013) Soulafa Mamlouk et al. INTERNATIONAL JOURNAL OF CANCER
- Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by InducingP4HA1, P4HA2,andPLOD2Expression in Fibroblasts
- (2013) Daniele M. Gilkes et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A dynamic model of the hypoxia-inducible factor 1 (HIF-1 ) network
- (2013) L. K. Nguyen et al. JOURNAL OF CELL SCIENCE
- Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn’s disease/infectious colitis and healthy controls
- (2013) Sophie Van Welden et al. Journal of Inflammation-London
- Loss of Epithelial Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Accelerates Skin Wound Healing in Mice
- (2013) Joanna Kalucka et al. MOLECULAR AND CELLULAR BIOLOGY
- EGLN3 Inhibition of NF- B Is Mediated by Prolyl Hydroxylase-Independent Inhibition of I B Kinase Ubiquitination
- (2013) J. Fu et al. MOLECULAR AND CELLULAR BIOLOGY
- Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis
- (2013) S Keely et al. Mucosal Immunology
- Fundamental role for HIF-1α in constitutive expression of human β defensin-1
- (2013) C J Kelly et al. Mucosal Immunology
- Regulation of IL-1 -induced NF- B by hydroxylases links key hypoxic and inflammatory signaling pathways
- (2013) C. C. Scholz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis
- (2013) L. E. Glover et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Deletion of Phd2 in Myeloid Lineage Attenuates Hypertensive Cardiovascular Remodeling
- (2013) Jiro Ikeda et al. Journal of the American Heart Association
- Treatment with a Novel Hypoxia-Inducible Factor Hydroxylase Inhibitor (TRC160334) Ameliorates Ischemic Acute Kidney Injury
- (2012) Prashant Jamadarkhana et al. AMERICAN JOURNAL OF NEPHROLOGY
- Lactic Acid Is Elevated in Idiopathic Pulmonary Fibrosis and Induces Myofibroblast Differentiation via pH-Dependent Activation of Transforming Growth Factor-β
- (2012) Robert Matthew Kottmann et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Gene-Targeting of Phd2 Improves Tumor Response to Chemotherapy and Prevents Side-Toxicity
- (2012) Rodrigo Leite de Oliveira et al. CANCER CELL
- Hypoxia-Inducible Factor-2 Activation Promotes Colorectal Cancer Progression by Dysregulating Iron Homeostasis
- (2012) X. Xue et al. CANCER RESEARCH
- Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration
- (2012) Theresa Köhler et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- NF- B, the first quarter-century: remarkable progress and outstanding questions
- (2012) M. S. Hayden et al. GENES & DEVELOPMENT
- The hypoxic environment reprograms the cytokine/chemokine expression profile of human mature dendritic cells
- (2012) Fabiola Blengio et al. IMMUNOBIOLOGY
- Stabilization of HIF-2 Induces sVEGFR-1 Production from Tumor-Associated Macrophages and Decreases Tumor Growth in a Murine Melanoma Model
- (2012) J. M. Roda et al. JOURNAL OF IMMUNOLOGY
- The Prolyl Hydroxylase PHD3 Identifies Proinflammatory Macrophages and Its Expression Is Regulated by Activin A
- (2012) M. M. Escribese et al. JOURNAL OF IMMUNOLOGY
- Loss of the Oxygen Sensor PHD3 Enhances the Innate Immune Response to Abdominal Sepsis
- (2012) J. Kiss et al. JOURNAL OF IMMUNOLOGY
- HIF-1 in T cells ameliorated dextran sodium sulfate-induced murine colitis
- (2012) Masaaki Higashiyama et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function
- (2012) Laura E. Crotty Alexander et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection
- (2012) Cheryl Y. M. Okumura et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Involvement of Hypoxia-Inducible Factor-1 in the Inflammatory Responses of Human LAD2 Mast Cells and Basophils
- (2012) Vadim V. Sumbayev et al. PLoS One
- Effect of Iron Therapy on Platelet Counts in Patients with Inflammatory Bowel Disease-Associated Anemia
- (2012) Stefanie Kulnigg-Dabsch et al. PLoS One
- Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
- (2012) E. T. Clambey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
- (2011) Eric V. Dang et al. CELL
- HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia
- (2011) Thomas Hackenbeck et al. CELL CYCLE
- Hypoxia affects dendritic cell survival: Role of the hypoxia-inducible factor-1α and lipopolysaccharide
- (2011) Antonella Naldini et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
- (2011) Sarah R. Walmsley et al. JOURNAL OF CLINICAL INVESTIGATION
- Hypoxia-Inducible Factor-1α–Dependent Protection from Intestinal Ischemia/Reperfusion Injury Involves Ecto-5′-Nucleotidase (CD73) and the A2B Adenosine Receptor
- (2011) Melanie L. Hart et al. JOURNAL OF IMMUNOLOGY
- Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis
- (2011) Yukiji Takeda et al. NATURE
- Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo
- (2010) M. C. Bosco et al. BLOOD
- The role of the macrophage in sentinel responses in intestinal immunity
- (2010) Shehzad Z Sheikh et al. CURRENT OPINION IN GASTROENTEROLOGY
- Structural studies on human 2-oxoglutarate dependent oxygenases
- (2010) Michael A McDonough et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Hypoxia-Inducible Factor Signaling Provides Protection in Clostridium difficile-Induced Intestinal Injury
- (2010) Simon A. Hirota et al. GASTROENTEROLOGY
- Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function
- (2010) Murtaza M. Tambuwala et al. GASTROENTEROLOGY
- Differential activation and antagonistic function of HIF- isoforms in macrophages are essential for NO homeostasis
- (2010) N. Takeda et al. GENES & DEVELOPMENT
- Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation
- (2010) Hongxia Z. Imtiyaz et al. JOURNAL OF CLINICAL INVESTIGATION
- An Intact Canonical NF- B Pathway Is Required for Inflammatory Gene Expression in Response to Hypoxia
- (2010) S. F. Fitzpatrick et al. JOURNAL OF IMMUNOLOGY
- Hydroxylase Inhibition Abrogates TNF- -Induced Intestinal Epithelial Damage by Hypoxia-Inducible Factor-1-Dependent Repression of FADD
- (2010) P. Hindryckx et al. JOURNAL OF IMMUNOLOGY
- Absence of placental growth factor blocks dextran sodium sulfate-induced colonic mucosal angiogenesis, increases mucosal hypoxia and aggravates acute colonic injury
- (2010) Pieter Hindryckx et al. LABORATORY INVESTIGATION
- Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction
- (2010) Amaya Ortiz-Barahona et al. NUCLEIC ACIDS RESEARCH
- Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis
- (2010) J. Stagg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases
- (2010) Christoph Loenarz et al. TRENDS IN BIOCHEMICAL SCIENCES
- Reduced liver fibrosis in hypoxia-inducible factor-1α-deficient mice
- (2009) Jeon-OK Moon et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- The Role of NF-κB in Hypoxia-Induced Gene Expression
- (2009) Cormac T. Taylor et al. Annals of the New York Academy of Sciences
- Hypoxia Activates NF-κB–Dependent Gene Expression Through the Canonical Signaling Pathway
- (2009) Kathryn M. Oliver et al. ANTIOXIDANTS & REDOX SIGNALING
- Inhibition of Prolyl Hydroxylase Domain-Containing Protein Suppressed Lipopolysaccharide-Induced TNF-α Expression
- (2009) Kotaro Takeda et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization
- (2009) Massimiliano Mazzone et al. CELL
- Prolyl Hydroxylase-3 Is Down-regulated in Colorectal Cancer Cells and Inhibits IKKβ Independent of Hydroxylase Activity
- (2009) Jing Xue et al. GASTROENTEROLOGY
- Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor
- (2009) So Young Kim et al. IMMUNOLOGY
- Inflammatory bowel disease
- (2009) Hideo Yoshida et al. INFLAMMATORY BOWEL DISEASES
- Contribution of Adenosine A2B Receptors to Inflammatory Parameters of Experimental Colitis
- (2009) J.-S. Frick et al. JOURNAL OF IMMUNOLOGY
- Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia
- (2009) Peter Rosenberger et al. NATURE IMMUNOLOGY
- Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
- (2009) Peter Fraisl et al. NATURE REVIEWS DRUG DISCOVERY
- Colitis-associated cancer: the role of T cells in tumor development
- (2009) Maximilian J. Waldner et al. Seminars in Immunopathology
- Regulation of hypoxia-inducible factor-1α by NF-κB
- (2008) Patrick van Uden et al. BIOCHEMICAL JOURNAL
- HIF-1 regulates epithelial inflammation by cell autonomous NF B activation and paracrine stromal remodeling
- (2008) M. Scortegagna et al. BLOOD
- The human oxygen sensing machinery and its manipulation
- (2008) Rasheduzzaman Chowdhury et al. CHEMICAL SOCIETY REVIEWS
- Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1α
- (2008) Jeremy Ben-Shoshan et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Hypoxia-Inducible Factor Augments Experimental Colitis Through an MIF–Dependent Inflammatory Signaling Cascade
- (2008) Yatrik M. Shah et al. GASTROENTEROLOGY
- VEGF-A Links Angiogenesis and Inflammation in Inflammatory Bowel Disease Pathogenesis
- (2008) Franco Scaldaferri et al. GASTROENTEROLOGY
- Hypoxia-Inducible Factor–Dependent Repression of Equilibrative Nucleoside Transporter 2 Attenuates Mucosal Inflammation During Intestinal Hypoxia
- (2008) Julio C. Morote–Garcia et al. GASTROENTEROLOGY
- Enhancement of Angiogenesis Through Stabilization of Hypoxia-inducible Factor-1 by Silencing Prolyl Hydroxylase Domain-2 Gene
- (2008) Shourong Wu et al. MOLECULAR THERAPY
- NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
- (2008) Jordi Rius et al. NATURE
- Opposing functions of IKK during acute and chronic intestinal inflammation
- (2008) L. Eckmann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis
- (2007) Eoin P. Cummins et al. GASTROENTEROLOGY
- Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition
- (2007) Andreas Robinson et al. GASTROENTEROLOGY
- Hypoxia-induced IL-18 Increases Hypoxia-inducible Factor-1α Expression through a Rac1-dependent NF-κB Pathway
- (2007) Jeongki Kim et al. MOLECULAR BIOLOGY OF THE CELL
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