Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-β1 signaling

Stabilization of Hypoxia-inducible Factor by DMOG Inhibits Development of Chronic Hypoxia–Induced Right Ventricular Remodeling

(2016) Sen Zhang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Persistent or Recurrent Anemia Is Associated With Severe and Disabling Inflammatory Bowel Disease

(2015) Ioannis E. Koutroubakis et al.   Clinical Gastroenterology and Hepatology

Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis

(2015) Murtaza M. Tambuwala et al.   JOURNAL OF CONTROLLED RELEASE

Four-Week Studies of Oral Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor GSK1278863 for Treatment of Anemia

(2015) L. Holdstock et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Roxadustat (FG-4592): Correction of Anemia in Incident Dialysis Patients

(2015) A. Besarab et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hypoxia/HIF1α induces lapatinib resistance in ERBB2-positive breast cancer cells via regulation of DUSP2

(2015) Sergey V. Karakashev et al.   Oncotarget

Hypoxia-sensitive pathways in inflammation-driven fibrosis

(2014) Mario C. Manresa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Fibrosis in Ulcerative Colitis

(2014) Ilyssa O. Gordon et al.   INFLAMMATORY BOWEL DISEASES

Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury

(2014) Pinelopi P. Kapitsinou et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of HIF prolyl-4-hydroxylases by FG-4497 Reduces Brain Tissue Injury and Edema Formation during Ischemic Stroke

(2014) Stefan Reischl et al.   PLoS One

Epidermal or Dermal Specific Knockout of PHD-2 Enhances Wound Healing and Minimizes Ischemic Injury

(2014) Andrew S. Zimmermann et al.   PLoS One

Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis

(2013) Dimitrios C. Ziogas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A dynamic model of the hypoxia-inducible factor 1  (HIF-1 ) network

(2013) L. K. Nguyen et al.   JOURNAL OF CELL SCIENCE

Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn’s disease/infectious colitis and healthy controls

(2013) Sophie Van Welden et al.   Journal of Inflammation-London

Hydroxylases as therapeutic targets in inflammatory bowel disease

(2013) Eoin P Cummins et al.   LABORATORY INVESTIGATION

Loss of Epithelial Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Accelerates Skin Wound Healing in Mice

(2013) Joanna Kalucka et al.   MOLECULAR AND CELLULAR BIOLOGY

The Natural Inhibitor of DNA Topoisomerase I, Camptothecin, Modulates HIF-1  Activity by Changing miR Expression Patterns in Human Cancer Cells

(2013) D. Bertozzi et al.   MOLECULAR CANCER THERAPEUTICS

Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis

(2013) S Keely et al.   Mucosal Immunology

Wound Healing Improvement with PHD-2 Silenced Fibroblasts in Diabetic Mice

(2013) Xiongliang Zhang et al.   PLoS One

Regulation of IL-1 -induced NF- B by hydroxylases links key hypoxic and inflammatory signaling pathways

(2013) C. C. Scholz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simvastatin attenuates the development of pulmonary and cutaneous fibrosis in a murine model of systemic sclerosis

(2013) G. Bagnato et al.   RHEUMATOLOGY

TGF-β1 and hypoxia-dependent expression of MKP-1 leads tumor resistance to death receptor-mediated cell death

(2013) J Park et al.   Cell Death & Disease

Hypoxia and Integrin-Mediated Epithelial Restitution during Mucosal Inflammation

(2013) Bridie J. Goggins et al.   Frontiers in Immunology

Sequential expression of IGF-IB followed by active TGF-β1 induces synergistic pulmonary fibroproliferation in vivo

(2012) Graciela Andonegui et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

(2012) Fanli Meng et al.   GASTROENTEROLOGY

Loss of the Oxygen Sensor PHD3 Enhances the Innate Immune Response to Abdominal Sepsis

(2012) J. Kiss et al.   JOURNAL OF IMMUNOLOGY

Irsogladine maleate ameliorates inflammation and fibrosis in mice with chronic colitis induced by dextran sulfate sodium

(2012) Hana Yamaguchi et al.   Medical Molecular Morphology

Mucosal Healing and Fibrosis after Acute or Chronic Inflammation in Wild Type FVB-N Mice and C57BL6 Procollagen α1(I)-Promoter-GFP Reporter Mice

(2012) Shengli Ding et al.   PLoS One

TGF-Beta Induced Erk Phosphorylation of Smad Linker Region Regulates Smad Signaling

(2012) Chris Hough et al.   PLoS One

TGF-β Signaling via TAK1 Pathway: Role in Kidney Fibrosis

(2012) Mary E. Choi et al.   SEMINARS IN NEPHROLOGY

Fluorofenidone Attenuates Tubulointerstitial Fibrosis by Inhibiting TGF-β1-Induced Fibroblast Activation

(2011) Qiongjing Yuan et al.   AMERICAN JOURNAL OF NEPHROLOGY

Themes in fibrosis and gastrointestinal inflammation

(2011) Claudio Fiocchi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Interleukin-17A stimulates cardiac fibroblast proliferation and migration via negative regulation of the dual-specificity phosphatase MKP-1/DUSP-1

(2011) Anthony J. Valente et al.   CELLULAR SIGNALLING

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

TGF-β signaling in fibrosis

(2011) Anna Biernacka et al.   GROWTH FACTORS

Deletion of the Dual Specific Phosphatase-4 (DUSP-4) Gene Reveals an Essential Non-redundant Role for MAP Kinase Phosphatase-2 (MKP-2) in Proliferation and Cell Survival

(2011) Ahmed Lawan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological Characterization of 1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic Acid (JNJ-42041935), a Potent and Selective Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor

(2011) T. D. Barrett et al.   MOLECULAR PHARMACOLOGY

Genetic and pharmacological targeting of TPL-2 kinase ameliorates experimental colitis: a potential target for the treatment of Crohn's disease?

(2011) M Lawrenz et al.   Mucosal Immunology

Transient hypoxia-inducible factor activation in rat renal ablation and reduced fibrosis with L-mimosine

(2011) XIAOFANG YU et al.   NEPHROLOGY

Analysis of intestinal fibrosis in chronic colitis in mice induced by dextran sulfate sodium

(2011) Kenji Suzuki et al.   PATHOLOGY INTERNATIONAL

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia

(2010) P. P. Kapitsinou et al.   BLOOD

Smad linker region phosphorylation in the regulation of extracellular matrix synthesis

(2010) Micah L. Burch et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function

(2010) Murtaza M. Tambuwala et al.   GASTROENTEROLOGY

Post-transcriptional regulation of the DUSP6/MKP-3 phosphatase by MEK/ERK signaling and hypoxia

(2010) Olga Bermudez et al.   JOURNAL OF CELLULAR PHYSIOLOGY

An Intact Canonical NF- B Pathway Is Required for Inflammatory Gene Expression in Response to Hypoxia

(2010) S. F. Fitzpatrick et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD

(2010) W. M. Bernhardt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inhibition of Hypoxia-Inducible Factor-1α (HIF-1α) Protein Synthesis by DNA Damage Inducing Agents

(2010) Jessica Jie Wei Lou et al.   PLoS One

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

Modulation of Hepatic Fibrosis by c-Jun-N-Terminal Kinase Inhibition

(2009) Johannes Kluwe et al.   GASTROENTEROLOGY

Transforming growth factor   signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures

(2009) A Di Sabatino et al.   GUT

Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney

(2009) Y. R. Song et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Hypoxia. Regulation of NFκB signalling during inflammation: the role of hydroxylases

(2009) Kathryn M Oliver et al.   ARTHRITIS RESEARCH & THERAPY

Intestinal fibrosis in inflammatory bowel disease — Current knowledge and future perspectives

(2008) Florian Rieder et al.   Journal of Crohns & Colitis

TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β

(2008) Motozo Yamashita et al.   MOLECULAR CELL

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

(2007) Eoin P. Cummins et al.   GASTROENTEROLOGY

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

(2007) Andreas Robinson et al.   GASTROENTEROLOGY