Article
Biochemistry & Molecular Biology
Ying Jin, Yamu Pan, Shuang Zheng, Yao Liu, Jie Xu, Yazhi Peng, Zemei Zhang, Yadong Wang, Yulian Xiong, Lei Xu, Kaiyu Mu, Suwen Chen, Fei Zheng, Ye Yuan, Jian Fu
Summary: This study reveals the important role of EGLN3 in cancer growth, particularly in lung cancer. EGLN3 catalyzes the hydroxylation of Erk3, stabilizing it and enhancing cancer growth. Inactivation of EGLN3 can suppress tumor growth by reprogramming the tumor microenvironment.
Article
Biochemistry & Molecular Biology
Qiang Gu, Ying-Bin Xiao, Yong Wang
Summary: In hypoxic cardiomyocytes, silencing of SOCS3 induces apoptosis of H9c2 cells by regulating apoptosis-associated gene expression, possibly through activation of the p-STAT3/NF-kappa B signaling pathway under hypoxic conditions.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Cell Biology
Yoshinori Aoki, Hongmei Dai, Fumika Furuta, Tomohisa Akamatsu, Takuya Oshima, Naoto Takahashi, Yu-ichi Goto, Akira Oka, Masayuki Itoh
Summary: Microglial cells have an important role in the brain's immune system. LOX-1 expression was confirmed in microglial cells in the neonatal hypoxic-ischemic encephalopathy model brain. LOX-1 activates cytokines and chemokines through intracellular pathways. This study investigated the role and molecular mechanism of LOX-1 gene transcription in microglial cells under hypoxic and ischemic conditions.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Pharmacology & Pharmacy
Zengxin Jiang, Guobin Qi, Wei Lu, Hao Wang, Defang Li, Weibin Chen, Lei Ding, Xiuying Yang, Hengfeng Yuan, Qingmin Zeng
Summary: This study found that omaveloxolone exerts antioxidative, anti-inflammatory, antiapoptotic and anti-ECM degradation effects via activation of the Nrf2/ARE signaling pathway and inhibition of the NF-kappa B signaling pathway in chondrocytes in vitro and attenuates osteoarthritis progression in vivo, suggesting its potential as a therapeutic agent for OA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Jasper A. F. Demandt, Kim van Kuijk, Thomas L. Theelen, Elke Marsch, Sean P. Heffron, Edward A. Fisher, Peter Carmeliet, Erik A. L. Biessen, Judith C. Sluimer
Summary: The study found that whole-body PHD3 knockout led to an unfavorable lipid profile and increased hematocrit compared to other PHD isoforms, yet did not alter the development of atherosclerotic plaques.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Ana Garcia-del Rio, Endika Prieto-Fernandez, Leire Egia-Mendikute, Asier Antonana-Vildosola, Borja Jimenez-Lasheras, So Young Lee, Adrian Barreira-Manrique, Samanta Romina Zanetti, Ander de Blas, Paloma Velasco-Beltran, Alexandre Bosch, Ana M. Aransay, Asis Palazon
Summary: Factor-inhibiting HIF (FIH) is an asparagine hydroxylase expressed in tumors, and its deletion may lead to increased metabolism, decreased proliferation, and increased immune infiltration in cancer cells.
Article
Biochemistry & Molecular Biology
So-Ra Kim, Kyung-Joo Seong, Won-Jae Kim, Ji-Yeon Jung
Summary: EGCG protects microglia from hypoxia-induced inflammation and oxidative stress through inhibition of the NF-κB pathway and activation of the Nrf-2/HO-1 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Courtney A. Copeland, Benjamin A. Olenchock, David Ziehr, Sarah McGarrity, Kevin Leahy, Jamey D. Young, Joseph Loscalzo, William M. Oldham
Summary: The study found that hypoxia decreased glycolysis despite HIF-1 alpha activation, and identified a critical role for MYC in modulating HIF-1 alpha responses to hypoxia. Overall, the research contributes to understanding the role of HIF and cellular metabolism in pulmonary hypertension.
Article
Immunology
Shouye Hu, Yanqi Li, Bo Wang, Kan Peng
Summary: The study showed that TRIM38 can alleviate IL-1 beta-induced apoptosis and degeneration of chondrocytes by suppressing the NF-kappa B signaling pathway. This work suggests a potential role of TRIM38 in osteoarthritis and proposes it as a new therapeutic target for the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Eleanor Hay, Louise C. Wilson, Bethan Hoskins, Martin Samuels, Pinki Munot, Shamima Rahman
Summary: This study reports a patient with HIDEA syndrome, characterized by various symptoms including congenital hypotonia, central hypoventilation, intellectual disability, etc., who died at 7 months of age. Biallelic predicted truncating variants in the P4HTM gene were identified, indicating a possible association with the disease. Further investigations suggest that HIDEA syndrome may represent a primary mitochondrial disorder.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Urology & Nephrology
Jun-Yu Wei, Miao-Yue Hu, Xiu-Qi Chen, Feng-Ying Lei, Jin-Shuang Wei, Jie Chen, Xuan-Kai Qin, Yuan-Han Qin
Summary: The study found that rosiglitazone can alleviate hypoxia renal injury by inhibiting the activation of the NF-κB signaling pathway, increasing Bcl-2 expression, and decreasing Bax expression. These findings are of great significance for a deeper understanding of the pathophysiology of kidney diseases and exploring new therapeutic approaches.
Article
Biochemistry & Molecular Biology
Angel Gallego-Selles, Victor Galvan-Alvarez, Miriam Martinez-Canton, Eduardo Garcia-Gonzalez, David Morales-Alamo, Alfredo Santana, Juan Jose Gonzalez-Henriquez, Cecilia Dorado, Jose A. L. Calbet, Marcos Martin-Rincon
Summary: The NF-kappa B signaling pathway plays a critical role in various biological processes and can be activated during exercise. This study demonstrates that exercising to exhaustion activates NF-kappa B signaling in human skeletal muscle, and the regulation of this pathway is influenced by metabolite accumulation and oxygen levels. These findings have important implications for the interpretation of previous studies and the design of future experiments.
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Article
Cell Biology
Chenchen Zhou, Xueli Zhang, Cuiping Yang, Yuan He, Luo Zhang
Summary: The study reveals that PLEKHO2 acts as a novel inhibitor of apoptosis and necroptosis, playing a key role in regulating RIPK1 ubiquitination and activation. PLEKHO2 deficiency increases cell susceptibility to TNF-alpha induced apoptosis and necroptosis, affecting RIPK1 activation and NF-kappa B activation. Deficiency in PLEKHO2 leads to enhanced hepatotoxicity and lethality in mice after TNF alpha-induced hepatitis.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Aneri Shah, Jonathan A. Lindquist, Lars Rosendahl, Ingo Schmitz, Peter R. Mertens
Summary: YB-1 is a RNA binding protein involved in various cellular processes, its activation is associated with NF-kappa B and can affect the inflammatory response and cell survival mechanisms.
Review
Biochemistry & Molecular Biology
Gergana Zahmanova, Alaa A. Aljabali, Katerina Takova, Valentina Toneva, Murtaza M. Tambuwala, Anton P. Andonov, Georgi L. Lukov, Ivan Minkov
Summary: Plant viruses have expanded their role beyond pathogens and have become important in the production of nanomaterials, vaccines, and other pharmaceutical products. Plant molecular farming offers a fast and cost-effective approach to meeting global health needs. Various applications and advantages of plant-produced vaccines are discussed, as well as the challenges they face in becoming available on the market.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Alaa A. Aljabali, Mohammad A. Obeid, Rasha M. Bashatwah, Angel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Mohamed El-Tanani, Altijana Hromic-Jahjefendic, Deepak N. Kapoor, Rohit Goyal, Gowhar A. Naikoo, Murtaza M. Tambuwala
Summary: Nanomaterials have been extensively studied in the medical and industrial sectors, but their potential toxicities have raised concerns. Researchers are interested in how nanoparticles interact with the immune system and their biomolecules. This review examines literature on the immunostimulatory and immunosuppressive effects of nanomaterials and their interactions with immune cells, as well as the possibility of creating stealth nanomaterials that evade the immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Multidisciplinary
Abdulmajeed G. Almutary, Abdullah M. Alnuqaydan, Saleh A. Almatroodi, Hamid A. Bakshi, Dinesh Kumar Chellappan, Murtaza M. Tambuwala
Summary: Physiological barrier function is difficult to replicate in vitro, but a colitis-like condition model generated through 3D bioprinting can evaluate the barrier function of nanoencapsulated anti-inflammatory drugs. Histological characterization confirmed the presence of the disease in the 3D-bioprinted constructs, and a comparison of proliferation rates in 2D monolayer and 3D-bioprinted models was conducted. This model can be implemented as an effective tool for predicting drug efficacy and toxicity in the drug development process.
Review
Oncology
Neha Srivastava, Yachana Mishra, Vijay Mishra, Abhigyan Ranjan, Murtaza M. Tambuwala
Summary: Breast cancer is the leading cause of cancer-related death among women worldwide. Improved public awareness and screening have led to earlier diagnosis and surgical resection as well as curative therapies. Carbon nanotubes (CNTs) have emerged as a promising tool for targeted drug delivery systems in breast cancer treatment.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Meeting Abstract
Physiology
Caitriona Curley, Natalia Lajczak-McGinley, Murtaza Tambuwala, Luciano Adorini, Ciara Fallon, Jessica Smyth, Stephen Keely
Review
Chemistry, Analytical
Gowhar A. Naikoo, Fareeha Arshad, Israr U. Hassan, Fatima Ba Omar, Murtaza M. Tambuwala, Mujahid Mustaqeem, Tawfik A. Saleh
Summary: Diabetes mellitus is a rapidly rising chronic disease globally. Non-enzymatic sensors, known as fourth-generation glucose sensors, have been developed to overcome the limitations of enzymatic glucose sensors. Bimetallic nanocomposite-based sensors have gained attention due to their enhanced reproducibility and stability compared to monometallic nanomaterials.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Biology
Liliana Sokol, Anne Cuypers, Anh-Co K. Truong, Ann Bouche, Katleen Brepoels, Joris Souffreau, Katerina Rohlenova, Stefan Vinckier, Luc Schoonjans, Guy Eelen, Mieke Dewerchin, Laura P. M. H. de Rooij, Peter Carmeliet
Summary: Translation of academic results into clinical practice is a significant challenge. In this study, the authors addressed this challenge by prioritizing and validating potential target genes from single-cell RNA-sequencing data. They focused on tip endothelial cell markers and identified four candidates that showed tip EC characteristics. This study highlights the importance of targeted assessment and prioritization of candidate genes for successful translation into clinical practice.
COMMUNICATIONS BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Himanshu Gandhi, Shikha Mahant, Abhishek Kumar Sharma, Deepak Kumar, Kamal Dua, Dinesh Kumar Chellappan, Sachin Kumar Singh, Gaurav Gupta, Alaa A. A. Aljabali, Murtaza M. Tambuwala, Deepak N. Kapoor
Summary: Piceatannol is a natural compound found in fruits and vegetables, with a wide range of beneficial effects such as anti-inflammatory, antioxidant, anti-aging, and antidiabetic properties. It has shown promising potential in inhibiting the growth of various cancers. However, its bioavailability is lower compared to resveratrol, and further research is needed to enhance its effectiveness.
Article
Chemistry, Medicinal
Nosaibah Akkam, Alaa A. A. Aljabali, Yazan Akkam, Osama Abo Alrob, Bahaa Al-Trad, Hiba Alzoubi, Murtaza M. Tambuwala, Khalid M. Al-Batayneh
Summary: This study investigates the acute and chronic adverse effects of ∼50 nm gold nanoparticles (AuNPs) synthesized using Ziziphus zizyphus leaf extract in mice. The results indicate that AuNPs synthesized using Z. zizyphus leaf extract can induce adverse effects, particularly in the kidney, in mice. Safety concerns should be addressed when using AuNPs in medical applications.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Article
Endocrinology & Metabolism
Brenda Morant-Ferrando, Daniel Jimenez-Blasco, Paula Alonso-Batan, Jesus Agulla, Rebeca Lapresa, Dario Garcia-Rodriguez, Sara Yunta-Sanchez, Irene Lopez-Fabuel, Emilio Fernandez, Peter Carmeliet, Angeles Almeida, Marina Garcia-Macia, Juan P. P. Bolanos
Summary: Astrocytes, a type of glial cells in the brain, primarily rely on glycolysis for energy production, indicating glucose as their main metabolic precursor. However, recent studies have shown that astrocytes also have the ability to metabolize fatty acids, and this metabolic pathway may play a role in preserving mitochondrial function and cognitive performance.
Review
Oncology
Mohamed El-Tanani, Hamdi Nsairat, Ismail I. Matalka, Alaa A. A. Aljabali, Vijay Mishra, Yachana Mishra, Gowhar A. Naikoo, Sai Raghuveer Chava, Nitin B. Charbe, Murtaza M. Tambuwala
Summary: Pancreatic cancer is a highly aggressive tumor with poor prognosis. There are no accurate imaging techniques or biomarkers available for identification and prediction of its biological behavior. Exosomes, secreted by most cells, play a crucial role in the progression, metastasis, and chemoresistance of pancreatic cancer. They have the potential to serve as biomarkers and are vital for further research in this field.
Review
Psychology, Clinical
Lakshmi Pillai, Shayna Srivastava, Akhil Ajin, Sandeep Singh Rana, Darin Mansor Mathkor, Shafiul Haque, Murtaza M. Tambuwala, Faraz Ahmad
Summary: This article systematically reviews the impact of recent unfavorable environmental and geopolitical factors on postpartum depression. The results indicate that contemporary socio-geopolitical and environmental circumstances have a detrimental effect on the etiology and incidence of postpartum depression. A combination of socio-economic and psychological factors may contribute to a drastic increase in the incidence of postpartum depression. The article also outlines potential treatment regimens, including interpersonal psycho- and art-based therapies, which may be effective in alleviating postpartum depression symptoms.
JOURNAL OF PSYCHOSOMATIC OBSTETRICS & GYNECOLOGY
(2023)
Article
Cell Biology
Hamid A. Bakshi, Michella Mkhael, Hakkim L. Faruck, Asad Ullah Khan, Alaa A. A. Aljabali, Vijay Mishra, Mohamed El-Tanani, Nitin B. Charbe, Murtaza M. Tambuwala
Summary: The rewiring of cellular metabolism is a defining characteristic of cancer, as tumor cells adapt to acquire essential nutrients from a nutrient-poor environment to sustain their viability and biomass. Recent studies have shown that hypoxic cancer cells, which heavily rely on glucose, can utilize alternative energy sources such as mannose and maltose. This review comprehensively examines the hypoxic cancer microenvironment, its association with drug resistance, and potential therapeutic strategies for targeting this unique niche.
CELLULAR SIGNALLING
(2024)
Review
Pharmacology & Pharmacy
Lorca Alzoubi, Alaa A. A. Aljabali, Murtaza M. Tambuwala
Summary: This review explores the recent advancements and applications of 3D printing in healthcare, focusing on personalized medicine, tissue engineering, and medical device production. It highlights the potential of 3D printing in providing customized solutions, improving patient outcomes, and promoting economic viability and sustainability. However, addressing material biocompatibility, standardization, and ethical concerns is essential for responsible adoption.
Article
Chemistry, Multidisciplinary
Richa Tomar, Paratpar Sarkar, Vivek Srivastava, Pankaj Gupta, Sumira Malik, Azmat Ali Khan, Murtaza Tambuwala
Summary: This paper investigates the nuclease activity and potential drug-like properties of polymeric chemical compounds against bacterial genomic DNA, bacterial gyrase complex, and human topoisomerase. The synthesis and characterization of three different polymers were conducted, with poly-m-chloroaniline showing the highest affinity towards the selected targets. Biophysical interaction analysis and molecular docking studies confirmed the strong binding between poly-m-chloroaniline and the targets. The synthesized molecules demonstrated potential nuclease activity, supporting the findings from molecular docking studies against bacterial gyrase complex and human topoisomerase.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
