OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance

OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo

(2015) Diego Iglesias-Gato et al.   Molecular Cancer

Monoubiquitination Is Critical for Ovarian Tumor Domain-containing Ubiquitin Aldehyde Binding Protein 1 (Otub1) to Suppress UbcH5 Enzyme and Stabilize p53 Protein

(2014) Yuhuang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer

(2014) Yi Zhou et al.   Molecular Cancer

Colon cancer bears overexpression of OTUB1

(2014) Xin Liu et al.   PATHOLOGY RESEARCH AND PRACTICE

OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

(2013) Tycho E.T. Mevissen et al.   CELL

FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance

(2013) P Khongkow et al.   ONCOGENE

SUMOylation inhibits FOXM1 activity and delays mitotic transition

(2013) S S Myatt et al.   ONCOGENE

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Epirubicin: Is it like doxorubicin in breast cancer? A clinical review

(2012) Mustafa Khasraw et al.   BREAST

The p38 MAPK-MK2 Axis Regulates E2F1 and FOXM1 Expression after Epirubicin Treatment

(2012) N. de Olano et al.   MOLECULAR CANCER RESEARCH

The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment

(2012) L J Monteiro et al.   ONCOGENE

Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1

(2011) Xiao-Xin Sun et al.   EMBO JOURNAL

Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion

(2011) M. M. Cohen et al.   JOURNAL OF CELL SCIENCE

ATM and p53 Regulate FOXM1 Expression via E2F in Breast Cancer Epirubicin Treatment and Resistance

(2011) J. Millour et al.   MOLECULAR CANCER THERAPEUTICS

The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation

(2011) Allan M. Weissman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

FOXM1 Confers Acquired Cisplatin Resistance in Breast Cancer Cells

(2010) J. M.-M. Kwok et al.   MOLECULAR CANCER RESEARCH

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

(2010) Shinichiro Nakada et al.   NATURE

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

OTU Domain-containing Ubiquitin Aldehyde-binding Protein 1 (OTUB1) Deubiquitinates Estrogen Receptor (ER) α and Affects ERα Transcriptional Activity

(2009) Vladimir Stanišić et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for Bidentate Substrate Binding as the Basis for the K48 Linkage Specificity of Otubain 1

(2009) Tao Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer

(2009) U. B. McGovern et al.   MOLECULAR CANCER THERAPEUTICS

Structural basis and specificity of human otubain 1-mediated deubiquitination

(2008) Mariola J. Edelmann et al.   BIOCHEMICAL JOURNAL

Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression

(2008) J. M-M. Kwok et al.   MOLECULAR CANCER THERAPEUTICS

Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells

(2008) R. C-Y. Hui et al.   MOLECULAR CANCER THERAPEUTICS

ERβ in breast cancer—Onlooker, passive player, or active protector?

(2008) Emily M. Fox et al.   STEROIDS