ERK is a Pivotal Player of Chemo-Immune-Resistance in Cancer

Down-regulating IL-6/GP130 targets improved the anti-tumor effects of 5-fluorouracil in colon cancer

(2018) Sanhong Li et al.   APOPTOSIS

PD-L1 confers glioblastoma multiforme malignancy via Ras binding and Ras/Erk/EMT activation

(2018) Xin Yao Qiu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Down-regulation of RIP3 potentiates cisplatin chemoresistance by triggering HSP90-ERK pathway mediated DNA repair in esophageal squamous cell carcinoma

(2018) Yulin Sun et al.   CANCER LETTERS

Nogo-B receptor increases the resistance of estrogen receptor positive breast cancer to paclitaxel

(2018) Ying Jin et al.   CANCER LETTERS

Inhibition of Rspo-Lgr4 facilitates checkpoint blockade therapy by switching macrophage polarization

(2018) Binghe Tan et al.   CANCER RESEARCH

Erbin suppresses KSR1-mediated RAS/RAF signaling and tumorigenesis in colorectal cancer

(2018) Payton D Stevens et al.   CANCER RESEARCH

Downregulation of leucine-rich repeats and immunoglobulin-like domains 1 by microRNA-20a modulates gastric cancer multidrug resistance

(2018) Lin Zhou et al.   CANCER SCIENCE

Oncogenic KRAS suppresses store-operated Ca 2+ entry and I CRAC through ERK pathway-dependent remodelling of STIM expression in colorectal cancer cell lines

(2018) Cristina Pierro et al.   CELL CALCIUM

Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer

(2018) Xianmin Mu et al.   CELL CYCLE

FGFR4 Links Glucose Metabolism and Chemotherapy Resistance in Breast Cancer

(2018) Min Xu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Inhibition of microRNA-21-3p suppresses proliferation as well as invasion and induces apoptosis by targeting RNA-binding protein with multiple splicing through Smad4/extra cellular signal-regulated protein kinase signalling pathway in human colorectal can

(2018) Nengyi Hou et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Mechanistic Exploration of Cancer Stem Cell Marker Voltage-Dependent Calcium Channel α2δ1 Subunit-mediated Chemotherapy Resistance in Small-Cell Lung Cancer

(2018) Jiangyong Yu et al.   CLINICAL CANCER RESEARCH

Combinatorial Effects of VEGFR Kinase Inhibitor Axitinib and Oncolytic Virotherapy in Mouse and Human Glioblastoma Stem-Like Cell Models

(2018) Dipongkor Saha et al.   CLINICAL CANCER RESEARCH

Regulation of IL-1 signaling through control of focal adhesion assembly

(2018) Qin Wang et al.   FASEB JOURNAL

NRAGE confers poor prognosis and promotes proliferation, invasion, and chemoresistance in gastric cancer

(2018) Xiaodi Jiang et al.   GENE

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

Immune suppression and reversal of the suppressive tumor microenvironment

(2018) Kanako Shimizu et al.   INTERNATIONAL IMMUNOLOGY

Hexokinase 2 confers resistance to cisplatin in ovarian cancer cells by enhancing cisplatin-induced autophagy

(2018) Xiao-Yan Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inhibition of interleukin 8/C‑X-C chemokine receptor�1,/2 signaling reduces malignant features in human pancreatic cancer cells

(2018) Shengling Fu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

MICAL1 facilitates breast cancer cell proliferation via ROS-sensitive ERK/cyclin D pathway

(2018) Wenjie Deng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Scutellaria baicalensis targets the hypoxia-inducible factor-1α and enhances cisplatin efficacy in ovarian cancer

(2018) Imran Hussain et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Dacomitinib potentiates the efficacy of conventional chemotherapeutic agents via inhibiting the drug efflux function of ABCG2 in vitro and in vivo

(2018) Xiaoran Guo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Mitochondrial fission promotes cell migration by Ca2+ /CaMKII/ERK/FAK pathway in hepatocellular carcinoma

(2018) Xiacheng Sun et al.   LIVER INTERNATIONAL

The Unfolded Protein Response: A Novel Therapeutic Target for Poor PrognosticBRAFMutant Colorectal Cancer

(2018) Nicholas Forsythe et al.   MOLECULAR CANCER THERAPEUTICS

Notch Pathway Inhibition Using DAPT, a γ-secretase inhibitor (GSI), Enhances the Antitumor Effect of Cisplatin in Resistant Osteosarcoma

(2018) Guo Dai et al.   MOLECULAR CARCINOGENESIS

Calotropin regulates the apoptosis of non‑small cell cancer by regulating the cytotoxic T‑lymphocyte associated antigen 4‑mediated TGF‑β/ERK signaling pathway

(2018) Lu Tian et al.   Molecular Medicine Reports

Genetic, transcriptional and post-translational regulation of the programmed death protein ligand 1 in cancer: biology and clinical correlations

(2018) Ioannis Zerdes et al.   ONCOGENE

Transmembrane TNF-alpha promotes chemoresistance in breast cancer cells

(2018) Zunyue Zhang et al.   ONCOGENE

TRIB2 knockdown as a regulator of chemotherapy resistance and proliferation via the ERK/STAT3 signaling pathway in human chronic myelogenous leukemia K562/ADM cells

(2018) Xiancheng Ma et al.   ONCOLOGY REPORTS

Mechanism of ECM-induced dormancy and chemoresistance in A549 human lung carcinoma cells

(2018) Siriporn Keeratichamroen et al.   ONCOLOGY REPORTS

miR-27b-3p inhibits proliferation and potentially reverses multi-chemoresistance by targeting CBLB/GRB2 in breast cancer cells

(2018) Danni Chen et al.   Cell Death & Disease

Baicalein and baicalin inhibit colon cancer using two distinct fashions of apoptosis and senescence

(2018) Jie Dou et al.   Oncotarget

Cytoprotective mechanisms of DJ-1 against oxidative stress through modulating ERK1/2 and ASK1 signal transduction

(2018) Stephanie E. Oh et al.   Redox Biology

Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy

(2018) Feifei Liu et al.   Acta Pharmaceutica Sinica B

Olmutinib (HM61713) reversed multidrug resistance by inhibiting the activity of ATP-binding cassette subfamily G member 2 in vitro and in vivo

(2018) Zhiqiang Zhang et al.   Acta Pharmaceutica Sinica B

Knockdown of TMPRSS3 inhibits gastric cancer cell proliferation, invasion and EMT via regulation of the ERK1/2 and PI3K/Akt pathways

(2018) Shun-Le Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Dietary oleic acid-induced CD36 promotes cervical cancer cell growth and metastasis via up-regulation Src/ERK pathway

(2018) Ping Yang et al.   CANCER LETTERS

UBE2N promotes melanoma growth via MEK/FRA1/SOX10 signaling

(2018) Anushka Dikshit et al.   CANCER RESEARCH

Tanshinone IIA Attenuates Insulin Like Growth Factor 1 -Induced Cell Proliferation in PC12 Cells through the PI3K/Akt and MEK/ERK Pathways

(2018) Haitao Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Tumor Microenvironment in Chemoresistance: 3D Extracellular Matrices as Accomplices

(2018) Dimakatso Senthebane et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High response rate to PD-1 blockade in desmoplastic melanomas

(2018) Zeynep Eroglu et al.   NATURE

Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway

(2018) L. J. Bugaj et al.   SCIENCE

HMGB1 promotes ERK-mediated mitochondrial Drp1 phosphorylation for chemoresistance through RAGE in colorectal cancer

(2018) Chih-Yang Huang et al.   Cell Death & Disease

SPARCL1 suppresses the proliferation and migration of human ovarian cancer cells via the MEK/ERK signaling

(2018) Yan Ma et al.   Experimental and Therapeutic Medicine

Pirfenidone decreases mesothelioma cell proliferation and migration via inhibition of ERK and AKT and regulates mesothelioma tumor microenvironment in vivo

(2018) Chang Li et al.   Scientific Reports

Krukovine Suppresses KRAS-Mutated Lung Cancer Cell Growth and Proliferation by Inhibiting the RAF-ERK Pathway and Inactivating AKT Pathway

(2018) Huanling Lai et al.   Frontiers in Pharmacology

NK cell–mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

(2018) Marcus Ruscetti et al.   SCIENCE

An increase in BAG-1 by PD-L1 confers resistance to tyrosine kinase inhibitor in non–small cell lung cancer via persistent activation of ERK signalling

(2017) Po-Lin Lin et al.   EUROPEAN JOURNAL OF CANCER

Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA

(2017) Matthew A. Coelho et al.   IMMUNITY

Constitutively activated ERK sensitizes cancer cells to doxorubicin: Involvement of p53-EGFR-ERK pathway

(2017) Ratna Kumari et al.   JOURNAL OF BIOSCIENCES

Telomerase and N-Cadherin Differential Importance in Adrenocortical Cancers and Adenomas

(2017) Sofia S. Pereira et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Targeting P-glycoprotein and SORCIN: Dihydromyricetin strengthens anti-proliferative efficiency of adriamycin via MAPK/ERK and Ca2+ -mediated apoptosis pathways in MCF-7/ADR and K562/ADR

(2017) Yaoting Sun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance

(2017) Cecilia S. Leung et al.   JOURNAL OF CLINICAL INVESTIGATION

Trametinib plus 4-Methylumbelliferone Exhibits Antitumor Effects by ERK Blockade and CD44 Downregulation and Affects PD-1 and PD-L1 in Malignant Pleural Mesothelioma

(2017) Hiroyuki Cho et al.   Journal of Thoracic Oncology

CT45A1 siRNA silencing suppresses the proliferation, metastasis and invasion of lung cancer cells by downregulating the ERK/CREB signaling pathway

(2017) Feng Tang et al.   Molecular Medicine Reports

Chemotherapy induces tumor immune evasion by upregulation of programmed cell death ligand 1 expression in bone marrow stromal cells

(2017) Mengqi Yang et al.   Molecular Oncology

ERK-dependent IL-6 autocrine signaling mediates adaptive resistance to pan-PI3K inhibitor BKM120 in head and neck squamous cell carcinoma

(2017) M R Yun et al.   ONCOGENE

Silencing Aurora A leads to re-sensitization of breast cancer cells to Taxol through downregulation of SRC-mediated ERK and mTOR pathways

(2017) Yan Li et al.   ONCOLOGY REPORTS

Calreticulin promotes EGF-induced EMT in pancreatic cancer cells via Integrin/EGFR-ERK/MAPK signaling pathway

(2017) Weiwei Sheng et al.   Cell Death & Disease

Connective tissue growth factor promotes temozolomide resistance in glioblastoma through TGF-β1-dependent activation of Smad/ERK signaling

(2017) Huijun Zeng et al.   Cell Death & Disease

IL‑8 is upregulated in cervical cancer tissues and is associated with the proliferation and migration of HeLa cervical cancer cells

(2017) Linlin Jia et al.   Oncology Letters

Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme

(2017) Jennifer P. Newman et al.   Nature Communications

IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting

(2017) Kazuyoshi Takeda et al.   Nature Communications

Interleukin-34 sustains pro-tumorigenic signals in colon cancer tissue

(2017) Eleonora Franzè et al.   Oncotarget

The IL-17B-IL-17 receptor B pathway promotes resistance to paclitaxel in breast tumors through activation of the ERK1/2 pathway

(2017) Emilie Laprevotte et al.   Oncotarget

SHP2 negatively regulates HLA-ABC and PD-L1 expression via STAT1 phosphorylation in prostate cancer cells

(2017) Zhuqing Liu et al.   Oncotarget

Changes in programmed death-ligand 1 expression during cisplatin treatment in patients with head and neck squamous cell carcinoma

(2017) Chan-Young Ock et al.   Oncotarget

Immune profiling of NF1-associated tumors reveals histologic subtype distinctions and heterogeneity: Implications for immunotherapy

(2017) Kellie B. Haworth et al.   Oncotarget

PD-1/PD-L1 interaction up-regulates MDR1/P-gp expression in breast cancer cells via PI3K/AKT and MAPK/ERK pathways

(2017) Shengwei Liu et al.   Oncotarget

Radiation alters PD-L1/NKG2D ligand levels in lung cancer cells and leads to immune escape from NK cell cytotoxicity via IL-6-MEK/Erk signaling pathway

(2017) Ming Jing Shen et al.   Oncotarget

NID1, a new regulator of EMT required for metastasis and chemoresistance of ovarian cancer cells

(2017) Ya Zhou et al.   Oncotarget

Low-dose levels of bisphenol A inhibit telomerase via ER/GPR30-ERK signalling, impair DNA integrity and reduce cell proliferation in primary PBMC

(2017) Corinna Herz et al.   Scientific Reports

Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents

(2017) Oakley C. Olson et al.   Cell Reports

DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferation

(2017) Patrick Narbonne et al.   PLoS Genetics

miRNA-34c-5p inhibits amphiregulin-induced ovarian cancer stemness and drug resistance via downregulation of the AREG-EGFR-ERK pathway

(2017) S-L Tung et al.   Oncogenesis

Enhancing NK cell-mediated cytotoxicity to cisplatin-resistant lung cancer cells via MEK/Erk signaling inhibition

(2017) Li Yang et al.   Scientific Reports

Hypoxia regulates ABCG2activity through the activivation of ERK1/2/HIF-1α and contributes to chemoresistance in pancreatic cancer cells

(2016) Xiaodan He et al.   CANCER BIOLOGY & THERAPY

MiR-20a-5p represses multi-drug resistance in osteosarcoma by targeting the KIF26B gene

(2016) Youguang Pu et al.   Cancer Cell International

Inhibition of the NF-κB pathway by nafamostat mesilate suppresses colorectal cancer growth and metastasis

(2016) Yun-Xin Lu et al.   CANCER LETTERS

Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation

(2016) RYOTA KURIMOTO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The EGFR pathway is involved in the regulation of PD-L1 expression via the IL-6/JAK/STAT3 signaling pathway in EGFR-mutated non-small cell lung cancer

(2016) Nan Zhang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

RAS isoforms and mutations in cancer at a glance

(2016) G. Aaron Hobbs et al.   JOURNAL OF CELL SCIENCE

MiR-302a/b/c/d cooperatively sensitizes breast cancer cells to adriamycin via suppressing P-glycoprotein(P-gp) by targeting MAP/ERK kinase kinase 1 (MEKK1)

(2016) Lin Zhao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

CXCL2/MIF-CXCR2 signaling promotes the recruitment of myeloid-derived suppressor cells and is correlated with prognosis in bladder cancer

(2016) H Zhang et al.   ONCOGENE

Selective GPR55 antagonism reduces chemoresistance in cancer cells

(2016) Nagendra S. Singh et al.   PHARMACOLOGICAL RESEARCH

Cancer stem cells and chemoresistance: The smartest survives the raid

(2016) Jihe Zhao   PHARMACOLOGY & THERAPEUTICS

The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs)

(2016) Andrew M. Kidger et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Upregulation of CD44v6 contributes to acquired chemoresistance via the modulation of autophagy in colon cancer SW480 cells

(2016) Lin Lv et al.   TUMOR BIOLOGY

The roles of serum CXCL16 in circulating Tregs and gastrointestinal stromal tumor cells

(2016) Hui-Mian Xu et al.   OncoTargets and Therapy

ERK/Drp1-dependent mitochondrial fission is involved in the MSC-induced drug resistance of T-cell acute lymphoblastic leukemia cells

(2016) Jianye Cai et al.   Cell Death & Disease

Zoledronic acid-encapsulating self-assembling nanoparticles and doxorubicin: a combinatorial approach to overcome simultaneously chemoresistance and immunoresistance in breast tumors

(2016) Joanna Kopecka et al.   Oncotarget

Positive feedback regulation between IL10 and EGFR promotes lung cancer formation

(2016) Tsung-I Hsu et al.   Oncotarget

Sorafenib-resistant hepatocellular carcinoma stratified by phosphorylated ERK activates PD-1 immune checkpoint

(2016) Jiang Chen et al.   Oncotarget

Activation of the PD-1/PD-L1 immune checkpoint confers tumor cell chemoresistance associated with increased metastasis

(2016) Madison Black et al.   Oncotarget

DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation

(2016) Francesca Megiorni et al.   Oncotarget

PAK1 confers chemoresistance and poor outcome in non-small cell lung cancer via β-catenin-mediated stemness

(2016) Ming-Jenn Chen et al.   Scientific Reports

Mutant KRAS Conversion of Conventional T Cells into Regulatory T Cells

(2016) S. Zdanov et al.   Cancer Immunology Research

Impaired functional responses in follicular lymphoma CD8+TIM-3+ T lymphocytes following TCR engagement

(2016) Pauline Gravelle et al.   OncoImmunology

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

(2016) Linda S. Steelman et al.   Aging-US

RAS–Mitogen-Activated Protein Kinase Signal Is Required for Enhanced PD-L1 Expression in Human Lung Cancers

(2016) Hidetoshi Sumimoto et al.   PLoS One

p-Hydroxylcinnamaldehyde induces the differentiation of oesophageal carcinoma cells via the cAMP-RhoA-MAPK signalling pathway

(2016) Ming Ma et al.   Scientific Reports

Primary pineal malignant melanoma with B-Raf V600E mutation: a case report and brief review of the literature

(2015) Kathleen Jetschke et al.   ACTA NEUROCHIRURGICA

DJ-1 as a human oncogene and potential therapeutic target

(2015) Ji Cao et al.   BIOCHEMICAL PHARMACOLOGY

Ras activation revisited: role of GEF and GAP systems

(2015) Anne Hennig et al.   BIOLOGICAL CHEMISTRY

Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia

(2015) Seyedmehdi Shojaee et al.   CANCER CELL

Aminoacyl-tRNA synthetase-interacting multifunctional protein 1 suppresses tumor growth in breast cancer-bearing mice by negatively regulating myeloid-derived suppressor cell functions

(2015) Hye-Jin Hong et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Identification of the Cell-Intrinsic and -Extrinsic Pathways Downstream of EGFR and IFN  That Induce PD-L1 Expression in Head and Neck Cancer

(2015) F. Concha-Benavente et al.   CANCER RESEARCH

Induction of PD-L1 Expression by the EML4-ALK Oncoprotein and Downstream Signaling Pathways in Non-Small Cell Lung Cancer

(2015) K. Ota et al.   CLINICAL CANCER RESEARCH

RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors

(2015) S. Loi et al.   CLINICAL CANCER RESEARCH

Polarization of Monocytic Myeloid-Derived Suppressor Cells by Hepatitis B Surface Antigen Is Mediated via ERK/IL-6/STAT3 Signaling Feedback and Restrains the Activation of T Cells in Chronic Hepatitis B Virus Infection

(2015) Zhong Fang et al.   JOURNAL OF IMMUNOLOGY

Upregulation of PD-L1 by EGFR Activation Mediates the Immune Escape in EGFR-Driven NSCLC: Implication for Optional Immune Targeted Therapy for NSCLC Patients with EGFR Mutation

(2015) Nan Chen et al.   Journal of Thoracic Oncology

Downregulation of P-gp, Ras and p-ERK1/2 contributes to the arsenic trioxide-induced reduction in drug resistance towards doxorubicin in gastric cancer cell lines

(2015) YUAN-YUAN ZHAO et al.   Molecular Medicine Reports

Interleukin-33 predicts poor prognosis and promotes ovarian cancer cell growth and metastasis through regulating ERK and JNK signaling pathways

(2015) Xiaoguang Tong et al.   Molecular Oncology

Multidrug Resistance-Associated Protein 2 Expression Is Upregulated by Adenosine 5’-Triphosphate in Colorectal Cancer Cells and Enhances Their Survival to Chemotherapeutic Drugs

(2015) Valérie Vinette et al.   PLoS One

Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance

(2015) Laetitia Seguin et al.   TRENDS IN CELL BIOLOGY

Endoplasmic Reticulum Stress-Activated Cell Reprogramming in Oncogenesis

(2015) E. Chevet et al.   Cancer Discovery

Self-assembling nanoparticles encapsulating zoledronic acid revert multidrug resistance in cancer cells

(2015) Joanna Kopecka et al.   Oncotarget

Simvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells

(2015) Micol Rigoni et al.   Oncotarget

A core of kinase-regulated interactomes defines the neoplastic MDSC lineage

(2015) Maria Gato-Cañas et al.   Oncotarget

TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

(2015) Victor Ho et al.   Oncotarget

LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma

(2015) Gabriella Cunha Vieira et al.   Oncotarget

Metformin Increases Sensitivity of Pancreatic Cancer Cells to Gemcitabine by Reducing CD133+ Cell Populations and Suppressing ERK/P70S6K Signaling

(2015) Xinqun Chai et al.   Scientific Reports

Paracrine communication maximizes cellular response fidelity in wound signaling

(2015) L Naomi Handly et al.   eLife

Phenformin Induces Cell Cycle Change, Apoptosis, and Mesenchymal-Epithelial Transition and Regulates the AMPK/mTOR/p70s6k and MAPK/ERK Pathways in Breast Cancer Cells

(2015) Zhao Liu et al.   PLoS One

Zoledronic acid overcomes chemoresistance and immunosuppression of malignant mesothelioma

(2015) Iris Chiara Salaroglio et al.   Oncotarget

Exogenous IGFBP-2 promotes proliferation, invasion and chemoresistance to temozolomide in glioma cells via the integrin β1-ERK pathway

(2014) S Han et al.   BRITISH JOURNAL OF CANCER

ABCB5 Maintains Melanoma-Initiating Cells through a Proinflammatory Cytokine Signaling Circuit

(2014) B. J. Wilson et al.   CANCER RESEARCH

Nitidine chloride induces apoptosis and inhibits tumor cell proliferation via suppressing ERK signaling pathway in renal cancer

(2014) Zhiqing Fang et al.   FOOD AND CHEMICAL TOXICOLOGY

Genistein-Inhibited Cancer Stem Cell-Like Properties and Reduced Chemoresistance of Gastric Cancer

(2014) Weifeng Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Environmental Stress Affects the Activity of Metabolic and Growth Factor Signaling Networks and Induces Autophagy Markers in MCF7 Breast Cancer Cells

(2014) Pedro Casado et al.   MOLECULAR & CELLULAR PROTEOMICS

CCN2 Enhances Resistance to Cisplatin-Mediating Cell Apoptosis in Human Osteosarcoma

(2014) Hsiao-Chi Tsai et al.   PLoS One

Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression

(2014) Linda K. Rushworth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ell3 stimulates proliferation, drug resistance, and cancer stem cell properties of breast cancer cells via a MEK/ERK-dependent signaling pathway

(2013) Hee-Jin Ahn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ERK differentially regulates Th17- and Treg-cell development and contributes to the pathogenesis of colitis

(2013) Houpu Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

An interleukin-17–mediated paracrine network promotes tumor resistance to anti-angiogenic therapy

(2013) Alicia S Chung et al.   NATURE MEDICINE

Temozolomide downregulates P-glycoprotein expression in glioblastoma stem cells by interfering with the Wnt3a/glycogen synthase-3 kinase/ -catenin pathway

(2013) C. Riganti et al.   NEURO-ONCOLOGY

PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling

(2013) B Zhu et al.   ONCOGENE

Zoledronic Acid Restores Doxorubicin Chemosensitivity and Immunogenic Cell Death in Multidrug-Resistant Human Cancer Cells

(2013) Chiara Riganti et al.   PLoS One

The Activation of MAPK in Melanoma Cells Resistant to BRAF Inhibition Promotes PD-L1 Expression That Is Reversible by MEK and PI3K Inhibition

(2012) X. Jiang et al.   CLINICAL CANCER RESEARCH

α2β1 Integrin Promotes Chemoresistance against Doxorubicin in Cancer Cells through Extracellular Signal-regulated Kinase (ERK)

(2012) Dalila Naci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High DGK-  and Disabled MAPK Pathways Cause Dysfunction of Human Tumor-Infiltrating CD8+ T Cells That Is Reversible by Pharmacologic Intervention

(2012) P. U. Prinz et al.   JOURNAL OF IMMUNOLOGY

Collagen/β1 integrin signaling up-regulates the ABCC1/MRP-1 transporter in an ERK/MAPK-dependent manner

(2012) Mohammed-Amine El Azreq et al.   MOLECULAR BIOLOGY OF THE CELL

The Activation of MEK/ERK Signaling Pathway by Bone Morphogenetic Protein 4 to Increase Hepatocellular Carcinoma Cell Proliferation and Migration

(2012) C.-Y. Chiu et al.   MOLECULAR CANCER RESEARCH

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions

(2012) Tsukasa Shibue et al.   Cancer Discovery

IL-4 induces proliferation in prostate cancer PC3 cells under nutrient-depletion stress through the activation of the JNK-pathway and survivin upregulation

(2011) Hernan Roca et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

MHC Class II Engagement by Its Ligand LAG-3 (CD223) Contributes to Melanoma Resistance to Apoptosis

(2011) P. Hemon et al.   JOURNAL OF IMMUNOLOGY

Activation of mitogen activated protein kinase-Erk kinase (MEK) increases T cell immunoglobulin mucin domain-3 (TIM-3) transcription in human T lymphocytes and a human mast cell line

(2011) Soo-Jin Yoon et al.   MOLECULAR IMMUNOLOGY

Chemotherapy resistance in acute lymphoblastic leukemia requires hERG1 channels and is overcome by hERG1 blockers

(2010) S. Pillozzi et al.   BLOOD

Mechanism of genotoxicity induced by targeted cytoplasmic irradiation

(2010) M Hong et al.   BRITISH JOURNAL OF CANCER

Nitric oxide and P-glycoprotein modulate the phagocytosis of colon cancer cells

(2010) Joanna Kopecka et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Activated MEK cooperates with Ink4a/Arf loss or Akt activation to induce gliomas in vivo

(2010) J P Robinson et al.   ONCOGENE

Down-Regulation of DUSP6 Expression in Lung Cancer

(2009) Koji Okudela et al.   AMERICAN JOURNAL OF PATHOLOGY

 1-Integrin Circumvents the Antiproliferative Effects of Trastuzumab in Human Epidermal Growth Factor Receptor-2-Positive Breast Cancer

(2009) D. Lesniak et al.   CANCER RESEARCH

Integrin  1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

(2009) T. Shibue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RSK family of kinases: emerging roles in cellular signalling

(2008) Rana Anjum et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY