Ras activation revisited: role of GEF and GAP systems

The role of homeostatic regulation between tumor suppressor DAB2IP and oncogenic Skp2 in prostate cancer growth

(2015) Yuh-Shyan Tsai et al.   Oncotarget

A Meta-analysis of Somatic Mutations from Next Generation Sequencing of 241 Melanomas: A Road Map for the Study of Genes with Potential Clinical Relevance

(2014) J. Xia et al.   MOLECULAR CANCER THERAPEUTICS

Functional Redundancy of Sos1 and Sos2 for Lymphopoiesis and Organismal Homeostasis and Survival

(2013) Fernando C. Baltanás et al.   MOLECULAR AND CELLULAR BIOLOGY

The role of DAB2IP in androgen receptor activation during prostate cancer progression

(2013) K Wu et al.   ONCOGENE

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

Dysregulated RasGRP1 Responds to Cytokine Receptor Input in T Cell Leukemogenesis

(2013) C. Hartzell et al.   Science Signaling

Identifying the Ubiquitin Ligase Complex That Regulates the NF1 Tumor Suppressor and Ras

(2013) P. E. Hollstein et al.   Cancer Discovery

Regulation of Ras Exchange Factors and Cellular Localization of Ras Activation by Lipid Messengers in T Cells

(2013) Jesse E. Jun et al.   Frontiers in Immunology

GPCR activation of Ras and PI3Kγ in neutrophils depends on PLCβ2/β3 and the RasGEF RasGRP4

(2012) Sabine Suire et al.   EMBO JOURNAL

Structure-Function Relationships of the G Domain, a Canonical Switch Motif

(2011) Alfred Wittinghofer et al.   Annual Review of Biochemistry

Understanding SOS (Son of Sevenless)

(2011) Stéphane Pierre et al.   BIOCHEMICAL PHARMACOLOGY

Low expression of DAB2IP contributes to malignant development and poor prognosis in hepatocellular carcinoma

(2011) Xiaojing Zhang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Signalling by insulin and IGF receptors: supporting acts and new players

(2011) Kenneth Siddle   JOURNAL OF MOLECULAR ENDOCRINOLOGY

RasGRP3 Contributes to Formation and Maintenance of the Prostate Cancer Phenotype

(2010) D. Yang et al.   CANCER RESEARCH

Unravelling the mechanism of dual-specificity GAPs

(2010) Begoña Sot et al.   EMBO JOURNAL

Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer

(2010) Diego F. Calvisi et al.   JOURNAL OF HEPATOLOGY

Possible involvement of RasGRP4 in leukemogenesis

(2009) Naoko Watanabe-Okochi et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Inactivation of Ras by p120GAP via Focal Adhesion Kinase Dephosphorylation Mediates RGMa-Induced Growth Cone Collapse

(2009) M. Endo et al.   JOURNAL OF NEUROSCIENCE

Cell fate decisions are specified by the dynamic ERK interactome

(2009) Alex von Kriegsheim et al.   NATURE CELL BIOLOGY

Characterization of the Intrinsic and TSC2-GAP-Regulated GTPase Activity of Rheb by Real-Time NMR

(2009) C. B. Marshall et al.   Science Signaling

Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins

(2008) Noriko Gotoh   CANCER SCIENCE

The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction

(2008) Vladimir Pena et al.   EMBO REPORTS

Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused byRASA1 mutations

(2008) Nicole Revencu et al.   HUMAN MUTATION

Membrane-dependent signal integration by the Ras activator Son of sevenless

(2008) Jodi Gureasko et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy

(2008) C. Kotting et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

(2007) Marie Dance et al.   CELLULAR SIGNALLING