Tanshinone IIA Attenuates Insulin Like Growth Factor 1 -Induced Cell Proliferation in PC12 Cells through the PI3K/Akt and MEK/ERK Pathways

Sodium Tanshinone II-A Sulfonate (DS-201) Induces Vasorelaxation of Rat Mesenteric Arteries via Inhibition of L-Type Ca2+ Channel

(2018) Xiao-Dong Zhang et al.   Frontiers in Pharmacology

Tanshinone IIA ameliorates apoptosis of myocardiocytes by up-regulation of miR-133 and suppression of Caspase-9

(2017) Tao Song et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Evaluation of Tanshinone IIA Developmental Toxicity in Zebrafish Embryos

(2017) Tao Wang et al.   MOLECULES

Synergistic effect of tanshinone IIA and mesenchymal stem cells on preventing learning and memory deficits via anti-apoptosis, attenuating tau phosphorylation and enhancing the activity of central cholinergic system in vascular dementia

(2017) Deyan Kong et al.   NEUROSCIENCE LETTERS

Tanshinone IIA induces intrinsic apoptosis in osteosarcoma cells both in vivo and in vitro associated with mitochondrial dysfunction

(2017) Sheng-Teng Huang et al.   Scientific Reports

Cyclin G2 promotes cell cycle arrest in breast cancer cells responding to fulvestrant and metformin and correlates with patient survival

(2016) Maike Zimmermann et al.   CELL CYCLE

Tanshinone IIA induces TRAIL sensitization of human lung cancer cells through selective ER stress induction

(2016) EUN-OK KIM et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Involvement of PI3K/Akt/FoxO3a and PKA/CREB Signaling Pathways in the Protective Effect of Fluoxetine Against Corticosterone-Induced Cytotoxicity in PC12 Cells

(2016) Bingqing Zeng et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Tanshinones and diethyl blechnics with anti-inflammatory and anti-cancer activities from Salvia miltiorrhiza Bunge (Danshen)

(2016) Hongwei Gao et al.   Scientific Reports

Mechanisms of protection against diabetes-induced impairment of endothelium-dependent vasorelaxation by Tanshinone IIA

(2015) Yan-Hua Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Apicidin inhibits cell growth by downregulating IGF-1R in salivary mucoepidermoid carcinoma cells

(2015) MEE-YOUNG AHN et al.   ONCOLOGY REPORTS

Salvia miltiorrhiza: A source for anti-Alzheimer’s disease drugs

(2015) Xiu-Zhen Zhang et al.   PHARMACEUTICAL BIOLOGY

The potential utility of acetyltanshinone IIA in the treatment of HER2-overexpressed breast cancer: Induction of cancer cell death by targeting apoptotic and metabolic signaling pathways

(2015) Mounia Guerram et al.   Oncotarget

Insulin-Like Growth Factor System in Cancer: Novel Targeted Therapies

(2015) Varsha P. Brahmkhatri et al.   Biomed Research International

A virtual screen identified C96 as a novel inhibitor of phosphatidylinositol 3-kinase that displays potent preclinical activity against multiple myeloma in vitro and in vivo

(2015) Juan Tang et al.   Oncotarget

GSK-3 as potential target for therapeutic intervention in cancer

(2015) James A. McCubrey et al.   Oncotarget

Tanshinone II-A sodium sulfonate (DS-201) enhances human BKCa channel activity by selectively targeting the pore-forming α subunit

(2014) Xiao-qiu Tan et al.   ACTA PHARMACOLOGICA SINICA

The cardioprotective effect of sodium tanshinone IIA sulfonate and the optimizing of therapeutic time window in myocardial ischemia/reperfusion injury in rats

(2014) Bo Wei et al.   ATHEROSCLEROSIS

GSK3 Protein Positively Regulates Type I Insulin-like Growth Factor Receptor through Forkhead Transcription Factors FOXO1/3/4

(2014) Xiaodong Huo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IGF-1 Signaling via the PI3K/Akt Pathway Confers Neuroprotection in Human Retinal Pigment Epithelial Cells Exposed to Sodium Nitroprusside Insult

(2014) Haitao Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Tanshinone IIA reduces the risk of Alzheimer’s disease by inhibiting iNOS, MMP-2 and NF-κBp65 transcription and translation in the temporal lobes of rat models of Alzheimer’s disease

(2014) PING JIANG et al.   Molecular Medicine Reports

Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: Targets for disease modification?

(2014) Fares Bassil et al.   PROGRESS IN NEUROBIOLOGY

Tanshinones Inhibit Amyloid Aggregation by Amyloid-β Peptide, Disaggregate Amyloid Fibrils, and Protect Cultured Cells

(2013) Qiuming Wang et al.   ACS Chemical Neuroscience

Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation

(2013) Leonard Girnita et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting IGF-1 signaling pathways in gynecologic malignancies

(2013) Ilan Bruchim et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

FOXO3a Involvement in the Release of TNF-α Stimulated by ATP in Spinal Cord Astrocytes

(2013) Maosheng Xia et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

UDP-Glucuronosyltransferase 1A Compromises Intracellular Accumulation and Anti-Cancer Effect of Tanshinone IIA in Human Colon Cancer Cells

(2013) Miao Liu et al.   PLoS One

The emerging multiple roles of nuclear Akt

(2012) Alberto M. Martelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

IGF-I Regulates Pheochromocytoma Cell Proliferation and SurvivalIn VitroandIn Vivo

(2012) María Celia Fernández et al.   ENDOCRINOLOGY

Tanshinone II-A: new perspectives for old remedies

(2012) Suowen Xu et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Insulin-like growth factor-1 induces the phosphorylation of PRAS40 via the PI3K/Akt signaling pathway in PC12 cells

(2012) Haitao Wang et al.   NEUROSCIENCE LETTERS

Receptor Tyrosine Kinases and Targeted Cancer Therapeutics

(2011) Kenji Takeuchi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Anti-angiogenic effect of Tanshinone IIA involves inhibition of matrix invasion and modification of MMP-2/TIMP-2 secretion in vascular endothelial cells

(2011) Ming-Yen Tsai et al.   CANCER LETTERS

The Complex Biology of FOXO

(2011) Maria Monsalve et al.   CURRENT DRUG TARGETS

De novo transcriptome sequencing in Salvia miltiorrhiza to identify genes involved in the biosynthesis of active ingredients

(2011) Hua Wenping et al.   GENOMICS

Antiandrogenic, Maspin Induction, and Antiprostate Cancer Activities of Tanshinone IIA and Its Novel Derivatives with Modification in Ring A

(2011) Weiguo Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

IGF-1 receptor is down-regulated by sunitinib induces MDM2-dependent ubiquitination

(2011) Hongchang Shen et al.   FEBS Open Bio