Targeting P-glycoprotein and SORCIN: Dihydromyricetin strengthens anti-proliferative efficiency of adriamycin via MAPK/ERK and Ca2+ -mediated apoptosis pathways in MCF-7/ADR and K562/ADR

Toward a Better Understanding of the Complexity of Cancer Drug Resistance

(2016) Michael M. Gottesman et al.   Annual Review of Pharmacology and Toxicology

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade

(2016) Zhaolin Chen et al.   CANCER LETTERS

Suppression of reactive oxygen species-mediated ERK and JNK activation sensitizes dihydromyricetin-induced mitochondrial apoptosis in human non-small cell lung cancer

(2016) Shang-Jyh Kao et al.   ENVIRONMENTAL TOXICOLOGY

Overexpression ofSORCINis a Prognostic Biomarker for Multidrug-Resistant Pediatric Acute Lymphoblastic Leukemia and Correlates with UpregulatedMDR1/P-gp

(2016) Mohammad Dabaghi et al.   Genetic Testing and Molecular Biomarkers

Sequestration of sorcin by aberrant forms of tau results in the defective calcium homeostasis

(2016) Song-In Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Targeting P-glycoprotein expression and cancer cell energy metabolism: combination of metformin and 2-deoxyglucose reverses the multidrug resistance of K562/Dox cells to doxorubicin

(2016) Chaojun Xue et al.   TUMOR BIOLOGY

Protective effects of formononetin against rhabdomyolysis-induced acute kidney injury by upregulating Nrf2 in vivo and in vitro

(2016) Di Huang et al.   RSC Advances

Dioscin strengthens the efficiency of adriamycin in MCF-7 and MCF-7/ADR cells through autophagy induction: More than just down-regulation of MDR1

(2016) Changyuan Wang et al.   Scientific Reports

The potential predictive role of nuclear NHERF1 expression in advanced gastric cancer patients treated with epirubicin/oxaliplatin/capecitabine first line chemotherapy

(2015) Anita Mangia et al.   CANCER BIOLOGY & THERAPY

CBP-dependent Wnt/β-catenin signaling is crucial in regulation of MDR1 transcription

(2015) Zanxian Xia et al.   CURRENT CANCER DRUG TARGETS

The modulation of ABC transporter-mediated multidrug resistance in cancer: A review of the past decade

(2015) Rishil J. Kathawala et al.   DRUG RESISTANCE UPDATES

Resveratrol Increases Anti-Proliferative Activity of Bestatin Through Downregulating P-Glycoprotein Expression Via Inhibiting PI3K/Akt/mTOR Pathway in K562/ADR Cells

(2015) Li Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Suppression of Inflammatory Responses by Dihydromyricetin, a Flavonoid from Ampelopsis grossedentata, via Inhibiting the Activation of NF-κB and MAPK Signaling Pathways

(2015) X. L. Hou et al.   JOURNAL OF NATURAL PRODUCTS

Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: A randomized controlled trial

(2015) Shihui Chen et al.   PHARMACOLOGICAL RESEARCH

Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy

(2015) Renata Silva et al.   PHARMACOLOGY & THERAPEUTICS

Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway

(2014) Ting Chen et al.   CANCER BIOLOGY & THERAPY

ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development

(2014) Young Choi et al.   CURRENT PHARMACEUTICAL DESIGN

Reversing effect and mechanism of soluble resistance-related calcium-binding protein on multidrug resistance in human lung cancer A549/DDP cells

(2014) YANYAN GAO et al.   Molecular Medicine Reports

Sorcin, a Calcium Binding Protein Involved in the Multidrug Resistance Mechanisms in Cancer Cells

(2014) Gianni Colotti et al.   MOLECULES

Dihydromyricetin promotes hepatocellular carcinoma regression via a p53 activation-dependent mechanism

(2014) Qingyu Zhang et al.   Scientific Reports

Inhibition of sorcin reverses multidrug resistance of K562/A02 cells and MCF-7/A02 cells via regulating apoptosis-related proteins

(2013) Yunhui Hu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Sorcin modulates mitochondrial Ca2+ handling and reduces apoptosis in neonatal rat cardiac myocytes

(2012) Jorge Suarez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds

(2012) A. Palmeira et al.   CURRENT MEDICINAL CHEMISTRY

Recent advances in apoptosis, mitochondria and drug resistance in cancer cells

(2011) Inthrani R. Indran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia

(2011) E. Park et al.   BLOOD

Preliminary investigations of antioxidation of dihydromyricetin in polymers

(2010) Qiukai Zheng et al.   BULLETIN OF MATERIALS SCIENCE

Quercetin: A potential drug to reverse multidrug resistance

(2010) Chen Chen et al.   LIFE SCIENCES

The BCL-2 Family Reunion

(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

Comparative proteomic profiling identified sorcin being associated with gemcitabine resistance in non-small cell lung cancer

(2009) Yiqing Qu et al.   MEDICAL ONCOLOGY

Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer

(2008) Helen M. Coley   CANCER TREATMENT REVIEWS

A subcelluar proteomic investigation into vincristine-resistant gastric cancer cell line

(2008) Yi-Xuan Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY