The effect of diet and exercise on lipid droplet dynamics in human muscle tissue

Partial Disruption of Lipolysis Increases Postexercise Insulin Sensitivity in Skeletal Muscle Despite Accumulation of DAG

(2016) Annette Karen Serup et al.   DIABETES

Resveratrol as Add-on Therapy in Subjects With Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial

(2016) Silvie Timmers et al.   DIABETES CARE

Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans

(2016) Anne Gemmink et al.   DIABETOLOGIA

Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans

(2016) Bryan C. Bergman et al.   DIABETOLOGIA

Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans

(2016) Katherine T. Tonks et al.   Obesity

Lipid-Induced Insulin Resistance in Skeletal Muscle: The Chase for the Culprit Goes from Total Intramuscular Fat to Lipid Intermediates, and Finally to Species of Lipid Intermediates

(2016) Soressa Kitessa et al.   Nutrients

Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity

(2016) Ditte Søgaard et al.   Journal of Diabetes Research

Microscopy tools for the investigation of intracellular lipid storage and dynamics

(2016) Sabine Daemen et al.   Molecular Metabolism

DAG tales: the multiple faces of diacylglycerol—stereochemistry, metabolism, and signaling

(2015) Thomas Oliver Eichmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lipid droplet–organelle interactions: emerging roles in lipid metabolism

(2015) Antonio Daniel Barbosa et al.   CURRENT OPINION IN CELL BIOLOGY

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

Mechanism by which caloric restriction improves insulin sensitivity in sedentary obese adults

(2015) Matthew L. Johnson et al.   DIABETES

Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes

(2015) Lara Bellini et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Resistance to the Beneficial Effects of Exercise in Type 2 Diabetes: Are Some Individuals Programmed to Fail?

(2015) Natalie A. Stephens et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Human Muscle Fiber Type–Specific Insulin Signaling: Impact of Obesity and Type 2 Diabetes

(2014) Peter H. Albers et al.   DIABETES

Chronic muscle stimulation improves insulin sensitivity while increasing subcellular lipid droplets and reducing selected diacylglycerol and ceramide species in obese Zucker rats

(2014) Graham P. Holloway et al.   DIABETOLOGIA

The effect of a single 2 h bout of aerobic exercise on ectopic lipids in skeletal muscle, liver and the myocardium

(2014) Julie Bucher et al.   DIABETOLOGIA

Skeletal muscle ceramide species in men with abdominal obesity

(2014) Maria Pia de la Maza et al.   Journal of Nutrition Health & Aging

Cellular Localization and Associations of the Major Lipolytic Proteins in Human Skeletal Muscle at Rest and during Exercise

(2014) Rachael R. Mason et al.   PLoS One

Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

(2014) Julia Szendroedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Bezafibrate Treatment in a Patient and a Carrier With Mutations in the PNPLA2 Gene, Causing Neutral Lipid Storage Disease With Myopathy

(2013) Tineke van de Weijer et al.   CIRCULATION RESEARCH

Endurance Training Modulates Intramyocellular Lipid Compartmentalization and Morphology in Skeletal Muscle of Lean and Obese Women

(2013) Michaela C. Devries et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The biophysics and cell biology of lipid droplets

(2013) Abdou Rachid Thiam et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Markers of Skeletal Muscle Mitochondrial Function and Lipid Accumulation Are Moderately Associated with the Homeostasis Model Assessment Index of Insulin Resistance in Obese Men

(2013) Imtiaz A. Samjoo et al.   PLoS One

The Effect of Aerobic Exercise on Intrahepatocellular and Intramyocellular Lipids in Healthy Subjects

(2013) Andrea Egger et al.   PLoS One

Exercise and Type 2 Diabetes Mellitus: Changes in Tissue-specific Fat Distribution and Cardiac Function

(2013) Jacqueline T. Jonker et al.   RADIOLOGY

Dynamics of skeletal muscle lipid pools

(2013) Pierre-Marie Badin et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Prolonged exercise training increases intramuscular lipid content and perilipin 2 expression in type I muscle fibers of patients with type 2 diabetes

(2012) C. S. Shaw et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lipid Droplets and Cellular Lipid Metabolism

(2012) Tobias C. Walther et al.   Annual Review of Biochemistry

Perilipin family (PLIN) proteins in human skeletal muscle: the effect of sex, obesity, and endurance training

(2012) Sandra J. Peters et al.   Applied Physiology Nutrition and Metabolism

Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels

(2012) M. Bosma et al.   DIABETES

High Oxidative Capacity Due to Chronic Exercise Training Attenuates Lipid-Induced Insulin Resistance

(2012) E. Phielix et al.   DIABETES

Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans

(2012) B. C. Bergman et al.   DIABETOLOGIA

Preferential utilization of perilipin 2-associated intramuscular triglycerides during 1 h of moderate-intensity endurance-type exercise

(2012) S. O. Shepherd et al.   EXPERIMENTAL PHYSIOLOGY

PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans

(2012) Timothy R. Koves et al.   JOURNAL OF LIPID RESEARCH

Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5

(2012) S. O. Shepherd et al.   JOURNAL OF PHYSIOLOGY-LONDON

Skeletal muscle1H MRSI before and after prolonged exercise. I. muscle specific depletion of intramyocellular lipids

(2012) Peter Vermathen et al.   MAGNETIC RESONANCE IN MEDICINE

Effects of an overnight intravenous lipid infusion on intramyocellular lipid content and insulin sensitivity in African–American versus Caucasian adolescents

(2012) SoJung Lee et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes

(2012) K. F. Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

(2011) Silvie Timmers et al.   Cell Metabolism

Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance: Another Paradox in Endurance-Trained Athletes?

(2011) F. Amati et al.   DIABETES

Subcellular lipid droplet distribution in red and white muscles in the obese Zucker rat

(2011) J. S. V. Lally et al.   DIABETOLOGIA

Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide

(2011) J. J. Dubé et al.   DIABETOLOGIA

The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria

(2011) Madeleen Bosma et al.   HISTOCHEMISTRY AND CELL BIOLOGY

High-fat diet overrules the effects of training on fiber-specific intramyocellular lipid utilization during exercise

(2011) Karen Van Proeyen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Long- and Medium-Chain Fatty Acids Induce Insulin Resistance to a Similar Extent in Humans Despite Marked Differences in Muscle Fat Accumulation

(2011) Joris Hoeks et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men

(2011) Jeffrey D. Browning et al.   JOURNAL OF LIPID RESEARCH

Morning to evening changes of intramyocellular lipid content in dependence on nutrition and physical activity during one single day: a volume selective 1H-MRS study

(2011) Jürgen Machann et al.   MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

Skeletal Muscle Fatty Acid Handling in Insulin Resistant Men

(2011) Anneke M.J. van Hees et al.   Obesity

Factors regulating fat oxidation in human skeletal muscle

(2011) B. Kiens et al.   Obesity Reviews

Expression of perilipins in human skeletal musclein vitroandin vivoin relation to diet, exercise and energy balance

(2011) I.M.F. Gjelstad et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Improved glucose tolerance after intensive life style intervention occurs without changes in muscle ceramide or triacylglycerol in morbidly obese subjects

(2010) J. W. Helge et al.   Acta Physiologica

Acute elevation of plasma lipids does not affect ATP synthesis in human skeletal muscle

(2010) A. Brehm et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Prolonged Fasting Identifies Skeletal Muscle Mitochondrial Dysfunction as Consequence Rather Than Cause of Human Insulin Resistance

(2010) J. Hoeks et al.   DIABETES

Effects of dietary fat modification on skeletal muscle fatty acid handling in the metabolic syndrome

(2010) A M J van Hees et al.   INTERNATIONAL JOURNAL OF OBESITY

Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes

(2010) Bryan C. Bergman et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle

(2010) Agnieszka Blachnio-Zabielska et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Low-carbohydrate diet does not affect intramyocellular lipid concentration or insulin sensitivity in lean, physically fit men when protein intake is elevated

(2010) Jackson G. Green et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Diacylglycerol-mediated insulin resistance

(2010) Derek M Erion et al.   NATURE MEDICINE

Altered Intramuscular Lipid Metabolism Relates to Diminished Insulin Action in Men, but Not Women, in Progression to Diabetes

(2010) Leigh Perreault et al.   Obesity

Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men

(2010) Yuko Sakurai et al.   Journal of Diabetes Investigation

Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5

(2009) Martina Schweiger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Increased subsarcolemmal lipids in type 2 diabetes: effect of training on localization of lipids, mitochondria, and glycogen in sedentary human skeletal muscle

(2009) Joachim Nielsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

SnapShot: Lipid Droplets

(2009) Natalie Krahmer et al.   CELL

Lipid Droplets Finally Get a Little R-E-S-P-E-C-T

(2009) Robert V. Farese et al.   CELL

Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity

(2009) R. C.R. Meex et al.   DIABETES

Insulin Resistance Is Associated With Higher Intramyocellular Triglycerides in Type I but Not Type II Myocytes Concomitant With Higher Ceramide Content

(2009) P. M. Coen et al.   DIABETES

Skeletal Muscle Lipogenic Protein Expression Is Not Different between Lean and Obese Individuals: A Potential Factor in Ceramide Accumulation

(2009) A. Brianne Thrush et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Influence of Gender, Obesity, and Muscle Lipase Activity on Intramyocellular Lipids in Sedentary Individuals

(2009) Cedric Moro et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins: TABLE 1.

(2009) Alan R. Kimmel et al.   JOURNAL OF LIPID RESEARCH

Relationship between plasma free fatty acid, intramyocellular triglycerides and long-chain acylcarnitines in resting humans

(2009) Jill A. Kanaley et al.   JOURNAL OF PHYSIOLOGY-LONDON

Diabetes mellitus is associated with increased intramyocellular triglyceride, but not diglyceride, content in obese humans

(2009) Costas A. Anastasiou et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited

(2008) John J. Dubé et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The life of lipid droplets

(2008) Tobias C. Walther et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mitochondrial Capacity in Skeletal Muscle Is Not Stimulated by Weight Loss Despite Increases in Insulin Action and Decreases in Intramyocellular Lipid Content

(2008) F. G.S. Toledo et al.   DIABETES

Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity

(2008) M. Skovbro et al.   DIABETOLOGIA

Effect of gender on lipid-induced insulin resistance in obese subjects

(2008) Bodil Vistisen et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults

(2008) Thomas P. J. Solomon et al.   JOURNAL OF APPLIED PHYSIOLOGY

The C-terminal Region of Human Adipose Triglyceride Lipase Affects Enzyme Activity and Lipid Droplet Binding

(2008) Martina Schweiger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Dietary Fat on Serum and Intramyocellular Lipids and Running Performance

(2008) D. ENETTE LARSON-MEYER et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Imaging of Lipid Biosynthesis: How a Neutral Lipid Enters Lipid Droplets

(2008) Lars Kuerschner et al.   TRAFFIC

Effects of short-term very low-calorie diet on intramyocellular lipid and insulin sensitivity in nondiabetic and type 2 diabetic subjects

(2007) Cristina Lara-Castro et al.   METABOLISM-CLINICAL AND EXPERIMENTAL