Causes and mechanisms of adipocyte enlargement and adipose expansion

The mitochondrial outer membrane protein mitoNEET is a redox enzyme catalyzing electron transfer from FMNH2to oxygen or ubiquinone

(2017) Yiming Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic determination of body fat distribution and the attributive influence on metabolism

(2017) Ellen Fehlert et al.   Obesity

Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?

(2016) M. Bluher   CLINICAL SCIENCE

Adipose Cell Size and Regional Fat Deposition as Predictors of Metabolic Response to Overfeeding in Insulin-Resistant and Insulin-Sensitive Humans

(2016) Tracey McLaughlin et al.   DIABETES

Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues

(2016) Vanessa Pellegrinelli et al.   DIABETOLOGIA

Adipose tissue development and the molecular regulation of lipid metabolism

(2016) A. Raajendiran et al.   Essays in Biochemistry

Adipose tissue hypoxia and insulin resistance

(2016) Neda Rasouli   JOURNAL OF INVESTIGATIVE MEDICINE

Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants

(2016)   LANCET

Comparative analysis of three human adipocyte size measurement methods and their relevance for cardiometabolic risk

(2016) Sofia Laforest et al.   Obesity

A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo

(2016) J. C. Wong et al.   Science Signaling

Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction

(2016) Hadi Khodabandehloo et al.   Translational Research

Caveolae: One Function or Many?

(2016) Jade P.X. Cheng et al.   TRENDS IN CELL BIOLOGY

Visceral adiposity syndrome

(2016) Heno F. Lopes et al.   Diabetology & Metabolic Syndrome

A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo

(2016) J. C. Wong et al.   Science Signaling

Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

(2016) Sung Sik Choe et al.   Frontiers in Endocrinology

Lipid accumulation product and visceral adiposity index are effective markers for identifying the metabolically obese normal-weight phenotype

(2015) Tingting Du et al.   ACTA DIABETOLOGICA

Is the Metabolically Healthy Obesity Phenotype an Irrelevant Artifact for Public Health?

(2015) Juan Pablo Rey-López et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Nonalcoholic Fatty Liver Disease, Diabetes, Obesity, and Hepatocellular Carcinoma

(2015) Mazen Noureddin et al.   Clinics in Liver Disease

Adipocyte size as a determinant of metabolic disease and adipose tissue dysfunction

(2015) Sofia Laforest et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Abdominal adipocyte populations in women with visceral obesity

(2015) Andréanne Michaud et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Curbing the Diabetes Pandemic

(2015) Frank B. Hu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cavin family proteins and the assembly of caveolae

(2015) O. Kovtun et al.   JOURNAL OF CELL SCIENCE

Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies

(2015) Prasenjit Manna et al.   Metabolic Syndrome and Related Disorders

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

(2015) Felix M Wensveen et al.   NATURE IMMUNOLOGY

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

Exercise improves adipose function and inflammation and ameliorates fatty liver disease in obese diabetic mice

(2015) Fahrettin Haczeyni et al.   Obesity

Obesity, inflammation, and the gut microbiota

(2015) Amanda J Cox et al.   Lancet Diabetes & Endocrinology

Pathways commonly dysregulated in mouse and human obese adipose tissue: FAT/CD36 modulates differentiation and lipogenesis

(2015) E Berger et al.   Adipocyte

The cell size and distribution of adipocytes from subcutaneous and visceral fat is associated with type 2 diabetes mellitus in humans

(2015) Lingling Fang et al.   Adipocyte

Association of metabolically abnormal but normal weight (MANW) and metabolically healthy but obese (MHO) individuals with arterial stiffness and carotid atherosclerosis

(2014) Hye Jin Yoo et al.   ATHEROSCLEROSIS

Loss of White Adipose Hyperplastic Potential Is Associated with Enhanced Susceptibility to Insulin Resistance

(2014) Soo M. Kim et al.   Cell Metabolism

A Smooth Muscle-Like Origin for Beige Adipocytes

(2014) Jonathan Z. Long et al.   Cell Metabolism

Molecular mechanisms of GLUT4 regulation in adipocytes

(2014) R. Govers   DIABETES & METABOLISM

Insulin action in morbid obesity: a focus on muscle and adipose tissue

(2014) Panayota Mitrou et al.   Hormones-International Journal of Endocrinology and Metabolism

Adipocyte morphology and implications for metabolic derangements in acquired obesity

(2014) S Heinonen et al.   INTERNATIONAL JOURNAL OF OBESITY

Nutrient regulation of insulin secretion and action

(2014) Philip Newsholme et al.   JOURNAL OF ENDOCRINOLOGY

Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent

(2014) Lay T. Gan et al.   JOURNAL OF HEPATOLOGY

CGI-58/ABHD5 is phosphorylated on Ser239 by protein kinase A: control of subcellular localization

(2014) Anita Sahu-Osen et al.   JOURNAL OF LIPID RESEARCH

Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults

(2014) Krishnan Bhaskaran et al.   LANCET

MiR-146b is a regulator of human visceral preadipocyte proliferation and differentiation and its expression is altered in human obesity

(2014) Ling Chen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Metabolically healthy and unhealthy obese - the 2013 Stock Conference report

(2014) D. Samocha-Bonet et al.   Obesity Reviews

The prevalence of metabolically healthy obesity: a systematic review and critical evaluation of the definitions used

(2014) J. P. Rey-López et al.   Obesity Reviews

Metabolically healthy obesity and risk of incident type 2 diabetes: a meta-analysis of prospective cohort studies

(2014) J. A. Bell et al.   Obesity Reviews

Relationship of Adipocyte Size with Adiposity and Metabolic Risk Factors in Asian Indians

(2014) Ved Prakash Meena et al.   PLoS One

GLUT4 Defects in Adipose Tissue Are Early Signs of Metabolic Alterations in Alms1GT/GT, a Mouse Model for Obesity and Insulin Resistance

(2014) Francesca Favaretto et al.   PLoS One

Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed

(2014) Joan Sanchez-Gurmaches et al.   Nature Communications

Hypercholesterolemia Induces Adipose Dysfunction in Conditions of Obesity and Nonobesity

(2014) David Aguilar et al.   Advances in Nutrition

Modulation of adipose tissue lipolysis and body weight by high-density lipoproteins in mice

(2014) H Wei et al.   Nutrition & Diabetes

Adipocyte size and cellular expression of caveolar proteins analyzed by confocal microscopy

(2013) V. Hulstrøm et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Improving human health through understanding the complex structure of glucose polymers

(2013) Robert G. Gilbert et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Apolipoprotein AI and High-Density Lipoprotein Have Anti-Inflammatory Effects on Adipocytes via Cholesterol Transporters

(2013) Tomio Umemoto et al.   CIRCULATION RESEARCH

Insulin Resistance, Obesity, and Liver Cancer

(2013) Geoffrey Farrell   Clinical Gastroenterology and Hepatology

The developmental origins of adipose tissue

(2013) Daniel C. Berry et al.   DEVELOPMENT

Characterising metabolically healthy obesity in weight-discordant monozygotic twins

(2013) J. Naukkarinen et al.   DIABETOLOGIA

A comparative perspective on lipid storage in animals

(2013) K. Birsoy et al.   JOURNAL OF CELL SCIENCE

Fatty acid metabolism, energy expenditure and insulin resistance in muscle

(2013) Nigel Turner et al.   JOURNAL OF ENDOCRINOLOGY

FXR activation normalizes insulin sensitivity in visceral preadipocytes of a rabbit model of MetS

(2013) Elena Maneschi et al.   JOURNAL OF ENDOCRINOLOGY

Insulin responsiveness of glucose transporter 4 in 3T3-L1 cells depends on the presence of sortilin

(2013) Guanrong Huang et al.   MOLECULAR BIOLOGY OF THE CELL

Dietary intervention impact on gut microbial gene richness

(2013) Aurélie Cotillard et al.   NATURE

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

(2013) Qiong A Wang et al.   NATURE MEDICINE

Caveolae as plasma membrane sensors, protectors and organizers

(2013) Robert G. Parton et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CD36 is important for adipocyte recruitment and affects lipolysis

(2013) Irene O.C.M. Vroegrijk et al.   Obesity

Pathophysiology of Human Visceral Obesity: An Update

(2013) André Tchernof et al.   PHYSIOLOGICAL REVIEWS

Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

(2013) Paul Trayhurn   PHYSIOLOGICAL REVIEWS

Regulation of energy metabolism by long-chain fatty acids

(2013) Manabu T. Nakamura et al.   PROGRESS IN LIPID RESEARCH

Molecular Composition and Ultrastructure of the Caveolar Coat Complex

(2013) Alexander Ludwig et al.   PLOS BIOLOGY

Adipose tissue depot and cell size dependency of adiponectin synthesis and secretion in human obesity

(2013) Lauren K Meyer et al.   Adipocyte

Lipid Droplets and Cellular Lipid Metabolism

(2012) Tobias C. Walther et al.   Annual Review of Biochemistry

Postprandial metabolism of meal triglyceride in humans

(2012) Jennifer E. Lambert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The evolution of human adiposity and obesity: where did it all go wrong?

(2012) J. C. K. Wells   Disease Models & Mechanisms

Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes

(2012) Yu Chen et al.   JOURNAL OF CELL BIOLOGY

Do Changes in Sex Steroid Hormones Precede or Follow Increases in Body Weight during the Menopause Transition? Results from The Study of Women's Health Across the Nation

(2012) Rachel P. Wildman et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Distinct Developmental Signatures of Human Abdominal and Gluteal Subcutaneous Adipose Tissue Depots

(2012) Kalypso Karastergiou et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Prediabetes: a high-risk state for diabetes development

(2012) Adam G Tabák et al.   LANCET

The effect of the menopausal transition on body composition and cardiometabolic risk factors

(2012) Joseph Abdulnour et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity

(2012) Christine M Kusminski et al.   NATURE MEDICINE

Cholesterol Depletion in Adipocytes Causes Caveolae Collapse Concomitant with Proteosomal Degradation of Cavin-2 in a Switch-Like Fashion

(2012) Michael R. Breen et al.   PLoS One

Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) γ Activators and Pan-PPAR Partial Agonists

(2012) Marcelo Vizoná Liberato et al.   PLoS One

Diabetes reduces β-cell mitochondria and induces distinct morphological abnormalities, which are reproducible by high glucose in vitro with attendant dysfunction

(2012) Zuheng Ma et al.   Islets

Potential role of insulin signaling on vascular smooth muscle cell migration, proliferation, and inflammation pathways

(2011) Eugenio Cersosimo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The relationship between fat depot-specific preadipocyte differentiation and metabolic syndrome in obese women

(2011) Hyun Tae Park et al.   CLINICAL ENDOCRINOLOGY

Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis

(2011) K. Birsoy et al.   DEVELOPMENT

Dissociation of the insulin receptor from caveolae during TNFα-induced insulin resistance and its recovery byd-PDMP

(2011) Junji Sekimoto et al.   FEBS LETTERS

Lipid Bodies in Inflammatory Cells

(2011) Rossana C. N. Melo et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

De novo lipogenesis in the differentiating human adipocyte can provide all fatty acids necessary for maturation

(2011) Jennifer M. Collins et al.   JOURNAL OF LIPID RESEARCH

The global obesity pandemic: shaped by global drivers and local environments

(2011) Boyd A Swinburn et al.   LANCET

High-fat diet feeding alters metabolic response to fasting/non fasting conditions. Effect on caveolin expression and insulin signalling

(2011) Ana Gómez-Ruiz et al.   Lipids in Health and Disease

Longitudinal Associations of the Endocrine Environment on Fat Partitioning in Postmenopausal Women

(2011) Amy M. Goss et al.   Obesity

Regulation of Lipogenesis by Glucocorticoids and Insulin in Human Adipose Tissue

(2011) Laura L. Gathercole et al.   PLoS One

Adipokines: A treasure trove for the discovery of biomarkers for metabolic disorders

(2011) Stefan Lehr et al.   Proteomics Clinical Applications

The Sugar Is sIRVed: Sorting Glut4 and Its Fellow Travelers

(2011) Konstantin V. Kandror et al.   TRAFFIC

Fat cell turnover in humans

(2010) Peter Arner et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease

(2010) Zhao-Xia Yang et al.   Hepatology International

Body composition phenotypes in pathways to obesity and the metabolic syndrome

(2010) A G Dulloo et al.   INTERNATIONAL JOURNAL OF OBESITY

The Farnesoid X Receptor Regulates Adipocyte Differentiation and Function by Promoting Peroxisome Proliferator-activated Receptor-γ and Interfering with the Wnt/β-Catenin Pathways

(2010) Mouaadh Abdelkarim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional control of preadipocyte determination by Zfp423

(2010) Rana K. Gupta et al.   NATURE

Lipodystrophy: pathophysiology and advances in treatment

(2010) Christina G. Fiorenza et al.   Nature Reviews Endocrinology

Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease

(2010) Jan F. C. Glatz et al.   PHYSIOLOGICAL REVIEWS

Lipid droplets in inflammation and cancer

(2010) Patricia T. Bozza et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Lipid Droplets Finally Get a Little R-E-S-P-E-C-T

(2009) Robert V. Farese et al.   CELL

Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans

(2009) R. Roberts et al.   DIABETOLOGIA

Caveolin-1 Loss of Function Accelerates Glucose Transporter 4 and Insulin Receptor Degradation in 3T3-L1 Adipocytes

(2009) Elena González-Muñoz et al.   ENDOCRINOLOGY

Forkhead transcription factor Foxo1 is essential for adipocyte differentiation

(2009) Keisuke Munekata et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

TIP47 functions in the biogenesis of lipid droplets

(2009) Anna V. Bulankina et al.   JOURNAL OF CELL BIOLOGY

Lipid droplet growth by fusion: insights from freeze-fracture imaging

(2009) Horst Robenek et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Roles of adipose restriction and metabolic factors in progression of steatosis to steatohepatitis in obese, diabetic mice

(2009) Claire Z Larter et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The Bile Acid Sensor Farnesoid X Receptor Is a Modulator of Liver Immunity in a Rodent Model of Acute Hepatitis

(2009) A. Mencarelli et al.   JOURNAL OF IMMUNOLOGY

Proteomic insights into an expanded cellular role for cytoplasmic lipid droplets

(2009) Brittany D. M. Hodges et al.   JOURNAL OF LIPID RESEARCH

Functional interaction of hormone-sensitive lipase and perilipin in lipolysis

(2009) Wen-Jun Shen et al.   JOURNAL OF LIPID RESEARCH

Cholesterol imbalance in adipocytes: a possible mechanism of adipocytes dysfunction in obesity

(2009) B.-L. Yu et al.   Obesity Reviews

Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway

(2009) Hui H. Zhang et al.   PLoS One

Lipolysis and lipid mobilization in human adipose tissue

(2009) Max Lafontan et al.   PROGRESS IN LIPID RESEARCH

Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth

(2009) Junghyo Jo et al.   PLoS Computational Biology

The Obese Without Cardiometabolic Risk Factor Clustering and the Normal Weight With Cardiometabolic Risk Factor Clustering

(2008) Rachel P. Wildman   ARCHIVES OF INTERNAL MEDICINE

Insulin-induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4

(2008) M VANOORT   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Identification of White Adipocyte Progenitor Cells In Vivo

(2008) Matthew S. Rodeheffer et al.   CELL

Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores

(2008) Rudolf Zechner et al.   JOURNAL OF LIPID RESEARCH

Dynamics of fat cell turnover in humans

(2008) Kirsty L. Spalding et al.   NATURE

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY