Allosteric regulation of pathologic angiogenesis: potential application for angiogenesis-related blindness

Aflibercept for Age-Related Macular Degeneration: A Game-Changer or Quiet Addition?

(2012) David J. Browning et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Allostery and the Monod-Wyman-Changeux Model After 50 Years

(2012) Jean-Pierre Changeux   Annual Review of Biophysics

Structural and Energetic Basis of Allostery

(2012) Vincent J. Hilser et al.   Annual Review of Biophysics

Long-term Effects of Ranibizumab on Diabetic Retinopathy Severity and Progression

(2012) Michael S. Ip   ARCHIVES OF OPHTHALMOLOGY

Macular ischaemia: a contraindication for anti-VEGF treatment in retinal vascular disease?

(2012) Kleanthis Manousaridis et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Human Apolipoprotein(a) Kringle V Inhibits Ischemia-Induced Retinal Neovascularization via Suppression of Fibronectin-Mediated Angiogenesis

(2012) Y. Lim et al.   DIABETES

Delayed onset atypical vitreoretinal traction band formation after an intravitreal injection of bevacizumab in stage 3 retinopathy of prematurity

(2012) B J Lee et al.   EYE

Age-related macular degeneration

(2012) Laurence S Lim et al.   LANCET

Targeting Extracellular Domains D4 and D7 of Vascular Endothelial Growth Factor Receptor 2 Reveals Allosteric Receptor Regulatory Sites

(2012) C. A. C. Hyde et al.   MOLECULAR AND CELLULAR BIOLOGY

The Thymidine Phosphorylase Inhibitor 5'-O-Tritylinosine (KIN59) Is an Antiangiogenic Multitarget Fibroblast Growth Factor-2 Antagonist

(2012) S. Liekens et al.   MOLECULAR CANCER THERAPEUTICS

Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma

(2012) Kang Zhang et al.   NATURE REVIEWS DRUG DISCOVERY

Diabetic Retinopathy

(2012) David A. Antonetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ranibizumab for Diabetic Macular Edema

(2012) Quan Dong Nguyen et al.   OPHTHALMOLOGY

Vascular Endothelial Growth Factor A in Intraocular Vascular Disease

(2012) Joan W. Miller et al.   OPHTHALMOLOGY

Inhibitory Activity of Bevacizumab to Differentiation of Retinoblastoma Cells

(2012) Jang Won Heo et al.   PLoS One

NEW INSIGHTS INTO THE PATHOANATOMY OF DIABETIC MACULAR EDEMA

(2012) Suk Ho Byeon et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Prevalence of Age-Related Macular Degeneration in the US Population

(2011) Ronald Klein   ARCHIVES OF OPHTHALMOLOGY

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Epigenetic Changes in Mitochondrial Superoxide Dismutase in the Retina and the Development of Diabetic Retinopathy

(2011) Q. Zhong et al.   DIABETES

FGF-dependent regulation of VEGF receptor 2 expression in mice

(2011) Masahiro Murakami et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Efficacy of Intravitreal Bevacizumab for Stage 3+ Retinopathy of Prematurity

(2011) Helen A. Mintz-Hittner et al.   NEW ENGLAND JOURNAL OF MEDICINE

How to overcome retinal neuropathy: The fight against angiogenesisrelated blindness

(2010) Dong Hyun Jo et al.   ARCHIVES OF PHARMACAL RESEARCH

Exploring and exploiting allostery: Models, evolution, and drug targeting

(2010) Alessio Peracchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Serotonin derivatives as a new class of non-ATP-competitive receptor tyrosine kinase inhibitors

(2010) Anita Büttner et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Current update on retinopathy of prematurity: screening and treatment

(2010) Jing Chen et al.   CURRENT OPINION IN PEDIATRICS

VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts

(2010) Ingrid Nilsson et al.   EMBO JOURNAL

Tumor vasculature as target for therapeutic intervention

(2010) Marcel HAM Fens et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life

(2010) Przemyslaw Sapieha et al.   JOURNAL OF CLINICAL INVESTIGATION

Incidence of Retinopathy of Prematurity over the Last Decade in the Central Netherlands

(2010) A. Hoogerwerf et al.   Neonatology

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Allosteric modulation of G protein-coupled receptors: A pharmacological perspective

(2010) Peter Keov et al.   NEUROPHARMACOLOGY

Allosteric modulation of metabotropic glutamate receptors: Structural insights and therapeutic potential

(2010) Karen J. Gregory et al.   NEUROPHARMACOLOGY

ASD: a comprehensive database of allosteric proteins and modulators

(2010) Z. Huang et al.   NUCLEIC ACIDS RESEARCH

Incidence of Retinopathy of Prematurity in the United States: 1997 through 2005

(2009) Eleonora M. Lad et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Extracellular Matrix Proteins in Epiretinal Membranes and in Diabetic Retinopathy

(2009) Biju George et al.   CURRENT EYE RESEARCH

Decursin Inhibits VEGF-Mediated Inner Blood—Retinal Barrier Breakdown by Suppression of VEGFR-2 Activation

(2009) Jin Hyoung Kim et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Adverse effects of anticancer agents that target the VEGF pathway

(2009) Helen X. Chen et al.   Nature Reviews Clinical Oncology

The FGF family: biology, pathophysiology and therapy

(2009) Andrew Beenken et al.   NATURE REVIEWS DRUG DISCOVERY

Vitreous Levels of Erythropoietin and Vascular Endothelial Growth Factor in Eyes with Retinopathy of Prematurity

(2009) Tatsuhiko Sato et al.   OPHTHALMOLOGY

The Origin of Allosteric Functional Modulation: Multiple Pre-existing Pathways

(2009) Antonio del Sol et al.   STRUCTURE

Prolonged Effect of Intensive Therapy on the Risk of Retinopathy Complications in Patients With Type 1 Diabetes Mellitus

(2008)   ARCHIVES OF OPHTHALMOLOGY

Integrins

(2008) Rita Silva et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

VEGF receptor protein–tyrosine kinases: Structure and regulation

(2008) Robert Roskoski   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A peptoid antagonist of VEGF Receptor 2 recognizes a ‘hotspot’ in the extracellular domain distinct from the hormone-binding site

(2008) D. Gomika Udugamasooriya et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Expression of integrins in human proliferative diabetic retinopathy membranes

(2008) Allison Ning et al.   CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE

Allosteric Regulation of Proteases

(2008) Patrick Hauske et al.   CHEMBIOCHEM

Decorin Regulates Endothelial Cell Motility on Collagen I through Activation of Insulin-like Growth Factor I Receptor and Modulation of α2β1 Integrin Activity

(2008) Lorna R. Fiedler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The FGF system has a key role in regulating vascular integrity

(2008) Masahiro Murakami et al.   JOURNAL OF CLINICAL INVESTIGATION

Allostery: Absence of a Change in Shape Does Not Imply that Allostery Is Not at Play

(2008) Chung-Jung Tsai et al.   JOURNAL OF MOLECULAR BIOLOGY

A Peptoid “Antibody Surrogate” That Antagonizes VEGF Receptor 2 Activity

(2008) D. Gomika Udugamasooriya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allosteric regulation and catalysis emerge via a common route

(2008) Nina M Goodey et al.   Nature Chemical Biology

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic monoclonal antibodies in ophthalmology

(2008) Eduardo B. Rodrigues et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Selected-fit versus induced-fit protein binding: Kinetic differences and mutational analysis

(2008) Thomas R. Weikl et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS