Splicing and cancer: Challenges and opportunities

Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations

(2018) Andrea Pellagatti et al.   BLOOD

Structure of the human activated spliceosome in three conformational states

(2018) Xiaofeng Zhang et al.   CELL RESEARCH

The role of alternative splicing in cancer drug resistance

(2018) Zahava Siegfried et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Anti‐tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC‐dependent vulnerability

(2018) Kenichi Iwai et al.   EMBO Molecular Medicine

MALAT1 modulates the autophagy of retinoblastoma cell through miR-124-mediated stx17 regulation

(2018) Jun Huang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds

(2018) Constantin Cretu et al.   MOLECULAR CELL

The long tail of oncogenic drivers in prostate cancer

(2018) Joshua Armenia et al.   NATURE GENETICS

H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

(2018) Michael Seiler et al.   NATURE MEDICINE

Global Profiling of hnRNP A2/B1-RNA Binding on Chromatin Highlights LncRNA Interactions

(2018) Eric D. Nguyen et al.   RNA Biology

Systematic Analysis of Splice-Site-Creating Mutations in Cancer

(2018) Reyka G. Jayasinghe et al.   Cell Reports

Prespliceosome structure provides insights into spliceosome assembly and regulation

(2018) Clemens Plaschka et al.   NATURE

Alternative splicing in prostate cancer

(2018) Alec Paschalis et al.   Nature Reviews Clinical Oncology

Coregulation of alternative splicing by hnRNPM and ESRP1 during EMT

(2018) Samuel E. Harvey et al.   RNA

Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis

(2018) Simon Braun et al.   Nature Communications

The prognostic significance of global aberrant alternative splicing in patients with myelodysplastic syndrome

(2018) Yi-Tsung Yang et al.   Blood Cancer Journal

The long non-coding RNA MALAT1 promotes ovarian cancer progression by regulating RBFOX2-mediated alternative splicing

(2018) Michael A. Gordon et al.   MOLECULAR CARCINOGENESIS

Long noncoding RNA MALAT1 suppresses breast cancer metastasis

(2018) Jongchan Kim et al.   NATURE GENETICS

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

(2017) Karl Bertram et al.   NATURE

Potential effect of spliceosome inhibition in small cell lung cancer irrespective of the MYC status

(2017) Kenichi Suda et al.   PLoS One

Regulatory mechanisms of long noncoding RNAs on gene expression in cancers

(2017) Weiliang Sun et al.   Cancer Genetics

The Functional Impact of Alternative Splicing in Cancer

(2017) Héctor Climente-González et al.   Cell Reports

Long noncoding RNAs: Re-writing dogmas of RNA processing and stability

(2016) Jeremy E. Wilusz   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Molecular Pathways: Understanding and Targeting Mutant Spliceosomal Proteins

(2016) Akihide Yoshimi et al.   CLINICAL CANCER RESEARCH

The hnRNP family: insights into their role in health and disease

(2016) Thomas Geuens et al.   HUMAN GENETICS

Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins

(2016) Stanley Chun-Wei Lee et al.   NATURE MEDICINE

Therapeutic targeting of splicing in cancer

(2016) Stanley Chun-Wei Lee et al.   NATURE MEDICINE

Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages

(2016) Kerstin A. Effenberger et al.   RNA

Characterization of RON protein isoforms in pancreatic cancer: implications for biology and therapeutics

(2016) Jeffery Chakedis et al.   Oncotarget

Modulating splicing with small molecular inhibitors of the spliceosome

(2016) Kerstin A. Effenberger et al.   Wiley Interdisciplinary Reviews-RNA

Welcoming Treat: Astrocyte-Derived Exosomes Induce PTEN Suppression to Foster Brain Metastasis

(2015) Maša Alečković et al.   CANCER CELL

Motor neuron cell-nonautonomous rescue of spinal muscular atrophy phenotypes in mild and severe transgenic mouse models

(2015) Yimin Hua et al.   GENES & DEVELOPMENT

Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B

(2015) M. K. Kashyap et al.   HAEMATOLOGICA

The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1

(2015) M Larrayoz et al.   LEUKEMIA

SRSF1-Regulated Alternative Splicing in Breast Cancer

(2015) Olga Anczuków et al.   MOLECULAR CELL

The spliceosome is a therapeutic vulnerability in MYC-driven cancer

(2015) Tiffany Y.-T. Hsu et al.   NATURE

Intron retention is a widespread mechanism of tumor-suppressor inactivation

(2015) Hyunchul Jung et al.   NATURE GENETICS

RON alternative splicing regulation in primary ovarian cancer

(2015) SEBASTIAN MAYER et al.   ONCOLOGY REPORTS

Inhibitors of CLK Protein Kinases Suppress Cell Growth and Induce Apoptosis by Modulating Pre-mRNA Splicing

(2015) Shinsuke Araki et al.   PLoS One

Conformational dynamics of stem II of the U2 snRNA

(2015) Margaret L. Rodgers et al.   RNA

Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome

(2015) Vikas Madan et al.   Nature Communications

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

(2015) E. Sotillo et al.   Cancer Discovery

The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia

(2015) Sílvia Xargay-Torrent et al.   Oncotarget

The network organization of protein interactions in the spliceosome is reproduced by the simple rules of food-web models

(2015) Mathias M. Pires et al.   Scientific Reports

A germline mutation in SRRM2, a splicing factor gene, is implicated in papillary thyroid carcinoma predisposition

(2015) Jerneja Tomsic et al.   Scientific Reports

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point

(2015) Rachel B. Darman et al.   Cell Reports

Transcriptome Sequencing Reveals Potential Mechanism of Cryptic 3’ Splice Site Selection in SF3B1-mutated Cancers

(2015) Christopher DeBoever et al.   PLoS Computational Biology

Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B

(2015) M. K. Kashyap et al.   HAEMATOLOGICA

Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340)

(2015) Raoni Pais Siqueira et al.   PLoS One

Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers

(2014) Fran Supek et al.   CELL

An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth

(2014) A. S. Adler et al.   GENES & DEVELOPMENT

Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing

(2014) Y. Xu et al.   GENES & DEVELOPMENT

U2AF1mutations alter splice site recognition in hematological malignancies

(2014) Janine O. Ilagan et al.   GENOME RESEARCH

Identification of Small Molecule Inhibitors of Pre-mRNA Splicing

(2014) Andrea Pawellek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SF3B1mutations constitute a novel therapeutic target in breast cancer

(2014) Sarah L Maguire et al.   JOURNAL OF PATHOLOGY

PRPF8 defects cause missplicing in myeloid malignancies

(2014) A Kurtovic-Kozaric et al.   LEUKEMIA

Context-dependent control of alternative splicing by RNA-binding proteins

(2014) Xiang-Dong Fu et al.   NATURE REVIEWS GENETICS

A day in the life of the spliceosome

(2014) A. Gregory Matera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural requirement of Ntc77 for spliceosome activation and first catalytic step

(2014) Hsin-Chou Chen et al.   NUCLEIC ACIDS RESEARCH

Characterization of the RNA recognition mode of hnRNP G extends its role in SMN2 splicing regulation

(2014) Ahmed Moursy et al.   NUCLEIC ACIDS RESEARCH

Sudemycin E influences alternative splicing and changes chromatin modifications

(2014) Paolo Convertini et al.   NUCLEIC ACIDS RESEARCH

Alternative splicing in cancer: implications for biology and therapy

(2014) J Chen et al.   ONCOGENE

Brain metastasis is predetermined in early stages of cutaneous melanoma by CD44v6 expression through epigenetic regulation of the spliceosome

(2014) Diego M. Marzese et al.   Pigment Cell & Melanoma Research

A Pan-Cancer Analysis of Transcriptome Changes Associated with Somatic Mutations in U2AF1 Reveals Commonly Altered Splicing Events

(2014) Angela N. Brooks et al.   PLoS One

The RNA-Binding Protein QKI Suppresses Cancer-Associated Aberrant Splicing

(2014) Feng-Yang Zong et al.   PLoS Genetics

Long Non-Coding RNA NEAT1 Associates with SRp40 to Temporally Regulate PPARγ2 Splicing during Adipogenesis in 3T3-L1 Cells

(2014) Denise Cooper et al.   Genes

Pre-mRNA Splicing-Modulatory Pharmacophores: The Total Synthesis of Herboxidiene, a Pladienolide–Herboxidiene Hybrid Analog and Related Derivatives

(2013) Chandraiah Lagisetti et al.   ACS Chemical Biology

Long non-coding RNA HOTAIR in carcinogenesis and metastasis

(2013) J. Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

The GLI1 splice variant TGLI1 promotes glioblastoma angiogenesis and growth

(2013) Hu Zhu et al.   CANCER LETTERS

Phase I Pharmacokinetic and Pharmacodynamic Study of the First-in-Class Spliceosome Inhibitor E7107 in Patients with Advanced Solid Tumors

(2013) F. A. L. M. Eskens et al.   CLINICAL CANCER RESEARCH

Prognostic significance of bone invasion for oral cavity squamous cell carcinoma considered T1/T2 by American joint committee on cancer size criteria

(2013) David Fried et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Isolation and characterization of spliceostatin B, a new analogue of FR901464, from Pseudomonas sp. No. 2663

(2013) Xiangyang Liu et al.   JOURNAL OF ANTIBIOTICS

RBM5, 6, and 10 Differentially Regulate NUMB Alternative Splicing to Control Cancer Cell Proliferation

(2013) Elias G. Bechara et al.   MOLECULAR CELL

Competition between Pre-mRNAs for the Splicing Machinery Drives Global Regulation of Splicing

(2013) Elizabeth M. Munding et al.   MOLECULAR CELL

Genome-wide Analysis Reveals SR Protein Cooperation and Competition in Regulated Splicing

(2013) Shatakshi Pandit et al.   MOLECULAR CELL

Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3

(2013) Marcel Martin et al.   NATURE GENETICS

Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma

(2013) J William Harbour et al.   NATURE GENETICS

Alternative splicing: a pivotal step between eukaryotic transcription and translation

(2013) Alberto R. Kornblihtt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hallmarks of alternative splicing in cancer

(2013) S Oltean et al.   ONCOGENE

On the classification of long non-coding RNAs

(2013) Lina Ma et al.   RNA Biology

Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes

(2012) F. Thol et al.   BLOOD

SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)

(2012) M. Meggendorfer et al.   BLOOD

SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes

(2012) V. Visconte et al.   BLOOD

Biologic and clinical significance of somatic mutations of SF3B1 in myeloid and lymphoid neoplasms

(2012) M. Cazzola et al.   BLOOD

Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis

(2012) H. Makishima et al.   BLOOD

Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

(2012) Marcin Imielinski et al.   CELL

Snail Represses the Splicing Regulator Epithelial Splicing Regulatory Protein 1 to Promote Epithelial-Mesenchymal Transition

(2012) Lauren M. Reinke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spliceosome and other novel mutations in chronic lymphocytic leukemia and myeloid malignancies

(2012) F Damm et al.   LEUKEMIA

RBFOX2 Is an Important Regulator of Mesenchymal Tissue-Specific Splicing in both Normal and Cancer Tissues

(2012) J. P. Venables et al.   MOLECULAR AND CELLULAR BIOLOGY

The landscape of cancer genes and mutational processes in breast cancer

(2012) Philip J. Stephens et al.   NATURE

Whole-genome analysis informs breast cancer response to aromatase inhibition

(2012) Matthew J. Ellis et al.   NATURE

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

(2012) Andrew V. Biankin et al.   NATURE

The spliceosome as a target of novel antitumour drugs

(2012) Sophie Bonnal et al.   NATURE REVIEWS DRUG DISCOVERY

The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation

(2012) Olga Anczuków et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A complex network of factors with overlapping affinities represses splicing through intronic elements

(2012) Yang Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules

(2012) Yang Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression

(2012) Y Li et al.   ONCOGENE

HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer

(2012) K Kim et al.   ONCOGENE

A crypticBAP1splice mutation in a family with uveal and cutaneous melanoma, and paraganglioma

(2012) Karin Wadt et al.   Pigment Cell & Melanoma Research

Regulation of Mcl-1 by SRSF1 and SRSF5 in Cancer Cells

(2012) Hannah L. Gautrey et al.   PLoS One

Hallmarks of cancer: of all cancer cells, all the time?

(2012) Sébastien L. Floor et al.   TRENDS IN MOLECULAR MEDICINE

The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle

(2012) Shauna A Henley et al.   Cell Division

Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC

(2012) Shipra Das et al.   Cell Reports

Integrative Genome-wide Analysis Reveals Cooperative Regulation of Alternative Splicing by hnRNP Proteins

(2012) Stephanie C. Huelga et al.   Cell Reports

Sudemycins, Novel Small Molecule Analogues of FR901464, Induce Alternative Gene Splicing

(2011) Liying Fan et al.   ACS Chemical Biology

Exon array analysis reveals neuroblastoma tumors have distinct alternative splicing patterns according to stage and MYCN amplification status

(2011) Xiang Guo et al.   BMC Medical Genomics

c-Myc Regulates RNA Splicing of the A-Raf Kinase and Its Activation of the ERK Pathway

(2011) J. Rauch et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas

(2011) Clare V LeFave et al.   EMBO JOURNAL

Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A

(2011) A. Corrionero et al.   GENES & DEVELOPMENT

The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region

(2011) E. G. Folco et al.   GENES & DEVELOPMENT

The t(11;19)(q23;p13) fusing MLL with MYO1F is recurrent in infant acute myeloid leukemias

(2011) Francois P. Duhoux et al.   LEUKEMIA RESEARCH

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

(2011) Poulikos I. Poulikakos et al.   NATURE

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

(2011) Timothy A Graubert et al.   NATURE GENETICS

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

(2011) Víctor Quesada et al.   NATURE GENETICS

SomaticSF3B1Mutation in Myelodysplasia with Ring Sideroblasts

(2011) E. Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

SF3B1and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia

(2011) Lili Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

An EMT–Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype

(2011) Irina M. Shapiro et al.   PLoS Genetics

Deregulated expression of hnRNP A/B proteins in human non-small cell lung cancer: parallel assessment of protein and mRNA levels in paired tumour/non-tumour tissues

(2010) Georgios Boukakis et al.   BMC CANCER

Identification of ASF/SF2 as a Critical, Allele-Specific Effector of the Cyclin D1b Oncogene

(2010) N. A. Olshavsky et al.   CANCER RESEARCH

An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis

(2010) Michael J. Moore et al.   CELL

Structural Requirements for the Antiproliferative Activity of Pre-mRNA Splicing Inhibitor FR901464

(2010) Sami Osman et al.   CHEMISTRY-A EUROPEAN JOURNAL

Serine-arginine protein kinases: a small protein kinase family with a large cellular presence

(2010) Thomas Giannakouros et al.   FEBS Journal

RBM5 as a Putative Tumor Suppressor Gene for Lung Cancer

(2010) Leslie C. Sutherland et al.   Journal of Thoracic Oncology

Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies

(2010) H Makishima et al.   LEUKEMIA

SR Proteins Induce Alternative Exon Skipping through Their Activities on the Flanking Constitutive Exons

(2010) J. Han et al.   MOLECULAR AND CELLULAR BIOLOGY

Invariant U2 snRNA Nucleotides Form a Stem Loop to Recognize the Intron Early in Splicing

(2010) Rhonda Perriman et al.   MOLECULAR CELL

The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation

(2010) Vidisha Tripathi et al.   MOLECULAR CELL

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

(2010) Thomas Ernst et al.   NATURE GENETICS

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation

(2010) Gabriel A. Roybal et al.   NUCLEIC ACIDS RESEARCH

Spliceosome Structure and Function

(2010) C. L. Will et al.   Cold Spring Harbor Perspectives in Biology

A Six-Gene Signature Predicts Survival of Patients with Localized Pancreatic Ductal Adenocarcinoma

(2010) Jeran K. Stratford et al.   PLOS MEDICINE

Identification and characterisation of a novel antisense non-coding RNA from the RBM5 gene locus

(2009) Nina D. Rintala-Maki et al.   GENE

Synthetic mRNA Splicing Modulator Compounds with in Vivo Antitumor Activity

(2009) Chandraiah Lagisetti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B andKRASmutations in colorectal carcinoma

(2009) Jehad Abubaker et al.   JOURNAL OF PATHOLOGY

Cancer-associated regulation of alternative splicing

(2009) Julian P Venables et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antisense Masking of an hnRNP A1/A2 Intronic Splicing Silencer Corrects SMN2 Splicing in Transgenic Mice

(2008) Yimin Hua et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The SR protein family of splicing factors: master regulators of gene expression

(2008) Jennifer C. Long et al.   BIOCHEMICAL JOURNAL

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

Splicing factor SFRS1 recognizes a functionally diverse landscape of RNA transcripts

(2008) J. R. Sanford et al.   GENOME RESEARCH

Patterns of missplicing caused byRB1gene mutations in patients with retinoblastoma and association with phenotypic expression

(2008) Katherine Zhang et al.   HUMAN MUTATION

The Splicing Factor SF2/ASF Regulates Translation Initiation by Enhancing Phosphorylation of 4E-BP1

(2008) Gracjan Michlewski et al.   MOLECULAR CELL

p53-repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation

(2008) Ran Brosh et al.   Molecular Systems Biology

Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome

(2008) Shalini Sharma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5

(2008) K. Fushimi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Splicing regulation: From a parts list of regulatory elements to an integrated splicing code

(2008) Z. Wang et al.   RNA