Remodeling the cancer epigenome: mutations in the SWI/SNF complex offer new therapeutic opportunities

CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary

(2019) Yibo Xue et al.   Nature Communications

SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer

(2019) Yibo Xue et al.   Nature Communications

MDM2 and MDM4 are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors

(2019) Thomas P Howard et al.   CANCER RESEARCH

SWI/SNF-compromised cancers are susceptible to bromodomain inhibitors

(2019) Tatiana Shorstova et al.   CANCER RESEARCH

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

(2019) Alessandro Carugo et al.   CANCER CELL

SWI/SNF Chromatin-remodeling Complex Status in SMARCB1/INI1-preserved Epithelioid Sarcoma

(2018) Kenichi Kohashi et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Immunohistochemical Detection and Molecular Characterization of IDH-mutant Sinonasal Undifferentiated Carcinomas

(2018) Jeffrey K. Mito et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma

(2018) Matthew J. McBride et al.   CANCER CELL

BAFfling pathologies: Alterations of BAF complexes in cancer

(2018) Ophelie Arnaud et al.   CANCER LETTERS

The SWI/SNF complex subunit genes: Their functions, variations, and links to risk and survival outcomes in human cancers

(2018) Sevtap Savas et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Emerging therapeutic targets for the treatment of malignant rhabdoid tumors

(2018) Karolina Nemes et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Disruption of mammalian SWI/SNF and polycomb complexes in human sarcomas: mechanisms and therapeutic opportunities

(2018) Matthew J McBride et al.   JOURNAL OF PATHOLOGY

Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study

(2018) Antoine Italiano et al.   LANCET ONCOLOGY

SMARCA4-deficient undifferentiated uterine sarcoma (malignant rhabdoid tumor of the uterus): a clinicopathologic entity distinct from undifferentiated carcinoma

(2018) David L. Kolin et al.   MODERN PATHOLOGY

SMARCB1 Deficiency Integrates Epigenetic Signals to Oncogenic Gene Expression Program Maintenance in Human Acute Myeloid Leukemia

(2018) Shankha Subhra Chatterjee et al.   MOLECULAR CANCER RESEARCH

ARID1A mutation sensitizes most ovarian clear cell carcinomas to BET inhibitors

(2018) Katrien Berns et al.   ONCOGENE

ARID1A loss in cancer: Towards a mechanistic understanding

(2018) Radhika Mathur   PHARMACOLOGY & THERAPEUTICS

A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing

(2018) Deng Pan et al.   SCIENCE

Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma

(2018) Diana Miao et al.   SCIENCE

40 Years of Research Put p53 in Translation

(2018) Virginie Marcel et al.   Cancers

The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma

(2018) Ana Banito et al.   CANCER CELL

Undifferentiated Endometrial Carcinoma, an Immunohistochemical Study Including PD-L1 Testing of a Series of Cases From a Single Cancer Center

(2018) Maysa Al-Hussaini et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY

Histone deacetylase inhibitors synergizes with catalytic inhibitors of EZH2 to exhibit anti-tumor activity in small cell carcinoma of the ovary, hypercalcemic type

(2018) Yemin Wang et al.   MOLECULAR CANCER THERAPEUTICS

Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells

(2018) Changjie Wu et al.   Nature Communications

SMARCA4-deficient Thoracic Sarcomas

(2018) Raul Perret et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

(2018) Hanghang Zhang et al.   CELL

Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes

(2018) Nazar Mashtalir et al.   CELL

A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation

(2018) Brittany C. Michel et al.   NATURE CELL BIOLOGY

Chromatin regulatory mechanisms and therapeutic opportunities in cancer

(2018) Alfredo M. Valencia et al.   NATURE CELL BIOLOGY

Inactivation of SMARCA2 by promoter hypermethylation drives lung cancer development

(2018) Jixiang Wu et al.   GENE

Cellular senescence regulated by SWI/SNF complex subunits through p53/p21 and p16/pRB pathway

(2017) Ling He et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Individual Bromodomains of Polybromo-1 Contribute to Chromatin Association and Tumor Suppression in Clear Cell Renal Carcinoma

(2017) Elizabeth G. Porter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ARID2 modulates DNA damage response in human hepatocellular carcinoma cells

(2017) Atsushi Oba et al.   JOURNAL OF HEPATOLOGY

The histone methyltransferase EZH2 is a therapeutic target in small cell carcinoma of the ovary, hypercalcaemic type

(2017) Yemin Wang et al.   JOURNAL OF PATHOLOGY

Clinicopathological and molecular characterization of SMARCA4-deficient thoracic sarcomas with comparison to potentially related entities

(2017) Akihiko Yoshida et al.   MODERN PATHOLOGY

Recurrent IDH2 R172X mutations in sinonasal undifferentiated carcinoma

(2017) Vickie Y Jo et al.   MODERN PATHOLOGY

Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models

(2017) Elayne Chan-Penebre et al.   MOLECULAR CANCER THERAPEUTICS

AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection

(2017) Thomas Vierbuchen et al.   MOLECULAR CELL

ARID1A-mutated ovarian cancers depend on HDAC6 activity

(2017) Benjamin G. Bitler et al.   NATURE CELL BIOLOGY

SMARCB1 is required for widespread BAF complex–mediated activation of enhancers and bivalent promoters

(2017) Robert T Nakayama et al.   NATURE GENETICS

Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers

(2017) H. Courtney Hodges et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation

(2017) T Nakatsuka et al.   ONCOGENE

PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors

(2017) Thomas Januario et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers

(2017) Burak H. Alver et al.   Nature Communications

Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers

(2017) H. Courtney Hodges et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genetic and Genomic Characterization of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, and Cell Lines

(2017) Bradley Garman et al.   Cell Reports

The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma

(2017) Amrita M. Nargund et al.   Cell Reports

Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis

(2016) Martin Hasselblatt et al.   ACTA NEUROPATHOLOGICA

SWI/SNF Complex–deficient Undifferentiated/Rhabdoid Carcinomas of the Gastrointestinal Tract

(2016) Abbas Agaimy et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

(2016) Pascal D. Johann et al.   CANCER CELL

Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and Dysregulated Developmental Pathways

(2016) Hye-Jung E. Chun et al.   CANCER CELL

Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration

(2016) Xuxu Sun et al.   Cell Stem Cell

BRM Promoter Polymorphisms and Survival of Advanced Non–Small Cell Lung Cancer Patients in the Princess Margaret Cohort and CCTG BR.24 Trial

(2016) Geoffrey Liu et al.   CLINICAL CANCER RESEARCH

The SWI/SNF BAF-A complex is essential for neural crest development

(2016) Ronald L. Chandler et al.   DEVELOPMENTAL BIOLOGY

RB1: a prototype tumor suppressor and an enigma

(2016) Nicholas J. Dyson   GENES & DEVELOPMENT

The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type

(2016) Leora Witkowski et al.   GYNECOLOGIC ONCOLOGY

Loss of expression of SMARCA4 (BRG1), SMARCA2 (BRM) and SMARCB1 (INI1) in undifferentiated carcinoma of the endometrium is not uncommon and is not always associated with rhabdoid morphology

(2016) Preetha Ramalingam et al.   HISTOPATHOLOGY

LincRNA-Cox2 Promotes Late Inflammatory Gene Transcription in Macrophages through Modulating SWI/SNF-Mediated Chromatin Remodeling

(2016) Guoku Hu et al.   JOURNAL OF IMMUNOLOGY

Loss of switch/sucrose non-fermenting complex protein expression is associated with dedifferentiation in endometrial carcinomas

(2016) Anthony N Karnezis et al.   MODERN PATHOLOGY

Synthetic Lethal Targeting of ARID1A -Mutant Ovarian Clear Cell Tumors with Dasatinib

(2016) Rowan E. Miller et al.   MOLECULAR CANCER THERAPEUTICS

Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin

(2016) Benjamin Z Stanton et al.   NATURE GENETICS

Dynamics of BAF–Polycomb complex opposition on heterochromatin in normal and oncogenic states

(2016) Cigall Kadoch et al.   NATURE GENETICS

SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation

(2016) Xiaofeng Wang et al.   NATURE GENETICS

Targeting EZH2 in cancer

(2016) Kimberly H Kim et al.   NATURE MEDICINE

Atypical teratoid/rhabdoid tumors—current concepts, advances in biology, and potential future therapies

(2016) Michael C. Frühwald et al.   NEURO-ONCOLOGY

ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A

(2016) Chris T. Williamson et al.   Nature Communications

Loss of HDAC-Mediated Repression and Gain of NF-κB Activation Underlie Cytokine Induction in ARID1A- and PIK3CA-Mutation-Driven Ovarian Cancer

(2016) Minchul Kim et al.   Cell Reports

Pattern of SMARCB1 (INI1) and SMARCA4 (BRG1) in poorly differentiated endometrioid adenocarcinoma of the uterus: analysis of a series with emphasis on a novel SMARCA4-deficient dedifferentiated rhabdoid variant

(2015) Johanna D. Strehl et al.   Annals of Diagnostic Pathology

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling

(2015) Yanying Wang et al.   Cell Stem Cell

Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation

(2015) Nilotpal Roy et al.   GENES & DEVELOPMENT

Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulateVEGFR2in breast cancer cells

(2015) Neil T. Pfister et al.   GENES & DEVELOPMENT

Frequent co-inactivation of the SWI/SNF subunits SMARCB1, SMARCA2 and PBRM1 in malignant rhabdoid tumours

(2015) Qiu Rao et al.   HISTOPATHOLOGY

The genomic landscape of epithelioid sarcoma cell lines and tumours

(2015) Farzad Jamshidi et al.   JOURNAL OF PATHOLOGY

Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type

(2015) Anthony N Karnezis et al.   JOURNAL OF PATHOLOGY

Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type

(2015) Petar Jelinic et al.   MODERN PATHOLOGY

SMARCA4 inactivation defines a group of undifferentiated thoracic malignancies transcriptionally related to BAF-deficient sarcomas

(2015) Francois Le Loarer et al.   NATURE GENETICS

SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2

(2015) Kimberly H Kim et al.   NATURE MEDICINE

Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers

(2015) Benjamin G Bitler et al.   NATURE MEDICINE

The molecular aspects of chordoma

(2015) Sukru Gulluoglu et al.   NEUROSURGICAL REVIEW

Knockdown of long non-coding RNA HOTAIR inhibits proliferation and invasiveness and improves radiosensitivity in colorectal cancer

(2015) XIAO-DONG YANG et al.   ONCOLOGY REPORTS

SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies

(2015) Tetsuya Kawaguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis

(2015) Mark D. Allen et al.   STRUCTURE

Coexistent ARID1A–PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling

(2015) Ronald L. Chandler et al.   Nature Communications

Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profiling

(2015) Young Kwang Chae et al.   Oncotarget

Genome-Wide Transcriptional Regulation Mediated by Biochemically Distinct SWI/SNF Complexes

(2015) Jesse R. Raab et al.   PLoS Genetics

Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition

(2015) Eleftherios P. Samartzis et al.   Oncotarget

SMARCA4-mutated atypical teratoid/rhabdoid tumors are associated with inherited germline alterations and poor prognosis

(2014) Martin Hasselblatt et al.   ACTA NEUROPATHOLOGICA

SWI/SNF chromatin remodeling complexes and cancer

(2014) Jaclyn A. Biegel et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

BRG1/SMARCA4 Inactivation Promotes Non-Small Cell Lung Cancer Aggressiveness by Altering Chromatin Organization

(2014) T. Orvis et al.   CANCER RESEARCH

Expanding the mutational spectrum of LZTR1 in schwannomatosis

(2014) Irene Paganini et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

ConsistentSMARCB1homozygous deletions in epithelioid sarcoma and in a subset of myoepithelial carcinomas can be reliably detected by FISH in archival material

(2014) Francois Le Loarer et al.   GENES CHROMOSOMES & CANCER

Concurrent loss of INI1, PBRM1, and BRM expression in epithelioid sarcoma: implications for the cocontributions of multiple SWI/SNF complex members to pathogenesis

(2014) Li Li et al.   HUMAN PATHOLOGY

SNF5/INI1 Deficiency Redefines Chromatin Remodeling Complex Composition during Tumor Development

(2014) Darmood Wei et al.   MOLECULAR CANCER RESEARCH

Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4

(2014) Pilar Ramos et al.   NATURE GENETICS

Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type

(2014) Leora Witkowski et al.   NATURE GENETICS

Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer

(2014) Kai Wang et al.   NATURE GENETICS

Recurrent SMARCA4 mutations in small cell carcinoma of the ovary

(2014) Petar Jelinic et al.   NATURE GENETICS

Long non-coding RNA urothelial carcinoma associated 1 induces cell replication by inhibiting BRG1 in 5637 cells

(2014) XIUJUAN WANG et al.   ONCOLOGY REPORTS

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

(2014) G. R. Hoffman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathology and diagnosis of SMARCB1-deficient tumors

(2014) Ashley S. Margol et al.   Cancer Genetics

Mechanisms by which SMARCB1 loss drives rhabdoid tumor growth

(2014) Kimberly H. Kim et al.   Cancer Genetics

SMARCB1 mutations in schwannomatosis and genotype correlations with rhabdoid tumors

(2014) Miriam J. Smith et al.   Cancer Genetics

Renal Medullary Carcinoma

(2013) Qingyan Liu et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

A Synthetic Lethality-Based Strategy to Treat Cancers Harboring a Genetic Deficiency in the Chromatin Remodeling Factor BRG1

(2013) T. Oike et al.   CANCER RESEARCH

Association of two BRM promoter polymorphisms with head and neck squamous cell carcinoma risk

(2013) Jennifer R. Wang et al.   CARCINOGENESIS

Reversible Disruption of mSWI/SNF (BAF) Complexes by the SS18-SSX Oncogenic Fusion in Synovial Sarcoma

(2013) Cigall Kadoch et al.   CELL

Whole exome sequencing of adenoid cystic carcinoma

(2013) Philip J. Stephens et al.   JOURNAL OF CLINICAL INVESTIGATION

Familial rhabdoid tumour 'avant la lettre'-from pathology review to exome sequencing and back again

(2013) Leora Witkowski et al.   JOURNAL OF PATHOLOGY

Comprehensive molecular characterization of clear cell renal cell carcinoma

(2013)   NATURE

Integrated molecular analysis of clear-cell renal cell carcinoma

(2013) Yusuke Sato et al.   NATURE GENETICS

The mutational landscape of adenoid cystic carcinoma

(2013) Allen S Ho et al.   NATURE GENETICS

The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex

(2013) John R Prensner et al.   NATURE GENETICS

The Spectrum of SWI/SNF Mutations, Ubiquitous in Human Cancers

(2013) A. Hunter Shain et al.   PLoS One

Fibroblast Growth Factor Receptors as Novel Therapeutic Targets in SNF5-Deleted Malignant Rhabdoid Tumors

(2013) Simon Wöhrle et al.   PLoS One

Ovarian small cell carcinoma of hypercalcemic type – evidence of germline origin and smarca4 gene inactivation. a pilot study

(2013) Jolanta Kupryjańczyk et al.   POLISH JOURNAL OF PATHOLOGY

Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters

(2013) M. Y. Tolstorukov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

SNF5 Is an Essential Executor of Epigenetic Regulation during Differentiation

(2013) Jueng Soo You et al.   PLoS Genetics

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Structural and Physicochemical Aspects of Dasatinib Hydrate and Anhydrate Phases

(2012) Saikat Roy et al.   CRYSTAL GROWTH & DESIGN

High-resolution genomic analysis suggests the absence of recurrent genomic alterations other thanSMARCB1aberrations in atypical teratoid/rhabdoid tumors

(2012) Martin Hasselblatt et al.   GENES CHROMOSOMES & CANCER

SMARCB1/INI1 inactivation in renal medullary carcinoma

(2012) Julien Calderaro et al.   HISTOPATHOLOGY

A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers

(2012) Ryan S. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Alterations of the SWI/SNF chromatin remodelling subunit-BRG1 and BRM in hepatocellular carcinoma

(2012) Mio Endo et al.   LIVER INTERNATIONAL

Epithelioid sarcoma is associated with a high percentage of SMARCB1 deletions

(2012) Lisa M Sullivan et al.   MODERN PATHOLOGY

Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

(2012) Akihiro Fujimoto et al.   NATURE GENETICS

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

(2012) Cécile Guichard et al.   NATURE GENETICS

Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome

(2012) Yoshinori Tsurusaki et al.   NATURE GENETICS

Mutations and deletions of ARID1A in breast tumors

(2012) S Cornen et al.   ONCOGENE

The BRG1 Chromatin Remodeler Protects Against Ovarian Cysts, Uterine Tumors, and Mammary Tumors in a Lineage-Specific Manner

(2012) Daniel W. Serber et al.   PLoS One

Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer

(2012) A. H. Shain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Nonsense Mutation and Inactivation of SMARCA4 (BRG1) in an Atypical Teratoid/Rhabdoid Tumor Showing Retained SMARCB1 (INI1) Expression

(2011) Martin Hasselblatt et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

BRM and BRG1 subunits of the SWI/SNF chromatin remodelling complex are downregulated upon progression of benign skin lesions into invasive tumours

(2011) V.L. Bock et al.   BRITISH JOURNAL OF DERMATOLOGY

Dynamics of expression of ARID1A and ARID1B subunits in mouse embryos and in cells during the cell cycle

(2011) Angel Flores-Alcantar et al.   CELL AND TISSUE RESEARCH

Regulation of nucleosome landscape and transcription factor targeting at tissue-specific enhancers by BRG1

(2011) G. Hu et al.   GENOME RESEARCH

Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types

(2011) Siân Jones et al.   HUMAN MUTATION

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

(2011) Ignacio Varela et al.   NATURE

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

(2011) Yaoting Gui et al.   NATURE GENETICS

Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer

(2011) Kai Wang et al.   NATURE GENETICS

Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma

(2011) Meng Li et al.   NATURE GENETICS

Two novel BRM insertion promoter sequence variants are associated with loss of BRM expression and lung cancer risk

(2011) G Liu et al.   ONCOGENE

Loss of SMARCB1/INI1 expression in poorly differentiated chordomas

(2010) Bret C. Mobley et al.   ACTA NEUROPATHOLOGICA

Germline Nonsense Mutation and Somatic Inactivation of SMARCA4/BRG1 in a Family with Rhabdoid Tumor Predisposition Syndrome

(2010) Reinhard Schneppenheim et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The p53 tumor suppressor: A master regulator of diverse cellular processes and therapeutic target in cancer

(2010) Marianne Farnebo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation

(2010) Boris G. Wilson et al.   CANCER CELL

Prognostic determinants in epithelioid sarcoma

(2010) Patrizia Gasparini et al.   EUROPEAN JOURNAL OF CANCER

Massive parallel DNA pyrosequencing analysis of the tumor suppressor BRG1/SMARCA4 in lung primary tumors

(2010) Salvador Rodriguez-Nieto et al.   HUMAN MUTATION

ARID1AMutations in Endometriosis-Associated Ovarian Carcinomas

(2010) Kimberly C. Wiegand et al.   NEW ENGLAND JOURNAL OF MEDICINE

Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma

(2010) Siân Jones et al.   SCIENCE

The Genetic Landscape of the Childhood Cancer Medulloblastoma

(2010) D. W. Parsons et al.   SCIENCE

Loss of Heterozygosity at the 9p21–24 Region and Identification of BRM as a Candidate Tumor Suppressor Gene in Head and Neck Squamous Cell Carcinoma

(2009) Esra Gunduz et al.   CANCER INVESTIGATION

Oncogenesis Caused by Loss of the SNF5 Tumor Suppressor Is Dependent on Activity of BRG1, the ATPase of the SWI/SNF Chromatin Remodeling Complex

(2009) X. Wang et al.   CANCER RESEARCH

Understanding the Words of Chromatin Regulation

(2009) Jiang I. Wu et al.   CELL

Alterations in the SMARCB1 (INI1) tumor suppressor gene in familial schwannomatosis

(2009) C Boyd et al.   CLINICAL GENETICS

SWI/SNF Deficiency Results in Aberrant Chromatin Organization, Mitotic Failure, and Diminished Proliferative Capacity

(2009) Ryan J. Bourgo et al.   MOLECULAR BIOLOGY OF THE CELL

The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a

(2009) Therese M Becker et al.   Molecular Cancer

Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines

(2008) Pedro P. Medina et al.   HUMAN MUTATION

BAF60a Interacts with p53 to Recruit the SWI/SNF Complex

(2008) Jaehak Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hotspot Mutation of Brahma in Non-Melanoma Skin Cancer

(2008) Fergal J. Moloney et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Renal medullary carcinoma: rhabdoid features and the absence of INI1 expression as markers of aggressive behavior

(2008) Jason X Cheng et al.   MODERN PATHOLOGY

Loss of the Epigenetic Tumor Suppressor SNF5 Leads to Cancer without Genomic Instability

(2008) E. S. McKenna et al.   MOLECULAR AND CELLULAR BIOLOGY

Evidence of a four-hit mechanism involvingSMARCB1andNF2in schwannomatosis-associated schwannomas

(2007) Roberta Sestini et al.   HUMAN MUTATION