Disruption of mammalian SWI/SNF and polycomb complexes in human sarcomas: mechanisms and therapeutic opportunities

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

(2017) Wei Qi et al.   Nature Chemical Biology

SMARCB1 is required for widespread BAF complex–mediated activation of enhancers and bivalent promoters

(2017) Robert T Nakayama et al.   NATURE GENETICS

Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells

(2017) Robin M Meyers et al.   NATURE GENETICS

Loss of Snf5 Induces Formation of an Aberrant SWI/SNF Complex

(2017) Payel Sen et al.   Cell Reports

Managing sarcoma: where have we come from and where are we going?

(2017) Jenna S. Bleloch et al.   Therapeutic Advances in Medical Oncology

Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and Dysregulated Developmental Pathways

(2016) Hye-Jung E. Chun et al.   CANCER CELL

Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells

(2016) Unmesh Jadhav et al.   CELL

The diagnostic utility of reduced immunohistochemical expression of SMARCB1 in synovial sarcomas: a validation study

(2016) Junko Ito et al.   HUMAN PATHOLOGY

Erratum: Loss of H3K27 tri-methylation is a diagnostic marker for malignant peripheral nerve sheath tumors and an indicator for an inferior survival

(2016) Arjen HG Cleven et al.   MODERN PATHOLOGY

Dynamics of BAF–Polycomb complex opposition on heterochromatin in normal and oncogenic states

(2016) Cigall Kadoch et al.   NATURE GENETICS

SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation

(2016) Xiaofeng Wang et al.   NATURE GENETICS

Targeting EZH2 in cancer

(2016) Kimberly H Kim et al.   NATURE MEDICINE

PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

(2016) Kanak Raina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polycomb and trithorax opposition in development and disease

(2016) Steven T. Poynter et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Utility of characteristic ‘Weak to Absent’ INI1/SMARCB1/BAF47 expression in diagnosis of synovial sarcomas

(2015) Bharat Rekhi et al.   APMIS

The genomic landscape of epithelioid sarcoma cell lines and tumours

(2015) Farzad Jamshidi et al.   JOURNAL OF PATHOLOGY

Targeting Polycomb systems to regulate gene expression: modifications to a complex story

(2015) Neil P. Blackledge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phthalimide conjugation as a strategy for in vivo target protein degradation

(2015) G. E. Winter et al.   SCIENCE

Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics

(2015) C. Kadoch et al.   Science Advances

EWS-FLI1 Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Activate or Repress Enhancer Elements in Ewing Sarcoma

(2014) Nicolò Riggi et al.   CANCER CELL

Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation

(2014) B. G. Wilson et al.   MOLECULAR AND CELLULAR BIOLOGY

SNF5/INI1 Deficiency Redefines Chromatin Remodeling Complex Composition during Tumor Development

(2014) Darmood Wei et al.   MOLECULAR CANCER RESEARCH

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

(2014) Thomas De Raedt et al.   NATURE

Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors

(2014) Ming Zhang et al.   NATURE GENETICS

PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors

(2014) William Lee et al.   NATURE GENETICS

SUZ12 is involved in progression of non-small cell lung cancer by promoting cell proliferation and metastasis

(2014) Chunhua Liu et al.   TUMOR BIOLOGY

Advances in Therapy for Pediatric Sarcomas

(2014) Aaron Weiss et al.   Current Oncology Reports

The Genomic Landscape of Pediatric Ewing Sarcoma

(2014) B. D. Crompton et al.   Cancer Discovery

Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations

(2014) F. Tirode et al.   Cancer Discovery

The Genomic Landscape of the Ewing Sarcoma Family of Tumors Reveals Recurrent STAG2 Mutation

(2014) Andrew S. Brohl et al.   PLoS Genetics

Malignant peripheral nerve sheath tumor: pathology and genetics

(2013) Khin Thway et al.   Annals of Diagnostic Pathology

A Synthetic Lethality-Based Strategy to Treat Cancers Harboring a Genetic Deficiency in the Chromatin Remodeling Factor BRG1

(2013) T. Oike et al.   CANCER RESEARCH

Reversible Disruption of mSWI/SNF (BAF) Complexes by the SS18-SSX Oncogenic Fusion in Synovial Sarcoma

(2013) Cigall Kadoch et al.   CELL

Chromosome Instability Accounts for Reverse Metastatic Outcomes of Pediatric and Adult Synovial Sarcomas

(2013) Pauline Lagarde et al.   JOURNAL OF CLINICAL ONCOLOGY

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Targeted disruption of the EZH2–EED complex inhibits EZH2-dependent cancer

(2013) Woojin Kim et al.   Nature Chemical Biology

Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

(2013) Cigall Kadoch et al.   NATURE GENETICS

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

(2013) S. K. Knutson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripheral nerve sheath tumors: the elegant chapter in surgical neuropathology

(2012) Fausto J. Rodriguez   ACTA NEUROPATHOLOGICA

Oncologic Outcomes of Sporadic, Neurofibromatosis-Associated, and Radiation-Induced Malignant Peripheral Nerve Sheath Tumors

(2012) Jennifer LaFemina et al.   ANNALS OF SURGICAL ONCOLOGY

New Systemic Therapy Options for Advanced Sarcomas

(2012) Winette T. A. van der Graaf et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Inhibition of EZH2 suppresses self-renewal and induces radiation sensitivity in atypical rhabdoid teratoid tumor cells

(2012) Irina Alimova et al.   NEURO-ONCOLOGY

Children's Oncology Group's 2013 blueprint for research: Bone tumors

(2012) Richard Gorlick et al.   PEDIATRIC BLOOD & CANCER

Children's Oncology Group's 2013 blueprint for research: Soft tissue sarcomas

(2012) Douglas S. Hawkins et al.   PEDIATRIC BLOOD & CANCER

ATP-dependent chromatin remodeling: genetics, genomics and mechanisms

(2011) Diana C Hargreaves et al.   CELL RESEARCH

Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription

(2011) M. Patel et al.   GENOME RESEARCH

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

(2011) Ignacio Varela et al.   NATURE

MicroRNA-mediated conversion of human fibroblasts to neurons

(2011) Andrew S. Yoo et al.   NATURE

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Loss of SMARCB1/INI1 expression in poorly differentiated chordomas

(2010) Bret C. Mobley et al.   ACTA NEUROPATHOLOGICA

Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation

(2010) Boris G. Wilson et al.   CANCER CELL

Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming

(2010) Nishant Singhal et al.   CELL

The SSX Family of Cancer-Testis Antigens as Target Proteins for Tumor Therapy

(2010) Heath A. Smith et al.   Clinical & Developmental Immunology

Germline SMARCB1 mutation and somatic NF2 mutations in familial multiple meningiomas

(2010) I. Christiaans et al.   JOURNAL OF MEDICAL GENETICS

Reduced expression of SMARCB1/INI1 protein in synovial sarcoma

(2010) Kenichi Kohashi et al.   MODERN PATHOLOGY

Chromatin remodelling during development

(2010) Lena Ho et al.   NATURE

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

(2010) Ryan D Morin et al.   NATURE GENETICS

ARID1AMutations in Endometriosis-Associated Ovarian Carcinomas

(2010) Kimberly C. Wiegand et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical, Pathological, and Molecular Variables Predictive of Malignant Peripheral Nerve Sheath Tumor Outcome

(2009) Changye Zou et al.   ANNALS OF SURGERY

Comparing children and adults with synovial sarcoma in the Surveillance, Epidemiology, and End Results program, 1983 to 2005

(2009) Iyad Sultan et al.   CANCER

Oncogenesis Caused by Loss of the SNF5 Tumor Suppressor Is Dependent on Activity of BRG1, the ATPase of the SWI/SNF Chromatin Remodeling Complex

(2009) X. Wang et al.   CANCER RESEARCH

MicroRNA-mediated switching of chromatin-remodelling complexes in neural development

(2009) Andrew S. Yoo et al.   NATURE

Role of the polycomb protein EED in the propagation of repressive histone marks

(2009) Raphael Margueron et al.   NATURE

The Oncogenic EWS-FLI1 Protein Binds In Vivo GGAA Microsatellite Sequences with Potential Transcriptional Activation Function

(2009) Noëlle Guillon et al.   PLoS One

An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency

(2009) L. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EWS-FLI-1 Expression Triggers a Ewing's Sarcoma Initiation Program in Primary Human Mesenchymal Stem Cells

(2008) N. Riggi et al.   CANCER RESEARCH

SWI/SNF Mediates Polycomb Eviction and Epigenetic Reprogramming of the INK4b-ARF-INK4a Locus

(2008) S. K. Kia et al.   MOLECULAR AND CELLULAR BIOLOGY

Loss of the Epigenetic Tumor Suppressor SNF5 Leads to Cancer without Genomic Instability

(2008) E. S. McKenna et al.   MOLECULAR AND CELLULAR BIOLOGY

Roles of the EZH2 histone methyltransferase in cancer epigenetics

(2008) Jeffrey A. Simon et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Microsatellites as EWS/FLI response elements in Ewing's sarcoma

(2008) K. Gangwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA