Article
Oncology
Corey M. Gill, Joshua Loewenstern, John W. Rutland, Hanane Arib, Margaret Pain, Melissa Umphlett, Yayoi Kinoshita, Russell B. McBride, Joshua Bederson, Michael Donovan, Robert Sebra, Mary Fowkes, Raj K. Shrivastava
Summary: ARID1A mutations occur with similar frequency between low and high-grade meningiomas, but ARID1A mutations are independently prognostic of worse prognosis beyond clinical and histopathologic features.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Oncology
Motoyuki Tsuda, Akihisa Fukuda, Munenori Kawai, Osamu Araki, Hiroshi Seno
Summary: ATP-dependent chromatin remodeling complexes, particularly the SWI/SNF complex, play crucial roles in regulating gene expression and have been found to be mutated in a significant percentage of human cancers, including pancreatic ductal adenocarcinoma (PDA). Research has shown that the subunits of the SWI/SNF complex in PDA have context-dependent roles in tumorigenesis, with potential therapeutic implications for targeting their oncogenic or tumor-suppressive properties in PDA. Further understanding of the precise roles of SWI/SNF complex subunits in PDA is necessary for the development of novel therapeutic strategies against this lethal type of cancer.
Article
Plant Sciences
Elzbieta Sarnowska, Szymon Kubala, Pawel Cwiek, Sebastian Sacharowski, Paulina Oksinska, Jaroslaw Steciuk, Magdalena Zaborowska, Jakub M. Szurmak, Roman Dubianski, Anna Maassen, Malgorzata Stachowiak, Bruno Huettel, Monika Ciesla, Klaudia Nowicka, Anna T. Rolicka, Saleh Alseekh, Ernest Bucior, Rainer Franzen, Anna Skoneczna, Malgorzata A. Domagalska, Samija Amar, Mohammad-Reza Hajirezaei, Janusz A. Siedlecki, Alisdair R. Fernie, Seth J. Davis, Tomasz J. Sarnowski
Summary: The Arabidopsis ERECTA family of leucine-rich repeat receptor-like kinases (LRR-RLKs) controls various developmental processes and interacts with the SWI/SNF chromatin remodeling complex. The er/erl1/erl2 mutant shows impaired gibberellin signaling, decreased SWI3B protein level, and altered chromatin structure. ERf-SWI/SNF CRC interaction plays an important role in transcriptional control of gibberellin receptors.
Review
Biochemistry & Molecular Biology
Ieva Vaicekauskaite, Rasa Sabaliauskaite, Juozas Rimantas Lazutka, Sonata Jarmalaite
Summary: Ovarian cancer is the fifth leading cause of women's death from cancers, with high mortality rate due to late presence and lack of modern diagnostic tools. It is a highly heterogeneous disease, leading to early treatment failure. Exploring molecular mechanisms of ovarian cancer can enhance our understanding and provide new treatment options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Developmental Biology
Yu-Chun Tseng, Jennifer S. Crodian, Ryan Cabot
Summary: This study aims to determine the developmental requirements of two SWI/SNF subunits, SMARCB1 and BRD7, in porcine embryos. The findings indicate that knockdown of SMARCB1 dramatically reduces embryo developmental potential, while knockdown of BRD7 has a less severe impact. Furthermore, knockdown of SMARCB1 alters the expression of NANOG and POU5F1.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2022)
Article
Oncology
Carlotta Zampieri, Emanuele Panatta, Vincenzo Corbo, Alessandro Mauriello, Gerry Melino, Ivano Amelio
Summary: This study reveals the molecular mechanism of drug-tolerant phenotype caused by p53 mutants in pancreatic cancer. Mutant p53 fine-tunes chromatin accessibility and orchestrates transcriptional activity, influencing the phenotypic evolution of pancreatic cancer, and strongly correlates with drug response and aggressive phenotype.
MOLECULAR ONCOLOGY
(2022)
Review
Oncology
Jaren Mullen, Shumei Kato, Jason K. Sicklick, Razelle Kurzrock
Summary: Mutations in ARID1A, a subunit gene of the SWI/SNF chromatin remodeling complex, are common in various cancers and play a crucial role in regulating gene expression related to oncogenesis and tumor suppression. Targeting ARID1A-altered cancers may involve a combination of immune checkpoint blockade and inhibitors of various pathways.ARID1A alterations may also mediate resistance to specific chemotherapies and hormone therapies.
CANCER TREATMENT REVIEWS
(2021)
Review
Medicine, General & Internal
Mahsa Mollapour Sisakht, Mohammad Amir Amirkhani, Mohammad Ali Nilforoushzadeh
Summary: Therapeutic strategies based on epigenetic regulators are rapidly increasing due to recent advances in understanding the role of epigenetic factors in therapy response. Mutations in SWI/SNF subunits genes are important in a significant portion of melanomas, and exploring the potential of using inhibitors and synthetic lethality interactions between key subunits in melanoma progression is crucial. This article discusses the clinical application of SWI/SNF subunits as a promising therapeutic approach for melanoma.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Carlos Jimenez, Roberta Antonelli, Mariona Nadal-Ribelles, Laura Devis-Jauregui, Pablo Latorre, Carme Sole, Marc Masanas, Adria Molero-Valenzuela, Aroa Soriano, Josep Sanchez de Toledo, David Llobet-Navas, Josep Roma, Francesc Posas, Eulalia de Nadal, Soledad Gallego, Lucas Moreno, Miguel F. Segura
Summary: Loss of function of mSWI/SNF complexes in neuroblastoma impairs cell proliferation and inhibits tumor invasion and metastasis. Disruption of the BAF complex results in epigenetic repression of invasion-related genes, significantly inhibiting neuroblastoma metastasis. These findings provide important insights for the development of new therapeutic strategies targeting mSWI/SNF complexes in neuroblastoma.
Review
Biochemistry & Molecular Biology
Ji-Yun Shang, Xin-Jian He
Summary: Adenosine triphosphate-dependent chromatin remodeling complexes play a crucial role in transcription, DNA replication, and genome stability regulation in eukaryotes. However, the study of chromatin remodeling complexes in plants lags behind yeast and animals. Recent research has identified and characterized the composition and function of chromatin remodeling enzymes in Arabidopsis, providing a foundation for further investigation into the molecular mechanisms.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Corinna Lieleg, Ana Novacic, Sanja Musladin, Andrea Schmid, Goezde Gueclueler Akpinar, Slobodan Barbaric, Philipp Korber
Summary: Chromatin remodeling by ATP-dependent enzymes is crucial for genomic processes. The recruitment of remodelers, such as the SWI/SNF complex, in the removal of nucleosomes in yeast PHO gene induction is specific and may affect the outcome of remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Mingxuan Li, Yutao Shen, Yujia Xiong, Shuai Wang, Chuzhong Li, Jiwei Bai, Yazhuo Zhang
Summary: The study revealed that SMARCB1 functions as a tumor suppressor in chordoma by inhibiting the malignant phenotype of chordoma cells. SMARCB1 inhibits autophagy through direct binding to the ATG5 promoter, leading to decreased ATG5 expression and impaired autophagy. High ATG5 expression is associated with adverse outcomes in recurrent chordoma patients.
CELL PROLIFERATION
(2021)
Article
Oncology
Masayuki Hagiwara, Yota Yasumizu, Nami Yamashita, Hasan Rajabi, Atsushi Fushimi, Mark D. Long, Wei Li, Atrayee Bhattacharya, Rehan Ahmad, Mototsugu Oya, Song Liu, Donald Kufe
Summary: MUC1-C associates with E2F1 and activates a novel pathway related to prostate cancer stem cell function.
Article
Biology
Jiyoon Beon, Sungwook Han, Hyeokjun Yang, Seung Eun Park, Kwangbeom Hyun, Song-Yi Lee, Hyun-Woo Rhee, Jeong Kon Seo, Jaehoon Kim, Seyun Kim, Daeyoup Lee
Summary: Inositol polyphosphate multikinase (IPMK) interacts with the chromatin remodeling complex SWI/SNF and regulates its function in mouse embryonic stem cells, contributing to transcription and differentiation.
Review
Cell Biology
Ying Ye, Xi Chen, Wensheng Zhang
Summary: Embryonic stem cells have a unique ability to maintain and regulate the balance between self-renewal and multi-lineage cellular differentiation, largely dependent on gene expression regulations. Chromatin remodeling complexes play a crucial role in promoting chromatin structural changes that ultimately affect ESC fate choices.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Nursing
Tara Walhart
JANAC-JOURNAL OF THE ASSOCIATION OF NURSES IN AIDS CARE
(2015)
Review
Nursing
T. Walhart
INTERNATIONAL NURSING REVIEW
(2012)
Article
Nursing
Tara Walhart
JOURNAL OF ADVANCED NURSING
(2013)
Article
Biochemical Research Methods
Brett M. Noel, Steven B. Ouellette, Laura Marholz, Deborah Dickey, Connor Navis, Tzu-Yi Yang, Vinh Nguyen, Sarah J. Parker, David Bernlohr, Zohar Sachs, Laurie L. Parker
JOURNAL OF PROTEOME RESEARCH
(2019)
Article
Biochemical Research Methods
Tara Walhart, Erin Isaacson-Wechsler, Kean-Hooi Ang, Michelle Arkin, Sharof Tugizov, Joel M. Palefsky
Article
Oncology
Shujie Song, Vinh Nguyen, Travis Schrank, Kathleen Mulvaney, Vonn Walter, Darmood Wei, Tess Orvis, Nisarg Desai, Jiren Zhang, D. Neil Hayes, Yanfang Zheng, Michael B. Major, Bernard E. Weissman
MOLECULAR CANCER RESEARCH
(2020)
Article
Pathology
Tara A. Walgart, Bryann Vacca, Austin J. Heppala, Samera H. Hamad, James Potrongelli, Yemin Wang, Erin L. McKean, Michelle Moska, Qi Cao, Stephen Yip, Martin Hirst, Bernard E. Weissman
Summary: In poorly differentiated chordoma cell lines, loss of SMARCB1 expression leads to unhindered cell growth, possibly due to the loss of CDKN2A expression. Additionally, re-expression of SMARCB1 alters the composition of SWI/SNF complexes, restoring those associated with cellular differentiation.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Karen E. Preston, Tara A. Walhart, Ann L. O'Sullivan
AMERICAN JOURNAL OF LIFESTYLE MEDICINE
(2011)