SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer
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Title
SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer
Authors
Keywords
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Journal
Nature Communications
Volume 10, Issue 1, Pages -
Publisher
Springer Nature
Online
2019-02-04
DOI
10.1038/s41467-019-08380-1
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Note: Only part of the references are listed.- Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer
- (2018) Yonathan Lissanu Deribe et al. NATURE MEDICINE
- An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues
- (2017) M Ryan Corces et al. NATURE METHODS
- Co-regulation of transcription by BRG1 and BRM, two mutually exclusive SWI/SNF ATPase subunits
- (2017) Jesse R. Raab et al. Epigenetics & Chromatin
- SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers
- (2017) Vural Tagal et al. Nature Communications
- The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers
- (2017) Burak H. Alver et al. Nature Communications
- An Expression Signature as an Aid to the Histologic Classification of Non-Small Cell Lung Cancer
- (2016) L. Girard et al. CLINICAL CANCER RESEARCH
- New and emerging targeted treatments in advanced non-small-cell lung cancer
- (2016) Fred R Hirsch et al. LANCET
- Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
- (2016) Joshua D Campbell et al. NATURE GENETICS
- Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors
- (2016) A. Patnaik et al. Cancer Discovery
- Palbociclib (PD0332991)—a Selective and Potent Cyclin-Dependent Kinase Inhibitor
- (2016) Amy S. Clark et al. JAMA Oncology
- Brg1 modulates enhancer activation in mesoderm lineage commitment
- (2015) J. M. Alexander et al. DEVELOPMENT
- The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth
- (2015) Claudia Bossen et al. NATURE IMMUNOLOGY
- SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2
- (2015) Kimberly H Kim et al. NATURE MEDICINE
- The history and future of targeting cyclin-dependent kinases in cancer therapy
- (2015) Uzma Asghar et al. NATURE REVIEWS DRUG DISCOVERY
- Palbociclib in Hormone-Receptor–Positive Advanced Breast Cancer
- (2015) Nicholas C. Turner et al. NEW ENGLAND JOURNAL OF MEDICINE
- Targeting CDK4 and CDK6: From Discovery to Therapy
- (2015) C. J. Sherr et al. Cancer Discovery
- Molecular analyses reveal close similarities between small cell carcinoma of the ovary, hypercalcemic type and atypical teratoid/rhabdoid tumor
- (2015) Somayyeh Fahiminiya et al. Oncotarget
- ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases
- (2014) Li Shen et al. BMC GENOMICS
- Comprehensive molecular profiling of lung adenocarcinoma
- (2014) Eric A. Collisson et al. NATURE
- Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4
- (2014) Pilar Ramos et al. NATURE GENETICS
- Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type
- (2014) Leora Witkowski et al. NATURE GENETICS
- Recurrent SMARCA4 mutations in small cell carcinoma of the ovary
- (2014) Petar Jelinic et al. NATURE GENETICS
- deepTools: a flexible platform for exploring deep-sequencing data
- (2014) Fidel Ramírez et al. NUCLEIC ACIDS RESEARCH
- Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers
- (2014) G. R. Hoffman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Synthetic Lethality-Based Strategy to Treat Cancers Harboring a Genetic Deficiency in the Chromatin Remodeling Factor BRG1
- (2013) T. Oike et al. CANCER RESEARCH
- Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
- (2013) Jason D Buenrostro et al. NATURE METHODS
- Small cell ovarian carcinoma: genomic stability and responsiveness to therapeutics
- (2013) Lisa F Gamwell et al. Orphanet Journal of Rare Diseases
- Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
- (2012) Marcin Imielinski et al. CELL
- The accessible chromatin landscape of the human genome
- (2012) Robert E. Thurman et al. NATURE
- p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells
- (2012) L. Cen et al. NEURO-ONCOLOGY
- Expression of p16 and Retinoblastoma Determines Response to CDK4/6 Inhibition in Ovarian Cancer
- (2011) Gottfried E. Konecny et al. CLINICAL CANCER RESEARCH
- Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity
- (2011) L. Song et al. GENOME RESEARCH
- Integrative genomics viewer
- (2011) James T Robinson et al. NATURE BIOTECHNOLOGY
- BEDTools: a flexible suite of utilities for comparing genomic features
- (2010) Aaron R. Quinlan et al. BIOINFORMATICS
- A Synthetic Lethal Interaction between K-Ras Oncogenes and Cdk4 Unveils a Therapeutic Strategy for Non-small Cell Lung Carcinoma
- (2010) Marta Puyol et al. CANCER CELL
- Massive parallel DNA pyrosequencing analysis of the tumor suppressor BRG1/SMARCA4 in lung primary tumors
- (2010) Salvador Rodriguez-Nieto et al. HUMAN MUTATION
- Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
- (2010) Sven Heinz et al. MOLECULAR CELL
- A unique chromatin signature uncovers early developmental enhancers in humans
- (2010) Alvaro Rada-Iglesias et al. NATURE
- Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM
- (2010) W. R. Wiedemeyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Sequence Alignment/Map format and SAMtools
- (2009) H. Li et al. BIOINFORMATICS
- Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
- (2009) Ben Langmead et al. GENOME BIOLOGY
- Transcriptional regulation of the cyclin D1 gene at a glance
- (2008) E. A. Klein et al. JOURNAL OF CELL SCIENCE
- Enhanced identification and biological validation of differential gene expression via Illumina whole-genome expression arrays through the use of the model-based background correction methodology
- (2008) Liang-Hao Ding et al. NUCLEIC ACIDS RESEARCH
- Model-based Analysis of ChIP-Seq (MACS)
- (2008) Yong Zhang et al. GENOME BIOLOGY
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