Early B cell tolerance defects in neuromyelitis optica favour anti-AQP4 autoantibody production

Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity

(2019) Panos Stathopoulos et al.   JOURNAL OF IMMUNOLOGY

AIRE expression controls the peripheral selection of autoreactive B cells

(2019) Joel Sng et al.   Science Immunology

Autoimmune phenomena and disease in cancer patients treated with immune checkpoint inhibitors

(2018) Milena Tocut et al.   AUTOIMMUNITY REVIEWS

Condition-dependent generation of aquaporin-4 antibodies from circulating B cells in neuromyelitis optica

(2018) Robert Wilson et al.   BRAIN

The Multiple Roles of B Cells in Multiple Sclerosis and Their Implications in Multiple Sclerosis Therapies

(2018) Rui Li et al.   Cold Spring Harbor Perspectives in Medicine

Neuromyelitis optica spectrum disorder presenting with concurrent autoimmune diseases

(2018) Vlad C. Bibic et al.   Multiple Sclerosis and Related Disorders

Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis

(2017) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Brief Report: Defective Early B Cell Tolerance Checkpoints in Sjögren's Syndrome Patients

(2017) Salomé Glauzy et al.   Arthritis & Rheumatology

CNS Aquaporin-4-specific B cells connect with multiple B-cell compartments in neuromyelitis optica spectrum disorder

(2017) Markus C. Kowarik et al.   Annals of Clinical and Translational Neurology

Gut microbiome analysis in neuromyelitis optica reveals overabundance ofClostridium perfringens

(2016) Bruce A. C. Cree et al.   ANNALS OF NEUROLOGY

AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies

(2016) Steffen Meyer et al.   CELL

Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint

(2016) Tineke Cantaert et al.   JOURNAL OF CLINICAL INVESTIGATION

Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4

(2016) Sharon A. Sagan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compromised fidelity of B-cell tolerance checkpoints in AChR and MuSK myasthenia gravis

(2016) Jae-Yun Lee et al.   Annals of Clinical and Translational Neurology

Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data: Table 1.

(2015) Namita T. Gupta et al.   BIOINFORMATICS

Activation-Induced Cytidine Deaminase Expression in Human B Cell Precursors Is Essential for Central B Cell Tolerance

(2015) Tineke Cantaert et al.   IMMUNITY

Mutagenesis of the Aquaporin 4 Extracellular Domains Defines Restricted Binding Patterns of Pathogenic Neuromyelitis Optica IgG

(2015) Gregory P. Owens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lentiviral-mediated gene therapy restores B cell tolerance in Wiskott-Aldrich syndrome patients

(2015) Francesca Pala et al.   JOURNAL OF CLINICAL INVESTIGATION

Rituximab does not reset defective early B cell tolerance checkpoints

(2015) Nicolas Chamberlain et al.   JOURNAL OF CLINICAL INVESTIGATION

B Cell Antigen Presentation Is Sufficient To Drive Neuroinflammation in an Animal Model of Multiple Sclerosis

(2015) Chelsea R. Parker Harp et al.   JOURNAL OF IMMUNOLOGY

The cerebrospinal fluid immunoglobulin transcriptome and proteome in neuromyelitis optica reveals central nervous system-specific B cell populations

(2015) Markus C Kowarik et al.   Journal of Neuroinflammation

International consensus diagnostic criteria for neuromyelitis optica spectrum disorders

(2015) Dean M. Wingerchuk et al.   NEUROLOGY

Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis

(2015) Luca Piccoli et al.   Nature Communications

Treatment Outcomes With Rituximab in 100 Patients With Neuromyelitis Optica

(2015) Su-Hyun Kim et al.   JAMA Neurology

Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived Immunoglobulins

(2015) Simon N. Willis et al.   Frontiers in Immunology

High Affinity Antibodies against Influenza Characterize the Plasmablast Response in SLE Patients After Vaccination

(2015) Kaval Kaur et al.   PLoS One

Dedicator of cytokinesis 8–deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells

(2014) Erin Janssen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Single Dose of Glycoengineered Anti-CD19 Antibody (MEDI551) Disrupts Experimental Autoimmune Encephalomyelitis by Inhibiting Pathogenic Adaptive Immune Responses in the Bone Marrow and Spinal Cord while Preserving Peripheral Regulatory Mechanisms

(2014) Ding Chen et al.   JOURNAL OF IMMUNOLOGY

Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G

(2014) Nithi Asavapanumas et al.   Journal of Neuroinflammation

Rapid development of broadly influenza neutralizing antibodies through redundant mutations

(2014) Leontios Pappas et al.   NATURE

B cells in MS and NMO: pathogenesis and therapy

(2014) Markus Krumbholz et al.   Seminars in Immunopathology

Immunology of neuromyelitis optica: a T cell-B cell collaboration

(2013) Meike Mitsdoerffer et al.   Annals of the New York Academy of Sciences

Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance

(2013) Laurence Menard et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CVID-associated TACI mutations affect autoreactive B cell selection and activation

(2013) Neil Romberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Specific peripheral B cell tolerance defects in patients with multiple sclerosis

(2013) Tuure Kinnunen et al.   JOURNAL OF CLINICAL INVESTIGATION

MHC class II–dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies

(2013) Nicolas Molnarfi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IgBLAST: an immunoglobulin variable domain sequence analysis tool

(2013) Jian Ye et al.   NUCLEIC ACIDS RESEARCH

A 5-Year Follow-up of Rituximab Treatment in Patients With Neuromyelitis Optica Spectrum Disorder

(2013) Su-Hyun Kim et al.   JAMA Neurology

Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognizeClostridiumABC transporter

(2012) Michel Varrin-Doyer et al.   ANNALS OF NEUROLOGY

The establishment of early B cell tolerance in humans: lessons from primary immunodeficiency diseases

(2012) Eric Meffre   Annals of the New York Academy of Sciences

Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells

(2012) T. Kinnunen et al.   BLOOD

Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapy

(2012) Aisha V. Sauer et al.   JOURNAL OF CLINICAL INVESTIGATION

Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface

(2012) Giovanni Di Zenzo et al.   JOURNAL OF CLINICAL INVESTIGATION

Serologic diagnosis of NMO: A multicenter comparison of aquaporin-4-IgG assays

(2012) P. J. Waters et al.   NEUROLOGY

Myasthenia gravis and neuromyelitis optica spectrum disorder: A multicenter study of 16 patients

(2012) M. I. Leite et al.   NEUROLOGY

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

(2011) Laurence Menard et al.   JOURNAL OF CLINICAL INVESTIGATION

Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab

(2011) H. L. Pellkofer et al.   NEUROLOGY

Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes

(2011) S. R. Hinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans

(2011) G. Meyers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

(2011) D. Corti et al.   SCIENCE

Inflammation-independent defective early B cell tolerance checkpoints in rheumatoid arthritis

(2010) Laurence Menard et al.   ARTHRITIS AND RHEUMATISM

Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones

(2010) I. Isnardi et al.   BLOOD

Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice

(2010) Samira Saadoun et al.   BRAIN

Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine

(2010) Davide Corti et al.   JOURNAL OF CLINICAL INVESTIGATION

Intrathecal pathogenic anti–aquaporin-4 antibodies in early neuromyelitis optica

(2009) Jeffrey L. Bennett et al.   ANNALS OF NEUROLOGY

Neuromyelitis optica: Passive transfer to rats by human immunoglobulin

(2009) Makoto Kinoshita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

B-cell tolerance checkpoints in health and autoimmunity

(2008) Eric Meffre et al.   CURRENT OPINION IN IMMUNOLOGY

IRAK-4- and MyD88-Dependent Pathways Are Essential for the Removal of Developing Autoreactive B Cells in Humans

(2008) Isabelle Isnardi et al.   IMMUNITY

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis

(2008) X. Brochet et al.   NUCLEIC ACIDS RESEARCH

Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors

(2008) B. Mietzner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA