Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapy

Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID

(2011) A. V. Sauer et al.   BLOOD

Adenosine modulates Toll-like receptor function: basic mechanisms and translational opportunities

(2011) Melanie R Power Coombs et al.   Expert Review of Anti-Infective Therapy

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

(2011) Laurence Menard et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans

(2011) G. Meyers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hematopoietic Stem Cell Gene Therapy for Adenosine Deaminase-Deficient Severe Combined Immunodeficiency Leads to Long-Term Immunological Recovery and Metabolic Correction

(2011) H. B. Gaspar et al.   Science Translational Medicine

Inflammation-independent defective early B cell tolerance checkpoints in rheumatoid arthritis

(2010) Laurence Menard et al.   ARTHRITIS AND RHEUMATISM

Reference values for B cell subpopulations from infancy to adulthood

(2010) H. Morbach et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Update on gene therapy for adenosine deaminase-deficient severe combined immunodeficiency

(2010) Francesca Ferrua et al.   Current Opinion in Allergy and Clinical Immunology

Homeostatic expansion of autoreactive immunoglobulin-secreting cells in theRag2mouse model of Omenn syndrome

(2010) Barbara Cassani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Different Extent of B and T Cell Immune Reconstitution after Hematopoietic Stem Cell Transplantation and Enzyme Replacement Therapies in SCID Patients with Adenosine Deaminase Deficiency

(2010) F. Serana et al.   JOURNAL OF IMMUNOLOGY

Long-term outcome after hematopoietic stem cell transplantation of a single-center cohort of 90 patients with severe combined immunodeficiency

(2009) B. Neven et al.   BLOOD

ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency

(2009) A. V. Sauer et al.   BLOOD

How I treat ADA deficiency

(2009) H. B. Gaspar et al.   BLOOD

New insights into the pathogenesis of adenosine deaminase-severe combined immunodeficiency and progress in gene therapy

(2009) Aisha V Sauer et al.   Current Opinion in Allergy and Clinical Immunology

Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling

(2009) A. F. Arechiga et al.   JOURNAL OF IMMUNOLOGY

Gene Therapy for Immunodeficiency Due to Adenosine Deaminase Deficiency

(2009) Alessandro Aiuti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients

(2008) B. Cassani et al.   BLOOD

IRAK-4- and MyD88-Dependent Pathways Are Essential for the Removal of Developing Autoreactive B Cells in Humans

(2008) Isabelle Isnardi et al.   IMMUNITY

Single-center analysis of long-term outcome after hematopoietic cell transplantation in children with congenital severe T cell immunodeficiency

(2008) Evelina Mazzolari et al.   IMMUNOLOGIC RESEARCH