Cardiac Autophagy in Sepsis

High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding

(2018) Wei-Chung Chiang et al.   ACS Chemical Biology

Beclin-1-Dependent Autophagy Protects the Heart During Sepsis

(2018) Yuxiao Sun et al.   CIRCULATION

Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency

(2018) Aida Rodríguez‐Nuevo et al.   EMBO JOURNAL

Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK

(2018) Yuuki Shimizu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1

(2017) Traci L. Marin et al.   Science Signaling

The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia

(2017) Krishnendu Chakraborty et al.   Nature Communications

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

(2017) Rhianna C. Laker et al.   Nature Communications

AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1

(2017) Traci L. Marin et al.   Science Signaling

FOXO3a regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress

(2016) Antoine H. Chaanine et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

(2016) Federico Pietrocola et al.   CANCER CELL

Rapamycin Protects Sepsis-Induced Cognitive Impairment in Mouse Hippocampus by Enhancing Autophagy

(2016) Wenyu Liu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload–Induced Mitochondrial Dysfunction and Heart FailureCLINICAL PERSPECTIVE

(2016) Akihiro Shirakabe et al.   CIRCULATION

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Rapamycin attenuates acute lung injury induced by LPS through inhibition of Th17 cell proliferation in mice

(2016) Zhao Yan et al.   Scientific Reports

Understanding Long-Term Outcomes Following Sepsis: Implications and Challenges

(2016) Manu Shankar-Hari et al.   Current Infectious Disease Reports

Cytochrome c as a Potentially Clinical Useful Marker of Mitochondrial and Cellular Damage

(2016) Theodoros Eleftheriadis et al.   Frontiers in Immunology

mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1

(2016) Claudia Manzoni et al.   Scientific Reports

Mending a broken heart: the role of mitophagy in cardioprotection

(2015) Alexandra G. Moyzis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondria-Associated Membranes: Composition, Molecular Mechanisms, and Physiopathological Implications

(2015) Carlotta Giorgi et al.   ANTIOXIDANTS & REDOX SIGNALING

Rehospitalizations Following Sepsis

(2015) Dong W. Chang et al.   CRITICAL CARE MEDICINE

Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy

(2015) Katy J. Petherick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy

(2015) Davor Ivankovic et al.   JOURNAL OF NEUROCHEMISTRY

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration

(2015) Daniel A. Stevens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of autophagy by 3-methyladenine potentiates sulforaphane-induced cell death of BE(2)-C human neuroblastoma cells

(2015) IRENA HORWACIK et al.   Molecular Medicine Reports

Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model

(2015) Xiao Yao et al.   PLoS One

A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors

(2014) Debra Akin et al.   Autophagy

BECN1 is involved in the initiation of mitophagy

(2014) Vinay Choubey et al.   Autophagy

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Carbon Monoxide Confers Protection in Sepsis by Enhancing Beclin 1-Dependent Autophagy and Phagocytosis

(2013) Seonmin Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

Protective role of PARK2/Parkin in sepsis-induced cardiac contractile and mitochondrial dysfunction

(2013) Jérôme Piquereau et al.   Autophagy

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

(2013) Seok Min Jin et al.   Autophagy

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Complete Activation of Autophagic Process Attenuates Liver Injury and Improves Survival in Septic Mice

(2013) Chih-Wen Lin et al.   SHOCK

Specific inhibition of mitochondrial oxidative stress suppresses inflammation and improves cardiac function in a rat pneumonia-related sepsis model

(2012) Qun S. Zang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Where the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-associated membrane (MAM)

(2012) Arun Raturi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Cardiac-specific overexpression of catalase attenuates lipopolysaccharide-induced myocardial contractile dysfunction: Role of autophagy

(2012) Subat Turdi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Parkin Protein Deficiency Exacerbates Cardiac Injury and Reduces Survival following Myocardial Infarction

(2012) Dieter A. Kubli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy

(2012) Rita A. Hanna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Transcription Factor A Serves as a Danger Signal by Augmenting Plasmacytoid Dendritic Cell Responses to DNA

(2012) M. W. Julian et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Mammalian Target of Rapamycin Augments Lipopolysaccharide-Induced Lung Injury and Apoptosis

(2012) J. A. Fielhaber et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Sepsis-Induced Cardiac Mitochondrial Dysfunction Involves Altered Mitochondrial-Localization of Tyrosine Kinase Src and Tyrosine Phosphatase SHP2

(2012) Qun S. Zang et al.   PLoS One

Autophagy and Skeletal Muscles in Sepsis

(2012) Mahroo Mofarrahi et al.   PLoS One

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

Complete Induction of Autophagy Is Essential for Cardioprotection in Sepsis

(2011) Chi-Hsun Hsieh et al.   ANNALS OF SURGERY

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

Tuning flux: autophagy as a target of heart disease therapy

(2011) Min Xie et al.   CURRENT OPINION IN CARDIOLOGY

Diastolic dysfunction and mortality in severe sepsis and septic shock

(2011) G. Landesberg et al.   EUROPEAN HEART JOURNAL

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Suppression of Autophagy in Rat Liver at Late Stage of Polymicrobial Sepsis

(2011) Wei-Shan Chien et al.   SHOCK

The Decline of Autophagy Contributes to Proximal Tubular Dysfunction During Sepsis

(2011) Hsiu-Wen Hsiao et al.   SHOCK

Burn serum causes a CD14-dependent mitochondrial damage in primary cardiomyocytes

(2010) Qun S. Zang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy

(2010) S Michiorri et al.   CELL DEATH AND DIFFERENTIATION

The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis*

(2010) Mitchell M. Levy et al.   CRITICAL CARE MEDICINE

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

FoxO, Autophagy, and Cardiac Remodeling

(2010) Anwarul Ferdous et al.   Journal of Cardiovascular Translational Research

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors

(2009) Elliott D. Crouser et al.   CRITICAL CARE MEDICINE

Cardiac dysfunction in severe sepsis and septic shock

(2009) Sergio L Zanotti-Cavazzoni et al.   Current Opinion in Critical Care

Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study

(2009) Eizo Watanabe et al.   LABORATORY INVESTIGATION

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion

(2008) Dieter A. Kubli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection

(2008) Hua Yuan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

(2008) Eisuke Itakura et al.   MOLECULAR BIOLOGY OF THE CELL

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology