Article
Medicine, Research & Experimental
Jiucui Li, Kongmiao Lu, Fenglan Sun, Shanjuan Tan, Xiao Zhang, Wei Sheng, Wanming Hao, Min Liu, Weihong Lv, Wei Han
Summary: Panaxydol (PX) isolated from Panax ginseng roots attenuates ferroptosis against LPS-induced ALI via the Keap1-Nrf2/HO-1 pathway, showing promising therapeutic potential for ALI treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Xiaoling Li, Riming Huang, Kaifeng Liu, Mingyue Li, Hui Luo, Liao Cui, Lei Huang, Lianxiang Luo
Summary: Fucoxanthin alleviates lipopolysaccharide-induced acute lung injury by inhibiting inflammatory responses and the TLR4/MyD88 signaling axis, indicating a potential therapeutic strategy for controlling ALI.
Article
Pharmacology & Pharmacy
Lejing Lou, Min Wang, Jingjing He, Song Yang, Fanxi Meng, Shijia Wang, Xiao Jin, Jihao Cai, Chang Cai
Summary: The aim of this study was to investigate the role of Urolithin A (UA) in regulating lipopolysaccharide (LPS)-induced ferroptosis in acute lung injury (ALI). The results showed that UA effectively alleviated LPS-induced ALI by reducing lung wet/dry weight ratio, reactive oxygen species, and malondialdehyde production, as well as increasing antioxidant enzyme levels. Additionally, UA decreased ferroptosis levels by increasing GPX4 and SLC7A11 expression and decreasing Fe2+ levels. The Keap1-Nrf2/HO-1 pathway was upregulated by UA, inhibiting LPS-induced ALI and ferroptosis. ML385 inhibited the protective effect of UA against LPS-induced ALI.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ngan Nguyen, Simin Xu, Terence Yin Weng Lam, Wupeng Liao, W. S. Fred Wong, Ruowen Ge
Summary: This study reveals that ISM1 plays an anti-inflammatory role in acute lung injury (ALI), and its deficiency leads to intensified acute lung inflammation and increased post-ALI lung fibrosis. Recombinant ISM1 effectively suppresses acute lung inflammation and ALI, and inhibits NF-κB activation in mouse alveolar macrophages.
MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Xiang Li, Bo Liao, Rongming Liu, Yanli Ma
Summary: This study aimed to investigate the mechanism and effects of abietic acid (AA) in a mouse model of acute lung injury (ALI). The results showed that AA attenuated LPS-induced lung injury and pneumonia by restoring Th17/Treg balance.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Sahebgowda Sidramagowda Patil, Helena Hernandez-Cueryo, Jutaro Fukumoto, Sudarshan Krishnamurthy, Muling Lin, Matthew Alleyn, Mason Breitzig, Venkata Ramireddy Narala, Ramani Soundararajan, Richard F. Lockey, Narasaiah Kolliputi, Lakshmi Galam
Summary: Acute lung injury (ALI) is a leading cause of mortality in older adults, and oxygen therapy is a common treatment method. Alda-1 protects against oxidative stress by enhancing ALDH2 activity, and also shows protective effects against ischemic reperfusion injury, heart failure, and other conditions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhi-Feng Luo, Xiang-Hui Jiang, Huan Liu, Li-Yuan He, Xiong Luo, Fu-Chun Chen, Yu-Lin Tan
Summary: Inflammatory responses play a significant role in infectious etiology-induced acute lung injury, where miR-23b has the potential to suppress inflammation by targeting HDAC2. LPS treatment stimulated inflammatory responses through inhibition of miR-23b and enhanced HDAC2 expression in macrophages. Overexpression of miR-23b shows promise as a therapeutic target for ALI treatment.
BIOCHEMICAL GENETICS
(2021)
Article
Medicine, Research & Experimental
Dan Song, Min Zhao, Liuxiang Feng, Pingyi Wang, Yimei Li, Wenhua Li
Summary: Salidroside attenuates acute lung injury by inhibiting inflammatory cytokine production, reducing LPS-induced pathological damage, and suppressing TNF-α and IL-6 secretion in the lung. This suggests that Salidroside may have a potential therapeutic effect in LPS-induced acute lung injury.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Jing Yue, Kai Su, Guangxin Zhang, Jinghui Yang, Chengbi Xu, Xueshibojie Liu
Summary: Dihydrotanshinone (DIH) can regulate LPS-induced acute lung injury (ALI) in mice by inhibiting the NF-κB signaling pathway.
Article
Pharmacology & Pharmacy
Yunduan Song, Yusen Gou, Jiameng Gao, Dongxin Chen, Haibo Zhang, Wenjuan Zhao, Feng Qian, Ajing Xu, Yao Shen
Summary: This study demonstrates that lomerizine (LMZ) effectively reduces pulmonary edema, neutrophil infiltration, and pro-inflammatory cytokine production in lipopolysaccharide (LPS)-induced acute lung injury (ALI) mice. LMZ treatment attenuates the expression of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α in macrophages, and inhibits the phosphorylation of p38 MAPK, ERK1/2, JNK, and NF-kappa B p65. Additionally, LMZ reduces LPS-induced Ca2+ influx and suppresses pro-inflammatory cytokine production.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Xiang Li, Chuan Xiao, Jia Yuan, Xianjun Chen, Qing Li, Feng Shen
Summary: Rhein promotes macrophage M2 polarization transition by targeting the NFATc1/Trem2 axis to regulate inflammation response and prognosis after ALI/ARDS, which sheds more light on possibilities for the clinical treatments of this pathological process.
INFLAMMATION RESEARCH
(2023)
Article
Physiology
Gabriela Viegas Haute, Carolina Luft, Leonardo Pedrazza, Gessica Luana Antunes, Josiane Silveira, Bruno de Souza Basso, Vitor Giancarlo Schneider Levorse, Matheus Scherer Bastos, Denizar Melo, Ketlin Fernanda Rodrigues, Maria Claudia Garcia, Mariana Severo da Costa, Lucas Strassburger Matzenbacher, Daniela Benvenutti Kaiber, Marcio Vinicius Fagundes Donadio, Jordi Gracia-Sancho, Jarbas Rodrigues de Oliveira
Summary: Acute lung injury (ALI) is a prevalent disease characterized by excessive production of inflammatory mediators in the lungs. Inhibition of inflammatory cytokines has been proposed as an alternative treatment for ALI. This study evaluated the effects of Simvastatin (SV) on LPS-induced alveolar macrophages and ALI in mice. The results showed that SV protected alveolar macrophages from LPS activation and reduced inflammatory response in vitro and in vivo. These findings suggest that SV could be used as an anti-inflammatory agent for ALI.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shuo Wang, Jinqian Liu, Jing Dong, Zongqiang Fan, Fugui Wang, Ping Wu, Xiaojing Li, Ruirui Kou, Fang Chen
Summary: This study found that Allyl methyl trisulfide (AMTS) can significantly alleviate lipopolysaccharide (LPS)-induced acute lung injury (ALI). The results showed that AMTS improved lung pathology, reduced pulmonary edema and protein leakage, and inhibited inflammation response and infiltration of inflammation-regulation cells. In vitro experiments also demonstrated that AMTS could inhibit macrophage M1 polarization. Mechanistically, AMTS was found to attenuate the activation of NF-kappa B and MAPKs pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Yao Wang, Yanchun Wang, Jun Ma, Yanan Li, Lu Cao, Tianxiang Zhu, Haiming Hu, Hongtao Liu
Summary: The study demonstrates that Yupingfengsan (YPFS) can alleviate acute lung injury (ALI) and suppress the production of inflammatory factors. Additionally, YPFS reduces pulmonary edema by promoting the expressions of aquaporin and sodium channel-related genes. Furthermore, YPFS exhibits a therapeutic effect on ALI by inhibiting the activation of the NLRP3 inflammasome and MAPK signaling pathways. Finally, YPFS improves gut barrier integrity and suppresses intestinal inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Gen Li, Jingwei Ma, Yang Yang, Caixia Zang, Cheng Ju, Fangyu Yuan, Jingwen Ning, Meiyu Shang, Qiuzhu Chen, Yueqi Jiang, Fangfang Li, Xiuqi Bao, Degui Mu, Dan Zhang
Summary: Yinma Jiedu Granule (YMJD) is a traditional Chinese patent medicine with anti-inflammatory effects and therapeutic effects on obstructive pulmonary disease. The study found that YMJD can alleviate acute lung injury induced by lipopolysaccharide in rats by suppressing inflammation and oxidative stress.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Critical Care Medicine
Zhixin Song, Xuemei Zhang, Liping Zhang, Fang Xu, Xintong Tao, Hua Zhang, Xue Lin, Lihua Kang, Yu Xiang, Xaiofei Lai, Qun Zhang, Kun Huang, Yubing Dai, Yibing Yin, Ju Cao
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2016)
Article
Immunology
Song Gao, Lingbin Zeng, Xuemei Zhang, Yingying Wu, Jingjing Cui, Zhixin Song, Xiaoyu Sun, Hong Wang, Yibing Yin, Wenchun Xu
IMMUNOLOGY LETTERS
(2016)
Article
Immunology
Xintong Tao, Zhixin Song, Chuanjiang Wang, Hongchun Luo, Qin Luo, Xue Lin, Liping Zhang, Yibing Yin, Ju Cao
JOURNAL OF INFECTIOUS DISEASES
(2017)
Article
Immunology
Hong Zhang, Lihua Kang, Hua Yao, Yujuan He, Xiaofang Wang, Wenchun Xu, Zhixin Song, Yibing Yin, Xuemei Zhang
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2016)
Article
Immunology
Shan Zou, Qin Luo, Zhixin Song, Liping Zhang, Yun Xia, Huajian Xu, Yu Xiang, Yibing Yin, Ju Cao
JOURNAL OF INFECTIOUS DISEASES
(2017)
Article
Critical Care Medicine
Xue Lin, Hongchun Luo, Xingxing Yan, Zhixin Song, Xun Gao, Yun Xia, Liping Zhang, Yibing Yin, Ju Cao
CRITICAL CARE MEDICINE
(2018)
Article
Critical Care Medicine
Xun Gao, Yi Liu, Fang Xu, Shihui Lin, Zhixin Song, Jun Duan, Yibing Yin, Ju Cao
Article
Biochemistry & Molecular Biology
Chunmei Jing, Xuemei Zhang, Zhixin Song, Yuqiang Zheng, Yibing Yin
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Lubei Rao, Zhixin Song, Xiaoyan Yu, Qianqian Tu, Yu He, Yetao Luo, Yibing Yin, Dapeng Chen
Article
Immunology
Xiaoyan Yu, Zhixin Song, Lubei Rao, Qianqian Tu, Jie Zhou, Yibing Yin, Dapeng Chen
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Endocrinology & Metabolism
Han Wang, Yanjun Jia, Xiaoyan Yu, Li Peng, Chunfeng Mou, Zhixin Song, Dapeng Chen, Xiaoqiang Li
Summary: This study found that serum PK2 levels were higher in children with obesity compared to normal-weight children, and circulating PK2 levels related to obesity were not associated with NAFLD, while PK2 was positively correlated with obesity-related indicators such as BMI and insulin resistance.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Critical Care Medicine
Xiaoyan Yu, Jingyi Chen, Hong Tang, Qianqian Tu, Yue Li, Xi Yuan, Xuemei Zhang, Ju Cao, David Paul Molloy, Yibing Yin, Dapeng Chen, Zhixin Song, Pingyong Xu
Summary: This study reveals the significant role of Prokineticin2 in the clinical diagnosis and treatment of sepsis. Prokineticin2 protects against sepsis-induced death by regulating macrophage function, presenting a new strategy for sepsis immunotherapy.
CRITICAL CARE MEDICINE
(2022)
Article
Immunology
Xi Yuan, Zihan Xiong, Wei Liu, Yue Li, Hongdong Li, Xuemei Zhang, Yibing Yin, Pingyong Xu, Ju Cao, Dapeng Chen, Zhixin Song
Summary: This study found that the high expression of CCL3 promotes intestinal epithelial cell apoptosis and exacerbates intestinal injury in NEC patients. Blocking CCL3, CCR4, or NF-kappa B may represent a novel effective immunotherapy for NEC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Hua Yao, Hong Zhang, Kai Lan, Hong Wang, Yufeng Su, Dagen Li, Zhixin Song, Fang Cui, Yibing Yin, Xuemei Zhang
INFECTION AND IMMUNITY
(2017)