- Home
- Publications
- Publication Search
- Publication Details
Title
The lysosomal protein cathepsin L is a progranulin protease
Authors
Keywords
Progranulin, Lysosome, Cathepsin L, Neutrophil elastase, Frontotemporal lobar degeneration, Neuronal ceroid lipofuscinosis
Journal
Molecular Neurodegeneration
Volume 12, Issue 1, Pages -
Publisher
Springer Nature
Online
2017-07-25
DOI
10.1186/s13024-017-0196-6
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations
- (2017) Xiaolai Zhou et al. Nature Communications
- Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin
- (2015) Xiaolai Zhou et al. JOURNAL OF CELL BIOLOGY
- The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels
- (2015) D. A. Salazar et al. JOURNAL OF NEUROSCIENCE
- Ultrasensitive internally quenched substrates of human cathepsin L
- (2014) Monika Łęgowska et al. ANALYTICAL BIOCHEMISTRY
- Frontotemporal dementia: a bridge between dementia and neuromuscular disease
- (2014) Adeline S.L. Ng et al. Annals of the New York Academy of Sciences
- Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice
- (2014) Yoshinori Tanaka et al. Acta Neuropathologica Communications
- Targeted manipulation of the sortilin–progranulin axis rescues progranulin haploinsufficiency
- (2013) Wing C. Lee et al. HUMAN MOLECULAR GENETICS
- Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis
- (2013) K. R. Smith et al. HUMAN MOLECULAR GENETICS
- Improved Quenched Fluorescent Probe for Imaging of Cysteine Cathepsin Activity
- (2013) Martijn Verdoes et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Magnetic Fractionation and Proteomic Dissection of Cellular Organelles Occupied by the Late Replication Complexes of Semliki Forest Virus
- (2013) M. Varjak et al. JOURNAL OF VIROLOGY
- Strikingly Different Clinicopathological Phenotypes Determined by Progranulin-Mutation Dosage
- (2012) Katherine R. Smith et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Progranulin: An emerging target for FTLD therapies
- (2012) Jennifer Gass et al. BRAIN RESEARCH
- Progranulin regulates neuronal outgrowth independent of Sortilin
- (2012) Jennifer Gass et al. Molecular Neurodegeneration
- Regulation of Progranulin Expression in Human Microglia and Proteolysis of Progranulin by Matrix Metalloproteinase-12 (MMP-12)
- (2012) Hyeon-Sook Suh et al. PLoS One
- Induced Pluripotent Stem Cell Models of Progranulin-Deficient Frontotemporal Dementia Uncover Specific Reversible Neuronal Defects
- (2012) Sandra Almeida et al. Cell Reports
- Granulin Is a Soluble Cofactor for Toll-like Receptor 9 Signaling
- (2011) Boyoun Park et al. IMMUNITY
- Structure, Function, and Mechanism of Progranulin; the Brain and Beyond
- (2011) Huishi Toh et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Development and application of mass spectrometric methods for the analysis of progranulin N-glycosylation
- (2010) Kriangsak Songsrirote et al. Journal of Proteomics
- Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin
- (2010) Fenghua Hu et al. NEURON
- The granulin gene family: from cancer to dementia
- (2009) Andrew Bateman et al. BIOESSAYS
- Progranulin is expressed within motor neurons and promotes neuronal cell survival
- (2009) Cara L Ryan et al. BMC NEUROSCIENCE
- Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression
- (2009) Ardalan Minokadeh et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
- (2008) Philip Van Damme et al. JOURNAL OF CELL BIOLOGY
- Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression
- (2008) Lydiane Funkelstein et al. JOURNAL OF NEUROCHEMISTRY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More