Progranulin Gene Delivery Protects Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease

Activity-dependent secretion of progranulin from synapses

(2013) E. Petoukhov et al.   JOURNAL OF CELL SCIENCE

Mitotic and mitogenic Wnt signalling

(2012) Christof Niehrs et al.   EMBO JOURNAL

Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models

(2012) Arnaud Tauffenberger et al.   HUMAN MOLECULAR GENETICS

Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson's Disease Involves Cross Talk between Inflammatory and Wnt/ -Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair

(2012) F. L'Episcopo et al.   JOURNAL OF NEUROSCIENCE

Progranulin regulates neuronal outgrowth independent of Sortilin

(2012) Jennifer Gass et al.   Molecular Neurodegeneration

Inhibition of the canonical Wnt pathway by Dickkopf-1 contributes to the neurodegeneration in 6-OHDA-lesioned rats

(2012) Yaoyan Dun et al.   NEUROSCIENCE LETTERS

Wnt Signaling Enhances Neurogenesis and Improves Neurological Function after Focal Ischemic Injury

(2012) Adi Shruster et al.   PLoS One

Wnt signaling in development and disease

(2012) Yingzi Yang   Cell and Bioscience

Neuroprotective effects of progranulin in ischemic mice

(2011) Jiang Tao et al.   BRAIN RESEARCH

Progranulin and TDP-43: Mechanistic Links and Future Directions

(2011) Samir Kumar-Singh   JOURNAL OF MOLECULAR NEUROSCIENCE

Progranulin Deficiency Decreases Gross Neural Connectivity But Enhances Transmission at Individual Synapses

(2011) L. Tapia et al.   JOURNAL OF NEUROSCIENCE

Synaptic dysfunction in progranulin-deficient mice

(2011) Terri L. Petkau et al.   NEUROBIOLOGY OF DISEASE

Functional Genomic Analyses Identify Pathways Dysregulated by Progranulin Deficiency, Implicating Wnt Signaling

(2011) Ezra Y. Rosen et al.   NEURON

Expression of brain-derived neurotrophic factor is regulated by the Wnt signaling pathway

(2011) Hyun Yi et al.   NEUROREPORT

Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3β phosphorylation

(2011) T. Nedachi et al.   NEUROSCIENCE

A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells

(2011) A. W. Kao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection by tetrahydroxystilbene glucoside against neurotoxicity induced by MPP+: The involvement of PI3K/Akt pathway activation

(2011) Rong Qin et al.   TOXICOLOGY LETTERS

Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging

(2010) Zeshan Ahmed et al.   AMERICAN JOURNAL OF PATHOLOGY

Progranulin deficiency leads to enhanced cell vulnerability and TDP-43 translocation in primary neuronal cultures

(2010) Aobo Guo et al.   BRAIN RESEARCH

The role of Wnt signaling in neuroprotection

(2010) W. Cerpa et al.   DRUG NEWS & PERSPECTIVES

Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia

(2010) Fangfang Yin et al.   FASEB JOURNAL

Myricetin Protects Cells against Oxidative Stress-Induced Apoptosis via Regulation of PI3K/Akt and MAPK Signaling Pathways

(2010) Kyoung Ah Kang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

(2010) F. L'Episcopo et al.   NEUROBIOLOGY OF DISEASE

Hypoxia induces up-regulation of progranulin in neuroblastoma cell lines

(2010) Paola Piscopo et al.   NEUROCHEMISTRY INTERNATIONAL

Progranulin is expressed within motor neurons and promotes neuronal cell survival

(2009) Cara L Ryan et al.   BMC NEUROSCIENCE

α-Synuclein contributes to GSK-3β-catalyzed Tau phosphorylation in Parkinson’s disease models

(2009) Tetyana Duka et al.   FASEB JOURNAL

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

(2009) Fangfang Yin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Emerging roles of Wnts in the adult nervous system

(2009) Nibaldo C. Inestrosa et al.   NATURE REVIEWS NEUROSCIENCE

Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway

(2009) R. Kimura et al.   NEUROSCIENCE

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

(2009) Y.-J. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The life of a cell: apoptosis regulation by the PI3K/PKB pathway

(2008) Vincent Duronio   BIOCHEMICAL JOURNAL

Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study

(2008) Isabelle Le Ber et al.   BRAIN

Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

(2008) Philip Van Damme et al.   JOURNAL OF CELL BIOLOGY

Colocalization of Transactivation-Responsive DNA-Binding Protein 43 and Huntingtin in Inclusions of Huntington Disease

(2008) Claudia Schwab et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Progranulin (PGRN) expression in ALS: An immunohistochemical study

(2008) D. Irwin et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES