New discovery rarely runs smooth: an update on progranulin/TNFR interactions

Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner

(2015) Huixia Li et al.   CELL CYCLE

Progranulin is preferentially expressed in patients with psoriasis vulgaris and protects mice from psoriasis-like skin inflammation

(2015) Kun Huang et al.   IMMUNOLOGY

The molecular basis for development of proinflammatory autoantibodies to progranulin

(2015) Lorenz Thurner et al.   JOURNAL OF AUTOIMMUNITY

Therapeutic opportunities to prevent post-traumatic arthritis: Lessons from the natural history of arthritis after articular fracture

(2015) Steven A. Olson et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

NODding off in acute kidney injury with progranulin?

(2015) Raghu K. Tadagavadi et al.   KIDNEY INTERNATIONAL

Progranulin protects against renal ischemia/reperfusion injury in mice

(2015) Meng Zhou et al.   KIDNEY INTERNATIONAL

PGRN Induces Impaired Insulin Sensitivity and Defective Autophagy in Hepatic Insulin Resistance

(2015) Jiali Liu et al.   MOLECULAR ENDOCRINOLOGY

Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies

(2015) Giulio Cavalli et al.   RHEUMATOLOGY

3D-Printed Atsttrin-Incorporated Alginate/Hydroxyapatite Scaffold Promotes Bone Defect Regeneration with TNF/TNFR Signaling Involvement

(2015) Quan Wang et al.   Advanced Healthcare Materials

Intra-Articular Transplantation of Atsttrin-Transduced Mesenchymal Stem Cells Ameliorate Osteoarthritis Development

(2015) Qingqing Xia et al.   Stem Cells Translational Medicine

The Evolution of the Secreted Regulatory Protein Progranulin

(2015) Roger G. E. Palfree et al.   PLoS One

Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling

(2014) Yun-peng Zhao et al.   ANNALS OF THE RHEUMATIC DISEASES

Progranulin is required for proper ER stress response and inhibits ER stress-mediated apoptosis through TNFR2

(2014) Meiling Li et al.   CELLULAR SIGNALLING

Proinflammatory Progranulin Antibodies in Inflammatory Bowel Diseases

(2014) Lorenz Thurner et al.   DIGESTIVE DISEASES AND SCIENCES

Etanercept: A Review of Its Use in Autoimmune Inflammatory Diseases

(2014) Lesley J. Scott   DRUGS

Three TNFR-binding domains of PGRN act independently in inhibition of TNF-alpha binding and activity

(2014) Qingyun Tian   Frontiers in Bioscience-Landmark

Increased Serum GP88 (Progranulin) Concentrations in Rheumatoid Arthritis

(2014) Yasuko Yamamoto et al.   INFLAMMATION

Progranulin-Derived Atsttrin Directly Binds to TNFRSF25 (DR3) and Inhibits TNF-Like Ligand 1A (TL1A) Activity

(2014) Cui Liu et al.   PLoS One

Progranulin Facilitates Conversion and Function of Regulatory T Cells under Inflammatory Conditions

(2014) Fanhua Wei et al.   PLoS One

PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner

(2014) Fanhua Wei et al.   Scientific Reports

Editorial: Balancing Tumor Necrosis Factor Receptor I and Tumor Necrosis Factor Receptor II Jointly for Joint Inflammation

(2014) Bharat B. Aggarwal   Arthritis & Rheumatology

Selective Tumor Necrosis Factor Receptor I Blockade Is Antiinflammatory and Reveals Immunoregulatory Role of Tumor Necrosis Factor Receptor II in Collagen-Induced Arthritis

(2014) Fiona E. McCann et al.   Arthritis & Rheumatology

The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling

(2013) Yun-peng Zhao et al.   BIOMATERIALS

Mesenchymal stromal cell ciliogenesis is abrogated in response to tumor necrosis factor-α and requires NF-κB signaling

(2013) Amélie Vézina et al.   CANCER LETTERS

Deletion of progranulin exacerbates atherosclerosis in ApoE knockout mice

(2013) Ryota Kawase et al.   CARDIOVASCULAR RESEARCH

Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains

(2013) Jinlong Jian et al.   FEBS LETTERS

Progranulin deficiency exaggerates, whereas progranulin-derived Atsttrin attenuates, severity of dermatitis in mice

(2013) Yun-Peng Zhao et al.   FEBS LETTERS

The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment

(2013) Yusuke Egashira et al.   Journal of Neuroinflammation

Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells

(2013) X. Chen et al.   JOURNAL OF NEUROSCIENCE

Progranulin Protects Vascular Endothelium against Atherosclerotic Inflammatory Reaction via Akt/eNOS and Nuclear Factor-κB Pathways

(2013) Hwan-Jin Hwang et al.   PLoS One

Progranulin antibodies entertain a proinflammatory environment in a subgroup of patients with psoriatic arthritis

(2013) Lorenz Thurner et al.   ARTHRITIS RESEARCH & THERAPY

Efficacy of Infliximab in a Rabbit Model of Osteoarthritis

(2012) Qiankun Zhang et al.   CONNECTIVE TISSUE RESEARCH

Targeting TNF receptors in rheumatoid arthritis

(2012) S. Bluml et al.   INTERNATIONAL IMMUNOLOGY

PKC Signaling is Involved in the Regulation of Progranulin (Acrogranin/PC-Cell-Derived Growth Factor/Granulin-Epithelin Precursor) Protein Expression in Human Ovarian Cancer Cell Lines

(2012) Laura Diaz-Cueto et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Progranulin antibodies in autoimmune diseases

(2012) Lorenz Thurner et al.   JOURNAL OF AUTOIMMUNITY

Insights into the role of progranulin in immunity, infection, and inflammation

(2012) J. Jian et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Targeting tumour necrosis factor alleviates signs and symptoms of inflammatory osteoarthritis of the knee

(2012) Walter P Maksymowych et al.   ARTHRITIS RESEARCH & THERAPY

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin

(2012) Qing-Yun Tian et al.   Jove-Journal of Visualized Experiments

Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints: a double blind, randomised trial on structure modification

(2011) Gust Verbruggen et al.   ANNALS OF THE RHEUMATIC DISEASES

Towards the next generation of anti-TNF drugs

(2011) Petros P. Sfikakis et al.   CLINICAL IMMUNOLOGY

Progranulin: A promising therapeutic target for rheumatoid arthritis

(2011) Chuan-ju Liu   FEBS LETTERS

Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism

(2011) Gabriel Frampton et al.   GUT

Progranulin expression in brain tissue and cerebrospinal fluid levels in multiple sclerosis

(2011) Marco Vercellino et al.   Multiple Sclerosis Journal

Progranulin: A growth factor, a novel TNFR ligand and a drug target

(2011) Chuan-ju Liu et al.   PHARMACOLOGY & THERAPEUTICS

C-Terminus of Progranulin Interacts with the Beta-Propeller Region of Sortilin to Regulate Progranulin Trafficking

(2011) Yanqiu Zheng et al.   PLoS One

Progranulin, a Glycoprotein Deficient in Frontotemporal Dementia, Is a Novel Substrate of Several Protein Disulfide Isomerase Family Proteins

(2011) Sandra Almeida et al.   PLoS One

Progranulin Resolves Inflammation

(2011) H. Wu et al.   SCIENCE

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis

(2010) Stephan Blüml et al.   ARTHRITIS AND RHEUMATISM

Anti-inflammatory and cartilage-protecting effects of an intra-articularly injected anti-TNF  single-chain Fv antibody (ESBA105) designed for local therapeutic use

(2009) D M Urech et al.   ANNALS OF THE RHEUMATIC DISEASES

The granulin gene family: from cancer to dementia

(2009) Andrew Bateman et al.   BIOESSAYS

Surface plasmon resonance for high-throughput ligand screening of membrane-bound proteins

(2009) Jennifer A. Maynard et al.   Biotechnology Journal

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

(2009) Fangfang Yin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutations in Progranulin Gene: Clinical, Pathological, and Ribonucleic Acid Expression Findings

(2008) Adolfo López de Munain et al.   BIOLOGICAL PSYCHIATRY

Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

(2008) Philip Van Damme et al.   JOURNAL OF CELL BIOLOGY

Structural basis for EGFR ligand sequestration by Argos

(2008) Daryl E. Klein et al.   NATURE