An Insight into the Roles of MicroRNAs and Exosomes in Sarcoma

MicroRNA-506-3p inhibits osteosarcoma cell proliferation and metastasis by suppressing RAB3D expression

(2018) Wang Jiashi et al.   Aging-US

Exosomal miR-675 from metastatic osteosarcoma promotes cell migration and invasion by targeting CALN1

(2018) Liangzhi Gong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Expression and therapeutic implications of cyclin-dependent kinase 4 (CDK4) in osteosarcoma

(2018) Yubing Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MicroRNA-134 inhibits osteosarcoma angiogenesis and proliferation by targeting the VEGFA/VEGFR1 pathway

(2018) Long Zhang et al.   FEBS Journal

Extracellular vesicles in cancer — implications for future improvements in cancer care

(2018) Rong Xu et al.   Nature Reviews Clinical Oncology

miR‑142 suppresses proliferation and induces apoptosis of osteosarcoma cells by upregulating Rb

(2018) Yan‑Fang Gao et al.   Oncology Letters

Exosomes from BM-MSCs increase the population of CSCs via transfer of miR-142-3p

(2018) Hongdan Li et al.   BRITISH JOURNAL OF CANCER

MiR-125b suppresses the carcinogenesis of osteosarcoma cells via the MAPK-STAT3 pathway

(2018) Tao Xiao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Regulation of microRNA biogenesis and its crosstalk with other cellular pathways

(2018) Thomas Treiber et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exosomal miR-1228 from cancer-associated fibroblasts promotes cell migration and invasion of osteosarcoma by directly targeting SCAI.

(2018) JIAN-WEI WANG et al.   ONCOLOGY RESEARCH

Prognostic Implication of Immunohistochemical Runx2 Expression in Osteosarcoma

(2018) Kyu Yeoun Won et al.   TUMORI

MicroRNA-338-3p inhibits tumor growth and metastasis in osteosarcoma cells by targeting RUNX2/CDK4 and inhibition of MAPK pathway

(2018) Feng Jia et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Exosomes from Osteosarcoma and normal osteoblast differ in proteomic cargo and immunomodulatory effects on T cells

(2017) Ryan M. Troyer et al.   EXPERIMENTAL CELL RESEARCH

DNA Methylation Mediated Downregulation of miR-449c Controls Osteosarcoma Cell Cycle Progression by Directly Targeting Oncogene c-Myc

(2017) Qing Li et al.   International Journal of Biological Sciences

The role of exosomes and miRNAs in drug-resistance of cancer cells

(2017) Duc-Hiep Bach et al.   INTERNATIONAL JOURNAL OF CANCER

In vitro effect of microRNA-107 targeting Dkk-1 by regulation of Wnt/β-catenin signaling pathway in osteosarcoma

(2017) Zhi-Cai Zhang et al.   MEDICINE

Overexpression of miR-214 promotes the progression of human osteosarcoma by regulating the Wnt/β-catenin signaling pathway

(2017) Xun-Bing Zhu et al.   Molecular Medicine Reports

Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression

(2017) Chun-Hao Tsai et al.   Molecular Oncology

Disruption of Circulating Extracellular Vesicles as a Novel Therapeutic Strategy against Cancer Metastasis

(2017) Nao Nishida-Aoki et al.   MOLECULAR THERAPY

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

Tumour exosomes from cells harbouring PTPRZ1–MET fusion contribute to a malignant phenotype and temozolomide chemoresistance in glioblastoma

(2017) A-L Zeng et al.   ONCOGENE

Anti-angiogenesis target therapy for advanced osteosarcoma

(2017) Lu Xie et al.   ONCOLOGY REPORTS

MicroRNA-381 suppresses the proliferation of osteosarcoma cells through LRH-1/Wnt/β-catenin signaling pathway

(2017) Yanbing Wang et al.   ONCOLOGY REPORTS

MicroRNA-373 Promotes Growth and Cellular Invasion in Osteosarcoma Cells by Activation of the PI3K/AKT‐Rac1‐JNK Pathway: The Potential Role in Spinal Osteosarcoma

(2017) Yufeng Liu et al.   ONCOLOGY RESEARCH

Brain-derived neurotrophic factor promotes VEGF-C-dependent lymphangiogenesis by suppressing miR-624-3p in human chondrosarcoma cells

(2017) Chih-Yang Lin et al.   Cell Death & Disease

Exosomes containing differential expression of microRNA and mRNA in osteosarcoma that can predict response to chemotherapy

(2017) Ji-Feng Xu et al.   Oncotarget

Clinical significance of circulating miR-25-3p as a novel diagnostic and prognostic biomarker in osteosarcoma

(2017) Tomohiro Fujiwara et al.   Oncotarget

WISP-3 inhibition of miR-452 promotes VEGF-A expression in chondrosarcoma cells and induces endothelial progenitor cells angiogenesis

(2017) Chih-Yang Lin et al.   Oncotarget

Fibulin-4 is a novel Wnt/β-Catenin pathway activator in human osteosarcoma

(2016) Renzeng Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ovarian cancer stem-like cells differentiate into endothelial cells and participate in tumor angiogenesis through autocrine CCL5 signaling

(2016) Shu Tang et al.   CANCER LETTERS

Mesenchymal Stem Cell–Derived Exosomes Stimulate Cycling Quiescence and Early Breast Cancer Dormancy in Bone Marrow

(2016) Sarah A. Bliss et al.   CANCER RESEARCH

 Np63  Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGF -Induced Metastasis

(2016) L. Rodriguez Calleja et al.   CANCER RESEARCH

Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth

(2016) Lifeng Yang et al.   Cell Metabolism

Adiponectin promotes VEGF-C-dependent lymphangiogenesis by inhibiting miR-27b through a CaMKII/AMPK/p38 signaling pathway in human chondrosarcoma cells

(2016) C.-Y. Huang et al.   CLINICAL SCIENCE

Meta-analysis of alkaline phosphatase and prognosis for osteosarcoma

(2016) H. Hao et al.   EUROPEAN JOURNAL OF CANCER CARE

Multimodal transfer of MDR by exosomes in human osteosarcoma

(2016) ELENA TORREGGIANI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Versatile roles of extracellular vesicles in cancer

(2016) Nobuyoshi Kosaka et al.   JOURNAL OF CLINICAL INVESTIGATION

IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma

(2016) Salah-Eddine Lamhamedi-Cherradi et al.   JNCI-Journal of the National Cancer Institute

MiR-26a inhibits stem cell-like phenotype and tumor growth of osteosarcoma by targeting Jagged1

(2016) J Lu et al.   ONCOGENE

MicroRNA-20b Downregulates HIF-1α and Inhibits the Proliferation and Invasion of Osteosarcoma Cells

(2016) Ming Liu et al.   ONCOLOGY RESEARCH

Exosomal and Non-Exosomal Urinary miRNAs in Prostate Cancer Detection and Prognosis

(2016) Laura Foj et al.   PROSTATE

Basic fibroblast growth factor promotes VEGF-C-dependent lymphangiogenesis via inhibition of miR-381 in human chondrosarcoma cells

(2016) Huey-En Tzeng et al.   Oncotarget

Assessing the clinical value of microRNAs in formalin-fixed paraffin-embedded liposarcoma tissues: Overexpressed miR-155 is an indicator of poor prognosis

(2016) Nikolaos Kapodistrias et al.   Oncotarget

Leptin promotes VEGF-C production and induces lymphangiogenesis by suppressing miR-27b in human chondrosarcoma cells

(2016) Wei-Hung Yang et al.   Scientific Reports

IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma

(2016) Salah-Eddine Lamhamedi-Cherradi et al.   JNCI-Journal of the National Cancer Institute

Exosomes derived from embryonal and alveolar rhabdomyosarcoma carry differential miRNA cargo and promote invasion of recipient fibroblasts

(2016) Sandra E. Ghayad et al.   Scientific Reports

CCL5 promotes vascular endothelial growth factor expression and induces angiogenesis by down-regulating miR-199a in human chondrosarcoma cells

(2015) Guan-Ting Liu et al.   CANCER LETTERS

Notch signaling: An emerging therapeutic target for cancer treatment

(2015) Xun Yuan et al.   CANCER LETTERS

Obesity-Associated MiR-342-3p Promotes Adipogenesis of Mesenchymal Stem Cells by Suppressing CtBP2 and Releasing C/EBPα from CtBP2 Binding

(2015) Liang Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

MiR-25 Suppresses 3T3-L1 Adipogenesis by Directly Targeting KLF4 and C/EBPα

(2015) Wei-Cheng Liang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Serum miR-195 is a diagnostic and prognostic marker for osteosarcoma

(2015) Haikang Cai et al.   JOURNAL OF SURGICAL RESEARCH

miR-181a Targets RGS16 to Promote Chondrosarcoma Growth, Angiogenesis, and Metastasis

(2015) X. Sun et al.   MOLECULAR CANCER RESEARCH

MAPK7gene controls proliferation, migration and cell invasion in osteosarcoma

(2015) Francine Tesser-Gamba et al.   MOLECULAR CARCINOGENESIS

CD99 regulates neural differentiation of Ewing sarcoma cells through miR-34a-Notch-mediated control of NF-κB signaling

(2015) S Ventura et al.   ONCOGENE

RETRACTED ARTICLE: Evaluation of gene expression level of CDC5L and MACC1 in poor prognosis and progression of osteosarcoma

(2015) Mohsen Mohammadi et al.   TUMOR BIOLOGY

Mitogen-activated Protein Kinase 7 Promotes Cell Proliferation, Migration and Invasion in SOSP-M Human Osteosarcoma Cell Line

(2015) Yan Huang et al.   TUMORI

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier

(2015) Naoomi Tominaga et al.   Nature Communications

Deregulation of dicer and mir-155 expression in liposarcoma

(2015) Bruno Vincenzi et al.   Oncotarget

MicroRNA-494 inhibits cell proliferation and invasion of chondrosarcoma cells in vivo and in vitro by directly targeting SOX9

(2015) Jingyuan Li et al.   Oncotarget

Induction of p53-independent apoptosis by ectopic expression of HOXA5 in human liposarcomas

(2015) Dhong Hyun Lee et al.   Scientific Reports

Mitogen-activated Protein Kinase 7 Promotes Cell Proliferation, Migration and Invasion in SOSP-M Human Osteosarcoma Cell Line

(2015) Yan Huang et al.   TUMORI JOURNAL

Identification of a Plasma Four-microRNA Panel as Potential Noninvasive Biomarker for Osteosarcoma

(2015) Feng Lian et al.   PLoS One

CCL5 promotes VEGF-dependent angiogenesis by down-regulating miR-200b through PI3K/Akt signaling pathway in human chondrosarcoma cells

(2015) Guan-Ting Liu et al.   Oncotarget

MicroRNA-100 Resensitizes Resistant Chondrosarcoma Cells to Cisplatin through Direct Targeting of mTOR

(2014) Zhe Zhu et al.   Asian Pacific Journal of Cancer Prevention

Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration

(2014) Keisuke Shimbo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MiR-23a Functions as a Tumor Suppressor in Osteosarcoma

(2014) Yu He et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Paeonol Suppresses Chondrosarcoma Metastasis through Up-Regulation of miR-141 by Modulating PKCδ and c-Src Signaling Pathway

(2014) Chi-Ting Horng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Epigenetic Regulation of SOX9 by miR-145 in Human Chondrosarcoma

(2014) Isabella W.Y. Mak et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Serum miR-9 as a prognostic biomarker in patients with osteosarcoma

(2014) Dan Fei et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

MicroRNA-33b downregulates the differentiation and development of porcine preadipocytes

(2014) Masaaki Taniguchi et al.   MOLECULAR BIOLOGY REPORTS

Functional interplay between MDM2, p63/p73 and mutant p53

(2014) M H Stindt et al.   ONCOGENE

Circulating Exosomal microRNAs as Biomarkers of Colon Cancer

(2014) Hiroko Ogata-Kawata et al.   PLoS One

The Tumor-Suppressive MicroRNA-135b Targets c-Myc in Osteoscarcoma

(2014) Zheng Liu et al.   PLoS One

SOX9 Regulates Multiple Genes in Chondrocytes, Including Genes Encoding ECM Proteins, ECM Modification Enzymes, Receptors, and Transporters

(2014) Chun-do Oh et al.   PLoS One

MicroRNA-33b Suppresses Migration and Invasion by Targeting c-Myc in Osteosarcoma Cells

(2014) Ning Xu et al.   PLoS One

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

(2014) M. Ono et al.   Science Signaling

Depletion of pre-mRNA splicing factor Cdc5L inhibits mitotic progression and triggers mitotic catastrophe

(2014) R Mu et al.   Cell Death & Disease

Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

(2014) Xiang Chen et al.   Cell Reports

Vascular Pattern in Enchondroma and Chondrosarcoma

(2014) Francisco F. Cintra et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Advanced chondrosarcomas: role of chemotherapy and survival

(2013) A. Italiano et al.   ANNALS OF ONCOLOGY

Localized and metastatic myxoid/round cell liposarcoma

(2013) Aviad Hoffman et al.   CANCER

Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of osteosarcoma cells by switching on suppressor microRNAs and inactivating of Notch-1 signaling

(2013) Y. Li et al.   CARCINOGENESIS

MicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR-145 and miR-451 as tumor suppressors

(2013) Caroline M.M. Gits et al.   INTERNATIONAL JOURNAL OF CANCER

miR-29 Promotes Murine Osteoclastogenesis by Regulating Osteoclast Commitment and Migration

(2013) Tiziana Franceschetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-34c Inversely Couples the Biological Functions of the Runt-related Transcription Factor RUNX2 and the Tumor Suppressor p53 in Osteosarcoma

(2013) Margaretha van der Deen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

(2013) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNAs and other non-coding RNAs as targets for anticancer drug development

(2013) Hui Ling et al.   NATURE REVIEWS DRUG DISCOVERY

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of onco and tumor suppressor MiRNAs by mTORC1 inhibitor PRP-1 in human chondrosarcoma

(2013) Karina A. Galoian et al.   TUMOR BIOLOGY

Overexpression of miR-26a-2 in human liposarcoma is correlated with poor patient survival

(2013) D H Lee et al.   Oncogenesis

MicroRNA-145 targets vascular endothelial growth factor and inhibits invasion and metastasis of osteosarcoma cells

(2012) L. Fan et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Long-term results (>25 years) of a randomized, prospective clinical trial evaluating chemotherapy in patients with high-grade, operable osteosarcoma

(2012) Nicholas M. Bernthal et al.   CANCER

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

A three-plasma miRNA signature serves as novel biomarkers for osteosarcoma

(2012) Liu Ouyang et al.   MEDICAL ONCOLOGY

EWS/FLI1 Regulates EYA3 in Ewing Sarcoma via Modulation of miRNA-708, Resulting in Increased Cell Survival and Chemoresistance

(2012) T. P. Robin et al.   MOLECULAR CANCER RESEARCH

miR-214 targets ATF4 to inhibit bone formation

(2012) Xiaogang Wang et al.   NATURE MEDICINE

MicroRNA control of bone formation and homeostasis

(2012) Jane B. Lian et al.   Nature Reviews Endocrinology

Docetaxel-Resistance in Prostate Cancer: Evaluating Associated Phenotypic Changes and Potential for Resistance Transfer via Exosomes

(2012) Claire Corcoran et al.   PLoS One

Genetic amplification of the vascular endothelial growth factor (VEGF) pathway genes, includingVEGFA, in human osteosarcoma

(2011) Jilong Yang et al.   CANCER

MAPK7 and MAP2K4 as prognostic markers in osteosarcoma

(2011) Francine Tesser-Gamba et al.   HUMAN PATHOLOGY

Competitive Interactions of Cancer Cells and Normal Cells via Secretory MicroRNAs

(2011) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo-sensitivity and malignancy

(2011) Fumihiko Nakatani et al.   JOURNAL OF PATHOLOGY

Building strong bones: molecular regulation of the osteoblast lineage

(2011) Fanxin Long   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcoma

(2011) J Ban et al.   ONCOGENE

A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs

(2011) E L McKinsey et al.   ONCOGENE

miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARγ expression

(2010) Sang Yun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Clld7, A Candidate Tumor Suppressor on Chromosome 13q14, Regulates Pathways of DNA Damage/Repair and Apoptosis

(2010) X. Zhou et al.   CANCER RESEARCH

TGF-β1 signal pathway may contribute to rhabdomyosarcoma development by inhibiting differentiation

(2010) Shouli Wang et al.   CANCER SCIENCE

CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis

(2010) Anna Rocchi et al.   JOURNAL OF CLINICAL INVESTIGATION

Primary Disseminated Multifocal Ewing Sarcoma: Results of the Euro-EWING 99 Trial

(2010) Ruth Ladenstein et al.   JOURNAL OF CLINICAL ONCOLOGY

Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration

(2010) Yujing Zhang et al.   MOLECULAR CELL

miRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate

(2010) M. Mann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional delivery of viral miRNAs via exosomes

(2010) D. M. Pegtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

microRNA miR-27b impairs human adipocyte differentiation and targets PPARγ

(2009) Michael Karbiener et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma

(2009) Ayesha Abdeen et al.   CANCER

The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation

(2009) Riccardo Taulli et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiinstitutional phase II study of neoadjuvant chemotherapy for osteosarcoma (NECO study) in Japan: NECO-93J and NECO-95J

(2009) Yukihide Iwamoto et al.   JOURNAL OF ORTHOPAEDIC SCIENCE

The inflammatory chemokines CCL2 and CCL5 in breast cancer

(2008) Gali Soria et al.   CANCER LETTERS

EWS-FLI-1 Expression Triggers a Ewing's Sarcoma Initiation Program in Primary Human Mesenchymal Stem Cells

(2008) N. Riggi et al.   CANCER RESEARCH

Critical Role of Notch Signaling in Osteosarcoma Invasion and Metastasis

(2008) P. Zhang et al.   CLINICAL CANCER RESEARCH

The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis

(2008) Shusheng Wang et al.   DEVELOPMENTAL CELL

Impaired Micro-RNA Pathways Diminish Osteoclast Differentiation and Function

(2008) Toshifumi Sugatani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transforming growth factor- -regulated miR-24 promotes skeletal muscle differentiation

(2008) Q. Sun et al.   NUCLEIC ACIDS RESEARCH

The Clinical Approach Towards Chondrosarcoma

(2008) H. Gelderblom et al.   ONCOLOGIST

MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1

(2008) T. A. Harris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA