The role of exosomes and miRNAs in drug-resistance of cancer cells

ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5

(2016) Hui-Lung Sun et al.   CANCER CELL

Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils

(2016) Yanfang Liu et al.   CANCER CELL

Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA

(2016) Le Qu et al.   CANCER CELL

Ubiquitous Release of Exosomal Tumor Suppressor miR-6126 from Ovarian Cancer Cells

(2016) Pinar Kanlikilicer et al.   CANCER RESEARCH

ExoCarta: A Web-Based Compendium of Exosomal Cargo

(2016) Shivakumar Keerthikumar et al.   JOURNAL OF MOLECULAR BIOLOGY

Multiplicity of acquired cross-resistance in paclitaxel-resistant cancer cells is associated with feedback control of TUBB3 via FOXO3a-mediated ABCB1 regulation

(2016) Mark Borris D. Aldonza et al.   Oncotarget

Epithelial ovarian cancer-secreted exosomal miR-222-3p induces polarization of tumor-associated macrophages

(2016) Xiang Ying et al.   Oncotarget

Down-regulation of SerpinB2 is associated with gefitinib resistance in non-small cell lung cancer and enhances invadopodia-like structure protrusions

(2016) Song Yi Bae et al.   Scientific Reports

MiR-122 Reverses the Doxorubicin-Resistance in Hepatocellular Carcinoma Cells through Regulating the Tumor Metabolism

(2016) Chenwei Pan et al.   PLoS One

Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity

(2015) S.-C. Lee et al.   CANCER RESEARCH

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

(2015) Anoek Zomer et al.   CELL

Antagonism of miRNA-21 Sensitizes Human Gastric Cancer Cells to Paclitaxel

(2015) Bo Jin et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

The passenger strand, miR-21-3p, plays a role in mediating cisplatin resistance in ovarian cancer cells

(2015) Ryan Charles Pink et al.   GYNECOLOGIC ONCOLOGY

Exosome-Mediated Transfer of microRNAs Within the Tumor Microenvironment and Neuroblastoma Resistance to Chemotherapy

(2015) Kishore B. Challagundla et al.   JNCI-Journal of the National Cancer Institute

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

(2015) Lin Zhang et al.   NATURE

Intercellular Transfer of Cancer Drug Resistance Traits by Extracellular Vesicles

(2015) Diana Sousa et al.   TRENDS IN MOLECULAR MEDICINE

Targeting the degradation of AXL receptor tyrosine kinase to overcome resistance in gefitinib-resistant non-small cell lung cancer

(2015) Song Yi Bae et al.   Oncotarget

MiR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via the PTEN/Akt pathway

(2015) Changjun He et al.   Oncotarget

miR-134 in extracellular vesicles reduces triple-negative breast cancer aggression and increases drug sensitivity

(2015) Keith O’Brien et al.   Oncotarget

Exosome-Mediated Transfer of microRNAs Within the Tumor Microenvironment and Neuroblastoma Resistance to Chemotherapy

(2015) Kishore B. Challagundla et al.   JNCI-Journal of the National Cancer Institute

Suppression of MAPK Signaling and Reversal of mTOR-Dependent MDR1-Associated Multidrug Resistance by 21α-Methylmelianodiol in Lung Cancer Cells

(2015) Mark Borris Docdoc Aldonza et al.   PLoS One

CD44v6 Dependence of Premetastatic Niche Preparation by Exosomes

(2015) Thorsten Jung et al.   NEOPLASIA

Exosomal miR-221/222 enhances tamoxifen resistance in recipient ER-positive breast cancer cells

(2014) Yifang Wei et al.   BREAST CANCER RESEARCH AND TREATMENT

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

(2014) Sonia A. Melo et al.   CANCER CELL

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways

(2014) Mirjam C. Boelens et al.   CELL

Inhibition of microRNA miR-92a induces apoptosis and inhibits cell proliferation in human acute promyelocytic leukemia through modulation of p63 expression

(2014) Mohammadreza Sharifi et al.   MOLECULAR BIOLOGY REPORTS

Exosome Release and Low pH Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin

(2014) Cristina Federici et al.   PLoS One

Exosomes from Drug-Resistant Breast Cancer Cells Transmit Chemoresistance by a Horizontal Transfer of MicroRNAs

(2014) Wei-xian Chen et al.   PLoS One

miR-34a is an intracellular and exosomal predictive biomarker for response to docetaxel with clinical relevance to prostate cancer progression

(2014) Claire Corcoran et al.   PROSTATE

miR-106a confers cisplatin resistance by regulating PTEN/Akt pathway in gastric cancer cells

(2013) Y. Fang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN

(2013) Fang Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells

(2013) B. W. M. van Balkom et al.   BLOOD

Circulating microRNAs predict biochemical recurrence in prostate cancer patients

(2013) L A Selth et al.   BRITISH JOURNAL OF CANCER

Exosomes from triple-negative breast cancer cells can transfer phenotypic traits representing their cells of origin to secondary cells

(2013) Keith O’Brien et al.   EUROPEAN JOURNAL OF CANCER

miR-9 Regulation of BRCA1 and Ovarian Cancer Sensitivity to Cisplatin and PARP Inhibition

(2013) Chaoyang Sun et al.   JNCI-Journal of the National Cancer Institute

MiR-21 overexpression is associated with acquired resistance of EGFR-TKI in non-small cell lung cancer

(2013) Bing Li et al.   LUNG CANCER

High expression of microRNA-625-3p is associated with poor response to first-line oxaliplatin based treatment of metastatic colorectal cancer

(2013) Mads H. Rasmussen et al.   Molecular Oncology

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Circulating microRNAs as Specific Biomarkers for Breast Cancer Detection

(2013) Enders K. O. Ng et al.   PLoS One

miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN

(2013) Shou-mei Yang et al.   TOXICOLOGY

MicroRNAs delivered by extracellular vesicles: an emerging resistance mechanism for breast cancer

(2013) Wei-xian Chen et al.   TUMOR BIOLOGY

Serum microRNA 125b as a diagnostic or prognostic biomarker for advanced NSCLC patients receiving cisplatin-based chemotherapy

(2012) En-hai Cui et al.   ACTA PHARMACOLOGICA SINICA

Changes in circulating microRNA levels associated with prostate cancer

(2012) R J Bryant et al.   BRITISH JOURNAL OF CANCER

Clinical impact of serum exosomal microRNA-21 as a clinical biomarker in human esophageal squamous cell carcinoma

(2012) Youhei Tanaka et al.   CANCER

Circulating miR-125b is a novel biomarker for screening non-small-cell lung cancer and predicts poor prognosis

(2012) Ma Yuxia et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

MicroRNAs are exported from malignant cells in customized particles

(2012) Jaime Palma et al.   NUCLEIC ACIDS RESEARCH

Docetaxel-Resistance in Prostate Cancer: Evaluating Associated Phenotypic Changes and Potential for Resistance Transfer via Exosomes

(2012) Claire Corcoran et al.   PLoS One

Serum MicroRNA-155 as a Potential Biomarker to Track Disease in Breast Cancer

(2012) Yu Sun et al.   PLoS One

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosome-delivered microRNAs of “chromosome 19 microRNA cluster” as immunomodulators in pregnancy and tumorigenesis

(2012) Jörn Bullerdiek et al.   Molecular Cytogenetics

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

(2012) Hina Kalra et al.   PLOS BIOLOGY

Exosomal miRNAs: Biological Properties and Therapeutic Potential

(2012) Guoku Hu et al.   Frontiers in Genetics

Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC

(2011) Christina Battke et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche

(2011) C. Grange et al.   CANCER RESEARCH

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

(2011) J. L. Hood et al.   CANCER RESEARCH

Anti-proliferative activity and suppression of P-glycoprotein by (−)-antofine, a natural phenanthroindolizidine alkaloid, in paclitaxel-resistant human lung cancer cells

(2011) Eun-Hye Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Competitive Interactions of Cancer Cells and Normal Cells via Secretory MicroRNAs

(2011) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secretion of annexin A3 from ovarian cancer cells and its association with platinum resistance in ovarian cancer patients

(2011) Jie Yin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Potential role of HER2-overexpressing exosomes in countering trastuzumab-based therapy

(2011) Valentina Ciravolo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

miR-1254 and miR-574-5p: Serum-Based microRNA Biomarkers for Early-Stage Non-small Cell Lung Cancer

(2011) Kristen M. Foss et al.   Journal of Thoracic Oncology

Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells

(2011) Mei Yang et al.   Molecular Cancer

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3

(2011) T. Aung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Circulating microRNAs in plasma of patients with gastric cancers

(2010) M Tsujiura et al.   BRITISH JOURNAL OF CANCER

Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation

(2010) J. Webber et al.   CANCER RESEARCH

Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis

(2010) Nobuyoshi Kosaka et al.   CANCER SCIENCE

Direct Serum Assay for MicroRNA-21 Concentrations in Early and Advanced Breast Cancer

(2010) S. Asaga et al.   CLINICAL CHEMISTRY

miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines

(2010) Wei Zhu et al.   INTERNATIONAL JOURNAL OF CANCER

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration

(2010) Yujing Zhang et al.   MOLECULAR CELL

Serum miRNA-21: Elevated levels in patients with metastatic hormone-refractory prostate cancer and potential predictive factor for the efficacy of docetaxel-based chemotherapy

(2010) Hai-Liang Zhang et al.   PROSTATE

MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma

(2009) Yusuke Yamamoto et al.   BIOMARKERS

Oncosome Formation in Prostate Cancer: Association with a Region of Frequent Chromosomal Deletion in Metastatic Disease

(2009) Dolores Di Vizio et al.   CANCER RESEARCH

Circulating MicroRNA Signatures of Tumor-Derived Exosomes for Early Diagnosis of Non–Small-Cell Lung Cancer

(2009) Rafael Rosell et al.   Clinical Lung Cancer

Exosomal MicroRNA: A Diagnostic Marker for Lung Cancer

(2009) Guilherme Rabinowits et al.   Clinical Lung Cancer

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening

(2009) E K O Ng et al.   GUT

Systematic analysis of microRNA involved in resistance of the MCF-7 human breast cancer cell to doxorubicin

(2009) Guo-Qing Chen et al.   MEDICAL ONCOLOGY

MicroRNA-328 Negatively Regulates the Expression of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Cancer Cells

(2009) Y.-Z. Pan et al.   MOLECULAR PHARMACOLOGY

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

Down-Regulation of miR-92 in Human Plasma Is a Novel Marker for Acute Leukemia Patients

(2009) Masami Tanaka et al.   PLoS One

ExoCarta: A compendium of exosomal proteins and RNA

(2009) Suresh Mathivanan et al.   PROTEOMICS

Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3

(2008) Wing Pui Tsang et al.   APOPTOSIS

Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells

(2008) Yasunori Fujita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells

(2008) Hua Zhu et al.   BIOCHEMICAL PHARMACOLOGY

Computational analysis of microRNA profiles and their target genes suggests significant involvement in breast cancer antiestrogen resistance

(2008) Fuxiao Xin et al.   BIOINFORMATICS

Exosome-Like Vesicles with Dipeptidyl Peptidase IV in Human Saliva

(2008) Yuko Ogawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres

(2008) Qing Ji et al.   BMC CANCER

Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma

(2008) Charles H. Lawrie et al.   BRITISH JOURNAL OF HAEMATOLOGY

MicroRNA Microarray Identifies Let-7i as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer

(2008) N. Yang et al.   CANCER RESEARCH

Role of microRNAs in drug-resistant ovarian cancer cells

(2008) Antonio Sorrentino et al.   GYNECOLOGIC ONCOLOGY

MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer

(2008) Douglas D. Taylor et al.   GYNECOLOGIC ONCOLOGY

The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform

(2008) Kimberly E. Resnick et al.   GYNECOLOGIC ONCOLOGY

miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells

(2008) Lin Xia et al.   INTERNATIONAL JOURNAL OF CANCER

MicroRNA-221/222 Confers Tamoxifen Resistance in Breast Cancer by Targeting p27Kip1

(2008) Tyler E. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin

(2008) O. Kovalchuk et al.   MOLECULAR CANCER THERAPEUTICS

MicroRNAs modulate the chemosensitivity of tumor cells

(2008) P. E. Blower et al.   MOLECULAR CANCER THERAPEUTICS

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer

(2008) M Garofalo et al.   ONCOGENE

Antagomir-17-5p Abolishes the Growth of Therapy-Resistant Neuroblastoma through p21 and BIM

(2008) Laura Fontana et al.   PLoS One

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA