Functional interplay between MDM2, p63/p73 and mutant p53

Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome

(2015) Paul M. Neilsen et al.   Oncotarget

Interaction of mutant p53 with p73: A Surface Plasmon Resonance and Atomic Force Spectroscopy study

(2014) Simona Santini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Analysis of the oligomeric state and transactivation potential of TAp73α

(2013) L M Luh et al.   CELL DEATH AND DIFFERENTIATION

Interaction of p53 with the CCT Complex Promotes Protein Folding and Wild-Type p53 Activity

(2013) Antonio Garcia Trinidad et al.   MOLECULAR CELL

Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils

(2012) Ana P. D. Ano Bom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2

(2012) Milena Wiech et al.   PLoS One

Structure of p73 DNA-binding domain tetramer modulates p73 transactivation

(2012) A. S. Ethayathulla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Damage in Oocytes Induces a Switch of the Quality Control Factor TAp63α from Dimer to Tetramer

(2011) Gregor B. Deutsch et al.   CELL

MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity

(2011) Maren H. Stindt et al.   CELL CYCLE

Structure and Kinetic Stability of the p63 Tetramerization Domain

(2011) Eviatar Natan et al.   JOURNAL OF MOLECULAR BIOLOGY

Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells

(2011) D. Li et al.   MOLECULAR CANCER RESEARCH

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

(2011) Jie Xu et al.   Nature Chemical Biology

Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73

(2010) Michal Zdzalik et al.   CELL CYCLE

p63 and p73, the Ancestors of p53

(2010) V. Dotsch et al.   Cold Spring Harbor Perspectives in Biology

The C-terminus of p63 contains multiple regulatory elements with different functions

(2010) W E Straub et al.   Cell Death & Disease

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Mutant p53 Drives Invasion by Promoting Integrin Recycling

(2009) Patricia A.J. Muller et al.   CELL

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

Conformational stability and activity of p73 require a second helix in the tetramerization domain

(2009) D Coutandin et al.   CELL DEATH AND DIFFERENTIATION

Structural evolution of p53, p63, and p73: Implication for heterotetramer formation

(2009) A. C. Joerger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Isoforms of the p53 Protein

(2009) M. P. Khoury et al.   Cold Spring Harbor Perspectives in Biology

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

(2008) T. Terzian et al.   GENES & DEVELOPMENT

Chaperone-dependent stabilization and degradation of p53 mutants

(2008) P Muller et al.   ONCOGENE