EMT Regulation by Autophagy: A New Perspective in Glioblastoma Biology

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Autophagy modulates transforming growth factor beta 1 induced epithelial to mesenchymal transition in non-small cell lung cancer cells

(2018) Javad Alizadeh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy contributes to hypoxia-induced epithelial to mesenchymal transition of endometrial epithelial cells in endometriosis†

(2018) Hengwei Liu et al.   BIOLOGY OF REPRODUCTION

Mesenchymal stem cells promote cell invasion and migration and autophagy-induced epithelial-mesenchymal transition in A549 lung adenocarcinoma cells

(2018) Dan Luo et al.   CELL BIOCHEMISTRY AND FUNCTION

Knockdown of Beclin-1 impairs epithelial-mesenchymal transition of colon cancer cells

(2018) Hong Shen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A brief history of autophagy from cell biology to physiology and disease

(2018) Noboru Mizushima   NATURE CELL BIOLOGY

PP242 Counteracts Glioblastoma Cell Proliferation, Migration, Invasiveness and Stemness Properties by Inhibiting mTORC2/AKT

(2018) Carmen Mecca et al.   Frontiers in Cellular Neuroscience

DRAM1 regulates the migration and invasion of hepatoblastoma cells via autophagy‑EMT pathway

(2018) Chao Chen et al.   Oncology Letters

Autophagy induces transforming growth factor-β-dependent epithelial-mesenchymal transition in hepatocarcinoma cells through cAMP response element binding signalling

(2018) Shaobo Hu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Maternal exposure to di-n-butyl phthalate (DBP) promotes epithelial-mesenchymal transition via regulation of autophagy in uroepithelial cell

(2018) Sheng Zhao et al.   TOXICOLOGY

Autophagy induction impairs Wnt/β-catenin signalling through β-catenin relocalisation in glioblastoma cells

(2018) Barbara Colella et al.   CELLULAR SIGNALLING

Starvation-induced autophagy promotes the invasion and migration of human bladder cancer cells via TGF-β1/Smad3-mediated epithelial-mesenchymal transition activation

(2018) Hang Tong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

HGF induces EMT in non-small-cell lung cancer through the hBVR pathway

(2017) Fang Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The role of autophagy in the cross-talk between epithelial-mesenchymal transitioned tumor cells and cancer stem-like cells

(2017) Fabrizio Marcucci et al.   Molecular Cancer

Autophagy regulates TGF-β2-induced epithelial-mesenchymal transition in human retinal pigment epithelium cells

(2017) Jing Wu et al.   Molecular Medicine Reports

The critical role of EGF-β-catenin signaling in the epithelial-mesenchymal transition in human glioblastoma

(2017) Xingqiang Wang et al.   OncoTargets and Therapy

Autophagy inhibition impairs the epithelial-mesenchymal transition and enhances cisplatin sensitivity in nasopharyngeal carcinoma

(2017) Zhongwu Su et al.   Oncology Letters

From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home

(2017) Margaret M. Harnett et al.   Biomedical Journal

Suppression of autophagy impedes glioblastoma development and induces senescence

(2016) Noor Gammoh et al.   Autophagy

Inhibition of Autophagy by Chloroquine Enhances the Antitumor Efficacy of Sorafenib in Glioblastoma

(2016) Xiangyu Liu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Epithelial-to-Mesenchymal Transition-Like Process in Glioblastoma: An Updated Systematic Review and In Silico Investigation

(2016) Isabele C. Iser et al.   MEDICINAL RESEARCH REVIEWS

Autophagy and epithelial–mesenchymal transition: an intricate interplay in cancer

(2016) Mila Gugnoni et al.   Cell Death & Disease

AEG-1/MTDH-activated autophagy enhances human malignant glioma susceptibility to TGF-β1-triggered epithelial-mesenchymal transition

(2016) Meijuan Zou et al.   Oncotarget

EGF induces epithelial-mesenchymal transition through phospho-Smad2/3-Snail signaling pathway in breast cancer cells

(2016) Jinkyoung Kim et al.   Oncotarget

MicroRNA Regulation of Epithelial to Mesenchymal Transition

(2016) Mohammed Abba et al.   Journal of Clinical Medicine

Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition

(2016) Ramadevi Subramani et al.   Scientific Reports

MIR517Cinhibits autophagy and the epithelial-to-mesenchymal (-like) transition phenotype in human glioblastoma through KPNA2-dependent disruption of TP53 nuclear translocation

(2015) Yuntao Lu et al.   Autophagy

Single-cell analysis challenges the connection between autophagy and senescence induced by DNA damage

(2015) Eduardo Cremonese Filippi-Chiela et al.   Autophagy

Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes

(2015) Sheila R. Alcantara Llaguno et al.   CANCER CELL

Enhanced Epithelial-to-Mesenchymal Transition Associated with Lysosome Dysfunction in Podocytes: Role of p62/Sequestosome 1 as a Signaling Hub

(2015) Guangbi Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Danusertib Induces Apoptosis, Cell Cycle Arrest, and Autophagy but Inhibits Epithelial to Mesenchymal Transition Involving PI3K/Akt/mTOR Signaling Pathway in Human Ovarian Cancer Cells

(2015) Dan Zi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alisertib Induces Cell Cycle Arrest, Apoptosis, Autophagy and Suppresses EMT in HT29 and Caco-2 Cells

(2015) Bao-Jun Ren et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epithelial-to-mesenchymal transition in paired human primary and recurrent glioblastomas

(2015) CAROLIN KUBELT et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Autophagy: a druggable process that is deregulated in aging and human disease

(2015) Guido Kroemer   JOURNAL OF CLINICAL INVESTIGATION

WNT signaling in glioblastoma and therapeutic opportunities

(2015) Yeri Lee et al.   LABORATORY INVESTIGATION

Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells

(2015) Myriam Catalano et al.   Molecular Oncology

Erratum: Corrigendum: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

(2015) Valentina Cianfanelli et al.   NATURE CELL BIOLOGY

Beyond β-catenin: prospects for a larger catenin network in the nucleus

(2015) Pierre D. McCrea et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Emerging strategies to effectively target autophagy in cancer

(2015) V W Rebecca et al.   ONCOGENE

Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity

(2015) Mona Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Current treatment strategies for inhibiting mTOR in cancer

(2015) Francesca Chiarini et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation

(2015) G Grassi et al.   Cell Death & Disease

Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells

(2015) Wenjie Qin et al.   Oncotarget

ROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-κB-dependent activation of Snail

(2015) Magdalena A. Cichon et al.   Oncotarget

A radiosensitivity gene signature in predicting glioma prognostic via EMT pathway

(2015) Jin Meng et al.   Oncotarget

BH3 Mimetics Reactivate Autophagic Cell Death in Anoxia-Resistant Malignant Glioma Cells

(2015) Holger Hetschko et al.   NEOPLASIA

Autophagy revisited: A conversation with Christian de Duve

(2014) Daniel J. Klionsky   Autophagy

Autophagy deficiency stabilizes TWIST1 to promote epithelial-mesenchymal transition

(2014) Lei Qiang et al.   Autophagy

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

(2014) Myrna R Rosenfeld et al.   Autophagy

Radiation promotes malignant progression of glioma cells through HIF-1alpha stabilization

(2014) Young-Heon Kim et al.   CANCER LETTERS

Molecular Pathways: Linking Tumor Microenvironment to Epithelial-Mesenchymal Transition in Metastasis

(2014) H.-Y. Jung et al.   CLINICAL CANCER RESEARCH

Antiangiogenic Therapy for Glioblastoma: Current Status and Future Prospects

(2014) T. T. Batchelor et al.   CLINICAL CANCER RESEARCH

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

A cadherin switch underlies malignancy in high-grade gliomas

(2014) I Appolloni et al.   ONCOGENE

Micro-Environment Causes Reversible Changes in DNA Methylation and mRNA Expression Profiles in Patient-Derived Glioma Stem Cells

(2014) Mehmet Baysan et al.   PLoS One

Regulation of cell proliferation and migration by p62 through stabilization of Twist1

(2014) L. Qiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo radiation response of proneural glioma characterized by protective p53 transcriptional program and proneural-mesenchymal shift

(2014) J. Halliday et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic control of cell death

(2014) D. R. Green et al.   SCIENCE

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Degradation of mutant p53H175 protein by Zn(II) through autophagy

(2014) A Garufi et al.   Cell Death & Disease

TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion

(2014) J V Joseph et al.   Cell Death & Disease

A dual role for autophagy in a murine model of lung cancer

(2014) Shuan Rao et al.   Nature Communications

Autophagy Inhibition Improves Chemosensitivity in BRAFV600E Brain Tumors

(2014) J. M. M. Levy et al.   Cancer Discovery

Autophagy inhibition suppresses pulmonary metastasis of HCC in mice via impairing anoikis resistance and colonization of HCC cells

(2013) Yuan-Fei Peng et al.   Autophagy

The ULK1 complex

(2013) Pui-Mun Wong et al.   Autophagy

Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy

(2013) Y. Takahashi et al.   BLOOD

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

The MET Oncogene in Glioblastoma Stem Cells: Implications as a Diagnostic Marker and a Therapeutic Target

(2013) C. Boccaccio et al.   CANCER RESEARCH

Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial–mesenchymal transition

(2013) Jun Li et al.   CARCINOGENESIS

Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling

(2013) A Ko et al.   CELL DEATH AND DIFFERENTIATION

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Acquired Resistance to Anti-VEGF Therapy in Glioblastoma Is Associated with a Mesenchymal Transition

(2013) Y. Piao et al.   CLINICAL CANCER RESEARCH

The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance

(2013) Florian A. Siebzehnrubl et al.   EMBO Molecular Medicine

Autophagy and Cellular Immune Responses

(2013) Yuting Ma et al.   IMMUNITY

IKK  controls canonical TGF -SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in Panc1 cells

(2013) M. Brandl et al.   JOURNAL OF CELL SCIENCE

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

Sustained elevation of Snail promotes glial-mesenchymal transition after irradiation in malignant glioma

(2013) Roshan Mahabir et al.   NEURO-ONCOLOGY

Investigating the Link between Molecular Subtypes of Glioblastoma, Epithelial-Mesenchymal Transition, and CD133 Cell Surface Protein

(2013) Hadi Zarkoob et al.   PLoS One

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

DEDD, a novel tumor repressor, reverses epithelial-mesenchymal transition by activating selective autophagy

(2012) Qi Lv et al.   Autophagy

Pathogenic role of HIF-1α in prostate hyperplasia in the presence of chronic inflammation

(2012) Hye-Jin Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Epithelial-to-mesenchymal(-like) transition as a relevant molecular event in malignant gliomas

(2012) U.D. Kahlert et al.   CANCER LETTERS

Clusterin Mediates TGF- -Induced Epithelial-Mesenchymal Transition and Metastasis via Twist1 in Prostate Cancer Cells

(2012) M. Shiota et al.   CANCER RESEARCH

The MET Oncogene Is a Functional Marker of a Glioblastoma Stem Cell Subtype

(2012) F. De Bacco et al.   CANCER RESEARCH

DEDD Interacts with PI3KC3 to Activate Autophagy and Attenuate Epithelial-Mesenchymal Transition in Human Breast Cancer

(2012) Q. Lv et al.   CANCER RESEARCH

Emerging roles of PDGF-D in EMT progression during tumorigenesis

(2012) Qiong Wu et al.   CANCER TREATMENT REVIEWS

N-cadherin expression level modulates integrin-mediated polarity and strongly impacts on the speed and directionality of glial cell migration

(2012) Emeline Camand et al.   JOURNAL OF CELL SCIENCE

Different involvement of autophagy in human malignant glioma cell lines undergoing irradiation and temozolomide combined treatments

(2012) Silvia Palumbo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells

(2012) S Galavotti et al.   ONCOGENE

ZEB2 Mediates Multiple Pathways Regulating Cell Proliferation, Migration, Invasion, and Apoptosis in Glioma

(2012) Songtao Qi et al.   PLoS One

mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways

(2011) P. Gulhati et al.   CANCER RESEARCH

Blockade of TGF-  Signaling by the TGF R-I Kinase Inhibitor LY2109761 Enhances Radiation Response and Prolongs Survival in Glioblastoma

(2011) M. Zhang et al.   CANCER RESEARCH

Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma

(2011) Chong Liu et al.   CELL

Autophagy is required for self-renewal and differentiation of adult human stem cells

(2011) Souzan Salemi et al.   CELL RESEARCH

SNAI1 is Involved in the Proliferation and Migration of Glioblastoma Cells

(2011) Sung-Pil Han et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

The basics of epithelial-mesenchymal transition

(2011) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma

(2011) S. Torres et al.   MOLECULAR CANCER THERAPEUTICS

The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Induces Tumor Regression in a Genetically Engineered Mouse Model of PIK3CA Wild-Type Colorectal Cancer

(2011) Jatin Roper et al.   PLoS One

 -catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness

(2011) E. Sanchez-Tillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype

(2011) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SNAI2/Slug promotes growth and invasion in human gliomas

(2010) Hong Wei Yang et al.   BMC CANCER

TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma

(2010) Judit Anido et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

mTOR-Mediated Activation of p70 S6K Induces Differentiation of Pluripotent Human Embryonic Stem Cells

(2010) Charles A. Easley et al.   Cellular Reprogramming

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

(2010) Sabrina Di Bartolomeo et al.   JOURNAL OF CELL BIOLOGY

TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype

(2010) Gianluca Storci et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Reduced expression of LC3B-II and Beclin 1 in glioblastoma multiforme indicates a down-regulated autophagic capacity that relates to the progression of astrocytic tumors

(2010) Xin Huang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

TWIST1 promotes invasion through mesenchymal change in human glioblastoma

(2010) Svetlana A Mikheeva et al.   Molecular Cancer

The Pan-Bcl-2 Inhibitor (-)-Gossypol Triggers Autophagic Cell Death in Malignant Glioma

(2010) V. Voss et al.   MOLECULAR CANCER RESEARCH

Misregulated E-Cadherin Expression Associated with an Aggressive Brain Tumor Phenotype

(2010) Laura J. Lewis-Tuffin et al.   PLoS One

The Role of Autophagy During Development in Higher Eukaryotes

(2010) Sabrina Di Bartolomeo et al.   TRAFFIC

The prognostic role of Beclin 1 protein expression in high-grade gliomas

(2009) Luigi Pirtoli et al.   Autophagy

Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model

(2009) Sheila Alcantara Llaguno et al.   CANCER CELL

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging

(2009) Rogerio M. Castilho et al.   Cell Stem Cell

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition

(2009) Theresa Vincent et al.   NATURE CELL BIOLOGY

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma

(2009) N Lindberg et al.   ONCOGENE

Prognostic significance of c-Met expression in glioblastomas

(2008) Doo-Sik Kong et al.   CANCER

Redox mechanisms switch on hypoxia-dependent epithelial–mesenchymal transition in cancer cells

(2008) Stefania Cannito et al.   CARCINOGENESIS

Combination of Vascular Endothelial Growth Factor Receptor/Platelet-Derived Growth Factor Receptor Inhibition Markedly Improves Radiation Tumor Therapy

(2008) C. Timke et al.   CLINICAL CANCER RESEARCH

Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells

(2008) T Yokoyama et al.   GENE THERAPY

Delta-24-RGD in Combination With RAD001 Induces Enhanced Anti-glioma Effect via Autophagic Cell Death

(2008) Marta M Alonso et al.   MOLECULAR THERAPY

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY