Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation

Enhanced Epithelial-to-Mesenchymal Transition Associated with Lysosome Dysfunction in Podocytes: Role of p62/Sequestosome 1 as a Signaling Hub

(2015) Guangbi Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

SQSTM1/p62 regulates the expression of junctional proteins through epithelial-mesenchymal transition factors

(2014) Matthieu Bertrand et al.   CELL CYCLE

AMBRA1 Interplay with Cullin E3 Ubiquitin Ligases Regulates Autophagy Dynamics

(2014) Manuela Antonioli et al.   DEVELOPMENTAL CELL

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis

(2014) Sayaka Inokuchi-Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy

(2014) Hong-Min Ni et al.   JOURNAL OF HEPATOLOGY

O24 HEPATOCYTE SPECIFIC KNOCK-OUT OF AUTOPHAGY INDUCES LIVER INJURY, BUT INHIBITS STEATOSIS AND IMPROVES SERUM LIPIDS IN MICE FED A CONTROL AND METHIONINE CHOLINE DEFICIENT DIET

(2014) W.J. Kwanten et al.   JOURNAL OF HEPATOLOGY

TGF- : Duality of Function Between Tumor Prevention and Carcinogenesis

(2014) D. R. Principe et al.   JNCI-Journal of the National Cancer Institute

Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte

(2014) Carla Cicchini et al.   LIVER INTERNATIONAL

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of cell proliferation and migration by p62 through stabilization of Twist1

(2014) L. Qiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy: A Multifaceted Partner in Liver Fibrosis

(2014) Ariane Mallat et al.   Biomed Research International

Autophagy inhibition suppresses pulmonary metastasis of HCC in mice via impairing anoikis resistance and colonization of HCC cells

(2013) Yuan-Fei Peng et al.   Autophagy

Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial–mesenchymal transition

(2013) Jun Li et al.   CARCINOGENESIS

Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation

(2013) M Amir et al.   CELL DEATH AND DIFFERENTIATION

Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency

(2013) Nunzia Pastore et al.   EMBO Molecular Medicine

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Liver autophagy: much more than just taking out the trash

(2013) Jaime L. Schneider et al.   Nature Reviews Gastroenterology & Hepatology

Coordinated elevation of mitochondrial oxidative phosphorylation and autophagy help drive hepatocyte polarization

(2013) D. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy: shaping the tumor microenvironment and therapeutic response

(2013) Hannelore Maes et al.   TRENDS IN MOLECULAR MEDICINE

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

DEDD Interacts with PI3KC3 to Activate Autophagy and Attenuate Epithelial-Mesenchymal Transition in Human Breast Cancer

(2012) Q. Lv et al.   CANCER RESEARCH

TGF- -induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion

(2012) S. Lamouille et al.   JOURNAL OF CELL SCIENCE

TGFβ overrides HNF4α tumor suppressing activity through GSK3β inactivation: implication for hepatocellular carcinoma gene therapy

(2012) Angela Maria Cozzolino et al.   JOURNAL OF HEPATOLOGY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

An epistatic mini-circuitry between the transcription factors Snail and HNF4α controls liver stem cell and hepatocyte features exhorting opposite regulation on stemness-inhibiting microRNAs

(2011) F Garibaldi et al.   CELL DEATH AND DIFFERENTIATION

Molecular Pathogenesis of Hepatocellular Carcinoma: Altering Transforming Growth Factor-β Signaling in Hepatocarcinogenesis

(2011) Ken Yamazaki et al.   DIGESTIVE DISEASES

Pathophysiological Role of Autophagy: Lesson from Autophagy-Deficient Mouse Models

(2011) Yoshinobu ICHIMURA et al.   EXPERIMENTAL ANIMALS

Autophagy Protects Cells From HCV-Induced Defects in Lipid Metabolism

(2011) Tiziana Vescovo et al.   GASTROENTEROLOGY

The stable repression of mesenchymal program is required for hepatocyte identity: A novel role for hepatocyte nuclear factor 4α

(2011) Laura Santangelo et al.   HEPATOLOGY

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

(2011) Yoshihiro Inami et al.   JOURNAL OF CELL BIOLOGY

Hepatocyte-Derived Snail1 Propagates Liver Fibrosis Progression

(2011) R. G. Rowe et al.   MOLECULAR AND CELLULAR BIOLOGY

Glycogen synthase kinase 3 -dependent Snail degradation directs hepatocyte proliferation in normal liver regeneration

(2011) S. Sekiya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatic Fibrosis and Carcinogenesis in  1-Antitrypsin Deficiency: A Prototype for Chronic Tissue Damage in Gain-of-Function Disorders

(2011) D. H. Perlmutter et al.   Cold Spring Harbor Perspectives in Biology

Rapamycin reduces intrahepatic alpha-1-antitrypsin mutant Z protein polymers and liver injury in a mouse model

(2010) Shalesh Kaushal et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Phosphorylation of Serine 11 and Serine 92 as New Positive Regulators of Human Snail1 Function: Potential Involvement of Casein Kinase-2 and the cAMP-activated Kinase Protein Kinase A

(2009) Matthew Reid MacPherson et al.   MOLECULAR BIOLOGY OF THE CELL

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

TGFβ-induced EMT requires focal adhesion kinase (FAK) signaling

(2007) Carla Cicchini et al.   EXPERIMENTAL CELL RESEARCH