Endogenous Pancreatic β Cell Regeneration: A Potential Strategy for the Recovery of β Cell Deficiency in Diabetes

Artemether Does Not Turn α Cells into β Cells

(2018) Talitha van der Meulen et al.   Cell Metabolism

Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes

(2018) Cristina Aguayo-Mazzucato et al.   Cell Metabolism

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism

(2018) Eleonora Trotta et al.   NATURE MEDICINE

How does glucagon-like peptide 1 stimulate human β-cell proliferation? A lesson from islet graft experiments

(2018) Yoshio Fujitani   Journal of Diabetes Investigation

GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4 + T Cells and Is Immunosuppressive in Type 1 Diabetes

(2018) Amol K. Bhandage et al.   EBioMedicine

Pancreas regeneration

(2018) Qiao Zhou et al.   NATURE

Regulatory T-cell therapy for autoimmune and autoinflammatory diseases: The next frontier

(2018) Jonathan H. Esensten et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Treg cells—the next frontier of cell therapy

(2018) Jeffrey A. Bluestone et al.   SCIENCE

All mixed up: defining roles for β-cell subtypes in mature islets

(2017) Jennifer S.E. Liu et al.   GENES & DEVELOPMENT

Ectopic expression ofPax4in pancreatic δ cells results in β-like cell neogenesis

(2017) Noémie Druelle et al.   JOURNAL OF CELL BIOLOGY

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling

(2017) Chunhua Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Type 1 diabetes induction in humanized mice

(2017) Shulian Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor

(2017) Joseph Fusco et al.   Scientific Reports

β-Cell dedifferentiation, reduced duct cell plasticity, and impaired β-cell mass regeneration in middle-aged rats

(2016) Noèlia Téllez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

SerpinB1 Promotes Pancreatic β Cell Proliferation

(2016) Abdelfattah El Ouaamari et al.   Cell Metabolism

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Liraglutide Compromises Pancreatic β Cell Function in a Humanized Mouse Model

(2016) Midhat H. Abdulreda et al.   Cell Metabolism

ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells

(2016) Eiji Yoshihara et al.   Cell Metabolism

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas

(2016) Yue J. Wang et al.   Cell Metabolism

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

Tet-On Systems For Doxycycline-inducible Gene Expression

(2016) Atze T. Das et al.   CURRENT GENE THERAPY

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

(2016) Ercument Dirice et al.   DIABETES

Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor

(2016) Rachel E. Stamateris et al.   DIABETES

Novel factors modulating human β-cell proliferation

(2016) J. Shirakawa et al.   DIABETES OBESITY & METABOLISM

β-Cell adaptation in pregnancy

(2016) L. Baeyens et al.   DIABETES OBESITY & METABOLISM

Targeting insulin-producing beta cells for regenerative therapy

(2016) Adriana Migliorini et al.   DIABETOLOGIA

High-throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation

(2016) Karine Robitaille et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PAX4 Gene Transfer Induces α-to-β Cell Phenotypic Conversion and Confers Therapeutic Benefits for Diabetes Treatment

(2016) Yanqing Zhang et al.   MOLECULAR THERAPY

Identification of proliferative and mature β-cells in the islets of Langerhans

(2016) Erik Bader et al.   NATURE

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

(2016) Arturo J Vegas et al.   NATURE MEDICINE

Impact of islet architecture on β-cell heterogeneity, plasticity and function

(2016) Sara S. Roscioni et al.   Nature Reviews Endocrinology

Growth factors and medium hyperglycemia induce Sox9+ductal cell differentiation into β cells in mice with reversal of diabetes

(2016) Mingfeng Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Corrigendum: Generation of stem cell-derived β-cells from patients with type 1 diabetes

(2016) Jeffrey R. Millman et al.   Nature Communications

Human islets contain four distinct subtypes of β cells

(2016) Craig Dorrell et al.   Nature Communications

Insulin-positive, Glut2-low cells present within mouse pancreas exhibit lineage plasticity and are enriched within extra-islet endocrine cell clusters

(2016) Christine A. Beamish et al.   Islets

Autonomous interconversion between adult pancreatic α-cells and β-cells after differential metabolic challenges

(2016) Risheng Ye et al.   Molecular Metabolism

Interleukin-6 as a potential positive modulator of human beta-cell function: an exploratory analysis—the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 6

(2015) Marco Dauriz et al.   ACTA DIABETOLOGICA

Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway

(2015) Nagesha Guthalu Kondegowda et al.   Cell Metabolism

Tolerance Induction and Reversal of Diabetes in Mice Transplanted with Human Embryonic Stem Cell-Derived Pancreatic Endoderm

(2015) Gregory L. Szot et al.   Cell Stem Cell

Weaning Triggers a Maturation Step of Pancreatic β Cells

(2015) Miri Stolovich-Rain et al.   DEVELOPMENTAL CELL

Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells

(2015) Hainan Chen et al.   DIABETES

Human β-Cell Proliferation and Intracellular Signaling: Part 3

(2015) Andrew F. Stewart et al.   DIABETES

Prolactin-stimulated survivin induction is required for beta cell mass expansion during pregnancy in mice

(2015) Yili Xu et al.   DIABETOLOGIA

The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scidMice

(2015) Maximiliano Presa et al.   JOURNAL OF IMMUNOLOGY

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

(2015) Peng Wang et al.   NATURE MEDICINE

Pax4 acts as a key player in pancreas development and plasticity

(2015) Tiziana Napolitano et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pancreatic islet cell development and regeneration

(2015) Anthony I. Romer et al.   Current Opinion in Endocrinology Diabetes and Obesity

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

(2015) Weijun Shen et al.   Nature Communications

The Edges of Pancreatic Islet β Cells Constitute Adhesive and Signaling Microdomains

(2015) Erez Geron et al.   Cell Reports

Glucagon-like polypeptide agonists in type 2 diabetes mellitus: efficacy and tolerability, a balance

(2015) Sri Harsha Tella et al.   Therapeutic Advances in Endocrinology and Metabolism

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Adipsin Is an Adipokine that Improves β Cell Function in Diabetes

(2014) James C. Lo et al.   CELL

Successful β cells islet regeneration in streptozotocin-induced diabetic baboons using ultrasound-targeted microbubble gene therapy with cyclinD2/CDK4/GLP1

(2014) Shuyuan Chen et al.   CELL CYCLE

Cell Replacement Strategies Aimed at Reconstitution of the β-Cell Compartment in Type 1 Diabetes

(2014) Giuseppe Orlando et al.   DIABETES

Partial Duct Ligation:  -Cell Proliferation and Beyond

(2014) M. Van de Casteele et al.   DIABETES

GABA Promotes Human  -Cell Proliferation and Modulates Glucose Homeostasis

(2014) I. Purwana et al.   DIABETES

Human  -Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map

(2014) E. Bernal-Mizrachi et al.   DIABETES

A Humanized Mouse Model of Autoimmune Insulitis

(2014) Ashley A. Viehmann Milam et al.   DIABETES

MafA is critical for maintenance of the mature beta cell phenotype in mice

(2014) Wataru Nishimura et al.   DIABETOLOGIA

Glutamine Stimulates Biosynthesis and Secretion of Insulin-like Growth Factor 2 (IGF2), an Autocrine Regulator of Beta Cell Mass and Function

(2014) Honey Modi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Menin determines K-RAS proliferative outputs in endocrine cells

(2014) Chester E. Chamberlain et al.   JOURNAL OF CLINICAL INVESTIGATION

Activated FoxM1 Attenuates Streptozotocin-Mediated β-Cell Death

(2014) Maria L. Golson et al.   MOLECULAR ENDOCRINOLOGY

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

(2014) Simona Chera et al.   NATURE

Single-cell RNA-seq reveals dynamic paracrine control of cellular variation

(2014) Alex K. Shalek et al.   NATURE

Revealing transcription factors during human pancreatic β cell development

(2014) Elizabeth Conrad et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pancreatic β-Cell Proliferation in Obesity

(2014) Amelia K. Linnemann et al.   Advances in Nutrition

Flattop regulates basal body docking and positioning in mono- and multiciliated cells

(2014) Moritz Gegg et al.   eLife

The role of clusterin on pancreatic beta cell regeneration after exendin-4 treatment in neonatal streptozotocin administrated rats

(2013) Fatma Kaya-Dagistanli et al.   ACTA HISTOCHEMICA

Adult Duct-Lining Cells Can Reprogram into β-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes

(2013) Keith Al-Hasani et al.   DEVELOPMENTAL CELL

Soluble Factors Secreted by T Cells Promote  -Cell Proliferation

(2013) E. Dirice et al.   DIABETES

 -Aminobutyric Acid Regulates Both the Survival and Replication of Human  -Cells

(2013) J. Tian et al.   DIABETES

Hepatocyte Growth Factor/c-Met Signaling Is Required for  -Cell Regeneration

(2013) J. C. Alvarez-Perez et al.   DIABETES

 -Cells Are Not Generated in Pancreatic Duct Ligation-Induced Injury in Adult Mice

(2013) M. M. Rankin et al.   DIABETES

Third-party Mesenchymal Stem Cells Improved Human Islet Transplantation in a Humanized Diabetic Mouse Model

(2013) Hao Wu et al.   MOLECULAR THERAPY

Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

(2013) Luc Baeyens et al.   NATURE BIOTECHNOLOGY

Liver-Derived Systemic Factors Drive β Cell Hyperplasia in Insulin-Resistant States

(2013) Abdelfattah El Ouaamari et al.   Cell Reports

Advancing Animal Models of Human Type 1 Diabetes by Engraftment of Functional Human Tissues in Immunodeficient Mice

(2013) M. A. Brehm et al.   Cold Spring Harbor Perspectives in Medicine

Recovery from diabetes in neonatal mice after a low-dose streptozotocin treatment

(2012) Masateru Kataoka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lineage Tracing

(2012) Kai Kretzschmar et al.   CELL

Human  -Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map

(2012) R. N. Kulkarni et al.   DIABETES

 -Cell Mass and Turnover in Humans: Effects of obesity and aging

(2012) Y. Saisho et al.   DIABETES CARE

Serum adipokines as biomarkers of beta-cell function in patients with type 1 diabetes: positive association with leptin and resistin and negative association with adiponectin

(2012) Minh Nguyet Pham et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

TCF7L2 promotes beta cell regeneration in human and mouse pancreas

(2012) L. Shu et al.   DIABETOLOGIA

Adaptive changes of human islets to an obesogenic environment in the mouse

(2012) S. Gargani et al.   DIABETOLOGIA

GATA believe it: new essential regulators of pancreas development

(2012) Santiago Rodríguez-Seguí et al.   JOURNAL OF CLINICAL INVESTIGATION

Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis

(2012) Shouhong Xuan et al.   JOURNAL OF CLINICAL INVESTIGATION

Overexpression of Hepatocyte Nuclear Factor-4α Initiates Cell Cycle Entry, but Is not Sufficient to Promote β-Cell Expansion in Human Islets

(2012) Sebastian Rieck et al.   MOLECULAR ENDOCRINOLOGY

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3

(2012) Barak Blum et al.   NATURE BIOTECHNOLOGY

GABA is an effective immunomodulatory molecule

(2011) Zhe Jin et al.   AMINO ACIDS

Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas

(2011) J. L. Kopp et al.   DEVELOPMENT

Ongoing β-Cell Turnover in Adult Nonhuman Primates Is Not Adaptively Increased in Streptozotocin-Induced Diabetes

(2011) Yoshifumi Saisho et al.   DIABETES

Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice

(2011) Fabrizio Thorel et al.   DIABETES

Epidermal growth factor (EGF)-receptor signalling is needed for murine beta cell mass expansion in response to high-fat diet and pregnancy but not after pancreatic duct ligation

(2011) E. Hakonen et al.   DIABETOLOGIA

Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets

(2011) C. Dai et al.   DIABETOLOGIA

Context-specific  -to- -cell reprogramming by forced Pdx1 expression

(2011) Y.-P. Yang et al.   GENES & DEVELOPMENT

Transient expression of Ngn3 inXenopusendoderm promotes early and ectopic development of pancreatic beta and delta cells

(2011) Daniel Oropez et al.   GENESIS

GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes

(2011) N. Soltani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MafA and MafB activity in pancreatic β cells

(2011) Yan Hang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity

(2010) Chunyan Gu et al.   Cell Metabolism

Parameters for establishing humanized mouse models to study human immunity: Analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rγnull mutation

(2010) Michael A. Brehm et al.   CLINICAL IMMUNOLOGY

Nkx6 Transcription Factors and Ptf1a Function as Antagonistic Lineage Determinants in Multipotent Pancreatic Progenitors

(2010) Ashleigh E. Schaffer et al.   DEVELOPMENTAL CELL

 -Aminobutyric Acid (GABA) Is an Autocrine Excitatory Transmitter in Human Pancreatic  -Cells

(2010) M. Braun et al.   DIABETES

Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-Rag1null IL2r null Ins2Akita Mice

(2010) M. A. Brehm et al.   DIABETES

Parathyroid Hormone-Related Protein Enhances Human  -Cell Proliferation and Function With Associated Induction of Cyclin-Dependent Kinase 2 and Cyclin E Expression

(2010) N. Guthalu Kondegowda et al.   DIABETES

In Vivo Expression of HGF/NK1 and GLP-1 From dsAAV Vectors Enhances Pancreatic  -Cell Proliferation and Improves Pathology in the db/db Mouse Model of Diabetes

(2010) D. F. Gaddy et al.   DIABETES

Unique Arrangement of  - and  -Cells in Human Islets of Langerhans

(2010) D. Bosco et al.   DIABETES

 -Cell Growth and Regeneration: Replication Is Only Part of the Story

(2010) S. Bonner-Weir et al.   DIABETES

Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy

(2010) A. E. Butler et al.   DIABETOLOGIA

Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells

(2010) C. Aguayo-Mazzucato et al.   DIABETOLOGIA

Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats

(2010) W.-C. Li et al.   JOURNAL OF CELL SCIENCE

Genetic lineage tracing, a powerful tool to investigate the embryonic organogenesis and adult organ maintenance of the pancreas

(2010) Yoshiya Kawaguchi et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Serotonin regulates pancreatic beta cell mass during pregnancy

(2010) Hail Kim et al.   NATURE MEDICINE

Glycemic Control Promotes Pancreatic Beta-Cell Regeneration in Streptozotocin-Induced Diabetic Mice

(2010) Eric J. Grossman et al.   PLoS One

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

Adaptive  -Cell Proliferation Is Severely Restricted With Advanced Age

(2009) M. M. Rankin et al.   DIABETES

Single pancreatic beta cells co-express multiple islet hormone genes in mice

(2009) H. Katsuta et al.   DIABETOLOGIA

Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft

(2009) E. H. Liu et al.   DIABETOLOGIA

Polycomb protein Ezh2 regulates pancreatic  -cell Ink4a/Arf expression and regeneration in diabetes mellitus

(2009) H. Chen et al.   GENES & DEVELOPMENT

Endocrine Cell Clustering During Human Pancreas Development

(2009) Jongmin Jeon et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Identification of small-molecule inducers of pancreatic  -cell expansion

(2009) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of β-cell mass in response to pregnancy

(2009) Sebastian Rieck et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Transdifferentiation of pancreatic ductal cells to endocrine β-cells

(2008) Susan Bonner-Weir et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas

(2008) Xiaobo Xu et al.   CELL

A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation

(2008) Philip A. Seymour et al.   DEVELOPMENTAL BIOLOGY

 -Cell Proliferation, but Not Neogenesis, Following 60% Partial Pancreatectomy Is Impaired in the Absence of FoxM1

(2008) A. Ackermann Misfeldt et al.   DIABETES

PANIC-ATTAC: A Mouse Model for Inducible and Reversible  -Cell Ablation

(2008) Z. V. Wang et al.   DIABETES

Exendin-4 Stimulation of Cyclin A2 in  -Cell Proliferation

(2008) W.-J. Song et al.   DIABETES

 -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of  -Cell Mass in Humans

(2008) J. J. Meier et al.   DIABETES

Relationship between β-cell mass and diabetes onset

(2008) A. V. Matveyenko et al.   DIABETES OBESITY & METABOLISM

IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice

(2008) J. Agudo et al.   DIABETOLOGIA

Maturation of Adult β-Cells Revealed Using aPdx1/InsulinDual-Reporter Lentivirus

(2008) Marta Szabat et al.   ENDOCRINOLOGY

Prolactin Receptor Is Required for Normal Glucose Homeostasis and Modulation of β-Cell Mass during Pregnancy

(2008) Carol Huang et al.   ENDOCRINOLOGY

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth

(2008) A. Inada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-Term Effects of Central Leptin and Resistin on Body Weight, Insulin Resistance, and β-Cell Function and Mass by the Modulation of Hypothalamic Leptin and Insulin Signaling

(2007) Sunmin Park et al.   ENDOCRINOLOGY