All mixed up: defining roles for β-cell subtypes in mature islets

Disallowed and Allowed Gene Expression: Two Faces of Mature Islet Beta Cells

(2016) Katleen Lemaire et al.   Annual Review of Nutrition

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

(2016) H. Efsun Arda et al.   Cell Metabolism

ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells

(2016) Eiji Yoshihara et al.   Cell Metabolism

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas

(2016) Yue J. Wang et al.   Cell Metabolism

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

Single-Cell Transcriptomics of the Human Endocrine Pancreas

(2016) Yue J. Wang et al.   DIABETES

Effects of ageing and senescence on pancreatic β-cell function

(2016) A. Helman et al.   DIABETES OBESITY & METABOLISM

The quest to make fully functional human pancreatic beta cells from embryonic stem cells: climbing a mountain in the clouds

(2016) James D. Johnson   DIABETOLOGIA

PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus

(2016) José Manuel Mellado-Gil et al.   DIABETOLOGIA

Identification of proliferative and mature β-cells in the islets of Langerhans

(2016) Erik Bader et al.   NATURE

Revealing the vectors of cellular identity with single-cell genomics

(2016) Allon Wagner et al.   NATURE BIOTECHNOLOGY

Impact of islet architecture on β-cell heterogeneity, plasticity and function

(2016) Sara S. Roscioni et al.   Nature Reviews Endocrinology

Human islets contain four distinct subtypes of β cells

(2016) Craig Dorrell et al.   Nature Communications

A Single-Cell Transcriptome Atlas of the Human Pancreas

(2016) Mauro J. Muraro et al.   Cell Systems

Pancreatic β-cell identity, glucose sensing and the control of insulin secretion

(2015) Guy A. Rutter et al.   BIOCHEMICAL JOURNAL

Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function

(2015) Dana Avrahami et al.   Cell Metabolism

Plasticity and Dedifferentiation within the Pancreas: Development, Homeostasis, and Disease

(2015) Sapna Puri et al.   Cell Stem Cell

Islet formation in mice and men: lessons for the generation of functional insulin-producing β-cells from human pluripotent stem cells

(2015) Gopika Nair et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Weaning Triggers a Maturation Step of Pancreatic β Cells

(2015) Miri Stolovich-Rain et al.   DEVELOPMENTAL CELL

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

MAFA and T3Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC

(2015) Cristina Aguayo-Mazzucato et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

DNA methylation directs functional maturation of pancreatic β cells

(2015) Sangeeta Dhawan et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Islet Morphology Revisited

(2015) Susan Bonner-Weir et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

DICER Inactivation Identifies Pancreatic β-Cell “Disallowed” Genes Targeted by MicroRNAs

(2015) Aida Martinez-Sanchez et al.   MOLECULAR ENDOCRINOLOGY

Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion

(2015) Talitha van der Meulen et al.   NATURE MEDICINE

Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning

(2015) Cécile Jacovetti et al.   Nature Communications

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Differentiated human stem cells resemble fetal, not adult, β cells

(2014) Sinisa Hrvatin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revealing transcription factors during human pancreatic β cell development

(2014) Elizabeth Conrad et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Phase Transitions in the Multi-cellular Regulatory Behavior of Pancreatic Islet Excitability

(2014) Thomas H. Hraha et al.   PLoS Computational Biology

Flattop regulates basal body docking and positioning in mono- and multiciliated cells

(2014) Moritz Gegg et al.   eLife

Thyroid Hormone Promotes Postnatal Rat Pancreatic  -Cell Development and Glucose-Responsive Insulin Secretion Through MAFA

(2013) C. Aguayo-Mazzucato et al.   DIABETES

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Distinctions Between the Islets of Mice and Men: Implications for New Therapies for Type 1 and 2 Diabetes

(2012) Claresa Levetan et al.   Endocrine Practice

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3

(2012) Barak Blum et al.   NATURE BIOTECHNOLOGY

Specific Silencing of the REST Target Genes in Insulin-Secreting Cells Uncovers Their Participation in Beta Cell Survival

(2012) David Martin et al.   PLoS One

Urocortin 3 Marks Mature Human Primary and Embryonic Stem Cell-Derived Pancreatic Alpha and Beta Cells

(2012) Talitha van der Meulen et al.   PLoS One

Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells

(2011) A. Jermendy et al.   DIABETOLOGIA

Defects in beta cell Ca2+ signalling, glucose metabolism and insulin secretion in a murine model of KATP channel-induced neonatal diabetes mellitus

(2011) R. K. P. Benninger et al.   DIABETOLOGIA

Transcriptomes of the major human pancreatic cell types

(2011) C. Dorrell et al.   DIABETOLOGIA

Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets

(2011) C. Dai et al.   DIABETOLOGIA

GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: Implications for understanding genetic association signals at this locus

(2011) Laura J. McCulloch et al.   MOLECULAR GENETICS AND METABOLISM

PDGF signalling controls age-dependent proliferation in pancreatic β-cells

(2011) Hainan Chen et al.   NATURE

Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity

(2010) Chunyan Gu et al.   Cell Metabolism

Regulation of MafA Expression in Pancreatic  -Cells in db/db Mice With Diabetes

(2010) T.-a. Matsuoka et al.   DIABETES

MafA and MafB Regulate Genes Critical to  -Cells in a Unique Temporal Manner

(2010) I. Artner et al.   DIABETES

Unique Arrangement of  - and  -Cells in Human Islets of Langerhans

(2010) D. Bosco et al.   DIABETES

Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells

(2010) C. Aguayo-Mazzucato et al.   DIABETOLOGIA

Tissue-specific disallowance of housekeeping genes: The other face of cell differentiation

(2010) L. Thorrez et al.   GENOME RESEARCH

Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program

(2010) J. van Arensbergen et al.   GENOME RESEARCH

Identification of genes selectively disallowed in the pancreatic islet

(2010) Timothy J. Pullen et al.   Islets

Secondary Consequences of β Cell Inexcitability: Identification and Prevention in a Murine Model of KATP-Induced Neonatal Diabetes Mellitus

(2009) Maria Sara Remedi et al.   Cell Metabolism

Hyperinsulinism and Diabetes: Genetic Dissection of β Cell Metabolism-Excitation Coupling in Mice

(2009) Maria Sara Remedi et al.   Cell Metabolism

Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells

(2008) D. Martin et al.   DIABETOLOGIA

Urocortins: emerging metabolic and energy homeostasis perspectives

(2008) Yael Kuperman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM