Dysregulation of synaptic and extrasynaptic N-methyl-D-aspartate receptors induced by amyloid-β

Disturbed Neurotransmitter Transporter Expression in Alzheimer’s Disease Brain

(2016) Kevin H. Chen et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-  Peptide Oligomers Disrupt Axonal Transport through an NMDA Receptor-Dependent Mechanism That Is Mediated by Glycogen Synthase Kinase 3  in Primary Cultured Hippocampal Neurons

(2013) H. Decker et al.   JOURNAL OF NEUROSCIENCE

Endoplasmic reticulum stress occurs downstream of GluN2B subunit ofN-methyl-D-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers

(2012) Rui O. Costa et al.   AGING CELL

Amyloid-Beta Peptide 1-42 Causes Microtubule Deregulation through N-methyl-D-aspartate Receptors in Mature Hippocampal Cultures

(2012) Sandra I. Mota et al.   Current Alzheimer Research

Opposing Roles of Synaptic and Extrasynaptic NMDA Receptor Signaling in Cocultured Striatal and Cortical Neurons

(2012) A. M. Kaufman et al.   JOURNAL OF NEUROSCIENCE

Activation of NMDA Receptors Upregulates A Disintegrin and Metalloproteinase 10 via a Wnt/MAPK Signaling Pathway

(2012) X.-Z. Wan et al.   JOURNAL OF NEUROSCIENCE

Amyloid β peptide oligomers directly activate NMDA receptors

(2011) Laura Texidó et al.   CELL CALCIUM

Amyloid beta peptide 1–42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures

(2011) I.L. Ferreira et al.   CELL CALCIUM

Aβ Oligomers Induce Glutamate Release from Hippocampal Neurons

(2011) J. Brito-Moreira et al.   Current Alzheimer Research

Striatal-enriched protein tyrosine phosphatase (STEP) knockout mice have enhanced hippocampal memory

(2011) Deepa V. Venkitaramani et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Opposing Synaptic Regulation of Amyloid-  Metabolism by NMDA Receptors In Vivo

(2011) D. K. Verges et al.   JOURNAL OF NEUROSCIENCE

A Signaling Cascade of Nuclear Calcium-CREB-ATF3 Activated by Synaptic NMDA Receptors Defines a Gene Repression Module That Protects against Extrasynaptic NMDA Receptor-Induced Neuronal Cell Death and Ischemic Brain Damage

(2011) S.-J. Zhang et al.   JOURNAL OF NEUROSCIENCE

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

The selective and competitive N-methyl-D-aspartate receptor antagonist, (−)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid, prevents synaptic toxicity induced by amyloid-β in mice

(2011) M.A. Bicca et al.   NEUROSCIENCE

Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats

(2010) Brigitte Potier et al.   AGING CELL

Nonfibrillar Abeta1–42 Inhibits Glutamate Uptake and Phosphorylates p38 in Human Fibroblasts

(2010) Chiara Paola Zoia et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of α7 nicotinic receptors and internalization of NMDA receptors

(2010) H Shen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Amyloid β oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors

(2010) Elena Alberdi et al.   CELL CALCIUM

Atorvastatin prevents hippocampal cell death, neuroinflammation and oxidative stress following amyloid-β1–40 administration in mice: Evidence for dissociation between cognitive deficits and neuronal damage

(2010) Tetsadê C.B. Piermartiri et al.   EXPERIMENTAL NEUROLOGY

Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer’s disease

(2010) Guilian Tian et al.   JOURNAL OF NEUROCHEMISTRY

N-Methyl-d-aspartate receptors are required for synaptic targeting of Alzheimer’s toxic amyloid-β peptide oligomers

(2010) Helena Decker et al.   JOURNAL OF NEUROCHEMISTRY

Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-  Production

(2010) K. Bordji et al.   JOURNAL OF NEUROSCIENCE

Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses

(2010) P. Xia et al.   JOURNAL OF NEUROSCIENCE

A -Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP61

(2010) P. Kurup et al.   JOURNAL OF NEUROSCIENCE

Wnt-5a occludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons

(2010) Waldo Cerpa et al.   Molecular Neurodegeneration

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

(2010) Raik Rönicke et al.   NEUROBIOLOGY OF AGING

Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model

(2010) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-fibrillar amyloid-β peptide reduces NMDA-induced neurotoxicity, but not AMPA-induced neurotoxicity

(2009) Tetsuhiro Niidome et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

S 24795 Limits β-Amyloid–α7 Nicotinic Receptor Interaction and Reduces Alzheimer's Disease-Like Pathologies

(2009) Hoau-Yan Wang et al.   BIOLOGICAL PSYCHIATRY

Essential involvement of the NMDA receptor in ethanol preconditioning-dependent neuroprotection from amyloid-βin vitro

(2009) Robert M. Mitchell et al.   JOURNAL OF NEUROCHEMISTRY

Synaptic NMDA Receptor Activation Stimulates  -Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-  Production

(2009) S. E. Hoey et al.   JOURNAL OF NEUROSCIENCE

Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP

(2009) J. Xu et al.   JOURNAL OF NEUROSCIENCE

Deletion of the  7 Nicotinic Acetylcholine Receptor Gene Improves Cognitive Deficits and Synaptic Pathology in a Mouse Model of Alzheimer's Disease

(2009) G. Dziewczapolski et al.   JOURNAL OF NEUROSCIENCE

Memantine lowers amyloid-β peptide levels in neuronal cultures and in APP/PS1 transgenic mice

(2009) George M. Alley et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

Protection against Aβ-mediated rapid disruption of synaptic plasticity and memory by memantine

(2009) Igor Klyubin et al.   NEUROBIOLOGY OF AGING

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

GluN2B subunit-containing NMDA receptor antagonists prevent A -mediated synaptic plasticity disruption in vivo

(2009) N.-W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity

(2009) R. I. Stanika et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Memantine protects rat cortical cultured neurons against β-amyloid-induced toxicity by attenuating tau phosphorylation

(2008) M. S. Song et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors

(2008) F. Léveillé et al.   FASEB JOURNAL

Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N-methyl-d-aspartate receptor signaling

(2008) Masamitsu Shimazawa et al.   JOURNAL OF NEUROCHEMISTRY

Extrasynaptic NR2D-Containing NMDARs Are Recruited to the Synapse during LTP of NMDAR-EPSCs

(2008) S. C. Harney et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

(2008) Sofia Papadia et al.   NATURE NEUROSCIENCE

β-Amyloid Oligomers Affect the Structure and Function of the Postsynaptic Region: Role of the Wnt Signaling Pathway

(2008) Margarita C. Dinamarca et al.   Neurodegenerative Diseases

Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades

(2008) M. Matos et al.   NEUROSCIENCE

Intracerebroventricular Administration of Amyloid β-protein Oligomers Selectively Increases Dorsal Hippocampal Dialysate Glutamate Levels in the Awake Rat

(2008) Sean O’Shea et al.   SENSORS

Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice

(2007) I. Dewachter et al.   NEUROBIOLOGY OF AGING