Therapeutic Molecules and Endogenous Ligands Regulate the Interaction between Brain Cellular Prion Protein (PrPC) and Metabotropic Glutamate Receptor 5 (mGluR5)
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Title
Therapeutic Molecules and Endogenous Ligands Regulate the Interaction between Brain Cellular Prion Protein (PrPC) and Metabotropic Glutamate Receptor 5 (mGluR5)
Authors
Keywords
-
Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 289, Issue 41, Pages 28460-28477
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2014-08-23
DOI
10.1074/jbc.m114.584342
References
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- (2013) Federica Agostini et al. PLoS One
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- (2013) Ji Won Um et al. Prion
- Group I Metabotropic Glutamate Receptor Signalling and its Implication in Neurological Disease
- (2012) Fabiola M. Ribeiro et al. CNS & Neurological Disorders-Drug Targets
- The Complex PrPc-Fyn Couples Human Oligomeric A with Pathological Tau Changes in Alzheimer's Disease
- (2012) M. Larson et al. JOURNAL OF NEUROSCIENCE
- Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons
- (2012) Ji Won Um et al. NATURE NEUROSCIENCE
- Cellular Prion Protein: From Physiology to Pathology
- (2012) Sei-ichi Yusa et al. Viruses-Basel
- Cellular prion protein is essential for oligomeric amyloid- -induced neuronal cell death
- (2011) W. Kudo et al. HUMAN MOLECULAR GENETICS
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- (2011) Clive Bate et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyloid-β42 Interacts Mainly with Insoluble Prion Protein in the Alzheimer Brain
- (2011) Wen-Quan Zou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Alzheimer's Disease Brain-Derived Amyloid- -Mediated Inhibition of LTP In Vivo Is Prevented by Immunotargeting Cellular Prion Protein
- (2011) A. E. Barry et al. JOURNAL OF NEUROSCIENCE
- Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices
- (2011) Gerhard Rammes et al. NEUROPHARMACOLOGY
- Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites
- (2011) Darragh B. Freir et al. Nature Communications
- Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-β oligomers
- (2010) Sam Gandy et al. ANNALS OF NEUROLOGY
- Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an alzheimer's disease model mouse
- (2010) Erika Chung et al. BMC NEUROSCIENCE
- Prion protein and Aβ-related synaptic toxicity impairment
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- (2010) Flavio H. Beraldo et al. FASEB JOURNAL
- Interaction between Human Prion Protein and Amyloid-β (Aβ) Oligomers
- (2010) Shugui Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane
- (2010) Mariagioia Zampagni et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein
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- The prion protein as a receptor for amyloid-β
- (2010) Helmut W. Kessels et al. NATURE
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- The complexity of their activation mechanism opens new possibilities for the modulation of mGlu and GABAB class C G protein-coupled receptors
- (2010) Philippe Rondard et al. NEUROPHARMACOLOGY
- Allosteric modulation of metabotropic glutamate receptors: Structural insights and therapeutic potential
- (2010) Karen J. Gregory et al. NEUROPHARMACOLOGY
- Synthetic amyloid- oligomers impair long-term memory independently of cellular prion protein
- (2010) C. Balducci et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2009) A. Francesconi et al. JOURNAL OF NEUROSCIENCE
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