Immunomodulatory Effects of Glutathione, Garlic Derivatives, and Hydrogen Sulfide

S-allyl cysteine ameliorates cognitive deficits in streptozotocin-diabetic rats via suppression of oxidative stress, inflammation, and acetylcholinesterase

(2017) Tourandokht Baluchnejadmojarad et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPAR-γ activation

(2017) Limin Shi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Effects of intranasal treatment with slow (GYY4137) and rapid (NaHS) donors of hydrogen sulfide in lipopolysaccharide-induced airway inflammation in mice

(2017) Yesim Kaya-Yasar et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Neuroprotective Effects of Aged Garlic Extract on Cognitive Dysfunction and Neuroinflammation Induced by β-Amyloid in Rats

(2017) Nutchareeporn Nillert et al.   Nutrients

Glutathione inhibits antibody and complement-mediated immunologic cell injury via multiple mechanisms

(2017) Zhen Zhang et al.   Redox Biology

Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF-κB signaling pathways

(2017) Dongdong Wu et al.   Scientific Reports

Aged garlic has more potent antiglycation and antioxidant properties compared to fresh garlic extract in vitro

(2017) Abdulhakim Elosta et al.   Scientific Reports

Hydrogen sulfide depletion contributes to microvascular remodeling in obesity

(2016) Joseph Candela et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Garlic oil polysulfides: H2S- and O2-independent prooxidants in buffer and antioxidants in cells

(2016) Eric R. DeLeon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Allium sativum L. regulates in vitro IL-17 gene expression in human peripheral blood mononuclear cells

(2016) Mouna Moutia et al.   BMC Complementary and Alternative Medicine

Diallyl Disulfide (DADS), a Constituent of Garlic, Inactivates NF- B and Prevents Colitis-Induced Colorectal Cancer by Inhibiting GSK-3 

(2016) S. M. Saud et al.   Cancer Prevention Research

Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation

(2016) Liping Xie et al.   DIABETES

Protective effect of Allium sativum (garlic) aqueous extract against lead-induced oxidative stress in the rat brain, liver, and kidney

(2016) V. Manoj Kumar et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Cystathionine β-synthase regulates endothelial function via protein S-sulfhydration

(2016) Sounik Saha et al.   FASEB JOURNAL

S-Allyl cysteine alleviates inflammation by modulating the expression of NF-κB during chromium (VI)-induced hepatotoxicity in rats

(2016) SK Anandasadagopan et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Diet Supplementation with Allicin Protects against Alcoholic Fatty Liver Disease in Mice by Improving Anti-inflammation and Antioxidative Functions

(2016) Suraphan Panyod et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Biochemical Characterization and Antimicrobial and Antifungal Activity of Two Endemic Varieties of Garlic (Allium sativumL.) of the Campania Region, Southern Italy

(2016) Florinda Fratianni et al.   JOURNAL OF MEDICINAL FOOD

Effect of the Aged Garlic Extract on Cardiovascular Function in Metabolic Syndrome Rats

(2016) Israel Pérez-Torres et al.   MOLECULES

Aged garlic extract enhances heme oxygenase-1 and glutamate-cysteine ligase modifier subunit expression via the nuclear factor erythroid 2–related factor 2–antioxidant response element signaling pathway in human endothelial cells

(2016) Kei Hiramatsu et al.   NUTRITION RESEARCH

A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo

(2016) Caleb Weihao Huang et al.   PHARMACOLOGICAL RESEARCH

The Role of Hydrogen Sulfide in Evolution and the Evolution of Hydrogen Sulfide in Metabolism and Signaling

(2016) Kenneth R. Olson et al.   PHYSIOLOGY

Hydrogen sulfide mediates the protection of dietary restriction against renal senescence in aged F344 rats

(2016) Wen-juan Wang et al.   Scientific Reports

S-Glutathionylation Enhances Human Cystathionine β-Synthase Activity Under Oxidative Stress Conditions

(2015) Wei-Ning Niu et al.   ANTIOXIDANTS & REDOX SIGNALING

Anti-diabetic and anti-oxidant potential of aged garlic extract (AGE) in streptozotocin-induced diabetic rats

(2015) Martha Thomson et al.   BMC Complementary and Alternative Medicine

RETRACTED ARTICLE: High doses of garlic extract significantly attenuated the ratio of serum LDL to HDL level in rat-fed with hypercholesterolemia diet

(2015) Tahereh Ebrahimi et al.   Diagnostic Pathology

Calorie restriction and methionine restriction in control of endogenous hydrogen sulfide production by the transsulfuration pathway

(2015) Christopher Hine et al.   EXPERIMENTAL GERONTOLOGY

Hydrogen sulfide attenuates cytokine production through the modulation of chromatin remodeling

(2015) ESTER C.S. RIOS et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

S-allyl cysteine activates the Nrf2-dependent antioxidant response and protects neurons against ischemic injuryin vitroandin vivo

(2015) Huanying Shi et al.   JOURNAL OF NEUROCHEMISTRY

A Single Meal Containing Raw, Crushed Garlic Influences Expression of Immunity- and Cancer-Related Genes in Whole Blood of Humans

(2015) Craig S Charron et al.   JOURNAL OF NUTRITION

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

(2015) John L. Wallace et al.   NATURE REVIEWS DRUG DISCOVERY

Diallyl Trisulfide Is a Fast H2S Donor, but Diallyl Disulfide Is a Slow One: The Reaction Pathways and Intermediates of Glutathione with Polysulfides

(2015) Dong Liang et al.   ORGANIC LETTERS

Human CD4+ T cells require exogenous cystine for glutathione and DNA synthesis

(2015) Trine B. Levring et al.   Oncotarget

Effects of diallyl trisulfide on induction of apoptotic death in murine leukemia WEHI-3 cellsin vitroand alterations of the immune responses in normal and leukemic micein vivo

(2014) Fang-Ming Hung et al.   ENVIRONMENTAL TOXICOLOGY

Garlic powder intake and cardiovascular risk factors: a meta-analysis of randomized controlled clinical trials

(2014) Jin Sook Kwak et al.   Nutrition Research and Practice

Inhibition of Hydrogen Sulfide Production by Gene Silencing Attenuates Inflammatory Activity by Downregulation of NF-κB and MAP Kinase Activity in LPS-Activated RAW 264.7 Cells

(2014) Alireza Badiei et al.   Biomed Research International

Aged garlic extract with supplement is associated with increase in brown adipose, decrease in white adipose tissue and predict lack of progression in coronary atherosclerosis

(2013) Naser Ahmadi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Alliin, a Garlic (Allium sativum) Compound, Prevents LPS-Induced Inflammation in 3T3-L1 Adipocytes

(2013) Saray Quintero-Fabián et al.   MEDIATORS OF INFLAMMATION

Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells

(2013) Megan L. Steele et al.   Redox Biology

Redox biology of hydrogen sulfide: Implications for physiology, pathophysiology, and pharmacology

(2013) Asaf Stein et al.   Redox Biology

The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability

(2012) Benjamin L. Predmore et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hydrogen Sulfide in Biochemistry and Medicine

(2012) Benjamin Lee Predmore et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen Sulfide Protects Against Cellular Senescence via S-Sulfhydration of Keap1 and Activation of Nrf2

(2012) Guangdong Yang et al.   ANTIOXIDANTS & REDOX SIGNALING

The Gasotransmitter Hydrogen Sulfide Induces Nrf2-Target Genes by Inactivating the Keap1 Ubiquitin Ligase Substrate Adaptor Through Formation of a Disulfide Bond Between Cys-226 and Cys-613

(2012) John M. Hourihan et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione and infection

(2012) Devin Morris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Supplementation with aged garlic extract improves both NK and γδ-T cell function and reduces the severity of cold and flu symptoms: A randomized, double-blind, placebo-controlled nutrition intervention

(2012) Meri P. Nantz et al.   CLINICAL NUTRITION

Aged garlic extract reduces blood pressure in hypertensives: a dose–response trial

(2012) K Ried et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Inhibition of GTRAP3-18 May Increase Neuroprotective Glutathione (GSH) Synthesis

(2012) Koji Aoyama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nuclear Factor κB-Dependent Anti-inflammatory Effects of s-Allyl Cysteine and s-Propyl Cysteine in Kidney of Diabetic Mice

(2012) Mei-chin Mong et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Hydrogen Sulfide-Linked Sulfhydration of NF-κB Mediates Its Antiapoptotic Actions

(2012) Nilkantha Sen et al.   MOLECULAR CELL

The Antioxidant Mechanisms Underlying the Aged Garlic Extract- and S-Allylcysteine-Induced Protection

(2012) Ana L. Colín-González et al.   Oxidative Medicine and Cellular Longevity

S-adenosylmethionine in Liver Health, Injury, and Cancer

(2012) Shelly C. Lu et al.   PHYSIOLOGICAL REVIEWS

Hydrogen Sulfide Inhibits the Development of Atherosclerosis with Suppressing CX3CR1 and CX3CL1 Expression

(2012) Huili Zhang et al.   PLoS One

Aged Garlic Extract Scavenges Superoxide Radicals

(2011) Naoaki Morihara et al.   PLANT FOODS FOR HUMAN NUTRITION

Glutathione and Adaptive Immune Responses against Mycobacterium tuberculosis Infection in Healthy and HIV Infected Individuals

(2011) Carlos Guerra et al.   PLoS One

Interaction of hydrogen sulfide with ion channels

(2010) Guanghua Tang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide

(2010) M. Whiteman et al.   DIABETOLOGIA

Redox Biochemistry of Hydrogen Sulfide

(2010) Omer Kabil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulatory T Cells Interfere with Glutathione Metabolism in Dendritic Cells and T Cells

(2010) Zhonghua Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Brief Review of the Basics of Immunology: The Innate and Adaptive Response

(2010) Melissa A. Kennedy   VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

Hydrogen Sulfide: The Third Gasotransmitter in Biology and Medicine

(2009) Rui Wang   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria

(2009) Yuka Kimura et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen Sulfide Mediates Cardioprotection Through Nrf2 Signaling

(2009) John W. Calvert et al.   CIRCULATION RESEARCH

Garlic: Nature's Protection Against Physiological Threats

(2009) Masood Sadiq Butt et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Inflammation and cancer: how friendly is the relationship for cancer patients?

(2009) Bharat B Aggarwal et al.   CURRENT OPINION IN PHARMACOLOGY

NF-KappaB Independent Activation of a Series of Proinflammatory Genes by Hydrogen Sulfide

(2009) Karl M. Stuhlmeier et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Endogenous and Exogenous Hydrogen Sulfide Promotes Resolution of Colitis in Rats

(2009) John L. Wallace et al.   GASTROENTEROLOGY

Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line

(2009) Andrea Tarozzi et al.   JOURNAL OF NEUROCHEMISTRY

H2S Signals Through Protein S-Sulfhydration

(2009) A. K. Mustafa et al.   Science Signaling

3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide and Bound Sulfane Sulfur in the Brain

(2008) Norihiro Shibuya et al.   ANTIOXIDANTS & REDOX SIGNALING

The glutathione precursor N-acetylcysteine improves immune function in postmenopausal women

(2008) L ARRANZ et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

(2008) C.J. Harvey et al.   FREE RADICAL BIOLOGY AND MEDICINE

Natural Killer Cells, Glutathione, Cytokines, and Innate Immunity Against Mycobacterium tuberculosis

(2008) Ariel C. Millman et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine  -Lyase

(2008) G. Yang et al.   SCIENCE

Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis

(2007) S Fiorucci et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glutathione levels and immune responses in tuberculosis patients

(2007) Vishwanath Venketaraman et al.   MICROBIAL PATHOGENESIS