Morphogen Gradients: From Generation to Interpretation

Feedback regulation of Drosophila BMP signaling by the novel extracellular protein Larval Translucida

(2011) M. Szuperak et al.   DEVELOPMENT

Scaling of the Bicoid morphogen gradient by a volume-dependent production rate

(2011) D. Cheung et al.   DEVELOPMENT

Rapid differential transport of Nodal and Lefty on sulfated proteoglycan-rich extracellular matrix regulates left-right asymmetry in Xenopus

(2011) L. Marjoram et al.   DEVELOPMENT

Antagonistic Growth Regulation by Dpp and Fat Drives Uniform Cell Proliferation

(2011) Gerald Schwank et al.   DEVELOPMENTAL CELL

The evolution of dorsal-ventral patterning mechanisms in insects

(2011) J. A. Lynch et al.   GENES & DEVELOPMENT

Interpretation of the FGF8 morphogen gradient is regulated by endocytic trafficking

(2011) Matthias Nowak et al.   NATURE CELL BIOLOGY

Specificity of Drosophila Cytonemes for Distinct Signaling Pathways

(2011) S. Roy et al.   SCIENCE

Dynamics of Dpp Signaling and Proliferation Control

(2011) O. Wartlick et al.   SCIENCE

Hedgehog morphogen: from secretion to reception

(2011) Armel Gallet   TRENDS IN CELL BIOLOGY

The Formation of the Bicoid Morphogen Gradient Requires Protein Movement from Anteriorly Localized mRNA

(2011) Shawn C. Little et al.   PLOS BIOLOGY

Eukaryotic Chemotaxis: A Network of Signaling Pathways Controls Motility, Directional Sensing, and Polarity

(2010) Kristen F. Swaney et al.   Annual Review of Biophysics

High Mobility of Bicoid Captured by Fluorescence Correlation Spectroscopy: Implication for the Rapid Establishment of Its Gradient

(2010) Asmahan Abu-Arish et al.   BIOPHYSICAL JOURNAL

Extracellular regulation of BMP signaling

(2010) Lise Zakin et al.   CURRENT BIOLOGY

The Bicoid Morphogen System

(2010) Aude Porcher et al.   CURRENT BIOLOGY

Modelling the Bicoid gradient

(2010) O. Grimm et al.   DEVELOPMENT

The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development

(2010) D. Yan et al.   DEVELOPMENT

A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning

(2010) M. Lek et al.   DEVELOPMENT

The time to measure positional information: maternal Hunchback is required for the synchrony of the Bicoid transcriptional response at the onset of zygotic transcription

(2010) A. Porcher et al.   DEVELOPMENT

Robustness of positional specification by the Hedgehog morphogen gradient

(2010) David J. Irons et al.   DEVELOPMENTAL BIOLOGY

Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation

(2010) Adam Kleinschmit et al.   DEVELOPMENTAL BIOLOGY

Organism-Scale Modeling of Early Drosophila Patterning via Bone Morphogenetic Proteins

(2010) David M. Umulis et al.   DEVELOPMENTAL CELL

The Long-Range Activity of Hedgehog Is Regulated in the Apical Extracellular Space by the Glypican Dally and the Hydrolase Notum

(2010) Katie L. Ayers et al.   DEVELOPMENTAL CELL

Dynamic Filopodia Transmit Intermittent Delta-Notch Signaling to Drive Pattern Refinement during Lateral Inhibition

(2010) Michael Cohen et al.   DEVELOPMENTAL CELL

Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube

(2010) V. Ribes et al.   GENES & DEVELOPMENT

Positional information and patterning revisited

(2010) Lewis Wolpert   JOURNAL OF THEORETICAL BIOLOGY

Chromatin signature of embryonic pluripotency is established during genome activation

(2010) Nadine L. Vastenhouw et al.   NATURE

Control of Dpp morphogen signalling by a secreted feedback regulator

(2010) Robin Vuilleumier et al.   NATURE CELL BIOLOGY

Fates-shifted is an F-box protein that targets Bicoid for degradation and regulates developmental fate determination in Drosophila embryos

(2010) Junbo Liu et al.   NATURE CELL BIOLOGY

Scaling of morphogen gradients by an expansion-repression integral feedback control

(2010) D. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reaction-Diffusion Model as a Framework for Understanding Biological Pattern Formation

(2010) S. Kondo et al.   SCIENCE

Nodal Signaling Recruits the Histone Demethylase Jmjd3 to Counteract Polycomb-Mediated Repression at Target Genes

(2010) O. Dahle et al.   Science Signaling

Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog

(2010) Eric Dessaud et al.   PLOS BIOLOGY

Interpretation of the Wingless Gradient Requires Signaling-Induced Self-Inhibition

(2009) Eugenia Piddini et al.   CELL

Lipid-modified morphogens: functions of fats

(2009) Josefa Steinhauer et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Temporal dynamics of patterning by morphogen gradients

(2009) Eva Kutejova et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Formation of the bicoid morphogen gradient: an mRNA gradient dictates the protein gradient

(2009) A. Spirov et al.   DEVELOPMENT

The extracellular regulation of bone morphogenetic protein signaling

(2009) D. Umulis et al.   DEVELOPMENT

Syndecan-1 regulates BMP signaling and dorso-ventral patterning of the ectoderm during early Xenopus development

(2009) Gonzalo H. Olivares et al.   DEVELOPMENTAL BIOLOGY

The Core Protein of Glypican Dally-Like Determines Its Biphasic Activity in Wingless Morphogen Signaling

(2009) Dong Yan et al.   DEVELOPMENTAL CELL

Evidence that Fold-Change, and Not Absolute Level, of β-Catenin Dictates Wnt Signaling

(2009) Lea Goentoro et al.   MOLECULAR CELL

Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules

(2009) Shuizi Rachel Yu et al.   NATURE

Antagonistic action of Bicoid and the repressor Capicua determines the spatial limits of Drosophila head gene expression domains

(2009) U. Lohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anterior-posterior positional information in the absence of a strong Bicoid gradient

(2009) A. Ochoa-Espinosa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synchronous and Stochastic Patterns of Gene Activation in theDrosophilaEmbryo

(2009) Alistair N. Boettiger et al.   SCIENCE

The Measure of Success: Constraints, Objectives, and Tradeoffs in Morphogen-mediated Patterning

(2009) A. D. Lander et al.   Cold Spring Harbor Perspectives in Biology

Robust Generation and Decoding of Morphogen Gradients

(2009) N. Barkai et al.   Cold Spring Harbor Perspectives in Biology

Graded Dorsal and Differential Gene Regulation in the Drosophila Embryo

(2009) G. T. Reeves et al.   Cold Spring Harbor Perspectives in Biology

Models for the Generation and Interpretation of Gradients

(2009) H. Meinhardt   Cold Spring Harbor Perspectives in Biology

Nodal Morphogens

(2009) A. F. Schier   Cold Spring Harbor Perspectives in Biology

Gradients and the Specification of Planar Polarity in the Insect Cuticle

(2009) D. Strutt   Cold Spring Harbor Perspectives in Biology

Establishing and Interpreting Graded Sonic Hedgehog Signaling during Vertebrate Neural Tube Patterning: The Role of Negative Feedback

(2009) V. Ribes et al.   Cold Spring Harbor Perspectives in Biology

Shaping Morphogen Gradients by Proteoglycans

(2009) D. Yan et al.   Cold Spring Harbor Perspectives in Biology

Morphogen Gradient Formation

(2009) O. Wartlick et al.   Cold Spring Harbor Perspectives in Biology

Dynamic Interpretation of Hedgehog Signaling in the Drosophila Wing Disc

(2009) Marcos Nahmad et al.   PLOS BIOLOGY

Visualisation and Quantification of Morphogen Gradient Formation in the Zebrafish

(2009) Steven A Harvey et al.   PLOS BIOLOGY

Canalization of Gene Expression in the Drosophila Blastoderm by Gap Gene Cross Regulation

(2009) Manu et al.   PLOS BIOLOGY

Comparative Aspects of Animal Regeneration

(2008) Jeremy P. Brockes et al.   Annual Review of Cell and Developmental Biology

The control of size in animals: insights from selector genes

(2008) Michael A. Crickmore et al.   BIOESSAYS

Robust Stability of the Embryonic Axial Pattern Requires a Secreted Scaffold for Chordin Degradation

(2008) Hidehiko Inomata et al.   CELL

Nanoscale Organization of Hedgehog Is Essential for Long-Range Signaling

(2008) Neha Vyas et al.   CELL

The Decapentaplegic morphogen gradient: a precise definition

(2008) Anna Kicheva et al.   CURRENT OPINION IN CELL BIOLOGY

A translational block to HSPG synthesis permits BMP signaling in the early Drosophila embryo

(2008) D. J. Bornemann et al.   DEVELOPMENT

Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning

(2008) C. E. Chamberlain et al.   DEVELOPMENT

Precision of the Dpp gradient

(2008) T. Bollenbach et al.   DEVELOPMENT

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

(2008) E. Dessaud et al.   DEVELOPMENT

Shape and function of the Bicoid morphogen gradient in dipteran species with different sized embryos

(2008) Thomas Gregor et al.   DEVELOPMENTAL BIOLOGY

The BMP Signaling Gradient Patterns Dorsoventral Tissues in a Temporally Progressive Manner along the Anteroposterior Axis

(2008) Jennifer A. Tucker et al.   DEVELOPMENTAL CELL

Cellular Trafficking of the Glypican Dally-like Is Required for Full-Strength Hedgehog Signaling and Wingless Transcytosis

(2008) Armel Gallet et al.   DEVELOPMENTAL CELL

The BMP-Binding Protein Crossveinless 2 Is a Short-Range, Concentration-Dependent, Biphasic Modulator of BMP Signaling in Drosophila

(2008) Mihaela Serpe et al.   DEVELOPMENTAL CELL

Probing Intrinsic Properties of a Robust Morphogen Gradient in Drosophila

(2008) Feng He et al.   DEVELOPMENTAL CELL

Predicting expression patterns from regulatory sequence in Drosophila segmentation

(2008) Eran Segal et al.   NATURE

Chromatin decouples promoter threshold from dynamic range

(2008) Felix H. Lam et al.   NATURE

Scaling of the BMP activation gradient in Xenopus embryos

(2008) Danny Ben-Zvi et al.   NATURE

Multiple roles for lipids in the Hedgehog signalling pathway

(2008) Suzanne Eaton   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A quantitative model of transcription factor–activated gene expression

(2008) Harold D Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate

(2008) R. G. Thorne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Patched, the receptor of Hedgehog, is a lipoprotein receptor

(2008) A. Callejo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From Signals to Patterns: Space, Time, and Mathematics in Developmental Biology

(2008) J. Lewis   SCIENCE

Shadow Enhancers as a Source of Evolutionary Novelty

(2008) J.-W. Hong et al.   SCIENCE

Dally regulates Dpp morphogen gradient formation by stabilizing Dpp on the cell surface

(2007) Takuya Akiyama et al.   DEVELOPMENTAL BIOLOGY