Regulation of RabGAPs involved in insulin action

Electrical pulse stimulation induces GLUT4 translocation in C2C12 myotubes that depends on Rab8A, Rab13, and Rab14

(2018) Zhu Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Rab GAPs AS160 and Tbc1d1 play nonredundant roles in the regulation of glucose and energy homeostasis in mice

(2016) Stefan R. Hargett et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance

(2016) Reema P. Vazirani et al.   DIABETES

Toward Precision Medicine: TBC1D4 Disruption Is Common Among the Inuit and Leads to Underdiagnosis of Type 2 Diabetes

(2016) Despoina Manousaki et al.   DIABETES CARE

Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking

(2016) Zhou Zhou et al.   FEBS LETTERS

Tbc1d1 deletion suppresses obesity in leptin-deficient mice

(2016) J Dokas et al.   INTERNATIONAL JOURNAL OF OBESITY

Analysis of Genes Involved in Body Weight Regulation by Targeted Re-Sequencing

(2016) Anna-Lena Volckmar et al.   PLoS One

Deletion of the Rab GAP Tbc1d1 modifies glucose, lipid, and energy homeostasis in mice

(2015) Stefan R. Hargett et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The RabGAP TBC1D1 Plays a Central Role in Exercise-Regulated Glucose Metabolism in Skeletal Muscle

(2015) Jacqueline Stöckli et al.   DIABETES

The Adaptor Protein APPL2 Inhibits Insulin-Stimulated Glucose Uptake by Interacting With TBC1D1 in Skeletal Muscle

(2014) Kenneth K.Y. Cheng et al.   DIABETES

Deletion of Both Rab-GTPase–Activating Proteins TBC1D1 and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport

(2014) Alexandra Chadt et al.   DIABETES

Roles of TBC1D1 and TBC1D4 in insulin- and exercise-stimulated glucose transport of skeletal muscle

(2014) Gregory D. Cartee   DIABETOLOGIA

Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells

(2014) Yi Sun et al.   MOLECULAR BIOLOGY OF THE CELL

A Rab10:RalA G protein cascade regulates insulin-stimulated glucose uptake in adipocytes

(2014) Sheelarani Karunanithi et al.   MOLECULAR BIOLOGY OF THE CELL

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

(2014) Ida Moltke et al.   NATURE

A role for Rab14 in the endocytic trafficking of GLUT4 in 3T3-L1 adipocytes

(2013) S. E. Reed et al.   JOURNAL OF CELL SCIENCE

Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 proteins in human skeletal muscle

(2013) Jonas T. Treebak et al.   JOURNAL OF PHYSIOLOGY-LONDON

Deletion of Rab GAP AS160 modifies glucose uptake and GLUT4 translocation in primary skeletal muscles and adipocytes and impairs glucose homeostasis

(2012) Melissa N. Lansey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues

(2012) Hong Yu Wang et al.   BIOCHEMICAL JOURNAL

Identification and association analysis of several hundred single nucleotide polymorphisms within candidate genes for back fat thickness in Italian Large White pigs using a selective genotyping approach1

(2012) L. Fontanesi et al.   JOURNAL OF ANIMAL SCIENCE

Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes

(2012) Yu Chen et al.   JOURNAL OF CELL BIOLOGY

TBC proteins: GAPs for mammalian small GTPase Rab?

(2011) Mitsunori Fukuda   BIOSCIENCE REPORTS

Mice with AS160/TBC1D4-Thr649Ala Knockin Mutation Are Glucose Intolerant with Reduced Insulin Sensitivity and Altered GLUT4 Trafficking

(2011) Shuai Chen et al.   Cell Metabolism

Rab GEFs and GAPs

(2010) Francis Barr et al.   CURRENT OPINION IN CELL BIOLOGY

TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle

(2010) D. An et al.   DIABETES

Analysis of TBC1D4 in patients with severe insulin resistance

(2010) S. Dash et al.   DIABETOLOGIA

Exercise-induced TBC1D1 Ser237 phosphorylation and 14-3-3 protein binding capacity in human skeletal muscle

(2010) Christian Frøsig et al.   JOURNAL OF PHYSIOLOGY-LONDON

Insulin-regulated Aminopeptidase Is a Key Regulator of GLUT4 Trafficking by Controlling the Sorting of GLUT4 from Endosomes to Specialized Insulin-regulated Vesicles

(2010) Ingrid Jordens et al.   MOLECULAR BIOLOGY OF THE CELL

The porcine TBC1D1 gene: mapping, SNP identification, and association study with meat, carcass and production traits in Italian heavy pigs

(2010) Luca Fontanesi et al.   MOLECULAR BIOLOGY REPORTS

Whole-genome resequencing reveals loci under selection during chicken domestication

(2010) Carl-Johan Rubin et al.   NATURE

Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells

(2010) Y. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle

(2009) Jonas T. Treebak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

(2009) Christian Pehmøller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucose transporters in the 21st Century

(2009) Bernard Thorens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Insulin-stimulated Phosphorylation of the Rab GTPase-activating Protein TBC1D1 Regulates GLUT4 Translocation

(2009) Grantley R. Peck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Yin-Yang Regulation of Adiponectin Signaling by APPL Isoforms in Muscle Cells

(2009) Changhua Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia

(2009) S. Dash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation

(2008) Shuhei Ishikura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators

(2008) Shuai Chen et al.   BIOCHEMICAL JOURNAL

Membrane traffic in the secretory pathway

(2008) M. Fukuda   CELLULAR AND MOLECULAR LIFE SCIENCES

R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population

(2008) D. Meyre et al.   HUMAN MOLECULAR GENETICS

Discovery of TBC1D1 as an Insulin-, AICAR-, and Contraction-stimulated Signaling Nexus in Mouse Skeletal Muscle

(2008) Eric B. Taylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity

(2008) Alexandra Chadt et al.   NATURE GENETICS

The effect of exercise and insulin on AS160 phosphorylation and 14-3-3 binding capacity in human skeletal muscle

(2007) Kirsten F. Howlett et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM