IL-36, IL-37, and IL-38 Cytokines in Skin and Joint Inflammation: A Comprehensive Review of Their Therapeutic Potential
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Title
IL-36, IL-37, and IL-38 Cytokines in Skin and Joint Inflammation: A Comprehensive Review of Their Therapeutic Potential
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 6, Pages 1257
Publisher
MDPI AG
Online
2019-03-14
DOI
10.3390/ijms20061257
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Note: Only part of the references are listed.- Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis
- (2019) Jing Guo et al. Drug Design Development and Therapy
- The enigmatic role of IL-38 in inflammatory diseases
- (2018) Thomas Garraud et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Pharmacotherapeutic approaches for treating psoriasis in difficult-to-treat areas
- (2018) Dario Kivelevitch et al. EXPERT OPINION ON PHARMACOTHERAPY
- Role of the IL-23/IL-17 Axis in Psoriasis and Psoriatic Arthritis: The Clinical Importance of Its Divergence in Skin and Joints
- (2018) Marie-Astrid Boutet et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The severity of imiquimod-induced mouse skin inflammation is independent of endogenous IL-38 expression
- (2018) Jennifer Palomo et al. PLoS One
- Suppressing IL-36-driven inflammation using peptide pseudosubstrates for neutrophil proteases
- (2018) Graeme P. Sullivan et al. Cell Death & Disease
- Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing
- (2018) Danielle M. Clancy et al. Cell Reports
- Identification of small-molecule elastase inhibitors as antagonists of IL-36 cytokine activation
- (2018) Graeme P. Sullivan et al. FEBS Open Bio
- IL-36γ Is a Strong Inducer of IL-23 in Psoriatic Cells and Activates Angiogenesis
- (2018) Charlie Bridgewood et al. Frontiers in Immunology
- The Interplay Between Keratinocytes and Immune Cells in the Pathogenesis of Psoriasis
- (2018) Cristina Albanesi et al. Frontiers in Immunology
- Elevated levels of IL-37 correlate with T cell activation status in rheumatoid arthritis patients
- (2018) Dina Ragab et al. CYTOKINE
- Plasma interleukin-38 in patients with rheumatoid arthritis
- (2018) Wang-Dong Xu et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Association of IL-36γ with tertiary lymphoid structures and inflammatory immune infiltrates in human colorectal cancer
- (2018) Aliyah M. Weinstein et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Interleukin-37 inhibits osteoclastogenesis and alleviates inflammatory bone destruction
- (2018) Ruohui Tang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- IL-36 signaling is essential for psoriatic inflammation through the augmentation of innate immune responses
- (2018) Kentaro Ohko et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment
- (2018) Laura Mercurio et al. Cell Death & Disease
- Neutrophil extracellular traps can serve as platforms for processing and activation of IL-1 family cytokines
- (2017) Danielle M. Clancy et al. FEBS Journal
- In vivo anti-inflammatory activities of novel cytokine IL-38 in Murphy Roths Large (MRL)/lpr mice
- (2017) Man Chu et al. IMMUNOBIOLOGY
- Regulation and function of interleukin-36 cytokines
- (2017) Esen Yonca Bassoy et al. IMMUNOLOGICAL REVIEWS
- Suppression of inflammation and acquired immunity by IL-37
- (2017) Giulio Cavalli et al. IMMUNOLOGICAL REVIEWS
- Overview of the IL-1 family in innate inflammation and acquired immunity
- (2017) Charles A. Dinarello IMMUNOLOGICAL REVIEWS
- IL-36γ inhibits differentiation and induces inflammation of keratinocyte via Wnt signaling pathway in psoriasis
- (2017) Wenming Wang et al. International Journal of Medical Sciences
- IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis
- (2017) Andrew Johnston et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Toll-like receptor 4 antagonist TAK-242 inhibits autoinflammatory symptoms in DITRA
- (2017) Akitaka Shibata et al. JOURNAL OF AUTOIMMUNITY
- Quantitative ligand and receptor binding studies reveal the mechanism of interleukin-36 (IL-36) pathway activation
- (2017) Li Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IL-36γ signaling controls the induced regulatory T cell–Th9 cell balance via NFκB activation and STAT transcription factors
- (2017) A Harusato et al. Mucosal Immunology
- Psoriatic Arthritis
- (2017) Christopher T. Ritchlin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36γ
- (2017) Joseph S. Ainscough et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target
- (2017) Satveer K. Mahil et al. Science Translational Medicine
- Anti-interleukin and interleukin therapies for psoriasis: current evidence and clinical usefulness
- (2017) Ya-Chu Tsai et al. Therapeutic Advances in Musculoskeletal Disease
- The psoriasis-associated IL-17A induces and cooperates with IL-36 cytokines to control keratinocyte differentiation and function
- (2017) Carolina M. Pfaff et al. Scientific Reports
- Distinct expression of interleukin (IL)-36α, βandγ, their antagonist IL-36Ra and IL-38 in psoriasis, rheumatoid arthritis and Crohn's disease
- (2016) M.-A. Boutet et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation
- (2016) Rafael Penha et al. CYTOKINE
- Interleukin-36 potently stimulates human M2 macrophages, Langerhans cells and keratinocytes to produce pro-inflammatory cytokines
- (2016) Damien Dietrich et al. CYTOKINE
- Structural and Functional Attributes of the Interleukin-36 Receptor
- (2016) Guanghui Yi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Imiquimod Treatment Causes Systemic Disease in Mice Resembling Generalized Pustular Psoriasis in an IL-1 and IL-36 Dependent Manner
- (2016) Pilar Alvarez et al. MEDIATORS OF INFLAMMATION
- Production of recombinant human interleukin-38 and its inhibitory effect on the expression of proinflammatory cytokines in THP-1 cells
- (2016) X. L. Yuan et al. MOLECULAR BIOLOGY
- Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation
- (2016) Giulio Cavalli et al. RHEUMATOLOGY
- Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses
- (2016) Javier Mora et al. Journal of Molecular Cell Biology
- Neutrophil Elastase-mediated proteolysis activates the anti-inflammatory cytokine IL-36 Receptor antagonist
- (2016) Tom Macleod et al. Scientific Reports
- Interleukin-9 Overexpression and Th9 Polarization Characterize the Inflamed Gut, the Synovial Tissue, and the Peripheral Blood of Patients With Psoriatic Arthritis
- (2016) Francesco Ciccia et al. Arthritis & Rheumatology
- Regulatory Role of IL-1R8 in Immunity and Disease
- (2016) Martina Molgora et al. Frontiers in Immunology
- Towards a Stratified Targeted Approach with Biologic Treatments in Rheumatoid Arthritis: Role of Synovial Pathobiology
- (2015) Elisa Astorri et al. CURRENT PHARMACEUTICAL DESIGN
- Expression of IL-36 family cytokines and IL-37 but not IL-38 is altered in psoriatic skin
- (2015) Maris Keermann et al. JOURNAL OF DERMATOLOGICAL SCIENCE
- IL-37 Alleviates Rheumatoid Arthritis by Suppressing IL-17 and IL-17–Triggering Cytokine Production and Limiting Th17 Cell Proliferation
- (2015) Liang Ye et al. JOURNAL OF IMMUNOLOGY
- Unprocessed Interleukin-36α Regulates Psoriasis-Like Skin Inflammation in Cooperation With Interleukin-1
- (2015) Katelynn A. Milora et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction
- (2015) Claudia A Nold-Petry et al. NATURE IMMUNOLOGY
- The Epidemiology of Psoriatic Arthritis
- (2015) Alexis Ogdie et al. RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
- Potential involvement of IL-9 and Th9 cells in the pathogenesis of rheumatoid arthritis
- (2015) F. Ciccia et al. RHEUMATOLOGY
- Brief Report: Interleukin-38 Exerts Antiinflammatory Functions and Is Associated With Disease Activity in Systemic Lupus Erythematosus
- (2015) Ina Rudloff et al. Arthritis & Rheumatology
- The global burden of rheumatoid arthritis: estimates from the Global Burden of Disease 2010 study
- (2014) Marita Cross et al. ANNALS OF THE RHEUMATIC DISEASES
- IL-36γ Sustains a Proinflammatory Self-amplifying Loop with IL-17C in Anti-TNF–induced Psoriasiform Skin Lesions of Patients with Crohnʼs Disease
- (2014) Matthias Friedrich et al. INFLAMMATORY BOWEL DISEASES
- IL-37 Ameliorates the Inflammatory Process in Psoriasis by Suppressing Proinflammatory Cytokine Production
- (2014) X. Teng et al. JOURNAL OF IMMUNOLOGY
- IL-36 has proinflammatory effects in skin but not in joints
- (2014) Damien Dietrich et al. Nature Reviews Rheumatology
- Blockade of IL-36 Receptor Signaling Does Not Prevent from TNF-Induced Arthritis
- (2014) Anja Derer et al. PLoS One
- Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses
- (2014) A.-M. Bulau et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- New learnings on the pathophysiology of RA from synovial biopsies
- (2013) Costantino Pitzalis et al. CURRENT OPINION IN RHEUMATOLOGY
- The balance between pro- and anti-inflammatory cytokines is crucial in human allergic contact dermatitis pathogenesis: the role of IL-1 family members
- (2013) Martina Mattii et al. EXPERIMENTAL DERMATOLOGY
- The Interleukin-1 Family: Back to the Future
- (2013) Cecilia Garlanda et al. IMMUNITY
- Molecular signatures of antibody responses derived from a systems biology study of five human vaccines
- (2013) Shuzhao Li et al. NATURE IMMUNOLOGY
- The severity of experimental arthritis is independent of IL-36 receptor signaling
- (2013) Céline Lamacchia et al. ARTHRITIS RESEARCH & THERAPY
- The novel cytokine interleukin-36α is expressed in psoriatic and rheumatoid arthritis synovium
- (2012) Silke Frey et al. ANNALS OF THE RHEUMATIC DISEASES
- IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells
- (2012) S. Vigne et al. BLOOD
- New insights of T cells in the pathogenesis of psoriasis
- (2012) Yihua Cai et al. Cellular & Molecular Immunology
- The IL-36 receptor pathway regulatesAspergillus fumigatus-induced Th1 and Th17 responses
- (2012) Mark S. Gresnigt et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- IL-36γ/IL-1F9, an Innate T-bet Target in Myeloid Cells
- (2012) Malte Bachmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Psoriasiform dermatitis is driven by IL-36–mediated DC-keratinocyte crosstalk
- (2012) Luigi Tortola et al. JOURNAL OF CLINICAL INVESTIGATION
- The Double-Stranded RNA Analogue Polyinosinic-Polycytidylic Acid Induces Keratinocyte Pyroptosis and Release of IL-36γ
- (2012) Li-Hua Lian et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Global Epidemiology of Psoriasis: A Systematic Review of Incidence and Prevalence
- (2012) Rosa Parisi et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist
- (2012) F. L. van de Veerdonk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TIR8/SIGIRR is an Interleukin-1 Receptor/Toll Like Receptor Family Member with Regulatory Functions in Inflammation and Immunity
- (2012) Federica Riva et al. Frontiers in Immunology
- IL-36R ligands are potent regulators of dendritic and T cells
- (2011) S. Vigne et al. BLOOD
- Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels
- (2011) Abbas Dehghan et al. CIRCULATION
- Induction of phenotype modifying cytokines by FERMT1 mutations
- (2011) Anja Heinemann et al. HUMAN MUTATION
- Interleukin-36 (IL-36) Ligands Require Processing for Full Agonist (IL-36α, IL-36β, and IL-36γ) or Antagonist (IL-36Ra) Activity
- (2011) Jennifer E. Towne et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IL-1F5, -F6, -F8, and -F9: A Novel IL-1 Family Signaling System That Is Active in Psoriasis and Promotes Keratinocyte Antimicrobial Peptide Expression
- (2011) A. Johnston et al. JOURNAL OF IMMUNOLOGY
- Inter-Regulation of Th17 Cytokines and the IL-36 Cytokines In Vitro and In Vivo: Implications in Psoriasis Pathogenesis
- (2011) Yijun Carrier et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Interleukin-36–Receptor Antagonist Deficiency and Generalized Pustular Psoriasis
- (2011) Slaheddine Marrakchi et al. NEW ENGLAND JOURNAL OF MEDICINE
- IL-37 is a fundamental inhibitor of innate immunity
- (2010) Marcel F Nold et al. NATURE IMMUNOLOGY
- IL-1 pathways in inflammation and human diseases
- (2010) Cem Gabay et al. Nature Reviews Rheumatology
- The interleukin-1 family gene polymorphisms in Korean patients with rheumatoid arthritis
- (2010) MY Jung et al. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
- Association of IL-1 gene complex members with ankylosing spondylitis in Chinese Han population
- (2009) Z. S. Guo et al. International Journal of Immunogenetics
- Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium
- (2009) Frances Humby et al. PLOS MEDICINE
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