IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

The IL-1 Family Member 7b Translocates to the Nucleus and Down-Regulates Proinflammatory Cytokines

(2014) S. Sharma et al.   JOURNAL OF IMMUNOLOGY

Endogenous IL-32 Controls Cytokine and HIV-1 Production

(2014) M. F. Nold et al.   JOURNAL OF IMMUNOLOGY

Lack of Toll IL-1R8 Exacerbates Th17 Cell Responses in Fungal Infection

(2014) S. Bozza et al.   JOURNAL OF IMMUNOLOGY

Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses

(2014) A.-M. Bulau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-37 protects against obesity-induced inflammation and insulin resistance

(2014) Dov B. Ballak et al.   Nature Communications

IL-37 Inhibits Inflammasome Activation and Disease Severity in Murine Aspergillosis

(2014) Silvia Moretti et al.   PLoS Pathogens

Fyn Deficiency Promotes a Preferential Increase in Subcutaneous Adipose Tissue Mass and Decreased Visceral Adipose Tissue Inflammation

(2013) T.-W. A. Lee et al.   DIABETES

The PTEN inhibitor bisperoxovanadium enhances myelination by amplifying IGF-1 signaling in rat and human oligodendrocyte progenitors

(2013) Marcio L. De Paula et al.   GLIA

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

An endogenous factor mediates shock-induced injury

(2013) Peter A Ward   NATURE MEDICINE

Acute inflammation primes myeloid effector cells for anti-inflammatory STAT6 signaling

(2013) F. Wermeling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The interleukin-1 receptor family

(2013) Diana Boraschi et al.   SEMINARS IN IMMUNOLOGY

Autoimmunity, Intestinal Lymphoid Hyperplasia, and Defects in Mucosal B-Cell Homeostasis in Patients With PTEN Hamartoma Tumor Syndrome

(2012) Mario Heindl et al.   GASTROENTEROLOGY

Common Polymorphisms in the PKP3-SIGIRR-TMEM16J Gene Region Are Associated With Susceptibility to Tuberculosis

(2012) David J. Horne et al.   JOURNAL OF INFECTIOUS DISEASES

Structure of the activating IL-1 receptor signaling complex

(2012) Christoph Thomas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeting of TAK1 in inflammatory disorders and cancer

(2012) Hiroaki Sakurai   TRENDS IN PHARMACOLOGICAL SCIENCES

Interleukin 37 expression protects mice from colitis

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SIGIRR/TIR-8 is an inhibitor of toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis

(2010) Stefan K. Drexler et al.   ARTHRITIS AND RHEUMATISM

The Receptor SIGIRR Suppresses Th17 Cell Proliferation via Inhibition of the Interleukin-1 Receptor Pathway and mTOR Kinase Activation

(2010) Muhammet F. Gulen et al.   IMMUNITY

IL-37 is a fundamental inhibitor of innate immunity

(2010) Marcel F Nold et al.   NATURE IMMUNOLOGY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Increased Cytokine Production in Interleukin-18 Receptor α-deficient Cells Is Associated with Dysregulation of Suppressors of Cytokine Signaling

(2009) Claudia A. Nold-Petry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE

TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization

(2009) Cecilia Garlanda et al.   TRENDS IN IMMUNOLOGY

The Innate Immune Database (IIDB)

(2008) Martin Korb et al.   BMC IMMUNOLOGY