Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation

IL-37 Alleviates Rheumatoid Arthritis by Suppressing IL-17 and IL-17–Triggering Cytokine Production and Limiting Th17 Cell Proliferation

(2015) Liang Ye et al.   JOURNAL OF IMMUNOLOGY

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

(2015) Claudia A Nold-Petry et al.   NATURE IMMUNOLOGY

Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8

(2015) Suzhao Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies

(2015) Giulio Cavalli et al.   RHEUMATOLOGY

Disease-regulated local IL-10 gene therapy diminishes synovitis and cartilage proteoglycan depletion in experimental arthritis

(2014) Eline A Vermeij et al.   ANNALS OF THE RHEUMATIC DISEASES

Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells

(2014) Yuchun Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses

(2014) A.-M. Bulau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-37 protects against obesity-induced inflammation and insulin resistance

(2014) Dov B. Ballak et al.   Nature Communications

IL-37 Inhibits Inflammasome Activation and Disease Severity in Murine Aspergillosis

(2014) Silvia Moretti et al.   PLoS Pathogens

Interleukin-37

(2013) Charles A. Dinarello et al.   SEMINARS IN IMMUNOLOGY

Decoys and Regulatory “Receptors” of the IL-1/Toll-Like Receptor Superfamily

(2013) Cecilia Garlanda et al.   Frontiers in Immunology

From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines

(2012) Jacques Banchereau et al.   NATURE IMMUNOLOGY

Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis

(2011) David Saadoun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin 37 expression protects mice from colitis

(2011) E. N. McNamee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Expression of Interleukin-37 Reduces Local and Systemic Inflammation in Concanavalin A-Induced Hepatitis

(2011) Ana-Maria Bulau et al.   TheScientificWorldJOURNAL

IL-32  and Streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2

(2010) B. Heinhuis et al.   ANNALS OF THE RHEUMATIC DISEASES

Neutrophils in rheumatoid arthritis: More than simple final effectors

(2010) R. Cascão et al.   AUTOIMMUNITY REVIEWS

IL-37 is a fundamental inhibitor of innate immunity

(2010) Marcel F Nold et al.   NATURE IMMUNOLOGY

G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis

(2009) Ann L. Cornish et al.   Nature Reviews Rheumatology

Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis

(2009) Kathrin Schwager et al.   ARTHRITIS RESEARCH & THERAPY