IL-36γ signaling controls the induced regulatory T cell–Th9 cell balance via NFκB activation and STAT transcription factors

Increased Expression of Interleukin-36, a Member of the Interleukin-1 Cytokine Family, in Inflammatory Bowel Disease

(2016) Atsushi Nishida et al.   INFLAMMATORY BOWEL DISEASES

STAT3 Impairs STAT5 Activation in the Development of IL-9–Secreting T Cells

(2016) Matthew R. Olson et al.   JOURNAL OF IMMUNOLOGY

IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation

(2016) S E Russell et al.   Mucosal Immunology

IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity

(2016) Yoichiro Ohne et al.   NATURE IMMUNOLOGY

Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

(2016) Takuro Saito et al.   NATURE MEDICINE

Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines

(2016) Conor M. Henry et al.   Cell Reports

Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme

(2015) Inna S. Afonina et al.   IMMUNITY

Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage

(2015) Oscar Medina-Contreras et al.   JOURNAL OF IMMUNOLOGY

Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditions

(2015) Cem Gabay et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell–iTreg cell balance

(2015) Rajatava Basu et al.   NATURE IMMUNOLOGY

Glucocorticoid-induced tumor necrosis factor receptor–related protein co-stimulation facilitates tumor regression by inducing IL-9–producing helper T cells

(2015) Il-Kyu Kim et al.   NATURE MEDICINE

GITR subverts Foxp3+ Tregs to boost Th9 immunity through regulation of histone acetylation

(2015) Xiang Xiao et al.   Nature Communications

IL-9 and its receptor are predominantly involved in the pathogenesis of UC

(2014) Nancy Nalleweg et al.   GUT

Signaling through the Adaptor Molecule MyD88 in CD4+ T Cells Is Required to Overcome Suppression by Regulatory T Cells

(2014) Dominik Schenten et al.   IMMUNITY

The alarmin IL-33 promotes regulatory T-cell function in the intestine

(2014) Chris Schiering et al.   NATURE

The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells

(2014) Frédérique Végran et al.   NATURE IMMUNOLOGY

TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells

(2014) Katharina Gerlach et al.   NATURE IMMUNOLOGY

Human TH9 Cells Are Skin-Tropic and Have Autocrine and Paracrine Proinflammatory Capacity

(2014) C. Schlapbach et al.   Science Translational Medicine

Epigenetic Thpok silencing limits the time window to choose CD4+ helper-lineage fate in the thymus

(2013) Hirokazu Tanaka et al.   EMBO JOURNAL

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

NF-κB: roles and regulation in different CD4+T-cell subsets

(2013) Hyunju Oh et al.   IMMUNOLOGICAL REVIEWS

Transcriptional and Epigenetic Control of T Helper Cell Specification: Molecular Mechanisms Underlying Commitment and Plasticity

(2012) Yuka Kanno et al.   Annual Review of Immunology

IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells

(2012) S. Vigne et al.   BLOOD

Activin A and TGF-β promote TH9 cell–mediated pulmonary allergic pathology

(2012) Carla P. Jones et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut

(2012) Susan M. Schlenner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Robust tumor immunity to melanoma mediated by interleukin-9–producing T cells

(2012) Rahul Purwar et al.   NATURE MEDICINE

Predisposition to the development of IL-9–secreting T cells in atopic infants

(2011) Weiguo Yao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin-36 (IL-36) Ligands Require Processing for Full Agonist (IL-36α, IL-36β, and IL-36γ) or Antagonist (IL-36Ra) Activity

(2011) Jennifer E. Towne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation

(2011) Christoph Wilhelm et al.   NATURE IMMUNOLOGY

Interleukin-36–Receptor Antagonist Deficiency and Generalized Pustular Psoriasis

(2011) Slaheddine Marrakchi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Interferon-Regulatory Factor 4 Is Essential for the Developmental Program of T Helper 9 Cells

(2010) Valérie Staudt et al.   IMMUNITY

Regulation of IL-9 expression by IL-25 signaling

(2010) Pornpimon Angkasekwinai et al.   NATURE IMMUNOLOGY

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation

(2010) Hua-Chen Chang et al.   NATURE IMMUNOLOGY

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

(2009) Yeonseok Chung et al.   IMMUNITY

CD4 T-cell differentiation and inflammatory bowel disease

(2009) Lauren A. Zenewicz et al.   TRENDS IN MOLECULAR MEDICINE

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

(2008) Valérie Dardalhon et al.   NATURE IMMUNOLOGY

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology