Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury
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Title
Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury
Authors
Keywords
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Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 101, Issue 4, Pages 531-540
Publisher
Wiley
Online
2016-10-22
DOI
10.1002/cpt.541
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Related references
Note: Only part of the references are listed.- Plasma paracetamol concentration at hospital presentation has a dose-dependent relationship with liver injury despite prompt treatment with intravenous acetylcysteine
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- Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity
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- Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells
- (2015) Yuchao Xie et al. XENOBIOTICA
- Clinical and economic characteristics of emergency department visits due to acetaminophen toxicity in the USA
- (2015) Ahmed Altyar et al. BMJ Open
- Effect of the UK's revised paracetamol poisoning management guidelines on admissions, adverse reactions and costs of treatment
- (2014) D. Nicholas Bateman et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis
- (2014) Peter Huebener et al. JOURNAL OF CLINICAL INVESTIGATION
- Stratification of paracetamol overdose patients using new toxicity biomarkers: current candidates and future challenges
- (2014) James W Dear et al. Expert Review of Clinical Pharmacology
- Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital
- (2013) Daniel J. Antoine et al. HEPATOLOGY
- Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial
- (2013) D Nicholas Bateman et al. LANCET
- Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications
- (2013) Mitchell R. McGill et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Long term effect of reduced pack sizes of paracetamol on poisoning deaths and liver transplant activity in England and Wales: interrupted time series analyses
- (2013) K. Hawton et al. BMJ-British Medical Journal
- Scottish and Newcastle Antiemetic Pre-treatment for paracetamol poisoning study (SNAP)
- (2013) H K Ruben Thanacoody et al. BMC Pharmacology & Toxicology
- Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity
- (2012) Daniel J. Antoine et al. JOURNAL OF HEPATOLOGY
- Use of Pharmaco-Metabonomics for Early Prediction of Acetaminophen-Induced Hepatotoxicity in Humans
- (2010) J H Winnike et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Multiplying the serum aminotransferase by the acetaminophen concentration to predict toxicity following overdose
- (2010) Marco L.A. Sivilotti et al. CLINICAL TOXICOLOGY
- Pharmacokinetics of Acetaminophen-Protein Adducts in Adults with Acetaminophen Overdose and Acute Liver Failure
- (2009) L. P. James et al. DRUG METABOLISM AND DISPOSITION
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