Mitochondria, Microglia, and the Immune System—How Are They Linked in Affective Disorders?

Inflammation in psychiatric disorders: what comes first?

(2018) Moisés E. Bauer et al.   Annals of the New York Academy of Sciences

TRIF is a key inflammatory mediator of acute sickness behavior and cancer cachexia

(2018) Kevin G. Burfeind et al.   BRAIN BEHAVIOR AND IMMUNITY

Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis

(2018) Anja Jelinek et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Agents for Bipolar Disorder

(2018) Círia Pereira et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Investigation of short tandem repeats in major depression using whole-genome sequencing data

(2018) Chenglong Yu et al.   JOURNAL OF AFFECTIVE DISORDERS

A Systematic Review of Interleukin-1β in Post-Traumatic Stress Disorder: Evidence from Human and Animal Studies

(2018) Aysha Waheed et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

A meta-analysis of cytokine concentrations in eating disorders

(2018) Bethan Dalton et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Genes Linking Mitochondrial Function, Cognitive Impairment and Depression are Associated with Endophenotypes Serving Precision Medicine

(2018) Peter Petschner et al.   NEUROSCIENCE

Psychiatric risk gene Cacna1c determines mitochondrial resilience against oxidative stress in neurons

(2018) Susanne Michels et al.   Cell Death & Disease

Alterations of the Innate Immune System in Susceptibility and Resilience After Social Defeat Stress

(2018) Oliver Ambrée et al.   Frontiers in Behavioral Neuroscience

Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan

(2018) Tuan Leng Tay et al.   Frontiers in Molecular Neuroscience

Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression

(2018) Josh Allen et al.   Frontiers in Neuroscience

Neurobiology of the major psychoses: a translational perspective on brain structure and function—the FOR2107 consortium

(2018) Tilo Kircher et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Inflammasome signalling in brain function and neurodegenerative disease

(2018) Michael T. Heneka et al.   NATURE REVIEWS NEUROSCIENCE

P2X7 Receptor: A Potential Therapeutic Target for Depression?

(2018) Jan M. Deussing et al.   TRENDS IN MOLECULAR MEDICINE

Assessment of Translocator Protein Density, as Marker of Neuroinflammation, in Major Depressive Disorder: A Pilot, Multicenter, Comparative, Controlled, Brain PET Study (INFLADEP Study)

(2018) Antoine Yrondi et al.   Frontiers in Psychiatry

Mitochondrial function is required for extracellular ATP-induced NLRP3 inflammasome activation

(2017) Daichi Sadatomi et al.   JOURNAL OF BIOCHEMISTRY

Peripheral Alterations in Cytokine and Chemokine Levels After Antidepressant Drug Treatment for Major Depressive Disorder: Systematic Review and Meta-Analysis

(2017) Cristiano A. Köhler et al.   MOLECULAR NEUROBIOLOGY

Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs

(2017) M-X Li et al.   MOLECULAR PSYCHIATRY

Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism

(2017) Daniel J. Tyrrell et al.   Oxidative Medicine and Cellular Longevity

A SYSTEMATIC REVIEW OF TUMOR NECROSIS FACTOR-α IN POST-TRAUMATIC STRESS DISORDER: EVIDENCE FROM HUMAN AND ANIMAL STUDIES

(2017) Serkan Hussein et al.   Psychiatria Danubina

Microglia: An Interface between the Loss of Neuroplasticity and Depression

(2017) Gaurav Singhal et al.   Frontiers in Cellular Neuroscience

Inflammation and depression: a causal or coincidental link to the pathophysiology?

(2017) Brian E. Leonard   ACTA NEUROPSYCHIATRICA

Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia

(2017) Stephanie A. Amici et al.   Frontiers in Immunology

BID links ferroptosis to mitochondrial cell death pathways

(2017) Sandra Neitemeier et al.   Redox Biology

Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders

(2016) Miroslav Adzic et al.   DRUG DEVELOPMENT RESEARCH

Central CCL2 signaling onto MCH neurons mediates metabolic and behavioral adaptation to inflammation

(2016) Ophélia Le Thuc et al.   EMBO REPORTS

The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypes

(2016) Qiuying Zhao et al.   Journal of Neuroinflammation

Microglia across the lifespan: from origin to function in brain development, plasticity and cognition

(2016) Tuan Leng Tay et al.   JOURNAL OF PHYSIOLOGY-LONDON

A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression

(2016) D R Goldsmith et al.   MOLECULAR PSYCHIATRY

Cacna1c in the Prefrontal Cortex Regulates Depression-Related Behaviors via REDD1

(2016) Zeeba D Kabir et al.   NEUROPSYCHOPHARMACOLOGY

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

(2016) Monika Fleshner et al.   NEUROPSYCHOPHARMACOLOGY

Antidepressant therapies inhibit inflammation and microglial M1-polarization

(2016) Hans O. Kalkman et al.   PHARMACOLOGY & THERAPEUTICS

PPAR-γ Agonists for the Treatment of Major Depression: A Review

(2016) R. Colle et al.   PHARMACOPSYCHIATRY

The Bioenergetic Health Index is a sensitive measure of oxidative stress in human monocytes

(2016) Balu K. Chacko et al.   Redox Biology

Major depressive disorder

(2016) Christian Otte et al.   Nature Reviews Disease Primers

Chemical dampening of Ly6Chi monocytes in the periphery produces anti-depressant effects in mice

(2016) Xiao Zheng et al.   Scientific Reports

Clinical characteristics of inflammation-associated depression: Monocyte gene expression is age-related in major depressive disorder

(2015) Laura Grosse et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

New FDA-Approved Disease-Modifying Therapies for Multiple Sclerosis

(2015) Clayton English et al.   CLINICAL THERAPEUTICS

DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites

(2015) Rosalind Norkett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential effects of lipopolysaccharide on energy metabolism in murine microglial N9 and cholinergic SN56 neuronal cells

(2015) Joanna Klimaszewska-Łata et al.   JOURNAL OF NEUROCHEMISTRY

Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome

(2015) Elísabet Alcocer-Gómez et al.   MOLECULAR NEUROBIOLOGY

Erratum: Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons

(2015) T Yoshimizu et al.   MOLECULAR PSYCHIATRY

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Fluoxetine and S-citalopram inhibit M1 activation and promote M2 activation of microglia in vitro

(2015) F. Su et al.   NEUROSCIENCE

The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders

(2015) G.Z. Réus et al.   NEUROSCIENCE

Peripheral and central effects of repeated social defeat stress: Monocyte trafficking, microglial activation, and anxiety

(2015) B.F. Reader et al.   NEUROSCIENCE

Potential involvement of the mitochondrial unfolded protein response in depressive-like symptoms in mice

(2015) Yuki Kambe et al.   NEUROSCIENCE LETTERS

Plasma cytokine abnormalities in drug-naïve, comorbidity-free obsessive–compulsive disorder

(2015) Naren P. Rao et al.   PSYCHIATRY RESEARCH

Evidence of an IFN-γ by early life stress interaction in the regulation of amygdala reactivity to emotional stimuli

(2015) Ronny Redlich et al.   PSYCHONEUROENDOCRINOLOGY

Depression as a Microglial Disease

(2015) Raz Yirmiya et al.   TRENDS IN NEUROSCIENCES

Inflammation and neuronal plasticity: a link between childhood trauma and depression pathogenesis

(2015) Annamaria Cattaneo et al.   Frontiers in Cellular Neuroscience

K+ regulates Ca2+ to drive inflammasome signaling: dynamic visualization of ion flux in live cells

(2015) J R Yaron et al.   Cell Death & Disease

Are Anti-inflammatory Therapies Viable Treatments for Psychiatric Disorders?

(2015) Andrew H. Miller et al.   JAMA Psychiatry

Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis

(2015) Jan Van den Bossche et al.   Jove-Journal of Visualized Experiments

Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression

(2015) A Karabatsiakis et al.   Translational Psychiatry

Charcot-Marie-Tooth Disease, Psychiatric Indicators and Quality of Life: A Systematic Review

(2014) Joana L.C. Cordeiro et al.   ASN Neuro

The Bioenergetic Health Index: a new concept in mitochondrial translational research

(2014) Balu K. Chacko et al.   CLINICAL SCIENCE

Contribution of neural cell death to depressive phenotypes of streptozotocin-induced diabetic mice

(2014) C. Chen et al.   Disease Models & Mechanisms

Cellular Metabolism and Macrophage Functional Polarization

(2014) Linnan Zhu et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Microglia of Prefrontal White Matter in Suicide

(2014) Tatiana P. Schnieder et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Hippocampal Atrophy in Major Depression: a Function of Childhood Maltreatment Rather than Diagnosis?

(2014) Nils Opel et al.   NEUROPSYCHOPHARMACOLOGY

Exercise prevents raphe nucleus mitochondrial overactivity in a rat depression model

(2014) Li Wen et al.   PHYSIOLOGY & BEHAVIOR

A phase-specific neuroimmune model of clinical depression

(2014) H.A. Eyre et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The interplay between iron accumulation, mitochondrial dysfunction, and inflammation during the execution step of neurodegenerative disorders

(2014) Pamela J. Urrutia et al.   Frontiers in Pharmacology

Metabolic Reprograming in Macrophage Polarization

(2014) Silvia Galván-Peña et al.   Frontiers in Immunology

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

(2014) Meera Rath et al.   Frontiers in Immunology

Endotoxin-induced experimental systemic inflammation in humans: A model to disentangle immune-to-brain communication

(2013) Manfred Schedlowski et al.   BRAIN BEHAVIOR AND IMMUNITY

Involvement of Inflammasome Activation in Lipopolysaccharide-induced Mice Depressive-like Behaviors

(2013) Yi Zhang et al.   CNS Neuroscience & Therapeutics

M1 and M2 Macrophages: Oracles of Health and Disease

(2013) Charles Mills   CRITICAL REVIEWS IN IMMUNOLOGY

Research Review: The role of cytokines in depression in adolescents: a systematic review

(2013) Natalie T. Mills et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Therapeutic Efficacy of Suppressing the JAK/STAT Pathway in Multiple Models of Experimental Autoimmune Encephalomyelitis

(2013) Y. Liu et al.   JOURNAL OF IMMUNOLOGY

Evidence for a Dysregulated Immune System in the Etiology of Psychiatric Disorders

(2013) Sinead M. Gibney et al.   Journal of Neuroimmune Pharmacology

Stress-Induced Recruitment of Bone Marrow-Derived Monocytes to the Brain Promotes Anxiety-Like Behavior

(2013) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial activity and oxidative stress markers in peripheral blood mononuclear cells of patients with bipolar disorder, schizophrenia, and healthy subjects

(2013) Carolina Gubert et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Mitochondrial dysfunction and the inflammatory response

(2013) María J. López-Armada et al.   MITOCHONDRION

Mitochondrial respiration in blood platelets of depressive patients

(2013) Jana Hroudová et al.   MITOCHONDRION

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

(2013) S Hong Lee et al.   NATURE GENETICS

Exercising the worry away: How inflammation, oxidative and nitrogen stress mediates the beneficial effect of physical activity on anxiety disorder symptoms and behaviours

(2013) S. Moylan et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Mitochondria and the economy of stress (mal)adaptation

(2013) Éva Morava et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Tumor Necrosis Factor Gene Variation Predicts Hippocampus Volume in Healthy Individuals

(2012) Bernhard T. Baune et al.   BIOLOGICAL PSYCHIATRY

The role of immune genes in the association between depression and inflammation: A review of recent clinical studies

(2012) Chiara Bufalino et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibition of Drp1 provides neuroprotection in vitro and in vivo

(2012) J Grohm et al.   CELL DEATH AND DIFFERENTIATION

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

(2012) Arvand Haschemi et al.   Cell Metabolism

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Innate immunity in the central nervous system

(2012) Richard M. Ransohoff et al.   JOURNAL OF CLINICAL INVESTIGATION

The Psychiatric Manifestations of Mitochondrial Disorders

(2012) Rebecca E. Anglin et al.   JOURNAL OF CLINICAL PSYCHIATRY

Amygdaloid Signature of Peripheral Immune Activation by Bacterial Lipopolysaccharide or Staphylococcal Enterotoxin B

(2012) Geraldine Prager et al.   Journal of Neuroimmune Pharmacology

Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain

(2012) Bernhard T Baune et al.   Journal of Neuroinflammation

Impaired mitochondrial function in psychiatric disorders

(2012) Husseini Manji et al.   NATURE REVIEWS NEUROSCIENCE

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk

(2012) S. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of proteomic signatures associated with depression and psychotic depression in post-mortem brains from major depression patients

(2012) D Martins-de-Souza et al.   Translational Psychiatry

The Diagnostic Challenge of Psychiatric Symptoms in Neurodegenerative Disease

(2011) Josh D. Woolley et al.   JOURNAL OF CLINICAL PSYCHIATRY

Major depressive disorder: new clinical, neurobiological, and treatment perspectives

(2011) David J Kupfer et al.   LANCET

Targeting the BH3-interacting domain death agonist to develop mechanistically unique antidepressants

(2011) O Malkesman et al.   MOLECULAR PSYCHIATRY

Scaling of Brain Metabolism with a Fixed Energy Budget per Neuron: Implications for Neuronal Activity, Plasticity and Evolution

(2011) Suzana Herculano-Houzel   PLoS One

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) Dmitri V. Krysko et al.   TRENDS IN IMMUNOLOGY

Is Depression an Inflammatory Disorder?

(2011) Charles L. Raison et al.   Current Psychiatry Reports

Abnormalities in Mitochondrial Structure in Cells from Patients with Bipolar Disorder

(2010) Anne M. Cataldo et al.   AMERICAN JOURNAL OF PATHOLOGY

The Sterile Inflammatory Response

(2010) Kenneth L. Rock et al.   Annual Review of Immunology

Evaluation of Krebs cycle enzymes in the brain of rats after chronic administration of antidepressants

(2010) Giselli Scaini et al.   BRAIN RESEARCH BULLETIN

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Mitochondrial matters of the brain: the role in Huntington’s disease

(2010) C. Turner et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mitochondrial biology in Alzheimer’s disease pathogenesis

(2010) María F. Galindo et al.   JOURNAL OF NEUROCHEMISTRY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Chronic mild stress damages mitochondrial ultrastructure and function in mouse brain

(2010) Yu Gong et al.   NEUROSCIENCE LETTERS

Beyond the serotonin hypothesis: Mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders

(2010) Ann Gardner et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Inflammation-associated depression: From serotonin to kynurenine

(2010) Robert Dantzer et al.   PSYCHONEUROENDOCRINOLOGY

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo

(2009) A.L.C. Cardoso et al.   JOURNAL OF CONTROLLED RELEASE

The Use of Animal Models in Psychiatric Research and Treatment

(2008) Vaishnav Krishnan et al.   AMERICAN JOURNAL OF PSYCHIATRY

Role of mitochondrial DNA in calcium signaling abnormality in bipolar disorder

(2008) T KATO   CELL CALCIUM

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

(2008) Michael Maes et al.   METABOLIC BRAIN DISEASE

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE

Microglial clearance function in health and disease

(2008) I. Napoli et al.   NEUROSCIENCE

Neuroanatomical Pattern of Mitochondrial Complex I Pathology Varies between Schizophrenia, Bipolar Disorder and Major Depression

(2008) Dorit Ben-Shachar et al.   PLoS One

Early childhood adversity and adolescent depression: the mediating role of continued stress

(2008) N. A. Hazel et al.   PSYCHOLOGICAL MEDICINE

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

(2008) Claire Henchcliffe et al.   Nature clinical practice. Neurology

Paraoxonase-1 deficiency in mice predisposes to vascular inflammation, oxidative stress, and thrombogenicity in the absence of hyperlipidemia

(2007) Dominic S. Ng et al.   CARDIOVASCULAR PATHOLOGY

Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide

(2006) Johann Steiner et al.   JOURNAL OF PSYCHIATRIC RESEARCH