Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs

Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor

(2016) Masaaki Iwata et al.   BIOLOGICAL PSYCHIATRY

Chronic glucocorticoids exposure enhances neurodegeneration in the frontal cortex and hippocampus via NLRP-1 inflammasome activation in male mice

(2016) Wen Hu et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroinflammatory Dynamics Underlie Memory Impairments after Repeated Social Defeat

(2016) Daniel B. McKim et al.   JOURNAL OF NEUROSCIENCE

Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition

(2016) M-L Wong et al.   MOLECULAR PSYCHIATRY

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

ASC provides a potential link between depression and inflammatory disorders: A clinical study of depressed Iranian medical students

(2016) Mohammad Momeni et al.   NORDIC JOURNAL OF PSYCHIATRY

Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation

(2015) Ji-chun Zhang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome

(2015) Elísabet Alcocer-Gómez et al.   MOLECULAR NEUROBIOLOGY

Ketamine ameliorates depressive-like behaviors and immune alterations in adult rats following maternal deprivation

(2015) Gislaine Z. Réus et al.   NEUROSCIENCE LETTERS

Microglia activation regulates GluR1 phosphorylation in chronic unpredictable stress-induced cognitive dysfunction

(2015) Mingchao Liu et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

An excitatory synapse hypothesis of depression

(2015) Scott M. Thompson et al.   TRENDS IN NEUROSCIENCES

Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes

(2015) Elena Viganò et al.   Nature Communications

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

Impact of adolescent GluA1 AMPA receptor ablation in forebrain excitatory neurons on behavioural correlates of mood disorders

(2014) Miriam A. Vogt et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Interactions between N-Ethylmaleimide-Sensitive Factor and GluR2 in the Nucleus Accumbens Contribute to the Expression of Locomotor Sensitization to Cocaine

(2014) H.-F. Lu et al.   JOURNAL OF NEUROSCIENCE

Modulation of Intestinal Microbiota by the Probiotic VSL#3 Resets Brain Gene Expression and Ameliorates the Age-Related Deficit in LTP

(2014) Eleonora Distrutti et al.   PLoS One

Peripubertal stress-induced behavioral changes are associated with altered expression of genes involved in excitation and inhibition in the amygdala

(2014) S Tzanoulinou et al.   Translational Psychiatry

NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder

(2013) Elísabet Alcocer-Gómez et al.   BRAIN BEHAVIOR AND IMMUNITY

Involvement of Inflammasome Activation in Lipopolysaccharide-induced Mice Depressive-like Behaviors

(2013) Yi Zhang et al.   CNS Neuroscience & Therapeutics

Effects of chronic social defeat stress on behaviour, endoplasmic reticulum proteins and choline acetyltransferase in adolescent mice

(2013) Guang-Biao Huang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Interleukin-1 beta converting enzyme is necessary for development of depression-like behavior following intracerebroventricular administration of lipopolysaccharide to mice

(2013) Marcus A Lawson et al.   Journal of Neuroinflammation

Chronic Stress Induces a Selective Decrease in AMPA Receptor-Mediated Synaptic Excitation at Hippocampal Temporoammonic-CA1 Synapses

(2013) A. J. Kallarackal et al.   JOURNAL OF NEUROSCIENCE

Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression

(2013) Xiang Cai et al.   NATURE NEUROSCIENCE

The differential effects of acute vs. chronic stress and their combination on hippocampal parvalbumin and inducible heat shock protein 70 expression

(2013) D. Filipović et al.   NEUROSCIENCE

Antidepressant effects of AMPA and ketamine combination: role of hippocampal BDNF, synapsin, and mTOR

(2013) Luli Akinfiresoye et al.   PSYCHOPHARMACOLOGY

Brain-Derived Neurotrophic Factor-Dependent Synaptic Plasticity Is Suppressed by Interleukin-1  via p38 Mitogen-Activated Protein Kinase

(2012) L. Tong et al.   JOURNAL OF NEUROSCIENCE

Interleukin-1  Causes Anxiety by Interacting with the Endocannabinoid System

(2012) S. Rossi et al.   JOURNAL OF NEUROSCIENCE

Dysfunctional astrocytic regulation of glutamate transmission in a rat model of depression

(2012) M Gómez-Galán et al.   MOLECULAR PSYCHIATRY

Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens

(2012) Byung Kook Lim et al.   NATURE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Repeated Stress Causes Cognitive Impairment by Suppressing Glutamate Receptor Expression and Function in Prefrontal Cortex

(2012) Eunice Y. Yuen et al.   NEURON

Chronic restraint stress attenuates p53 function and promotes tumorigenesis

(2012) Z. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder

(2012) P H Lee et al.   Translational Psychiatry

Sensorimotor gating, working and social memory deficits in mice with reduced expression of the vesicular glutamate transporter VGLUT1

(2011) Dragos Inta et al.   BEHAVIOURAL BRAIN RESEARCH

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

A standardized protocol for repeated social defeat stress in mice

(2011) Sam A Golden et al.   Nature Protocols

Towards a glutamate hypothesis of depression

(2011) Gerard Sanacora et al.   NEUROPHARMACOLOGY

Cytokine levels in the blood may distinguish suicide attempters from depressed patients

(2010) Shorena Janelidze et al.   BRAIN BEHAVIOR AND IMMUNITY

Bacterial infection causes stress-induced memory dysfunction in mice

(2010) M. G. Gareau et al.   GUT

Stress Impairs GABAergic Network Function in the Hippocampus by Activating Nongenomic Glucocorticoid Receptors and Affecting the Integrity of the Parvalbumin-Expressing Neuronal Network

(2010) Wen Hu et al.   NEUROPSYCHOPHARMACOLOGY

Deficiency in Endocannabinoid Signaling in the Nucleus Accumbens Induced by Chronic Unpredictable Stress

(2010) Wei Wang et al.   NEUROPSYCHOPHARMACOLOGY

The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?

(2010) Christoph Anacker et al.   PSYCHONEUROENDOCRINOLOGY

Increased Vulnerability to Depressive-Like Behavior of Mice with Decreased Expression of VGLUT1

(2009) Alvaro L. Garcia-Garcia et al.   BIOLOGICAL PSYCHIATRY

Stress and IL-1β contribute to the development of depressive-like behavior following peripheral nerve injury

(2009) G J Norman et al.   MOLECULAR PSYCHIATRY

Stability of surface NMDA receptors controls synaptic and behavioral adaptations to amphetamine

(2009) Li-Min Mao et al.   NATURE NEUROSCIENCE

Reduced expression of glutamate transporters vGluT1, EAAT2 and EAAT4 in learned helpless rats, an animal model of depression

(2009) M. Zink et al.   NEUROPHARMACOLOGY

Interleukin-1 receptor null mutant mice show decreased anxiety-like behavior and enhanced fear memory

(2009) Ja Wook Koo et al.   NEUROSCIENCE LETTERS

AMPA receptor subunit 1 (GluR-A) knockout mice model the glutamate hypothesis of depression

(2008) S. Chourbaji et al.   FASEB JOURNAL

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE

IL-1 is an essential mediator of the antineurogenic and anhedonic effects of stress

(2008) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spine-Type-Specific Recruitment of Newly Synthesized AMPA Receptors with Learning

(2008) N. Matsuo et al.   SCIENCE

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

(2007) Sungho Maeng et al.   BIOLOGICAL PSYCHIATRY