Self-extracellular RNA acts in synergy with exogenous danger signals to promote inflammation

Targeting of Extracellular RNA Reduces Edema Formation and Infarct Size and Improves Survival After Myocardial Infarction in Mice

(2017) Philipp Stieger et al.   Journal of the American Heart Association

The expression and localization of RNase and RNase inhibitor in blood cells and vascular endothelial cells in homeostasis of the vascular system

(2017) Ayaka Ohashi et al.   PLoS One

Extracellular Ribonucleic Acids (RNA) Enter the Stage in Cardiovascular Disease

(2016) Alma Zernecke et al.   CIRCULATION RESEARCH

Recognition of Endogenous Nucleic Acids by the Innate Immune System

(2016) Axel Roers et al.   IMMUNITY

Influence of Extracellular RNAs, Released by Rheumatoid Arthritis Synovial Fibroblasts, on Their Adhesive and Invasive Properties

(2016) Birgit Zimmermann-Geller et al.   JOURNAL OF IMMUNOLOGY

RAGE Enhances TLR Responses through Binding and Internalization of RNA

(2016) Damien Bertheloot et al.   JOURNAL OF IMMUNOLOGY

Circulating cell-free DNA is elevated in community-acquired bacterial pneumonia and predicts short-term outcome

(2016) William W. Siljan et al.   JOURNAL OF INFECTION

Molecular mechanisms of regulation of Toll-like receptor signaling

(2016) Cynthia A. Leifer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Extracellular histones, cell-free DNA, or nucleosomes: differences in immunostimulation

(2016) Gerben Marsman et al.   Cell Death & Disease

Perivascular Mast Cells Govern Shear Stress-Induced Arteriogenesis by Orchestrating Leukocyte Function

(2016) Omary Chillo et al.   Cell Reports

Cardiac RNA Induces Inflammatory Responses in Cardiomyocytes and Immune CellsviaToll-like Receptor 7 Signaling

(2015) Yan Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of monocyte/macrophage polarisation by extracellular RNA

(2015) Hector Cabrera-Fuentes et al.   THROMBOSIS AND HAEMOSTASIS

Endogenous Damage-Associated Molecular Pattern Molecules at the Crossroads of Inflammation and Cancer

(2015) Geetha Srikrishna et al.   NEOPLASIA

Impact of extracellular RNA on endothelial barrier function

(2014) Silvia Fischer et al.   CELL AND TISSUE RESEARCH

Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

(2014) Liliana Schaefer   JOURNAL OF BIOLOGICAL CHEMISTRY

HMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines

(2014) Y. Sha et al.   JOURNAL OF IMMUNOLOGY

High Mobility Group Box 1 Protein Binding to Lipopolysaccharide Facilitates Transfer of Lipopolysaccharide to CD14 and Enhances Lipopolysaccharide-Mediated TNF-  Production in Human Monocytes

(2014) J. H. Youn et al.   JOURNAL OF IMMUNOLOGY

RNase1 prevents the damaging interplay between extracellular RNA and tumour necrosis factor-α in cardiac ischaemia/reperfusion injury

(2014) Hector Cabrera-Fuentes et al.   THROMBOSIS AND HAEMOSTASIS

Role of Extracellular RNA and TLR3‐Trif Signaling in Myocardial Ischemia–Reperfusion Injury

(2014) Chan Chen et al.   Journal of the American Heart Association

Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4

(2013) M. E. Jaax et al.   BLOOD

Extracellular RNA Liberates Tumor Necrosis Factor-  to Promote Tumor Cell Trafficking and Progression

(2013) S. Fischer et al.   CANCER RESEARCH

Extracellular RNA promotes leukocyte recruitment in the vascular system by mobilising proinflammatory cytokines

(2012) Judith I. Pagel et al.   THROMBOSIS AND HAEMOSTASIS

Histones induce rapid and profound thrombocytopenia in mice

(2011) T. A. Fuchs et al.   BLOOD

Deciphering the function of nucleic acid sensing TLRs one regulatory step at a time

(2011) Lorri et al.   Frontiers in Bioscience-Landmark

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) Dmitri V. Krysko et al.   TRENDS IN IMMUNOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Endogenous toll-like receptor ligands and their biological significance

(2010) Li Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

(2009) Hideyuki Yanai et al.   NATURE

Pattern recognition receptors and control of adaptive immunity

(2008) Noah W. Palm et al.   IMMUNOLOGICAL REVIEWS

Pathogen recognition by innate receptors

(2008) Yutaro Kumagai et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY