Icariside II Ameliorates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Inhibiting the Amyloidogenic Pathway: Involvement of BDNF/TrkB/CREB Signaling and Up-Regulation of PPARα and PPARγ in Rats

N-3 PUFA diet enrichment prevents amyloid beta-induced depressive-like phenotype

(2018) M.G. Morgese et al.   PHARMACOLOGICAL RESEARCH

Neprilysin degrades murine Amyloid-β (Aβ) more efficiently than human Aβ: Further implication for species-specific amyloid accumulation

(2018) Matthias Becker et al.   NEUROSCIENCE LETTERS

Can an Infection Hypothesis Explain the Beta Amyloid Hypothesis of Alzheimer’s Disease?

(2018) Tamas Fulop et al.   Frontiers in Aging Neuroscience

Identification of dibenzyl imidazolidine and triazole acetamide derivatives through virtual screening targeting amyloid beta aggregation and neurotoxicity in PC12 cells

(2017) Sukanya Das et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer’s Disease Neuropathology

(2017) Nadia Canu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of BDNF in Alzheimer's disease

(2017) Heikki Tanila   NEUROBIOLOGY OF DISEASE

Antidepressant drugs for beta amyloid-induced depression: A new standpoint?

(2017) Stefania Schiavone et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Islet amyloid polypeptide: Another key molecule in Alzheimer’s pathogenesis?

(2017) Yun Zhang et al.   PROGRESS IN NEUROBIOLOGY

Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice

(2017) Haobin Cai et al.   Oncotarget

Icariside II, a Broad-Spectrum Anti-cancer Agent, Reverses Beta-Amyloid-Induced Cognitive Impairment through Reducing Inflammation and Apoptosis in Rats

(2017) Yuanyuan Deng et al.   Frontiers in Pharmacology

Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer’s Disease Model Mice Targeting Beta-Amyloid Production

(2017) Lingli Yan et al.   Frontiers in Pharmacology

Protective Effect of 17β-Estradiol Upon Hippocampal Spine Density and Cognitive Function in an Animal Model of Vascular Dementia

(2017) Ying Zhu et al.   Scientific Reports

DL0410, a novel dual cholinesterase inhibitor, protects mouse brains against Aβ-induced neuronal damage via the Akt/JNK signaling pathway

(2016) Dan Zhou et al.   ACTA PHARMACOLOGICA SINICA

Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer’s disease?

(2016) Olga Pivovarova et al.   ANNALS OF MEDICINE

Baclofen ameliorates spatial working memory impairments induced by chronic cerebral hypoperfusion via up-regulation of HCN2 expression in the PFC in rats

(2016) Pan Luo et al.   BEHAVIOURAL BRAIN RESEARCH

Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model

(2016) Loqman A. Mohamed et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Rannasangpei Is a Therapeutic Agent in the Treatment of Vascular Dementia

(2016) Peng Wu et al.   Evidence-based Complementary and Alternative Medicine

A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis

(2016) Robert J. Andrew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of exercise-induced neurogenesis on cognitive function deficit in a rat model of vascular dementia

(2016) DONG-HEE CHOI et al.   Molecular Medicine Reports

Chronic cerebral hypoperfusion-induced impairment of Aβ clearance requires HB-EGF-dependent sequential activation of HIF1α and MMP9

(2016) Anushruti Ashok et al.   NEUROBIOLOGY OF DISEASE

Icariside II protects against cerebral ischemia–reperfusion injury in rats via nuclear factor-κB inhibition and peroxisome proliferator-activated receptor up-regulation

(2016) Yuanyuan Deng et al.   NEUROCHEMISTRY INTERNATIONAL

Icariside II, a novel phosphodiesterase-5 inhibitor, attenuates streptozotocin-induced cognitive deficits in rats

(2016) Caixia Yin et al.   NEUROSCIENCE

Killing Me Softly: Connotations to Unfolded Protein Response and Oxidative Stress in Alzheimer’s Disease

(2016) Beata Pająk et al.   Oxidative Medicine and Cellular Longevity

S-adenosylmethionine Administration Attenuates Low Brain-Derived Neurotrophic Factor Expression Induced by Chronic Cerebrovascular Hypoperfusion or Beta Amyloid Treatment

(2016) Qian Li et al.   Neuroscience Bulletin

The Anticancer Properties of Herba Epimedii and Its Main Bioactive Componentsicariin and Icariside II

(2016) Meixia Chen et al.   Nutrients

Current Research Therapeutic Strategies for Alzheimer’s Disease Treatment

(2016) Jaume Folch et al.   NEURAL PLASTICITY

Neurokinin-1 receptor inhibition reverses ischaemic brain injury and dementia in bilateral common carotid artery occluded rats: possible mechanisms

(2016) Jaspreet Kaur et al.   INFLAMMOPHARMACOLOGY

(−)-Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer׳s disease model mice by upregulating neprilysin expression

(2015) Xiang Chang et al.   EXPERIMENTAL CELL RESEARCH

Activation of Cdk5/p25 and tau phosphorylation following chronic brain hypoperfusion in rats involves microRNA-195 down-regulation

(2015) Li-Hua Sun et al.   JOURNAL OF NEUROCHEMISTRY

Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 Mice

(2015) D. R. Thakker et al.   JOURNAL OF NEUROSCIENCE

CREB expression mediates amyloid β-induced basal BDNF downregulation

(2015) Elyse Rosa et al.   NEUROBIOLOGY OF AGING

Icariin decreases both APP and Aβ levels and increases neurogenesis in the brain of Tg2576 mice

(2015) F. Li et al.   NEUROSCIENCE

Donepezil improves learning and memory deficits in APP/PS1 mice by inhibition of microglial activation

(2015) H.B. Guo et al.   NEUROSCIENCE

Ketamine-mediated alleviation of electroconvulsive shock-induced memory impairment is associated with the regulation of neuroinflammation and soluble amyloid-beta peptide in depressive-like rats

(2015) Xianlin Zhu et al.   NEUROSCIENCE LETTERS

Accumulation of BRI2-BRICHOS ectodomain correlates with a decreased clearance of Aβ by insulin degrading enzyme (IDE) in Alzheimer’s disease

(2015) M. Del Campo et al.   NEUROSCIENCE LETTERS

Icariin, a major constituent of flavonoids from Epimedium brevicornum, protects against cognitive deficits induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats

(2015) Wen-Xian Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Clonidine ameliorates cognitive impairment induced by chronic cerebral hypoperfusion via up-regulation of the GABABR1 and GAD67 in hippocampal CA1 in rats

(2015) Yun Lu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Intraperitoneal Administration of a Novel TAT-BDNF Peptide Ameliorates Cognitive Impairments via Modulating Multiple Pathways in Two Alzheimer’s Rodent Models

(2015) Yuanyuan Wu et al.   Scientific Reports

From Chronic Cerebral Hypoperfusion to Alzheimer-Like Brain Pathology and Neurodegeneration

(2014) Yang Zhao et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease

(2014) Arun K. Ghosh et al.   CHEMICAL SOCIETY REVIEWS

Fenofibrate reduces amyloidogenic processing of APP in APP/PS1 transgenic mice via PPAR-α/PI3-K pathway

(2014) Hua Zhang et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Sigma 1 receptor activation regulates brain-derived neurotrophic factor through NR2A-CaMKIV-TORC1 pathway to rescue the impairment of learning and memory induced by brain ischaemia/reperfusion

(2014) Qian Xu et al.   PSYCHOPHARMACOLOGY

Reciprocal modulation of Aβ42 aggregation by copper and homocysteine

(2014) Salla Keskitalo et al.   Frontiers in Aging Neuroscience

MicroRNA-195 Protects Against Dementia Induced by Chronic Brain Hypoperfusion via Its Anti-Amyloidogenic Effect in Rats

(2013) J. Ai et al.   JOURNAL OF NEUROSCIENCE

ADAM10 Prodomain Mutations Cause Late-Onset Alzheimer’s Disease: Not Just the Latest FAD

(2013) Robert Vassar   NEURON

Pharmacological prevention and treatment of vascular dementia: Approaches and perspectives

(2012) Andrius Baskys et al.   EXPERIMENTAL GERONTOLOGY