The Anticancer Properties of Herba Epimedii and Its Main Bioactive Componentsicariin and Icariside II

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Icariside II inhibits the EMT of NSCLC cells in inflammatory microenvironment via down-regulation of Akt/NF-κB signaling pathway

(2016) Jie Song et al.   MOLECULAR CARCINOGENESIS

Icariin inhibits oxidized low-density lipoprotein-induced proliferation of vascular smooth muscle cells by suppressing activation of extracellular signal-regulated kinase 1/2 and expression of proliferating cell nuclear antigen

(2016) YANWU HU et al.   Molecular Medicine Reports

Icariside II protects against cerebral ischemia–reperfusion injury in rats via nuclear factor-κB inhibition and peroxisome proliferator-activated receptor up-regulation

(2016) Yuanyuan Deng et al.   NEUROCHEMISTRY INTERNATIONAL

Icariside II, a novel phosphodiesterase-5 inhibitor, attenuates streptozotocin-induced cognitive deficits in rats

(2016) Caixia Yin et al.   NEUROSCIENCE

Icariside II, a natural mTOR inhibitor, disrupts aberrant energy homeostasis via suppressing mTORC1-4E-BP1 axis in sarcoma cells

(2016) Chao Zhang et al.   Oncotarget

Icariin displays anticancer activity against human esophageal cancer cells via regulating endoplasmic reticulum stress-mediated apoptotic signaling

(2016) Chongxi Fan et al.   Scientific Reports

Activation of endoplasmic reticulum stress is involved in the activity of icariin against human lung adenocarcinoma cells

(2015) Shouyin Di et al.   APOPTOSIS

Icariin Enhances Cytotoxicity of Doxorubicin in Human Multidrug-Resistant Osteosarcoma Cells by Inhibition of ABCB1 and Down-Regulation of the PI3K/Akt Pathway

(2015) Zhendong Wang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Icariside II-induced mitochondrion and lysosome mediated apoptosis is counterbalanced by an autophagic salvage response in hepatoblastoma

(2015) Ya-di Geng et al.   CANCER LETTERS

Icariin Exerts Protective Effect Against Myocardial Ischemia/Reperfusion Injury in Rats

(2015) Xing Meng et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Icariin Acts as a Potential Agent for Preventing Cardiac Ischemia/Reperfusion Injury

(2015) Minghe Zhai et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Arsenic Trioxide and Icariin Show Synergistic Anti-leukemic Activity

(2015) Zhi Wang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Herba Epimedii: An Ancient Chinese Herbal Medicine in the Prevention and Treatment of Osteoporosis

(2015) Lili Wang et al.   CURRENT PHARMACEUTICAL DESIGN

Regulation of Th17/Treg function contributes to the attenuation of chronic airway inflammation by icariin in ovalbumin-induced murine asthma model

(2015) Ying Wei et al.   IMMUNOBIOLOGY

Targeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer Cells

(2015) Muhammad Khan et al.   International Journal of Biological Sciences

Icariin: A promising osteoinductive compound for repairing bone defect and osteonecrosis

(2015) Xiaowei Xie et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Anti-proliferative and cytoskeleton-disruptive effects of icariin on HepG2 cells

(2015) ZHI-MIN WANG et al.   Molecular Medicine Reports

Icariin exerts an antidepressant effect in an unpredictable chronic mild stress model of depression in rats and is associated with the regulation of hippocampal neuroinflammation

(2015) B. Liu et al.   NEUROSCIENCE

Icariin regulates the proliferation and apoptosis of human ovarian cancer cells through microRNA-21 by targeting PTEN, RECK and Bcl-2

(2015) JINGWEI LI et al.   ONCOLOGY REPORTS

Roles of the antioxidant properties of icariin and its phosphorylated derivative in the protection against duck virus hepatitis

(2014) Wen Xiong et al.   BMC Veterinary Research

Icariin-Mediated Inhibition of NF-κB Activity Enhances the In Vitro and In Vivo Antitumour Effect of 5-Fluorouracil in Colorectal Cancer

(2014) De-Bing Shi et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Synergistic Anti-Cancer Effects of Icariin and Temozolomide in Glioblastoma

(2014) Lijuan Yang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Blockade of epidermal growth factor receptor/mammalian target of rapamycin pathway by Icariside II results in reduced cell proliferation of osteosarcoma cells

(2014) Ya-di Geng et al.   FOOD AND CHEMICAL TOXICOLOGY

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Icariside II inhibits cell proliferation and induces cell cycle arrest through the ROS-p38-p53 signaling pathway in A375 human melanoma cells

(2014) JINFENG WU et al.   Molecular Medicine Reports

Icariin Synergizes with Arsenic Trioxide to Suppress Human Hepatocellular Carcinoma

(2013) Wen Li et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Icariside II induces apoptosis via inhibition of the EGFR pathways in A431 human epidermoid carcinoma cells

(2013) JINFENG WU et al.   Molecular Medicine Reports

Icariside II Induces Apoptosis of Melanoma Cells Through the Downregulation of Survival Pathways

(2013) Jinfeng Wu et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Isolation, Purification and Characterization of Vinblastine and Vincristine from Endophytic Fungus Fusarium oxysporum Isolated from Catharanthus roseus

(2013) Ashutosh Kumar et al.   PLoS One

Icariin potentiates the antitumor activity of gemcitabine in gallbladder cancer by suppressing NF-κB

(2012) Dian-cai Zhang et al.   ACTA PHARMACOLOGICA SINICA

Induction of Apoptosis by Icariside II through Extrinsic and Intrinsic Signaling Pathways in Human Breast Cancer MCF7 Cells

(2012) Chaoqing HUANG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locations

(2012) Woody Han et al.   CANCER LETTERS

Plant natural compounds: targeting pathways of autophagy as anti-cancer therapeutic agents

(2012) X. Zhang et al.   CELL PROLIFERATION

Targeting the MAPK–RAS–RAF signaling pathway in cancer therapy

(2012) Libero Santarpia et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Icariside II potentiates paclitaxel-induced apoptosis in human melanoma A375 cells by inhibiting TLR4 signaling pathway

(2012) Jinfeng Wu et al.   FOOD AND CHEMICAL TOXICOLOGY

Icariside II Induces Apoptosis in U937 Acute Myeloid Leukemia Cells: Role of Inactivation of STAT3-Related Signaling

(2012) Sang-Hun Kang et al.   PLoS One

Delivery of interferon alpha using a novel Cox2-controlled adenovirus for pancreatic cancer therapy

(2012) Leonard Armstrong et al.   SURGERY

Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions

(2011) Junmin Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The genus Epimedium: An ethnopharmacological and phytochemical review

(2011) Huiping Ma et al.   JOURNAL OF ETHNOPHARMACOLOGY

Icariin Derivative Inhibits Inflammation through Suppression of p38 Mitogen-Activated Protein Kinase and Nuclear Factor-κB Pathways

(2010) Shao-Rui Chen et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Neuroprotective effects of icariin on corticosterone-induced apoptosis in primary cultured rat hippocampal neurons

(2010) Baojun Liu et al.   BRAIN RESEARCH

Icariin, a natural flavonol glycoside, induces apoptosis in human hepatoma SMMC-7721 cells via a ROS/JNK-dependent mitochondrial pathway

(2010) Songgang Li et al.   CANCER LETTERS

Icariin exterts negative effects on human gastric cancer cell invasion and migration by vasodilator-stimulated phosphoprotein via Rac1 pathway

(2010) Yongping Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Janus activated kinase 2/signal transducer and activator of transcription 3 pathway mediates icariside II-induced apoptosis in U266 multiple myeloma cells

(2010) Sun-Hee Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-Proliferative Efficacy of Icariin on HepG2 Hepatoma and Its Possible Mechanism of Action

(2009) Jin-Xia Yang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Cyclooxygenase-2/prostaglandin E2 pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells

(2009) Keun-Sung Lee et al.   CANCER LETTERS

Preparation of icariside II from icariin by enzymatic hydrolysis method

(2009) Quan Xia et al.   FITOTERAPIA

Perspectives for Cancer Prevention With Natural Compounds

(2009) A.R.M. Ruhul Amin et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Anti cancer effects of curcumin: cycle of life and death

(2008) Gaurisankar Sa et al.   Cell Division

Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1α in human osteosarcoma cells

(2007) Hwa Jung Choi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY