The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer’s Disease Neuropathology

Cerebrospinal Fluid Levels of a 20–22 kDa NH2 Fragment of Human Tau Provide a Novel Neuronal Injury Biomarker in Alzheimer's Disease and Other Dementias

(2018) Giuseppina Amadoro et al.   JOURNAL OF ALZHEIMERS DISEASE

ProNGF, but Not NGF, Switches from Neurotrophic to Apoptotic Activity in Response to Reductions in TrkA Receptor Levels

(2017) Maria Ioannou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons

(2017) Valentina Latina et al.   Frontiers in Cellular Neuroscience

Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents

(2017) Nadia Canu et al.   Frontiers in Molecular Neuroscience

Truncation of Tau Protein and its Pathological Significance in Alzheimer's Disease

(2017) Francisco García-Sierra et al.   JOURNAL OF ALZHEIMERS DISEASE

Activation of the Amyloidogenic Route by NGF Deprivation Induces Apoptotic Death in PC12 Cells

(2017) Carmela Matrone et al.   JOURNAL OF ALZHEIMERS DISEASE

A NH2 Tau Fragment Targets Neuronal Mitochondria at AD Synapses: Possible Implications for Neurodegeneration

(2017) Giuseppina Amadoro et al.   JOURNAL OF ALZHEIMERS DISEASE

NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease

(2016) Viviana Triaca et al.   AGING CELL

Alzheimer's disease: The amyloid hypothesis on trial

(2016) Judith R. Harrison et al.   BRITISH JOURNAL OF PSYCHIATRY

Amyloid precursor protein–mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration

(2016) Wei Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Suspected non-Alzheimer disease pathophysiology — concept and controversy

(2016) Clifford R. Jack et al.   Nature Reviews Neurology

Impairment of the nerve growth factor pathway driving amyloid accumulation in cholinergic neurons: the incipit of the Alzheimer′s disease story?

(2016) Viviana Triaca et al.   Neural Regeneration Research

Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer’s disease

(2015) Alaina Baker-Nigh et al.   BRAIN

The NGF Metabolic Pathway in the CNS and its Dysregulation in Down Syndrome and Alzheimer's Disease

(2015) M. Florencia Iulita et al.   Current Alzheimer Research

Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease

(2015) Sophie Sokolow et al.   JOURNAL OF NEUROCHEMISTRY

Tau-Directed Immunotherapy: A Promising Strategy for Treating Alzheimer’s Disease and Other Tauopathies

(2015) Sulana K. Schroeder et al.   Journal of Neuroimmune Pharmacology

Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer’s disease

(2015) S Kim et al.   MOLECULAR PSYCHIATRY

Tau Immunotherapy

(2015) Einar M. Sigurdsson   Neurodegenerative Diseases

Y682G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP–SorLA Interaction

(2015) Luca Rosario La Rosa et al.   Frontiers in Cellular Neuroscience

Nerve Growth Factor Gene Therapy

(2015) Mark H. Tuszynski et al.   JAMA Neurology

The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease

(2015) Josiane Budni et al.   Aging and Disease

Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease

(2014) Cassia R. Overk et al.   BIOCHEMICAL PHARMACOLOGY

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

(2014) Christiane Reitz et al.   BIOCHEMICAL PHARMACOLOGY

Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies

(2014) Chun-ling Dai et al.   JOURNAL OF NEURAL TRANSMISSION

Effects of sustained proNGF blockade on attentional capacities in aged rats with compromised cholinergic system

(2014) B. Yegla et al.   NEUROSCIENCE

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Cholinergic circuitry of the human nucleus basalis and its fate in Alzheimer's disease

(2013) M.-Marsel Mesulam   JOURNAL OF COMPARATIVE NEUROLOGY

Up-regulation of sortilin mediated by amyloid-β and p75NTR: safety lies in the middle course

(2013) Elizabeth J. Coulson et al.   JOURNAL OF NEUROCHEMISTRY

Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein

(2013) C. Gustafsen et al.   JOURNAL OF NEUROSCIENCE

Aβ-independent processes—rethinking preclinical AD

(2013) Gaël Chételat   Nature Reviews Neurology

Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway

(2013) Utpal Das et al.   NEURON

Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo

(2013) Kiran Yanamandra et al.   NEURON

An Intracellular Threonine of Amyloid-β Precursor Protein Mediates Synaptic Plasticity Deficits and Memory Loss

(2013) Franco Lombino et al.   PLoS One

APP Regulates NGF Receptor Trafficking and NGF-Mediated Neuronal Differentiation and Survival

(2013) Yun-wu Zhang et al.   PLoS One

Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance

(2012) Carmela Matrone et al.   AGING CELL

Diminished trkA receptor signaling reveals cholinergic-attentional vulnerability of aging

(2012) Vinay Parikh et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system

(2012) Nicholas M. Kanaan et al.   EXPERIMENTAL NEUROLOGY

Hippocampal ProNGF Signaling Pathways and β-Amyloid Levels in Mild Cognitive Impairment and Alzheimer Disease

(2012) Elliott J. Mufson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Nerve Growth Factor and Alzheimer's Disease: New Facts for an Old Hypothesis

(2012) Antonino Cattaneo et al.   MOLECULAR NEUROBIOLOGY

Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease

(2012) Michel Grothe et al.   NEUROBIOLOGY OF AGING

Mild cognitive impairment: pathology and mechanisms

(2011) Elliott J. Mufson et al.   ACTA NEUROPATHOLOGICA

Atrophy of the Cholinergic Basal Forebrain Over the Adult Age Range and in Early Stages of Alzheimer's Disease

(2011) Michel Grothe et al.   BIOLOGICAL PSYCHIATRY

APP is Phosphorylated by TrkA and Regulates NGF/TrkA Signaling

(2011) C. Matrone et al.   JOURNAL OF NEUROSCIENCE

Tau Protein Is Required for Amyloid  -Induced Impairment of Hippocampal Long-Term Potentiation

(2011) O. A. Shipton et al.   JOURNAL OF NEUROSCIENCE

Interaction between NH2-tau fragment and Aβ in Alzheimer's disease mitochondria contributes to the synaptic deterioration

(2011) Giuseppina Amadoro et al.   NEUROBIOLOGY OF AGING

SORLA/SORL1, a Neuronal Sorting Receptor Implicated in Alzheimer's Disease

(2011) Thomas E. Willnow et al.   REVIEWS IN THE NEUROSCIENCES

The pathological process underlying Alzheimer’s disease in individuals under thirty

(2010) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

The cholinergic system, nerve growth factor and the cytoskeleton

(2010) Grazyna Niewiadomska et al.   BEHAVIOURAL BRAIN RESEARCH

The cholinergic system in aging and neuronal degeneration

(2010) Reinhard Schliebs et al.   BEHAVIOURAL BRAIN RESEARCH

Proteolytic processing of tau

(2010) Yipeng Wang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Does the term ‘trophic’ actually mean anti-amyloidogenic? The case of NGF

(2010) P Calissano et al.   CELL DEATH AND DIFFERENTIATION

Nerve growth factor as a paradigm of neurotrophins related to Alzheimer's disease

(2010) P. Calissano et al.   Developmental Neurobiology

Neurotrophic factors in Alzheimer’s disease: role of axonal transport

(2010) K. Schindowski et al.   GENES BRAIN AND BEHAVIOR

ProNGF Induces PTEN via p75NTR to Suppress Trk-Mediated Survival Signaling in Brain Neurons

(2010) W. Song et al.   JOURNAL OF NEUROSCIENCE

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling

(2010) Christian B Vaegter et al.   NATURE NEUROSCIENCE

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Preservation of cortical sortilin protein levels in MCI and Alzheimer's disease

(2010) Elliott J. Mufson et al.   NEUROSCIENCE LETTERS

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

Selective vulnerability in Alzheimer's disease: Amyloid precursor protein and p75NTRinteraction

(2009) Joanna Fombonne et al.   ANNALS OF NEUROLOGY

Interaction of Mint2 with TrkA Is Involved in Regulation of Nerve Growth Factor-induced Neurite Outgrowth

(2009) Yong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains

(2009) Robert Tamayev et al.   Molecular Neurodegeneration

Endogenous Aβ causes cell death via early tau hyperphosphorylation

(2009) G. Amadoro et al.   NEUROBIOLOGY OF AGING

Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system

(2008) Raya Al-Shawi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications

(2008) Elliott J Mufson et al.   Expert Review of Neurotherapeutics

Regulation of Amyloid β-Protein Precursor by Phosphorylation and Protein Interactions

(2008) Toshiharu Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HUMAN PRONGF: BIOLOGICAL EFFECTS AND BINDING PROFILES AT TRKA, P75NTRAND SORTILIN

(2008) Oliver Clewes et al.   JOURNAL OF NEUROCHEMISTRY

Chronic Exposure to Nerve Growth Factor Increases Acetylcholine and Glutamate Release from Cholinergic Neurons of the Rat Medial Septum and Diagonal Band of Broca via Mechanisms Mediated by p75NTR

(2008) C. Y. L. Huh et al.   JOURNAL OF NEUROSCIENCE

Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer's disease models

(2008) V. Corsetti et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

NGF and BDNF signaling control amyloidogenic route and A  production in hippocampal neurons

(2008) C. Matrone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA