Review
Biochemistry & Molecular Biology
Marta Valenza, Roberta Facchinetti, Giorgia Menegoni, Luca Steardo, Caterina Scuderi
Summary: Alzheimer's disease treatments are not curative, new approaches are needed. Astrocytes are targeted as a specific method. Studies suggest that palmitoylethanolamide may have a potential therapeutic effect by modulating astrocytes.
Article
Biochemistry & Molecular Biology
Sareer Ahmad, Myeung Hoon Jo, Muhammad Ikram, Amjad Khan, Myeong Ok Kim
Summary: The study revealed that Luteolin has protective effects against amyloid-beta-induced neuroinflammation, amyloidogenesis, and synaptic dysfunction in mice, potentially through inhibition of JNK signaling and modulation of inflammatory and cell death markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Bibin Anand, Qi Wu, Maryam Nakhaei-Nejad, Govindarajan Karthivashan, Lyudmyla Dorosh, Sara Amidian, Abhishek Dahal, Xiuju Li, Maria Stepanova, Holger Wille, Fabrizio Giuliani, Satyabrata Kar
Summary: Native PLGA nanoparticles show therapeutic potential in the treatment of Alzheimer's disease by suppressing aggregation of beta-amyloid peptides, triggering their disassembly, reducing phosphorylation of tau protein, enhancing neuronal viability, and attenuating memory deficits and A beta levels in animal models of AD.
BIOACTIVE MATERIALS
(2022)
Article
Neurosciences
Justin Lines, Andres M. Baraibar, Cenxiao Fang, Eduardo D. Martin, Juan Aguilar, Michael K. Lee, Alfonso Araque, Paulo Kofuji
Summary: Research has found that dysfunction of astrocyte networks in AD mice may dysregulate cortical electrical activity, leading to cognitive decline.
Article
Biochemistry & Molecular Biology
Amanda B. Chai, Anika M. S. Hartz, Xuexin Gao, Alryel Yang, Richard Callaghan, Ingrid C. Gelissen
Summary: P-glycoprotein (P-gp) has been found to assist in the export of Aβ from neurons and across the blood-brain barrier (BBB) endothelium. Molecular data confirm direct interaction between Aβ(40) and Aβ(42) peptide isoforms with P-gp, suggesting that enhancing P-gp function could be a potential therapeutic approach for Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Pallabi Sil Paul, Jae-Young Cho, Qi Wu, Govindarajan Karthivashan, Emily Grabovac, Holger Wille, Mariana Kulka, Satyabrata Kar
Summary: The study found that native PLGA can inhibit the aggregation of A beta peptides and disassemble existing aggregates, protecting neurons from toxicity associated with Alzheimer's disease pathology at temperatures outside the physiological range. These findings support the unique therapeutic potential of PLGA nanoparticles in the treatment of AD.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Cell Biology
Muhammad Ikram, Myeung Hoon Jo, Kyonghwan Choe, Amjad Khan, Sareer Ahmad, Kamran Saeed, Min Woo Kim, Myeong Ok Kim
Summary: Cycloastragenol demonstrated positive effects against oxidative stress, neurogenic dysfunction, MAP kinase activation, mitochondrial apoptosis, and memory impairment in an A beta-induced mouse model of Alzheimer's disease.
Article
Biochemistry & Molecular Biology
Fernanda dos Santos Petry, Juliana Bender Hoppe, Caroline Peres Klein, Bernardo Gindri dos Santos, Regis Mateus Hozer, Felippo Bifi, Cristiane Matte, Christianne Gazzana Salbego, Vera Maria Treis Trindade
Summary: This study evaluated the protective effect of genistein against Aβ(1-42)-induced cognitive impairment and elucidated some possible mechanisms involved in its neuroprotective effects in the hippocampus, including attenuation of synaptotoxicity, prevention of Tau hyperphosphorylation, and inactivation of ERK.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Engineering, Biomedical
Bibin G. Anand, Qi Wu, Govindarajan Karthivashan, Kiran P. Shejale, Sara Amidian, Holger Wille, Satyabrata Kar
Summary: The study showed that surface-functionalized gold nanoparticles with mimosine can inhibit Aβ aggregation and stabilize it in its monomeric state, reducing neuronal toxicity associated with AD. Additionally, MimoAuNPs can trigger the disassembly of mature Aβ fibers, presenting a potential therapeutic effect on AD-related pathologies.
BIOACTIVE MATERIALS
(2021)
Article
Clinical Neurology
Ling-Zhi Ma, Hao Hu, Zuo-Teng Wang, Ya-Nan Ou, Qiang Dong, Lan Tan, Jin-Tai Yu
Summary: The study found that early accumulation of A beta protein in Alzheimer's disease has an independent effect on cognitive decline in normal controls, but has a tau and neurodegeneration-dependent effect on subsequent cognitive decline in patients with mild cognitive impairment.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Victor Valverde-Salazar, Daniel Ruiz-Gabarre, Vega Garcia-Escudero
Summary: Alzheimer's disease (AD) is a common form of dementia characterized by memory decline, cognitive impairment, and several pathological changes in the brain. Oxidative stress and inflammation play important roles in the development of AD. Green tea and its active compound EGCG have shown potential therapeutic effects in modulating AD through their antioxidative and anti-inflammatory properties. EGCG can regulate inflammatory processes, reduce protein aggregation, and promote neuronal survival pathways, making it a suitable candidate for the treatment of neurodegenerative disorders involving oxidative stress and inflammation.
Article
Biochemistry & Molecular Biology
Amjad Khan, Jun Sung Park, Min Hwa Kang, Hyeon Jin Lee, Jawad Ali, Muhammad Tahir, Kyonghwan Choe, Myeong Ok Kim
Summary: Caffeic acid has the potential to be used as a therapeutic agent for Alzheimer's disease due to its antioxidant and cognitive-enhancing effects. It reduces oxidative stress, regulates the expression of related proteins, decreases inflammation markers, enhances synaptic markers, and reduces the expression of Alzheimer's disease-related proteins.
Article
Plant Sciences
Antonis Ververis, Kristia Ioannou, Sotiris Kyriakou, Niki Violaki, Mihalis I. Panayiotidis, Michael Plioukas, Kyproula Christodoulou
Summary: Alzheimer's disease (AD) is a prevalent neurodegenerative condition in aging populations with no effective therapy available. Recent research has focused on reducing the toxic amyloid beta aggregates and oxidative stress, which are closely associated with AD. Medicinal plants, such as Sideritis scardica (SS), have shown neuroprotective effects against AD. We investigated the antioxidant and neuroprotective potential of eight solvent fractions derived from SS and found that most fractions were rich in phenolics and flavonoids, with significant antioxidant activity. Four SS extracts were able to partially restore cell viability in A beta(25-35)-treated neuroblastoma cells, indicating their neuroprotective properties. These extracts contained neuroprotective substances like apigenin, myricetin-3-galactoside, and ellagic acid. The findings suggest that specific SS mixtures have potential for the development of herbal drugs and functional food products to alleviate AD symptoms.
Article
Biochemistry & Molecular Biology
David Vicente-Zurdo, Leonardo Brunetti, Luca Piemontese, Beatriz Guedes, Sandra M. Cardoso, Daniel Chavarria, Fernanda Borges, Yolanda Madrid, Silvia Chaves, M. Amelia Santos
Summary: A series of Rivastigmine-Benzimidazole (RIV-BIM) hybrids were found to have multitarget effects in combating Alzheimer's disease (AD). They exhibited antioxidant activity, acted as cholinesterase inhibitors, inhibited amyloid-beta aggregation, and chelated redox-active biometal ions. Furthermore, they showed remarkable inhibitory activity against monoamine oxidases and neuroprotective effects in human neuroblastoma cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Natalia Salvadores, Ines Moreno-Gonzalez, Nazaret Gamez, Gabriel Quiroz, Laura Vegas-Gomez, Marcela Escandon, Sebastian Jimenez, Javier Vitorica, Antonia Gutierrez, Claudio Soto, Felipe A. Court
Summary: Alzheimer's disease is a neurodegenerative condition with no available treatment. Amyloid-beta is identified as the main cause of the disease, and its burden correlates with markers of necroptosis activation. Inhibition of necroptosis reduces neurodegeneration and memory impairment caused by amyloid-beta. Activation of TNF-alpha signaling in neurons by amyloid-beta-stimulated microglia triggers extensive neurodegeneration, which can be protected by inhibiting necroptosis.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Neurosciences
Valentina Cecarini, Laura Bonfili, Massimiliano Cuccioloni, Jeffrey N. Keller, Annadora J. Bruce-Keller, Anna Maria Eleuteri
MOLECULAR NEUROBIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Kalavathi Dasuri, Jennifer K. Pepping, Sun-Ok Fernandez-Kim, Sunita Gupta, Jeffrey N. Keller, Philipp E. Scherer, Annadora J. Bruce-Keller
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2016)
Article
Biochemistry & Molecular Biology
Kalavathi Dasuri, Le Zhang, Sun O. K. Fernandez Kim, Annadora J. Bruce-Keller, Jeffrey N. Keller
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2016)
Article
Psychology, Clinical
Rebecca K. MacAulay, Matthew R. Calamia, Alex S. Cohen, Katrina Daigle, Heather Foil, Robert Brouillette, Annadora J. Bruce-Keller, Jeffrey N. Keller
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2018)
Article
Geriatrics & Gerontology
Stephen R. Rapp, Jose A. Luchsinger, Laura D. Baker, George L. Blackburn, Helen P. Hazuda, Kathryn E. Demos-McDermott, Robert W. Jeffery, Jeffrey N. Keller, Jeanne M. McCaffery, Nicholas M. Pajewski, Mary Evans, Thomas A. Wadden, Steven E. Arnold, Mark A. Espeland
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2017)
Article
Geriatrics & Gerontology
O. T. Carmichael, S. Pillai, P. Shankapal, A. McLellan, D. G. Kay, B. T. Gold, J. N. Keller
JOURNAL OF NUTRITION HEALTH & AGING
(2018)
Article
Psychology, Clinical
John P. K. Bernstein, Matthew Calamia, Jeffrey N. Keller
Article
Psychology, Clinical
Matthew Calamia, Alyssa De Vito, John P. K. Bernstein, Daniel S. Weitzner, Owen T. Carmichael, Jeffrey N. Keller
Article
Biochemistry & Molecular Biology
Le Zhang, Sun-Ok Fernandez-Kim, Tina L. Beckett, Dana M. Niedowicz, Katharina Kohler, Kalavathi Dasuri, Annadora J. Bruce-Keller, M. Paul Murphy, Jeffrey N. Keller
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2019)
Article
Medicine, Research & Experimental
Amanda N. Szabo-Reed, Eric Vidoni, Ellen F. Binder, Jeffrey Burns, C. Munro Cullum, William P. Gahan, Aditi Gupta, Linda S. Hynan, Diana R. Kerwin, Heidi Rossetti, Ann M. Stowe, Wanpen Vongpatanasin, David C. Zhu, Rong Zhang, Jeffrey N. Keller
CONTEMPORARY CLINICAL TRIALS
(2019)
Article
Geriatrics & Gerontology
John P. K. Bernstein, Alyssa De Vito, Daniel S. Weitzner, Rebecca MacAulay, Matthew Calamia, Robert Brouillette, Heather Foil, Owen T. Carmichael, Jeffrey N. Keller
Review
Neurosciences
Romina Maria Uranga, Jeffrey Neil Keller
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Medicine, General & Internal
H. Raymond Allen, Doug Boudreaux, Jeffrey N. Keller
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Nutrition & Dietetics
Candida J. Rebello, Stephen Boue, Ronald J. Levy, Renee Puyau, Robbie A. Beyl, Frank L. Greenway, Mark L. Heiman, Jeffrey N. Keller, Charles F. Reynolds, John P. Kirwan
Summary: This study examined the safety of soybean products in Western diets and conducted a dose-escalating clinical trial in older adults with obesity. The results showed that consuming less than 30g of soybean flour per day is beneficial for cardiovascular and overall health, and can reduce the dependence on other food groups and nutrients in older adults with obesity.
Article
Nutrition & Dietetics
Jolene Zheng, Mingming Wang, Wenqian Wei, Jeffrey N. Keller, Binita Adhikari, Jason F. King, Michael L. King, Nan Peng, Roger A. Laine
FRONTIERS IN NUTRITION
(2016)
Review
Biochemistry & Molecular Biology
M. T. Ciubuc-Batcu, N. J. C. Stapelberg, J. P. Headrick, G. M. C. Renshaw
Summary: The nervous system relies on mitochondria, and impaired mitochondrial function is associated with major depressive disorder. Modulating mitochondrial function may be a therapeutic target for treating MDD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Correction
Biochemistry & Molecular Biology
Saowaluk Saisomboon, Ryusho Kariya, Piyanard Boonnate, Kanlayanee Sawanyawisuth, Ubon Cha'on, Vor Luvira, Yaovalux Chamgramol, Chawalit Pairojkul, Wunchana Seubwai, Atit Silsirivanit, Sopit Wongkham, Seiji Okada, Sarawut Jitrapakdee, Kulthida Vaeteewoottacharn
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Pavan Thapak, Zhe Ying, Victoria Palafox-Sanchez, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla
Summary: Traumatic brain injury (TBI) impairs cellular energy demand, compromising neuronal function and plasticity. This study demonstrates that the mitochondrial activator humanin (HN) can counteract the reduction in mitochondrial bioenergetics caused by TBI, restore memory function and synaptic protein levels, and suppress inflammation and astrocyte proliferation. HN plays an integral role in normalizing fundamental aspects of TBI pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Paul Murphy, Valeria A. Buzinova, Carrie E. Johnson
Summary: Progress has been made in the treatment of Alzheimer's disease through the development of anti-A beta therapeutics, which have shown modest efficacy in slowing the progression of the disease. However, the puzzling issue remains as to why completely removing A beta does not fully stop the disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Mengxin Li, Xuanzhong Wang, Xuyang Chen, Jinghui Hong, Ye Du, Dong Song
Summary: Pancreatic adenocarcinoma (PAAD) is a common digestive malignant tumor with limited treatment options. This study demonstrates that TGM2 may serve as a marker for treatment and prognosis in pancreatic cancer patients. Co-treatment of low dose cisplatin (DDP) and the TGM2 inhibitor GK921 effectively inhibits PAAD cell viability and proliferation in vitro and in vivo, by inhibiting epithelial-to-mesenchymal transition (EMT) induced by TGM2 and enhancing cell cycle arrest and apoptosis caused by DDP. These findings suggest that the combination of GK921 and DDP holds promise as a treatment for PAAD patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Liaoran Niu, Qi Wang, Fan Feng, Wanli Yang, Zhenyu Xie, Gaozan Zheng, Wei Zhou, Lili Duan, Kunli Du, Yiding Li, Ye Tian, Junfeng Chen, Qibin Xie, Aqiang Fan, Hanjun Dan, Jinqiang Liu, Daiming Fan, Liu Hong, Jian Zhang, Jianyong Zheng
Summary: This review provides a comprehensive summary of the interaction between cancer cells and macrophages in the tumor microenvironment, and discusses the role of small extracellular vesicles (sEVs) in this process. It also explores the various effects of macrophage-secreted sEVs on tumor malignant transformation, and addresses the therapeutic advancements and challenges associated with these vesicles.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Neha Sawant, Sudhir Kshirsagar, P. Hemachandra Reddy, Arubala P. Reddy
Summary: Depression is a common neuropsychiatric comorbidity in Alzheimer's disease (AD) and other Tauopathies. Selective serotonin reuptake inhibitor (SSRI) treatment, such as Citalopram, not only has anti-depressive and anxiolytic effects, but also helps improve neurogenesis, reduce amyloid burden & Tau pathologies, and neuroinflammation in AD. In this study, Citalopram was found to reduce pathologically pTau level, increase synaptic gene expression and cytoskeletal structure, as well as improve cell survival, mitochondrial respiration, and mitochondrial morphology in cells expressing mutant APP and Tau. These findings suggest that Citalopram could be a promising therapeutic drug for treating depression and AD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Chen, Jiulin Tan, Chuan Yang, Zhiguo Ling, Jianzhong Xu, Dong Sun, Fei Luo
Summary: Bone is a self-healing organ that undergoes continuous regeneration through the cooperation of osteoclasts and osteoblasts. This study used ATAC-seq and RNA-Seq techniques to investigate the chromatin accessibility and transcriptomic landscape of osteoblast differentiation and mineralization. The results showed that global chromatin accessibility was extensively improved during osteoblastogenesis. Additionally, several transcription factors including MEF2A, PRRX1, Shox2, and HOXB13 were found to modulate the promoter accessibility of target genes during osteoblast differentiation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang
Summary: The study demonstrates that BCAA metabolism is involved in the development of colorectal cancer (CRC). BCAT2 deficiency promotes CRC progression by inhibiting BCAA metabolism and chronically activating the mTORC1 pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Chao Zheng, Lingling Liu, Caiyun Liu, Fengna Chu, Yue Lang, Shan Liu, Yan Mi, Jie Zhu, Tao Jin
Summary: Inducing tolerogenic dendritic cells (tDCs) with low RelB expression could effectively alleviate symptoms and reduce immune cell infiltration and demyelination in experimental autoimmune encephalomyelitis (EAE) mouse model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Hang Lam Li, Simei Go, Jung-Chin Chang, Arthur Verhoeven, Ronald Oude Elferink
Summary: This review highlights the distinct characteristics and crucial role of soluble adenylyl cyclase (sAC) in cellular processes, as well as recent significant advancements in the field of sAC research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Seco-Cervera, D. Ortiz-Masia, D. C. Macias-Ceja, S. Coll, L. Gisbert-Ferrandiz, J. Cosin-Roger, C. Bauset, M. Ortega, B. Heras-Moran, F. Navarro-Vicente, M. Millan, J. V. Esplugues, S. Calatayud, M. D. Barrachina
Summary: The study revealed the presence of resistance to apoptosis in complicated ileal Crohn's disease, with PDGFB inducing an ETS1-mediated resistance to apoptosis associated with an inflammatory and fibrogenic pattern of expression in intestinal fibroblasts. Potential targets against ileal fibrosis include PDGFRB, IL1R1, or MCL1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yunmeng Wang, Ping Cheng
Summary: Oncolytic viruses (OVs) are emerging as therapeutically relevant anticancer agents, especially when combined with genetically modified bispecific T cell engagers (BiTEs). This combination strategy can overcome the limitations of BiTEs alone and provide targeted cytotoxicity to solid tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Stephanie Tannous, Hassan Y. Naim
Summary: Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder caused by variants in the SI gene. A frameshift mutation called c.273_274delAG (p.Gly92Leufs*8) has been identified in CSID patients in Greenlandic population, which leads to loss of digestive function of SI. Surprisingly, the truncated mutant can still be located on the cell surface and interacts with wild type SI, negatively affecting its enzymatic function. Furthermore, heterozygote carriers of this mutation may also exhibit CSID symptoms.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)