Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer’s Disease Model Mice Targeting Beta-Amyloid Production
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Title
Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer’s Disease Model Mice Targeting Beta-Amyloid Production
Authors
Keywords
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Journal
Frontiers in Pharmacology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2017-03-08
DOI
10.3389/fphar.2017.00106
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Note: Only part of the references are listed.- PPARγ Co-Activator-1α (PGC-1α) Reduces Amyloid-β Generation Through a PPARγ-Dependent Mechanism
- (2018) Loukia Katsouri et al. JOURNAL OF ALZHEIMERS DISEASE
- Ginsenoside Re reduces Aβ production by activating PPARγ to inhibit BACE1 in N2a/APP695 cells
- (2016) Guoqiong Cao et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Outstanding Phenotypic Differences in the Profile of Amyloid-β between Tg2576 and APPswe/PS1dE9 Transgenic Mouse Models of Alzheimer’s Disease
- (2016) José Antonio Allué et al. JOURNAL OF ALZHEIMERS DISEASE
- Icariside II, a novel phosphodiesterase 5 inhibitor, protects against H2O2-induced PC12 cells death by inhibiting mitochondria-mediated autophagy
- (2016) Jianmei Gao et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Clozapine Improves Memory Impairment and Reduces Aβ Level in the Tg-APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease
- (2016) Yura Choi et al. MOLECULAR NEUROBIOLOGY
- Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease
- (2016) Wenzhong Yang et al. NEUROBIOLOGY OF AGING
- Icariside II protects against cerebral ischemia–reperfusion injury in rats via nuclear factor-κB inhibition and peroxisome proliferator-activated receptor up-regulation
- (2016) Yuanyuan Deng et al. NEUROCHEMISTRY INTERNATIONAL
- Morin reverses neuropathological and cognitive impairments in APPswe/PS1dE9 mice by targeting multiple pathogenic mechanisms
- (2016) Ying Du et al. NEUROPHARMACOLOGY
- Icariside II, a novel phosphodiesterase-5 inhibitor, attenuates streptozotocin-induced cognitive deficits in rats
- (2016) Caixia Yin et al. NEUROSCIENCE
- Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2α pathway in Alzheimer’s disease
- (2016) J.-S. Zhang et al. NEUROSCIENCE
- APP Is a Context-Sensitive Regulator of the Hippocampal Presynaptic Active Zone
- (2016) Melanie Laßek et al. PLoS Computational Biology
- The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy
- (2016) Urmi Sengupta et al. EBioMedicine
- Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: Phase 3 study
- (2015) Osama Sabri et al. Alzheimers & Dementia
- 2015 Alzheimer's disease facts and figures
- (2015) Alzheimers & Dementia
- Sodium Hydrosulfide Attenuates Beta-Amyloid-Induced Cognitive Deficits and Neuroinflammation via Modulation of MAPK/NF-κB Pathway in Rats
- (2015) Huiyu Liu et al. Current Alzheimer Research
- A review of biotransformation and pharmacology of ginsenoside compound K
- (2015) Xi-Ding Yang et al. FITOTERAPIA
- Changes in the expression of genes related to neuroinflammation over the course of sporadic Alzheimer’s disease progression: CX3CL1, TREM2, and PPARγ
- (2015) S. Strobel et al. JOURNAL OF NEURAL TRANSMISSION
- Increased Alzheimer's disease–like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy
- (2015) Gururaj Joshi et al. NEUROBIOLOGY OF AGING
- Icariin decreases both APP and Aβ levels and increases neurogenesis in the brain of Tg2576 mice
- (2015) F. Li et al. NEUROSCIENCE
- PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer
- (2015) Anindita Das et al. PHARMACOLOGY & THERAPEUTICS
- DL0410 can reverse cognitive impairment, synaptic loss and reduce plaque load in APP/PS1 transgenic mice
- (2015) Ran-Yao Yang et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain
- (2015) Paul Saftig et al. PROGRESS IN NEUROBIOLOGY
- β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s disease
- (2015) Xiaojuan Sun et al. Frontiers in Pharmacology
- Icariside II improves cerebral microcirculatory disturbance and alleviates hippocampal injury in gerbils after ischemia–reperfusion
- (2014) Ben-Yong Yan et al. BRAIN RESEARCH
- Icariin, a phoshphodiesterase-5 inhibitor, improves learning and memory in APP/PS1 transgenic mice by stimulation of NO/cGMP signalling
- (2014) Feng Jin et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects
- (2014) Robert Vassar et al. JOURNAL OF NEUROCHEMISTRY
- PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease
- (2014) Latha Devi et al. NEUROBIOLOGY OF AGING
- Hydrogen sulfide improves spatial memory impairment and decreases production of Aβ in APP/PS1 transgenic mice
- (2014) Xuan-li He et al. NEUROCHEMISTRY INTERNATIONAL
- Combotherapy and current concepts as well as future strategies for the treatment of Alzheimer's disease
- (2014) Ming-Jang Chiu et al. Neuropsychiatric Disease and Treatment
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- (2014) Natalia N. Nalivaeva et al. Frontiers in Aging Neuroscience
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- (2013) Maria C. Carrillo et al. Alzheimers & Dementia
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- (2013) Junfang Zhang et al. BEHAVIOURAL BRAIN RESEARCH
- Denervation of the Olfactory Bulb Leads to Decreased Aβ Plaque Load in a Transgenic Mouse Model of Alzheimer’ s Disease
- (2013) OIivier Bibari et al. Current Alzheimer Research
- Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both -Amyloid Production and Clearance
- (2013) Z. Zhu et al. JOURNAL OF NEUROSCIENCE
- ADAM10 Prodomain Mutations Cause Late-Onset Alzheimer’s Disease: Not Just the Latest FAD
- (2013) Robert Vassar NEURON
- Therapeutics of Alzheimer's disease: Past, present and future
- (2013) R. Anand et al. NEUROPHARMACOLOGY
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- Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5YAPP+Cells Through PPARγ Involvement
- (2013) Caterina Scuderi et al. PHYTOTHERAPY RESEARCH
- Deletion of the eIF2α Kinase GCN2 Fails to Rescue the Memory Decline Associated with Alzheimer’s Disease
- (2013) Latha Devi et al. PLoS One
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- (2013) Per Nilsson et al. Cell Reports
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- (2012) Ana García-Osta et al. ACS Chemical Neuroscience
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- (2012) Kazumi Motoki et al. Brain and Behavior
- Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease
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- (2010) Annica Sjölander et al. Molecular Neurodegeneration
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- (2009) D. Puzzo et al. JOURNAL OF NEUROSCIENCE
- Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis
- (2008) Tracy O'Connor et al. NEURON
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