Damage-associated molecular patterns in inflammatory bowel disease: From biomarkers to therapeutic targets

Emerging Roles of Calreticulin in Cancer: Implications for Therapy

(2018) Kavya Venkateswaran et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Mitochondrial DNA Is a Pro-Inflammatory Damage-Associated Molecular Pattern Released During Active IBD

(2018) Ray K Boyapati et al.   INFLAMMATORY BOWEL DISEASES

Multifunctional Role of 35 Kilodalton Hyaluronan in Promoting Defense of the Intestinal Epithelium

(2018) Sean P. Kessler et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?

(2018) Luiz E. B. Savio et al.   Frontiers in Pharmacology

Overview of the IL-1 family in innate inflammation and acquired immunity

(2017) Charles A. Dinarello   IMMUNOLOGICAL REVIEWS

VEN-120, a Recombinant Human Lactoferrin, Promotes a Regulatory T Cell [Treg] Phenotype and Drives Resolution of Inflammation in Distinct Murine Models of Inflammatory Bowel Disease

(2017) Christopher F MacManus et al.   Journal of Crohns & Colitis

Alarmins: Feel the Stress

(2017) Peleg Rider et al.   JOURNAL OF IMMUNOLOGY

Calreticulin promotes immunity and type I interferon-dependent survival in mice with acute myeloid leukemia

(2017) Xiufen Chen et al.   OncoImmunology

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

(2016) Damien Bertheloot et al.   Cellular & Molecular Immunology

Hypoxia inducible factor-1α-induced interleukin-33 expression in intestinal epithelia contributes to mucosal homeostasis in inflammatory bowel disease

(2016) M. Sun et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Innate immune memory: Implications for host responses to damage-associated molecular patterns

(2016) Tania O. Crișan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Drug development in IBD: from novel target identification to early clinical trials

(2016) Silvio Danese et al.   GUT

Fecal HMGB1 Reveals Microscopic Inflammation in Adult and Pediatric Patients with Inflammatory Bowel Disease in Clinical and Endoscopic Remission

(2016) Francesca Palone et al.   INFLAMMATORY BOWEL DISEASES

Fecal Calprotectin Measured By Patients at Home Using Smartphones—A New Clinical Tool in Monitoring Patients with Inflammatory Bowel Disease

(2016) Kristoffer Kofod Vinding et al.   INFLAMMATORY BOWEL DISEASES

Adeno-associated virus-mediated colonic secretory expression of HMGB1 A box attenuates experimental colitis in mice

(2016) Xiaoyan Zheng et al.   JOURNAL OF GENE MEDICINE

Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications

(2016) R K Boyapati et al.   Mucosal Immunology

Interleukin 1α and the inflammatory process

(2016) Nelson C Di Paolo et al.   NATURE IMMUNOLOGY

Loss of interleukin 33 expression in colonic crypts - a potential marker for disease remission in ulcerative colitis

(2016) Mona Dixon Gundersen et al.   Scientific Reports

Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages

(2016) Dawn Z Eichenfield et al.   eLife

The Epithelial Danger Signal IL-1α Is a Potent Activator of Fibroblasts and Reactivator of Intestinal Inflammation

(2015) Melania Scarpa et al.   AMERICAN JOURNAL OF PATHOLOGY

CD44 and TLR4 mediate hyaluronic acid regulation of Lgr5+ stem cell proliferation, crypt fission, and intestinal growth in postnatal and adult mice

(2015) Terrence E. Riehl et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Safety and Efficacy of an Oral Inhibitor of the Purinergic Receptor P2X7 in Adult Patients with Moderately to Severely Active Crohnʼs Disease

(2015) Alexander Eser et al.   INFLAMMATORY BOWEL DISEASES

Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation

(2015) Xiaorong Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate immune memory: a paradigm shift in understanding host defense

(2015) Mihai G Netea et al.   NATURE IMMUNOLOGY

Epidemiology and risk factors for IBD

(2015) Ashwin N. Ananthakrishnan   Nature Reviews Gastroenterology & Hepatology

Immunopathogenesis of IBD: current state of the art

(2015) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes

(2014) Siroon Bekkering et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Loss of calreticulin function decreases NFκB activity by stabilizing IκB protein

(2014) Hamid Massaeli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Overexpression of ATP-activated P2X7 Receptors in the Intestinal Mucosa Is Implicated in the Pathogenesis of Crohnʼs Disease

(2014) Adriane R. Neves et al.   INFLAMMATORY BOWEL DISEASES

Targeted Inhibition of Heat Shock Protein 90 Suppresses Tumor Necrosis Factor–α and Ameliorates Murine Intestinal Inflammation

(2014) Colm B. Collins et al.   INFLAMMATORY BOWEL DISEASES

Role of HMGB1 as a Suitable Biomarker of Subclinical Intestinal Inflammation and Mucosal Healing in Patients with Inflammatory Bowel Disease

(2014) Francesca Palone et al.   INFLAMMATORY BOWEL DISEASES

Innate immunity in myasthenia gravis thymus: Pathogenic effects of Toll-like receptor 4 signaling on autoimmunity

(2014) Chiara Cordiglieri et al.   JOURNAL OF AUTOIMMUNITY

Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

(2014) Liliana Schaefer   JOURNAL OF BIOLOGICAL CHEMISTRY

Lactoferrin Acts as an Alarmin to Promote the Recruitment and Activation of APCs and Antigen-Specific Immune Responses

(2014) G. de la Rosa et al.   JOURNAL OF IMMUNOLOGY

Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies

(2014) Tiago Nunes et al.   MEDIATORS OF INFLAMMATION

Purinergic signalling and immune cells

(2014) Geoffrey Burnstock et al.   Purinergic Signalling

The role and utility of faecal markers in inflammatory bowel disease

(2014) Frank S. Lehmann et al.   Therapeutic Advances in Gastroenterology

TLR-Dependent Human Mucosal Epithelial Cell Responses to Microbial Pathogens

(2014) Ryan McClure et al.   Frontiers in Immunology

Epithelial Calreticulin Up-Regulation Promotes Profibrotic Responses and Tubulointerstitial Fibrosis Development

(2013) Niki Prakoura et al.   AMERICAN JOURNAL OF PATHOLOGY

Phenotypic Transitions of Macrophages Orchestrate Tissue Repair

(2013) Margaret L. Novak et al.   AMERICAN JOURNAL OF PATHOLOGY

DAMPs and autophagy

(2013) Qiuhong Zhang et al.   Autophagy

Prophylactic systemic P2X7 receptor blockade prevents experimental colitis

(2013) Carla Caldas Marques et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Latent Enhancers Activated by Stimulation in Differentiated Cells

(2013) Renato Ostuni et al.   CELL

Trained innate immunity and atherosclerosis

(2013) Siroon Bekkering et al.   CURRENT OPINION IN LIPIDOLOGY

Danger-Associated Molecular Patterns and Inflammatory Bowel Disease: Is There a Connection?

(2013) Christoph Mueller   DIGESTIVE DISEASES

Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice

(2013) Marina Bersudsky et al.   GUT

Improving Relapse Prediction in Inflammatory Bowel Disease by Neutrophil-Derived S100A12

(2013) Jan Däbritz et al.   INFLAMMATORY BOWEL DISEASES

Metabolic control of hyaluronan synthases

(2013) Davide Vigetti et al.   MATRIX BIOLOGY

The role of pattern recognition receptors in intestinal inflammation

(2013) M Fukata et al.   Mucosal Immunology

Personalizing medicine for autoimmune and inflammatory diseases

(2013) Andrew C Chan et al.   NATURE IMMUNOLOGY

Extracellular ATP induces cell death in human intestinal epithelial cells

(2012) Carolina O. Souza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice

(2012) Mamdouh A K Sedhom et al.   GUT

HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

(2012) Helena Erlandsson Harris et al.   Nature Reviews Rheumatology

Faecal calprotectin - a useful tool in the management of inflammatory bowel disease

(2012) E Burri et al.   SWISS MEDICAL WEEKLY

Fecal HMGB1 Is a Novel Marker of Intestinal Mucosal Inflammation in Pediatric Inflammatory Bowel Disease

(2011) Roberta Vitali et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Trained Immunity: A Memory for Innate Host Defense

(2011) Mihai G. Netea et al.   Cell Host & Microbe

Endocytosis by target cells: an essential means for perforin- and granzyme-mediated killing

(2011) Claire Gordy et al.   Cellular & Molecular Immunology

Regulation of T cell activation by TLR ligands

(2011) Hans-Heinrich Oberg et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy

(2011) G. Tomasello et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

The Utility of Biomarkers in the Diagnosis and Therapy of Inflammatory Bowel Disease

(2011) James D. Lewis   GASTROENTEROLOGY

A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis

(2011) G. Y. Chen et al.   JOURNAL OF IMMUNOLOGY

Dangers Within: DAMP Responses to Damage and Cell Death in Kidney Disease

(2011) D. L. Rosin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

(2011) S. Normand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory Bowel Disease-Associated Interleukin-33 Is Preferentially Expressed in Ulceration-Associated Myofibroblasts

(2010) Jon Sponheim et al.   AMERICAN JOURNAL OF PATHOLOGY

HMGB proteins: Interactions with DNA and chromatin

(2010) Michal Štros   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Moderate performance of serum S100A12, in distinguishing inflammatory bowel disease from irritable bowel syndrome

(2010) Anastassios C Manolakis et al.   BMC GASTROENTEROLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Hsp60 and Hsp10 increase in colon mucosa of Crohn’s disease and ulcerative colitis

(2010) Vito Rodolico et al.   CELL STRESS & CHAPERONES

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

(2010) C. Bauer et al.   GUT

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

(2010) Jeremy Dupaul-Chicoine et al.   IMMUNITY

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

(2010) Simon A. Hirota et al.   INFLAMMATORY BOWEL DISEASES

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

Differential release of chromatin-bound IL-1  discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation

(2010) I. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of purinergic receptors and modulation of P2X7 function by the inflammatory cytokine IFNγ in human epithelial cells

(2009) Lynn Welter-Stahl et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD?

(2009) Lenka Frol’ová et al.   INFLAMMATION RESEARCH

Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells

(2009) Paul L. Bollyky et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis

(2009) Shaival H. Davé et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer

(2009) Jan M. Ehrchen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy

(2009) H. Jarvelainen et al.   PHARMACOLOGICAL REVIEWS

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Hyaluronan-Mediated Leukocyte Adhesion and Dextran Sulfate Sodium-Induced Colitis Are Attenuated in the Absence of Signal Transducer and Activator of Transcription 1

(2008) Sudip K. Bandyopadhyay et al.   AMERICAN JOURNAL OF PATHOLOGY

The Inflammatory Response to Cell Death

(2008) Kenneth L. Rock et al.   Annual Review of Pathology-Mechanisms of Disease

Enhanced ubiquitin-proteasome activity in calreticulin deficient cells: A compensatory mechanism for cell survival

(2008) Anton V. Uvarov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

(2008) Alexandra-Chloé Villani et al.   NATURE GENETICS

The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’?

(2008) Christine Moussion et al.   PLoS One

Discriminating IBD from IBS: Comparison of the test performance of fecal markers, blood leukocytes, CRP, and IBD antibodies

(2007) Alain M. Schoepfer et al.   INFLAMMATORY BOWEL DISEASES

Fecal S100A12 and fecal calprotectin as noninvasive markers for inflammatory bowel disease in children

(2007) Marc A. Sidler et al.   INFLAMMATORY BOWEL DISEASES